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The map label for this gene is uxuA

Identifier: 50843762

GI number: 50843762

Start: 2528080

End: 2529153

Strand: Reverse

Name: uxuA

Synonym: PPA2327

Alternate gene names: 50843762

Gene position: 2529153-2528080 (Counterclockwise)

Preceding gene: 50843763

Following gene: 50843761

Centisome position: 98.78

GC content: 52.98

Gene sequence:

>1074_bases
ATGAAGATGACGTTTCGATGGTATGGTGCAGAAACCGACCCCATCACGTTGGAGAATATCCGTCAGATTCCAGGAGTCAG
CGGAATCATGGGCGCGATGGACTGGATTCCGGTCGGTGAGATGTGGTCTGATGAGGAGATTTCTTCTTACGTCCGGAAAG
TCAATGACGCTGGTTTGGAATGTGAAGTCATTGAATCGGTGAACGTCCACGAAGACATCAAGCTTGGTAAGCCGTCTCGT
GACATTTACATCGCCAACTATTGCAAGACCCTAGAGAATCTTGCCGCCCATGGTATTAAGGTCGTTGTCTACAATTTCAT
GCCGGTATTTGACTGGCTACGCACCGAACTCTTCCATCGTAACGAGGACGGCTCAACCTGCTTGTACTACGACCACGAGG
AGCTTGTGGGTCTAACTCCGCAAGACATCGTCAAGGCCACTCTGGATTCGTCGGCCTTCCCACTACCCGGATGGGAGCCC
GAGCGGCTGGCCGATCTCGATGAGGTTATGGCCCAGTACACCGACATGCCCCGGGATCAGCTGCGCAATAACTACCGCTA
CTTCCTTGAGGGAATCGTGCCGACCTGTGAGAAGGTCGGTATTCGGATGGCCGTCCACCCTGATGATCCTGCCTGGGGCA
TTTTCGGAATTCCGCGTATCGTGCACAGTGATTCTGACCTGCAGAGGATCGTTGATCTGGTGAATTCCCCGGCCAACTCA
CTGTGCGTGTGCGCTGGATCGCTAGGTTCGAATCCCGACAATGACGTGCCGGCCATCCTCGCGAAATATGGAGATATGGG
ACGGGTTGCTGCCGCTCATGTCAGAAATGTGAAGTTTCTGGGGTCGAAAAAATTCAAGGAGGCCTCGCATCTTTCCAGCG
ACGGGTCCCTCGATATGTATGCGATCATGAAGTCTATTCACGATCATTGCTCGAATTCTTATATTCGTCCCGACCACGGT
CGGATGATCTGGGGTGAAACGGGTCGTCCTGGTTACCCGCTATATGACCGTGCTTTGGGAATCACCTATCTCAATGGCCT
GTGGGAGGCTATCGAGAAAGCTTCCGCGTATTGA

Upstream 100 bases:

>100_bases
CGATGACACCTTTATCTGACGTCGTTGAACGATTTTTTATCCGCCTAACAGCCGGTCCAGGTGCCGTAAGGTCGGTTCTG
GATGAGGAGTTTGCGTAATC

Downstream 100 bases:

>100_bases
GCCTGAGCACCACGGGAGATGACCGGATGTCCTCCGCGGTCGTGCCGCATTTGTGGGATGAAGGCCGTTGACGAGGGCAA
GTTCGGTCGCCTGCTGACGG

Product: mannonate dehydratase

Products: NA

Alternate protein names: D-mannonate hydrolase

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MKMTFRWYGAETDPITLENIRQIPGVSGIMGAMDWIPVGEMWSDEEISSYVRKVNDAGLECEVIESVNVHEDIKLGKPSR
DIYIANYCKTLENLAAHGIKVVVYNFMPVFDWLRTELFHRNEDGSTCLYYDHEELVGLTPQDIVKATLDSSAFPLPGWEP
ERLADLDEVMAQYTDMPRDQLRNNYRYFLEGIVPTCEKVGIRMAVHPDDPAWGIFGIPRIVHSDSDLQRIVDLVNSPANS
LCVCAGSLGSNPDNDVPAILAKYGDMGRVAAAHVRNVKFLGSKKFKEASHLSSDGSLDMYAIMKSIHDHCSNSYIRPDHG
RMIWGETGRPGYPLYDRALGITYLNGLWEAIEKASAY

Sequences:

>Translated_357_residues
MKMTFRWYGAETDPITLENIRQIPGVSGIMGAMDWIPVGEMWSDEEISSYVRKVNDAGLECEVIESVNVHEDIKLGKPSR
DIYIANYCKTLENLAAHGIKVVVYNFMPVFDWLRTELFHRNEDGSTCLYYDHEELVGLTPQDIVKATLDSSAFPLPGWEP
ERLADLDEVMAQYTDMPRDQLRNNYRYFLEGIVPTCEKVGIRMAVHPDDPAWGIFGIPRIVHSDSDLQRIVDLVNSPANS
LCVCAGSLGSNPDNDVPAILAKYGDMGRVAAAHVRNVKFLGSKKFKEASHLSSDGSLDMYAIMKSIHDHCSNSYIRPDHG
RMIWGETGRPGYPLYDRALGITYLNGLWEAIEKASAY
>Mature_357_residues
MKMTFRWYGAETDPITLENIRQIPGVSGIMGAMDWIPVGEMWSDEEISSYVRKVNDAGLECEVIESVNVHEDIKLGKPSR
DIYIANYCKTLENLAAHGIKVVVYNFMPVFDWLRTELFHRNEDGSTCLYYDHEELVGLTPQDIVKATLDSSAFPLPGWEP
ERLADLDEVMAQYTDMPRDQLRNNYRYFLEGIVPTCEKVGIRMAVHPDDPAWGIFGIPRIVHSDSDLQRIVDLVNSPANS
LCVCAGSLGSNPDNDVPAILAKYGDMGRVAAAHVRNVKFLGSKKFKEASHLSSDGSLDMYAIMKSIHDHCSNSYIRPDHG
RMIWGETGRPGYPLYDRALGITYLNGLWEAIEKASAY

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG1312

COG function: function code G; D-mannonate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannonate dehydratase family

Homologues:

Organism=Escherichia coli, GI1790778, Length=396, Percent_Identity=37.1212121212121, Blast_Score=234, Evalue=5e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UXUA_PROAC (Q6A5D2)

Other databases:

- EMBL:   AE017283
- RefSeq:   YP_056989.1
- ProteinModelPortal:   Q6A5D2
- SMR:   Q6A5D2
- GeneID:   2931920
- GenomeReviews:   AE017283_GR
- KEGG:   pac:PPA2327
- NMPDR:   fig|267747.1.peg.2266
- HOGENOM:   HBG585927
- OMA:   DIKLGKP
- ProtClustDB:   PRK03906
- BioCyc:   PACN267747:PPA2327-MONOMER
- BRENDA:   4.2.1.8
- HAMAP:   MF_00106
- InterPro:   IPR004628
- InterPro:   IPR013022
- Gene3D:   G3DSA:3.20.20.150
- PIRSF:   PIRSF016049
- TIGRFAMs:   TIGR00695

Pfam domain/function: PF03786 UxuA; SSF51658 Xyl_isomerase-like_TIM-brl

EC number: =4.2.1.8

Molecular weight: Translated: 40130; Mature: 40130

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMTFRWYGAETDPITLENIRQIPGVSGIMGAMDWIPVGEMWSDEEISSYVRKVNDAGLE
CCEEEEECCCCCCCEEHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCE
CEVIESVNVHEDIKLGKPSRDIYIANYCKTLENLAAHGIKVVVYNFMPVFDWLRTELFHR
EEEECCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHC
NEDGSTCLYYDHEELVGLTPQDIVKATLDSSAFPLPGWEPERLADLDEVMAQYTDMPRDQ
CCCCCEEEEECHHHHHCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHH
LRNNYRYFLEGIVPTCEKVGIRMAVHPDDPAWGIFGIPRIVHSDSDLQRIVDLVNSPANS
HHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCHHHCCCHHHHHHHHHHCCCCCC
LCVCAGSLGSNPDNDVPAILAKYGDMGRVAAAHVRNVKFLGSKKFKEASHLSSDGSLDMY
EEEEECCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHH
AIMKSIHDHCSNSYIRPDHGRMIWGETGRPGYPLYDRALGITYLNGLWEAIEKASAY
HHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKMTFRWYGAETDPITLENIRQIPGVSGIMGAMDWIPVGEMWSDEEISSYVRKVNDAGLE
CCEEEEECCCCCCCEEHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCE
CEVIESVNVHEDIKLGKPSRDIYIANYCKTLENLAAHGIKVVVYNFMPVFDWLRTELFHR
EEEECCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHC
NEDGSTCLYYDHEELVGLTPQDIVKATLDSSAFPLPGWEPERLADLDEVMAQYTDMPRDQ
CCCCCEEEEECHHHHHCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHH
LRNNYRYFLEGIVPTCEKVGIRMAVHPDDPAWGIFGIPRIVHSDSDLQRIVDLVNSPANS
HHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCHHHCCCHHHHHHHHHHCCCCCC
LCVCAGSLGSNPDNDVPAILAKYGDMGRVAAAHVRNVKFLGSKKFKEASHLSSDGSLDMY
EEEEECCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHH
AIMKSIHDHCSNSYIRPDHGRMIWGETGRPGYPLYDRALGITYLNGLWEAIEKASAY
HHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA