Click here to switch to the map view.

The map label for this gene is cycA [H]

Identifier: 50843721

GI number: 50843721

Start: 2478067

End: 2479581

Strand: Direct

Name: cycA [H]

Synonym: PPA2284

Alternate gene names: 50843721

Gene position: 2478067-2479581 (Clockwise)

Preceding gene: 50843720

Following gene: 50843722

Centisome position: 96.79

GC content: 56.9

Gene sequence:

>1515_bases
ATGACTGGTTTTAACCAGATTCCAGATAGGGAGCGGTACCCGCACGCATTGGCGTCAAACGAGCACCGCGGCTTGACTGC
ACAGGAACCTGAATCGTCGCCATCCAGCCCCCACCCAGAGGCCCATCTGCATCGCAACCTGAACAACCGTCACATTCAGC
TCATCGCCATCGGTGGGGCTATCGGAACCGGACTGTTCCTAGGCTCTGGCAAAGCCATCCGCGCCGCCGGCCCTAGCATC
ATCGTGTCGTACCTCATCATCGGTACCATGCTTTATTTCGTCGTCAGGGCTATGGGCGAGTTGCTCATGTATAACCTCGA
CTACAAGAGTTTCCAAGACTTCGCAGCTGACCTGATCGGCCCTTGGGCTGGATTCTTTCTGGGGTGGACGTATTGGCTTT
GTTGGATCGTCACCGGTATGGCTGAGCTCATTGGAATTACAACCTATTGGGACTTCTGGGTTAAGAATAGAGGGACTGCA
GCTCTGCTCGCAGCCGCCACATTGTTTCTCCTACTCTGTTTAAATCTGCTCACCGTAAGGATGTTTGGAGAGTTAGAATT
CTGGTTTGCGCTCATCAAGATCATCGCGATTATTTCCCTCATCGTCCTCGCCATCGTGCTGGCGGTCATGAAGTTCCAGT
TTCCGTCGGGAAGCATGGCATCCGTGGCCAACCTGTGGAACCGTGGCGGCTTCATGCCCAACGGCTGGAGTGGGTTCTTC
GCTGGTTTTCAGATGGCAGCATTCGCGTTTGTGGGAATCGAGCTCATCGGGACCACCGCCGCCGAGACACGGGATCCCGA
GAAGACCCTGCCTCGGGCTATCAGCGCCGTCCCCGCTCGAATCCTCATCTTTTATGTCGGTGCCCTGCTCGCGATCATGA
CTGCCGTTCCGTGGGACGAGGTCCGGGCAGATTCCTCCCCGTTCGTGCAGGTTCTCGGGCTAGTTGGATTCGCTGGTGCA
GCTAGCGTGATGAATTTCGTCGTCCTGACATCGGCAGCCTCGTCGTCTAACTCTGGGATTTACTCCATCTCAAGAATGCT
TTTCGGACTCGCTCACAAGCGCATGGCGCCGAAGGTGTTCGGCGGACTCAGTAAGAACGGCGTCCCCCGCTGGGGCCTCG
TCATCACTGTCCTGGTCCTGAGCACGGCACTACTCCTAGCCGCATCAGAGTCGTTTGTCGAGGCATTCACCCTCGTGACG
ACAATTTCGTCGGTACTATTCATCTTCGTCTGGAGCATGATCGTCATCAGCTACATGAAATACCGCAGGGTTGCTCCCGC
AGCCCATGCTGCATCGAAGTACCCCATGCCTGGAGGTCGCGGCATGTGCTGGGCCGTGTTGGTGTTCTTCGTGTTCGTCC
TCGTGTTGCTGGCCCAGGAAGCCGACACTGCGCGAGCTCTGGCCCTCACACCAATATGGTTTGTCATCCTCGGCGTCGGC
TGGTTCTTCGACCGCCACCACGCTACCCATGACGACGTAGGCACCGACGAGGCCCATCCGAAGGGAGATAGCTAA

Upstream 100 bases:

>100_bases
TTACACTGCAATAAATCGCGTCGCGGCAAGTTGAGTCATCGTCGATTCAGCCTCATCGCGCGCCCCTGATCTTGGTGATC
GTTTTTAGGAGACGATTGAT

Downstream 100 bases:

>100_bases
GTGACGATAATCGTCAGGCACGGTTCCACCTGAACGCCGTGCCTGCGCCGCAGTTCTCTACTACCGACCCTCAATCCTCA
GGTTTTACTTTTCTATCCCC

Product: D-serine/D-alanine/glycine transporter

Products: D-glycine [Cytoplasm]; D-alanine [Cytoplasm]; Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 504; Mature: 503

Protein sequence:

>504_residues
MTGFNQIPDRERYPHALASNEHRGLTAQEPESSPSSPHPEAHLHRNLNNRHIQLIAIGGAIGTGLFLGSGKAIRAAGPSI
IVSYLIIGTMLYFVVRAMGELLMYNLDYKSFQDFAADLIGPWAGFFLGWTYWLCWIVTGMAELIGITTYWDFWVKNRGTA
ALLAAATLFLLLCLNLLTVRMFGELEFWFALIKIIAIISLIVLAIVLAVMKFQFPSGSMASVANLWNRGGFMPNGWSGFF
AGFQMAAFAFVGIELIGTTAAETRDPEKTLPRAISAVPARILIFYVGALLAIMTAVPWDEVRADSSPFVQVLGLVGFAGA
ASVMNFVVLTSAASSSNSGIYSISRMLFGLAHKRMAPKVFGGLSKNGVPRWGLVITVLVLSTALLLAASESFVEAFTLVT
TISSVLFIFVWSMIVISYMKYRRVAPAAHAASKYPMPGGRGMCWAVLVFFVFVLVLLAQEADTARALALTPIWFVILGVG
WFFDRHHATHDDVGTDEAHPKGDS

Sequences:

>Translated_504_residues
MTGFNQIPDRERYPHALASNEHRGLTAQEPESSPSSPHPEAHLHRNLNNRHIQLIAIGGAIGTGLFLGSGKAIRAAGPSI
IVSYLIIGTMLYFVVRAMGELLMYNLDYKSFQDFAADLIGPWAGFFLGWTYWLCWIVTGMAELIGITTYWDFWVKNRGTA
ALLAAATLFLLLCLNLLTVRMFGELEFWFALIKIIAIISLIVLAIVLAVMKFQFPSGSMASVANLWNRGGFMPNGWSGFF
AGFQMAAFAFVGIELIGTTAAETRDPEKTLPRAISAVPARILIFYVGALLAIMTAVPWDEVRADSSPFVQVLGLVGFAGA
ASVMNFVVLTSAASSSNSGIYSISRMLFGLAHKRMAPKVFGGLSKNGVPRWGLVITVLVLSTALLLAASESFVEAFTLVT
TISSVLFIFVWSMIVISYMKYRRVAPAAHAASKYPMPGGRGMCWAVLVFFVFVLVLLAQEADTARALALTPIWFVILGVG
WFFDRHHATHDDVGTDEAHPKGDS
>Mature_503_residues
TGFNQIPDRERYPHALASNEHRGLTAQEPESSPSSPHPEAHLHRNLNNRHIQLIAIGGAIGTGLFLGSGKAIRAAGPSII
VSYLIIGTMLYFVVRAMGELLMYNLDYKSFQDFAADLIGPWAGFFLGWTYWLCWIVTGMAELIGITTYWDFWVKNRGTAA
LLAAATLFLLLCLNLLTVRMFGELEFWFALIKIIAIISLIVLAIVLAVMKFQFPSGSMASVANLWNRGGFMPNGWSGFFA
GFQMAAFAFVGIELIGTTAAETRDPEKTLPRAISAVPARILIFYVGALLAIMTAVPWDEVRADSSPFVQVLGLVGFAGAA
SVMNFVVLTSAASSSNSGIYSISRMLFGLAHKRMAPKVFGGLSKNGVPRWGLVITVLVLSTALLLAASESFVEAFTLVTT
ISSVLFIFVWSMIVISYMKYRRVAPAAHAASKYPMPGGRGMCWAVLVFFVFVLVLLAQEADTARALALTPIWFVILGVGW
FFDRHHATHDDVGTDEAHPKGDS

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI181337167, Length=317, Percent_Identity=24.2902208201893, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI110347453, Length=347, Percent_Identity=24.7838616714697, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI4507047, Length=347, Percent_Identity=23.6311239193084, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI1790653, Length=445, Percent_Identity=60.2247191011236, Blast_Score=548, Evalue=1e-157,
Organism=Escherichia coli, GI1786302, Length=457, Percent_Identity=39.8249452954048, Blast_Score=325, Evalue=4e-90,
Organism=Escherichia coli, GI1786602, Length=453, Percent_Identity=39.514348785872, Blast_Score=317, Evalue=1e-87,
Organism=Escherichia coli, GI1786789, Length=453, Percent_Identity=39.514348785872, Blast_Score=310, Evalue=1e-85,
Organism=Escherichia coli, GI48994972, Length=466, Percent_Identity=35.1931330472103, Blast_Score=268, Evalue=7e-73,
Organism=Escherichia coli, GI87081915, Length=472, Percent_Identity=34.5338983050847, Blast_Score=259, Evalue=4e-70,
Organism=Escherichia coli, GI1788480, Length=444, Percent_Identity=34.2342342342342, Blast_Score=221, Evalue=6e-59,
Organism=Escherichia coli, GI1789017, Length=429, Percent_Identity=32.4009324009324, Blast_Score=212, Evalue=6e-56,
Organism=Escherichia coli, GI87081708, Length=394, Percent_Identity=32.2335025380711, Blast_Score=201, Evalue=7e-53,
Organism=Caenorhabditis elegans, GI17531343, Length=437, Percent_Identity=22.6544622425629, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17533459, Length=424, Percent_Identity=23.1132075471698, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322892, Length=434, Percent_Identity=31.5668202764977, Blast_Score=195, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6324061, Length=407, Percent_Identity=31.9410319410319, Blast_Score=193, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6320772, Length=424, Percent_Identity=32.0754716981132, Blast_Score=192, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6324924, Length=425, Percent_Identity=30.8235294117647, Blast_Score=178, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6321629, Length=475, Percent_Identity=29.4736842105263, Blast_Score=173, Evalue=6e-44,
Organism=Saccharomyces cerevisiae, GI6324059, Length=484, Percent_Identity=31.198347107438, Blast_Score=170, Evalue=5e-43,
Organism=Saccharomyces cerevisiae, GI6324990, Length=450, Percent_Identity=27.1111111111111, Blast_Score=168, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6319824, Length=417, Percent_Identity=28.537170263789, Blast_Score=159, Evalue=7e-40,
Organism=Saccharomyces cerevisiae, GI6324553, Length=390, Percent_Identity=31.5384615384615, Blast_Score=159, Evalue=9e-40,
Organism=Saccharomyces cerevisiae, GI6319543, Length=424, Percent_Identity=27.8301886792453, Blast_Score=155, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6320717, Length=409, Percent_Identity=26.4058679706601, Blast_Score=155, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6322967, Length=402, Percent_Identity=30.0995024875622, Blast_Score=146, Evalue=8e-36,
Organism=Saccharomyces cerevisiae, GI6321053, Length=437, Percent_Identity=25.858123569794, Blast_Score=144, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6320251, Length=421, Percent_Identity=26.3657957244656, Blast_Score=143, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6319608, Length=428, Percent_Identity=27.3364485981308, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6319542, Length=446, Percent_Identity=24.8878923766816, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6324981, Length=421, Percent_Identity=28.978622327791, Blast_Score=130, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6320364, Length=474, Percent_Identity=25.1054852320675, Blast_Score=112, Evalue=1e-25,
Organism=Drosophila melanogaster, GI221512776, Length=375, Percent_Identity=23.4666666666667, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24666159, Length=375, Percent_Identity=23.4666666666667, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24668806, Length=314, Percent_Identity=25.4777070063694, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI21356285, Length=314, Percent_Identity=25.4777070063694, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24668802, Length=314, Percent_Identity=25.4777070063694, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI161077963, Length=437, Percent_Identity=23.5697940503432, Blast_Score=79, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24667468, Length=430, Percent_Identity=22.5581395348837, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 54950; Mature: 54819

Theoretical pI: Translated: 8.73; Mature: 8.73

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGFNQIPDRERYPHALASNEHRGLTAQEPESSPSSPHPEAHLHRNLNNRHIQLIAIGGA
CCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCEEEEEEECCH
IGTGLFLGSGKAIRAAGPSIIVSYLIIGTMLYFVVRAMGELLMYNLDYKSFQDFAADLIG
HHHHEEECCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
PWAGFFLGWTYWLCWIVTGMAELIGITTYWDFWVKNRGTAALLAAATLFLLLCLNLLTVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
MFGELEFWFALIKIIAIISLIVLAIVLAVMKFQFPSGSMASVANLWNRGGFMPNGWSGFF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCHHHHH
AGFQMAAFAFVGIELIGTTAAETRDPEKTLPRAISAVPARILIFYVGALLAIMTAVPWDE
HHHHHHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
VRADSSPFVQVLGLVGFAGAASVMNFVVLTSAASSSNSGIYSISRMLFGLAHKRMAPKVF
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCHHHH
GGLSKNGVPRWGLVITVLVLSTALLLAASESFVEAFTLVTTISSVLFIFVWSMIVISYMK
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YRRVAPAAHAASKYPMPGGRGMCWAVLVFFVFVLVLLAQEADTARALALTPIWFVILGVG
HHHHCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
WFFDRHHATHDDVGTDEAHPKGDS
HHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TGFNQIPDRERYPHALASNEHRGLTAQEPESSPSSPHPEAHLHRNLNNRHIQLIAIGGA
CCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCEEEEEEECCH
IGTGLFLGSGKAIRAAGPSIIVSYLIIGTMLYFVVRAMGELLMYNLDYKSFQDFAADLIG
HHHHEEECCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
PWAGFFLGWTYWLCWIVTGMAELIGITTYWDFWVKNRGTAALLAAATLFLLLCLNLLTVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
MFGELEFWFALIKIIAIISLIVLAIVLAVMKFQFPSGSMASVANLWNRGGFMPNGWSGFF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCHHHHH
AGFQMAAFAFVGIELIGTTAAETRDPEKTLPRAISAVPARILIFYVGALLAIMTAVPWDE
HHHHHHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
VRADSSPFVQVLGLVGFAGAASVMNFVVLTSAASSSNSGIYSISRMLFGLAHKRMAPKVF
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCHHHH
GGLSKNGVPRWGLVITVLVLSTALLLAASESFVEAFTLVTTISSVLFIFVWSMIVISYMK
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YRRVAPAAHAASKYPMPGGRGMCWAVLVFFVFVLVLLAQEADTARALALTPIWFVILGVG
HHHHCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
WFFDRHHATHDDVGTDEAHPKGDS
HHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-glycine [Periplasm]; D-alanine [Periplasm]; Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-glycine [Periplasm] = Proton [Cytoplasm] + D-glycine [Cytoplasm] Proton [Periplasm] + D-alanine [Periplasm] = Proton [Cytoplasm] + D-alanine [Cytoplasm] Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cyto

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]