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The map label for this gene is mprA [H]

Identifier: 50843550

GI number: 50843550

Start: 2286118

End: 2286816

Strand: Direct

Name: mprA [H]

Synonym: PPA2112

Alternate gene names: 50843550

Gene position: 2286118-2286816 (Clockwise)

Preceding gene: 50843549

Following gene: 50843551

Centisome position: 89.29

GC content: 61.95

Gene sequence:

>699_bases
ATGAGCATGCACATTCTTGTCGTTGACGATGATCGCGCGGTACGAGAATCCCTCGCCCGATCCCTGCAGTACAGCGGCTA
CGAGGTCGATAGCGCCGCCGACGGCGTCGAGGCTCTCGCCCATCTATCCGGAACTCACCCCGACGCCGTCATTATGGACG
TCATGATGCCGCGTCTAGATGGCTTGGAAGCCACCCGGATGTTGCGCAGCAACGGCAATGACGTGCCGATCCTCATCCTC
ACCGCTCGCGATGCTGTCGACGATCGCGTTGACGGCCTAGACGCTGGTGCCGACGATTATATGGTCAAACCGTTCGCCCT
CGACGAACTCCTCGCCCGACTGCGTGCTCTCACGCGGCGTTCCCGCCCCGAGCCGGGTCCGGACGAAGCCCCTGAACACT
TGTCCTTCGCTGACCTCACCCTTGATCCAGCCACCCGCGAGGTCACCCGCGGGAACCGTCGCATCAGTCTGACGCGTACC
GAGTTCGCCTTGCTGACCGTCTTCCTACAAAACCCGGAGAGGGTGCTGGAACGGTCCTGGCTGCTCCATGAAGTGTGGGG
ATTCGACTTCCCGACCACTGCGAACTCCCTTGAGGTGTATATCGGATATTTGCGTCGCAAGACCGAGCACGACTGTGAGG
CGCGTCTCATCCACACCGTCCGCGGCGTCGGGTACGTGCTGCGGGAAGCGAATCCGTGA

Upstream 100 bases:

>100_bases
CCCAGGCTGCCGCGGATCCGACCCCGACGGCAGGCCCGGAACCCGATCCCCTCTCGGATGCCGATCCCACCGCACAGCCC
CCGATGGAGGACGTCAAGCC

Downstream 100 bases:

>100_bases
TCCGTCACTGGTGGCGGAGGTTACTCGATTGGCGTCCGCGTCCCTTGCGTATGACCATGGGGCGCCGAGTCAGCCTCCTG
GTATCGGTGTCTGTCGTCGT

Product: putative two-component response regulator

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 232; Mature: 231

Protein sequence:

>232_residues
MSMHILVVDDDRAVRESLARSLQYSGYEVDSAADGVEALAHLSGTHPDAVIMDVMMPRLDGLEATRMLRSNGNDVPILIL
TARDAVDDRVDGLDAGADDYMVKPFALDELLARLRALTRRSRPEPGPDEAPEHLSFADLTLDPATREVTRGNRRISLTRT
EFALLTVFLQNPERVLERSWLLHEVWGFDFPTTANSLEVYIGYLRRKTEHDCEARLIHTVRGVGYVLREANP

Sequences:

>Translated_232_residues
MSMHILVVDDDRAVRESLARSLQYSGYEVDSAADGVEALAHLSGTHPDAVIMDVMMPRLDGLEATRMLRSNGNDVPILIL
TARDAVDDRVDGLDAGADDYMVKPFALDELLARLRALTRRSRPEPGPDEAPEHLSFADLTLDPATREVTRGNRRISLTRT
EFALLTVFLQNPERVLERSWLLHEVWGFDFPTTANSLEVYIGYLRRKTEHDCEARLIHTVRGVGYVLREANP
>Mature_231_residues
SMHILVVDDDRAVRESLARSLQYSGYEVDSAADGVEALAHLSGTHPDAVIMDVMMPRLDGLEATRMLRSNGNDVPILILT
ARDAVDDRVDGLDAGADDYMVKPFALDELLARLRALTRRSRPEPGPDEAPEHLSFADLTLDPATREVTRGNRRISLTRTE
FALLTVFLQNPERVLERSWLLHEVWGFDFPTTANSLEVYIGYLRRKTEHDCEARLIHTVRGVGYVLREANP

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=226, Percent_Identity=42.9203539823009, Blast_Score=176, Evalue=1e-45,
Organism=Escherichia coli, GI87082012, Length=223, Percent_Identity=36.7713004484305, Blast_Score=154, Evalue=6e-39,
Organism=Escherichia coli, GI1789402, Length=227, Percent_Identity=39.2070484581498, Blast_Score=153, Evalue=9e-39,
Organism=Escherichia coli, GI1786599, Length=227, Percent_Identity=37.0044052863436, Blast_Score=150, Evalue=8e-38,
Organism=Escherichia coli, GI1786911, Length=223, Percent_Identity=38.5650224215247, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI1790552, Length=225, Percent_Identity=39.1111111111111, Blast_Score=143, Evalue=9e-36,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=39.2070484581498, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1787375, Length=225, Percent_Identity=34.6666666666667, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1790860, Length=225, Percent_Identity=32.8888888888889, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI2367329, Length=231, Percent_Identity=36.3636363636364, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI1788394, Length=222, Percent_Identity=31.981981981982, Blast_Score=112, Evalue=1e-26,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=33.0396475770925, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1787229, Length=234, Percent_Identity=30.7692307692308, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI1788550, Length=118, Percent_Identity=41.5254237288136, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788713, Length=123, Percent_Identity=40.650406504065, Blast_Score=84, Evalue=6e-18,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=30.3030303030303, Blast_Score=84, Evalue=6e-18,
Organism=Escherichia coli, GI1790299, Length=157, Percent_Identity=31.2101910828025, Blast_Score=77, Evalue=7e-16,
Organism=Escherichia coli, GI145693157, Length=120, Percent_Identity=38.3333333333333, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=35.6435643564356, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1790437, Length=113, Percent_Identity=36.283185840708, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1788191, Length=121, Percent_Identity=33.8842975206612, Blast_Score=65, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6322000, Length=108, Percent_Identity=35.1851851851852, Blast_Score=75, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26065; Mature: 25934

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMHILVVDDDRAVRESLARSLQYSGYEVDSAADGVEALAHLSGTHPDAVIMDVMMPRLD
CCEEEEEECCCHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
GLEATRMLRSNGNDVPILILTARDAVDDRVDGLDAGADDYMVKPFALDELLARLRALTRR
CHHHHHHHHCCCCCCEEEEEECCCHHHHHHCCCCCCCCCCEECCHHHHHHHHHHHHHHHH
SRPEPGPDEAPEHLSFADLTLDPATREVTRGNRRISLTRTEFALLTVFLQNPERVLERSW
CCCCCCCCCCCCCCCEEEEEECCCHHHHHCCCCEEEEEHHHHHHHHHHHCCHHHHHHHHH
LLHEVWGFDFPTTANSLEVYIGYLRRKTEHDCEARLIHTVRGVGYVLREANP
HHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SMHILVVDDDRAVRESLARSLQYSGYEVDSAADGVEALAHLSGTHPDAVIMDVMMPRLD
CEEEEEECCCHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
GLEATRMLRSNGNDVPILILTARDAVDDRVDGLDAGADDYMVKPFALDELLARLRALTRR
CHHHHHHHHCCCCCCEEEEEECCCHHHHHHCCCCCCCCCCEECCHHHHHHHHHHHHHHHH
SRPEPGPDEAPEHLSFADLTLDPATREVTRGNRRISLTRTEFALLTVFLQNPERVLERSW
CCCCCCCCCCCCCCCEEEEEECCCHHHHHCCCCEEEEEHHHHHHHHHHHCCHHHHHHHHH
LLHEVWGFDFPTTANSLEVYIGYLRRKTEHDCEARLIHTVRGVGYVLREANP
HHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA