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The map label for this gene is cycA [H]

Identifier: 50843720

GI number: 50843720

Start: 2476228

End: 2477703

Strand: Direct

Name: cycA [H]

Synonym: PPA2283

Alternate gene names: 50843720

Gene position: 2476228-2477703 (Clockwise)

Preceding gene: 50843719

Following gene: 50843721

Centisome position: 96.72

GC content: 58.47

Gene sequence:

>1476_bases
GTGAGTGCACGAGAAACGCAATCCGTCGACACACCGCGCCGCAGCGCCTTGGCCAGACCCGTGAAGAAACCGCCAGCCAC
TCTCGACCTGGAAAGCCCCACAGAGGAGCGCGAGCTACAACGCGGGCTGACCAACCGTCACCTACAGCTCATTGCTTTGG
GCGGTGCCATCGGCACCGGAATGTTCATGGGATCCAGCAGCACCATCCACCTTGCTGGCCCATCTAGTGCTCTCGTCTAC
GCTCTCATTGGGTTTTTCCTCTATTTCATGATGCGAGCCCTCGGTGAGATGCTGCTGTCCAATCTCAACTACAAGTCTTT
CCGAGATATCGCTGAGGACCTACTTGGCCCAGCTGGTGGTTTTATCGCCGGCTGGACGTATTGGTTCTCGTGGATCGTGG
CCGCCATGGGCGACATGGCCGCTATTACCGCCTACTTCCAATATTGGTGGCCGAATATCCCAAAGTGGCTACCCGCAACC
GCCCTGGCCGCTGTCCTCCTCGCCCTCAACATCATTGCCGTGCAGTTCTTTGGTGAAGCCGAATTCTGGTTCGCCCTCAT
CAAGCTCATCGCGGTCGGCGCGCTGGTCATTGTCGCCATCGCGCTGTTGGCAAGCCGCTTCGTCTCCCCTGACGGTGACC
CCGCTACTATCGCCAACCTGTGGAATGATGGCGGTTTCTTCCCCAACGGCCTGATGGGCTTCCTTGGTGGCTTCCAAATC
GCGTTCTTCGCCTTCGTCGGCATCGAACTCGTTGGTACTGCTGCCGCTGAAACTAAGGATCCTTGCACCACTCTCCCAAA
GGCGATCAATGCCATCCCGGTGCGGCTTGCCCTGTTCTACGTGTTCGCCCTGCTTGCTATTACCGCTGTCATTCCGTGGC
GCAAAGTCGTGCCCGGGGTAAGCCCCTTCGTGTCGCTGTTCGGCTTGGCGGGCTTCGGCGCAGCTGCCAGTGTGATGAAC
TTCGTCCTGCTTACCGCTGCGGCGTCCTCGGATAACTCTGGTCTGTATTCGACCTCACGAATGATGTACGGCTTAGCTCT
CGACGGTCAGGCTCCCTCGCGGTTCCGAAAACTGTCGAGTAACAACGTGCCACGCAACGCACTCGTCGCTTCGTGCCTGC
TGCTGCTAAGCGGCATCACTTTCCTCTACACCTCGGATTCGATCATGCAGGCCTTCGCCCTGGTGACGACAGTTGCCGCC
CTGCTGTTCCTTTTCACCTGGTCACTCATCGTTGTGTGCTACATCGTGTACCGCCGCAAGCGCCCACAGCTCCACGAAGA
GTCCATCTACAAGATGCCTGGTGGCGTCCCCATGTGCTGGGTTGTGCTGGCCTTCTTCACCATCAGCCTGGTCATTCTTA
CCTTGGACCCAACCACTCGGATCGCAGTGCTCATCACCCCGATCTGGTTCGCGTTCATCGGATCGATGTACTTCGTGCAC
CACCGCCACGAACAGCGTAAAGAGGCGCTGCGCTAA

Upstream 100 bases:

>100_bases
TACTCGCCACCGCCACCTCCTCTGCTGTGTGGAAGGCAGCGGCCACTCCCCATCGCCTATGAGGCGACCATCATCACCTT
CACCGAACAAAGGAGTTCCT

Downstream 100 bases:

>100_bases
TTTTTACCGTCACCCCAGCGCCGCAGGCACGCCACATGCTCGCCAGGCCGGGGCTCGGGGATTTTTACGTGAACCGAGGT
GACGCGGTTGACTGCGCACT

Product: D-serine/D-alanine/glycine transporter

Products: D-glycine [Cytoplasm]; D-alanine [Cytoplasm]; Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 491; Mature: 490

Protein sequence:

>491_residues
MSARETQSVDTPRRSALARPVKKPPATLDLESPTEERELQRGLTNRHLQLIALGGAIGTGMFMGSSSTIHLAGPSSALVY
ALIGFFLYFMMRALGEMLLSNLNYKSFRDIAEDLLGPAGGFIAGWTYWFSWIVAAMGDMAAITAYFQYWWPNIPKWLPAT
ALAAVLLALNIIAVQFFGEAEFWFALIKLIAVGALVIVAIALLASRFVSPDGDPATIANLWNDGGFFPNGLMGFLGGFQI
AFFAFVGIELVGTAAAETKDPCTTLPKAINAIPVRLALFYVFALLAITAVIPWRKVVPGVSPFVSLFGLAGFGAAASVMN
FVLLTAAASSDNSGLYSTSRMMYGLALDGQAPSRFRKLSSNNVPRNALVASCLLLLSGITFLYTSDSIMQAFALVTTVAA
LLFLFTWSLIVVCYIVYRRKRPQLHEESIYKMPGGVPMCWVVLAFFTISLVILTLDPTTRIAVLITPIWFAFIGSMYFVH
HRHEQRKEALR

Sequences:

>Translated_491_residues
MSARETQSVDTPRRSALARPVKKPPATLDLESPTEERELQRGLTNRHLQLIALGGAIGTGMFMGSSSTIHLAGPSSALVY
ALIGFFLYFMMRALGEMLLSNLNYKSFRDIAEDLLGPAGGFIAGWTYWFSWIVAAMGDMAAITAYFQYWWPNIPKWLPAT
ALAAVLLALNIIAVQFFGEAEFWFALIKLIAVGALVIVAIALLASRFVSPDGDPATIANLWNDGGFFPNGLMGFLGGFQI
AFFAFVGIELVGTAAAETKDPCTTLPKAINAIPVRLALFYVFALLAITAVIPWRKVVPGVSPFVSLFGLAGFGAAASVMN
FVLLTAAASSDNSGLYSTSRMMYGLALDGQAPSRFRKLSSNNVPRNALVASCLLLLSGITFLYTSDSIMQAFALVTTVAA
LLFLFTWSLIVVCYIVYRRKRPQLHEESIYKMPGGVPMCWVVLAFFTISLVILTLDPTTRIAVLITPIWFAFIGSMYFVH
HRHEQRKEALR
>Mature_490_residues
SARETQSVDTPRRSALARPVKKPPATLDLESPTEERELQRGLTNRHLQLIALGGAIGTGMFMGSSSTIHLAGPSSALVYA
LIGFFLYFMMRALGEMLLSNLNYKSFRDIAEDLLGPAGGFIAGWTYWFSWIVAAMGDMAAITAYFQYWWPNIPKWLPATA
LAAVLLALNIIAVQFFGEAEFWFALIKLIAVGALVIVAIALLASRFVSPDGDPATIANLWNDGGFFPNGLMGFLGGFQIA
FFAFVGIELVGTAAAETKDPCTTLPKAINAIPVRLALFYVFALLAITAVIPWRKVVPGVSPFVSLFGLAGFGAAASVMNF
VLLTAAASSDNSGLYSTSRMMYGLALDGQAPSRFRKLSSNNVPRNALVASCLLLLSGITFLYTSDSIMQAFALVTTVAAL
LFLFTWSLIVVCYIVYRRKRPQLHEESIYKMPGGVPMCWVVLAFFTISLVILTLDPTTRIAVLITPIWFAFIGSMYFVHH
RHEQRKEALR

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI181337167, Length=439, Percent_Identity=24.8291571753986, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI110347453, Length=361, Percent_Identity=24.0997229916898, Blast_Score=70, Evalue=6e-12,
Organism=Escherichia coli, GI1790653, Length=454, Percent_Identity=57.488986784141, Blast_Score=548, Evalue=1e-157,
Organism=Escherichia coli, GI1786302, Length=462, Percent_Identity=37.2294372294372, Blast_Score=315, Evalue=5e-87,
Organism=Escherichia coli, GI1786789, Length=470, Percent_Identity=35.3191489361702, Blast_Score=303, Evalue=2e-83,
Organism=Escherichia coli, GI1786602, Length=455, Percent_Identity=36.043956043956, Blast_Score=296, Evalue=3e-81,
Organism=Escherichia coli, GI87081915, Length=410, Percent_Identity=38.0487804878049, Blast_Score=288, Evalue=5e-79,
Organism=Escherichia coli, GI48994972, Length=460, Percent_Identity=35, Blast_Score=276, Evalue=2e-75,
Organism=Escherichia coli, GI1788480, Length=410, Percent_Identity=38.0487804878049, Blast_Score=252, Evalue=3e-68,
Organism=Escherichia coli, GI87081708, Length=469, Percent_Identity=32.409381663113, Blast_Score=239, Evalue=4e-64,
Organism=Escherichia coli, GI1789017, Length=439, Percent_Identity=30.0683371298405, Blast_Score=208, Evalue=8e-55,
Organism=Escherichia coli, GI87082023, Length=369, Percent_Identity=23.5772357723577, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17533459, Length=441, Percent_Identity=23.3560090702948, Blast_Score=69, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17532491, Length=443, Percent_Identity=23.4762979683973, Blast_Score=65, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6324924, Length=447, Percent_Identity=30.2013422818792, Blast_Score=185, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6324061, Length=410, Percent_Identity=30.2439024390244, Blast_Score=181, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6324990, Length=432, Percent_Identity=28.7037037037037, Blast_Score=174, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6320772, Length=447, Percent_Identity=27.9642058165548, Blast_Score=169, Evalue=8e-43,
Organism=Saccharomyces cerevisiae, GI6322892, Length=444, Percent_Identity=30.6306306306306, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6324059, Length=436, Percent_Identity=29.1284403669725, Blast_Score=150, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6324553, Length=413, Percent_Identity=29.0556900726392, Blast_Score=148, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6319608, Length=420, Percent_Identity=27.1428571428571, Blast_Score=147, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6319543, Length=501, Percent_Identity=25.748502994012, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6320251, Length=429, Percent_Identity=25.6410256410256, Blast_Score=138, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6321629, Length=425, Percent_Identity=26.3529411764706, Blast_Score=136, Evalue=7e-33,
Organism=Saccharomyces cerevisiae, GI6319542, Length=436, Percent_Identity=24.3119266055046, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6320717, Length=409, Percent_Identity=24.6943765281174, Blast_Score=130, Evalue=7e-31,
Organism=Saccharomyces cerevisiae, GI6319824, Length=432, Percent_Identity=25, Blast_Score=128, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6321053, Length=433, Percent_Identity=24.2494226327945, Blast_Score=121, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6322967, Length=431, Percent_Identity=26.6821345707657, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6324981, Length=477, Percent_Identity=25.7861635220126, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6320364, Length=479, Percent_Identity=23.3820459290188, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24667468, Length=421, Percent_Identity=23.2779097387173, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 53608; Mature: 53476

Theoretical pI: Translated: 9.37; Mature: 9.37

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSARETQSVDTPRRSALARPVKKPPATLDLESPTEERELQRGLTNRHLQLIALGGAIGTG
CCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHCHHHCCEEEEEECCHHHHC
MFMGSSSTIHLAGPSSALVYALIGFFLYFMMRALGEMLLSNLNYKSFRDIAEDLLGPAGG
EEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCC
FIAGWTYWFSWIVAAMGDMAAITAYFQYWWPNIPKWLPATALAAVLLALNIIAVQFFGEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCH
EFWFALIKLIAVGALVIVAIALLASRFVSPDGDPATIANLWNDGGFFPNGLMGFLGGFQI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHH
AFFAFVGIELVGTAAAETKDPCTTLPKAINAIPVRLALFYVFALLAITAVIPWRKVVPGV
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCH
SPFVSLFGLAGFGAAASVMNFVLLTAAASSDNSGLYSTSRMMYGLALDGQAPSRFRKLSS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHEEEEECCCCHHHHHHHCC
NNVPRNALVASCLLLLSGITFLYTSDSIMQAFALVTTVAALLFLFTWSLIVVCYIVYRRK
CCCCHHHHHHHHHHHHHCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RPQLHEESIYKMPGGVPMCWVVLAFFTISLVILTLDPTTRIAVLITPIWFAFIGSMYFVH
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHH
HRHEQRKEALR
HHHHHHHHHCC
>Mature Secondary Structure 
SARETQSVDTPRRSALARPVKKPPATLDLESPTEERELQRGLTNRHLQLIALGGAIGTG
CCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHCHHHCCEEEEEECCHHHHC
MFMGSSSTIHLAGPSSALVYALIGFFLYFMMRALGEMLLSNLNYKSFRDIAEDLLGPAGG
EEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCC
FIAGWTYWFSWIVAAMGDMAAITAYFQYWWPNIPKWLPATALAAVLLALNIIAVQFFGEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCH
EFWFALIKLIAVGALVIVAIALLASRFVSPDGDPATIANLWNDGGFFPNGLMGFLGGFQI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHH
AFFAFVGIELVGTAAAETKDPCTTLPKAINAIPVRLALFYVFALLAITAVIPWRKVVPGV
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCH
SPFVSLFGLAGFGAAASVMNFVLLTAAASSDNSGLYSTSRMMYGLALDGQAPSRFRKLSS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHEEEEECCCCHHHHHHHCC
NNVPRNALVASCLLLLSGITFLYTSDSIMQAFALVTTVAALLFLFTWSLIVVCYIVYRRK
CCCCHHHHHHHHHHHHHCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RPQLHEESIYKMPGGVPMCWVVLAFFTISLVILTLDPTTRIAVLITPIWFAFIGSMYFVH
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHH
HRHEQRKEALR
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-glycine [Periplasm]; D-alanine [Periplasm]; Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-glycine [Periplasm] = Proton [Cytoplasm] + D-glycine [Cytoplasm] Proton [Periplasm] + D-alanine [Periplasm] = Proton [Cytoplasm] + D-alanine [Cytoplasm] Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cyto

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]