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The map label for this gene is mprB [H]

Identifier: 50843551

GI number: 50843551

Start: 2286813

End: 2288243

Strand: Direct

Name: mprB [H]

Synonym: PPA2113

Alternate gene names: 50843551

Gene position: 2286813-2288243 (Clockwise)

Preceding gene: 50843550

Following gene: 50843552

Centisome position: 89.32

GC content: 61.98

Gene sequence:

>1431_bases
GTGATCCGTCACTGGTGGCGGAGGTTACTCGATTGGCGTCCGCGTCCCTTGCGTATGACCATGGGGCGCCGAGTCAGCCT
CCTGGTATCGGTGTCTGTCGTCGTCGCGGTAGCTCTGACCTCTTTGGCGGCATGGCTCATGACGCGCATCTCGCTGTATA
GCGAGCTGGACGAGCAGCTCACCCGAATGGCGGCCACTATCTCGCCAAGTGTCGCCGCCGATCCTCAAAACCTCGGTGGT
TTGGAAGCCAGCTCGTTGGCCGCCACCAACACCACCCTCATCCTGGTACGCGCCGACGGCCAAGTCACCACAGCCCCTGG
AACTGAGGTCACCGTCACCGCAGGACCTCAAGAGCTAGCAGTCGCCCGCACCGGGATCGGGGTTAAAGCACACACCGTCA
TTGACTCCCGCGGTGTTCCGGTGCGTATCGTCGCGGTCCCCTTCACCTCAGATGGCGTCCACTACGCTCTCGTCACAGGC
CAAGACCTCACCGGGACCAGGGCCACCCTAGGATCACTATGGATCGTCCTCGTAGGCACCGGATTCGTCGGCATCGTGCT
CACCGCCATCGCTGGATACGTGGCAGGCAACTCTGCAACTAGCCCTTTGCGCGACCTCTCGCGAGCTGTTCATCACGTCA
CCACCACCGAAGACCTGACACCCATCCAGGTCCACTCCCATGATGAGCTAGGCGATCTTGCCGTGTCGTTCAACAACATG
CTGTCCTCGTTGTCGAACTCCCGGGAGCGTCAGAAGCAGCTCATCGCTGACGCCTCCCACGAACTGCGAACCCCACTGAC
CTCGATGCGCACCAACGTCGAGTTGCTGATGGCCGATCAGAAGAGCCACATGCTCCCGGAGGAAGCACGCGGGGAGATCC
TTGACGACGTCGCCGCCCAGCTCGGTGAGTTCTCCAGCCTCATTGGCGACCTCGTCCAGCTCTCGCGCGAGGACGCCCCT
CCCCCGCGCCCGGAGTACTTCGACTTGTCAGATGCGGTATCCAAAGCGGTCGAGAGGGGACGACGACGCGGCCCGAACCT
GGAATTCGACGTCCACCTGGAGTCCCATTTGGTGCTTGGTGACGAGGCCACCCTGGAGCGGGCTGTCACCAACCTGCTCG
ATAATGCGGTGAAGTTCTCCCCCGCCGGTGGAACTGTAACGGTGTCTATGGAGGGCGACACCGTCGTCGTCAGTGACGAA
GGACCTGGCATCGCGGAGGCCGATCTGCCTTATATCTTCGATCGGTTTTACCGCTCTGATCGCGCCCGCAACACCCCCGG
AACCGGCCTCGGCCTGTCAATTGTGGCTCATACCGTCACTAGCCATCAGGGTTGGATCAAAGCGTCGCGGGCCCCAAGCG
GTGGCGCCATGTTCACGATGTACTTGCCGCGAGCAGAACCTCCGGTTGAGGAGCCCACGGTATTCTCATGA

Upstream 100 bases:

>100_bases
TGTATATCGGATATTTGCGTCGCAAGACCGAGCACGACTGTGAGGCGCGTCTCATCCACACCGTCCGCGGCGTCGGGTAC
GTGCTGCGGGAAGCGAATCC

Downstream 100 bases:

>100_bases
TTGCGACCGCGGCTGGTGAGTTATCCACAGGAGACCGGTGGAAAACCGGCCCGGCTGGGGAAAACACATCAATGTCGTTC
CCACAGGCGGGGTGAGAACC

Product: putative two-component system sensor kinase

Products: NA

Alternate protein names: Mycobacterial persistence regulator B [H]

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MIRHWWRRLLDWRPRPLRMTMGRRVSLLVSVSVVVAVALTSLAAWLMTRISLYSELDEQLTRMAATISPSVAADPQNLGG
LEASSLAATNTTLILVRADGQVTTAPGTEVTVTAGPQELAVARTGIGVKAHTVIDSRGVPVRIVAVPFTSDGVHYALVTG
QDLTGTRATLGSLWIVLVGTGFVGIVLTAIAGYVAGNSATSPLRDLSRAVHHVTTTEDLTPIQVHSHDELGDLAVSFNNM
LSSLSNSRERQKQLIADASHELRTPLTSMRTNVELLMADQKSHMLPEEARGEILDDVAAQLGEFSSLIGDLVQLSREDAP
PPRPEYFDLSDAVSKAVERGRRRGPNLEFDVHLESHLVLGDEATLERAVTNLLDNAVKFSPAGGTVTVSMEGDTVVVSDE
GPGIAEADLPYIFDRFYRSDRARNTPGTGLGLSIVAHTVTSHQGWIKASRAPSGGAMFTMYLPRAEPPVEEPTVFS

Sequences:

>Translated_476_residues
MIRHWWRRLLDWRPRPLRMTMGRRVSLLVSVSVVVAVALTSLAAWLMTRISLYSELDEQLTRMAATISPSVAADPQNLGG
LEASSLAATNTTLILVRADGQVTTAPGTEVTVTAGPQELAVARTGIGVKAHTVIDSRGVPVRIVAVPFTSDGVHYALVTG
QDLTGTRATLGSLWIVLVGTGFVGIVLTAIAGYVAGNSATSPLRDLSRAVHHVTTTEDLTPIQVHSHDELGDLAVSFNNM
LSSLSNSRERQKQLIADASHELRTPLTSMRTNVELLMADQKSHMLPEEARGEILDDVAAQLGEFSSLIGDLVQLSREDAP
PPRPEYFDLSDAVSKAVERGRRRGPNLEFDVHLESHLVLGDEATLERAVTNLLDNAVKFSPAGGTVTVSMEGDTVVVSDE
GPGIAEADLPYIFDRFYRSDRARNTPGTGLGLSIVAHTVTSHQGWIKASRAPSGGAMFTMYLPRAEPPVEEPTVFS
>Mature_476_residues
MIRHWWRRLLDWRPRPLRMTMGRRVSLLVSVSVVVAVALTSLAAWLMTRISLYSELDEQLTRMAATISPSVAADPQNLGG
LEASSLAATNTTLILVRADGQVTTAPGTEVTVTAGPQELAVARTGIGVKAHTVIDSRGVPVRIVAVPFTSDGVHYALVTG
QDLTGTRATLGSLWIVLVGTGFVGIVLTAIAGYVAGNSATSPLRDLSRAVHHVTTTEDLTPIQVHSHDELGDLAVSFNNM
LSSLSNSRERQKQLIADASHELRTPLTSMRTNVELLMADQKSHMLPEEARGEILDDVAAQLGEFSSLIGDLVQLSREDAP
PPRPEYFDLSDAVSKAVERGRRRGPNLEFDVHLESHLVLGDEATLERAVTNLLDNAVKFSPAGGTVTVSMEGDTVVVSDE
GPGIAEADLPYIFDRFYRSDRARNTPGTGLGLSIVAHTVTSHQGWIKASRAPSGGAMFTMYLPRAEPPVEEPTVFS

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to en

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=277, Percent_Identity=32.129963898917, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1786783, Length=374, Percent_Identity=28.6096256684492, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1790346, Length=237, Percent_Identity=31.6455696202532, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1786600, Length=276, Percent_Identity=32.2463768115942, Blast_Score=105, Evalue=9e-24,
Organism=Escherichia coli, GI1790551, Length=291, Percent_Identity=28.5223367697594, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1789808, Length=286, Percent_Identity=27.972027972028, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1787894, Length=243, Percent_Identity=30.8641975308642, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1786912, Length=237, Percent_Identity=30.8016877637131, Blast_Score=92, Evalue=9e-20,
Organism=Escherichia coli, GI1787374, Length=298, Percent_Identity=26.8456375838926, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1790861, Length=271, Percent_Identity=26.9372693726937, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1789403, Length=233, Percent_Identity=31.3304721030043, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1788279, Length=355, Percent_Identity=23.3802816901408, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI145693157, Length=242, Percent_Identity=26.0330578512397, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1788549, Length=223, Percent_Identity=27.8026905829596, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1788713, Length=253, Percent_Identity=24.5059288537549, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87081816, Length=267, Percent_Identity=26.2172284644195, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1789149, Length=232, Percent_Identity=26.7241379310345, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI87082128, Length=226, Percent_Identity=26.1061946902655, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51217; Mature: 51217

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRHWWRRLLDWRPRPLRMTMGRRVSLLVSVSVVVAVALTSLAAWLMTRISLYSELDEQL
CCHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TRMAATISPSVAADPQNLGGLEASSLAATNTTLILVRADGQVTTAPGTEVTVTAGPQELA
HHHHHHCCCCCCCCCCCCCCCCHHHEEECCEEEEEEEECCEEEECCCCEEEEECCCHHHH
VARTGIGVKAHTVIDSRGVPVRIVAVPFTSDGVHYALVTGQDLTGTRATLGSLWIVLVGT
HHHCCCCEEEEEEECCCCCCEEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHC
GFVGIVLTAIAGYVAGNSATSPLRDLSRAVHHVTTTEDLTPIQVHSHDELGDLAVSFNNM
CHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHH
LSSLSNSRERQKQLIADASHELRTPLTSMRTNVELLMADQKSHMLPEEARGEILDDVAAQ
HHHHHHHHHHHHHHHHHCHHHHHCCHHHHHCCEEEEEECCHHCCCCHHHHHHHHHHHHHH
LGEFSSLIGDLVQLSREDAPPPRPEYFDLSDAVSKAVERGRRRGPNLEFDVHLESHLVLG
HHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECEEEEC
DEATLERAVTNLLDNAVKFSPAGGTVTVSMEGDTVVVSDEGPGIAEADLPYIFDRFYRSD
CHHHHHHHHHHHHHHHEEECCCCCEEEEEECCCEEEEECCCCCCCCCCCHHHHHHHHHHC
RARNTPGTGLGLSIVAHTVTSHQGWIKASRAPSGGAMFTMYLPRAEPPVEEPTVFS
CCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCEEEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MIRHWWRRLLDWRPRPLRMTMGRRVSLLVSVSVVVAVALTSLAAWLMTRISLYSELDEQL
CCHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TRMAATISPSVAADPQNLGGLEASSLAATNTTLILVRADGQVTTAPGTEVTVTAGPQELA
HHHHHHCCCCCCCCCCCCCCCCHHHEEECCEEEEEEEECCEEEECCCCEEEEECCCHHHH
VARTGIGVKAHTVIDSRGVPVRIVAVPFTSDGVHYALVTGQDLTGTRATLGSLWIVLVGT
HHHCCCCEEEEEEECCCCCCEEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHC
GFVGIVLTAIAGYVAGNSATSPLRDLSRAVHHVTTTEDLTPIQVHSHDELGDLAVSFNNM
CHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHH
LSSLSNSRERQKQLIADASHELRTPLTSMRTNVELLMADQKSHMLPEEARGEILDDVAAQ
HHHHHHHHHHHHHHHHHCHHHHHCCHHHHHCCEEEEEECCHHCCCCHHHHHHHHHHHHHH
LGEFSSLIGDLVQLSREDAPPPRPEYFDLSDAVSKAVERGRRRGPNLEFDVHLESHLVLG
HHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECEEEEC
DEATLERAVTNLLDNAVKFSPAGGTVTVSMEGDTVVVSDEGPGIAEADLPYIFDRFYRSD
CHHHHHHHHHHHHHHHEEECCCCCEEEEEECCCEEEEECCCCCCCCCCCHHHHHHHHHHC
RARNTPGTGLGLSIVAHTVTSHQGWIKASRAPSGGAMFTMYLPRAEPPVEEPTVFS
CCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCEEEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]