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The map label for this gene is purC [H]

Identifier: 50843435

GI number: 50843435

Start: 2159076

End: 2160341

Strand: Reverse

Name: purC [H]

Synonym: PPA1988

Alternate gene names: 50843435

Gene position: 2160341-2159076 (Counterclockwise)

Preceding gene: 50843439

Following gene: 50843434

Centisome position: 84.38

GC content: 61.3

Gene sequence:

>1266_bases
ATGGTCACTTCGCACCTCGATCTTCCATTGCTGGCTGAGGGCAAGGTCCGACGCCTCTATCGTCTTCCCGATCAGCCGGG
CTGCCTGCTTATGGTCGCTACGGACCGGATTAGCGCCTACGACCACGTCCTGACCCCCGATGTTCCCGGCAAGGGAGCCA
TCTTGACGAATATGTCCTTGTGGTGGTTCGACCTGTTGGCCGACATCGTCGATAACCATCTCGTGAGCGTGGATGTCCCC
GCCGAGGTCGCGGGGCGCGCCATGGTCGTTGAGGAACTCGACATGTTCCCGGTCGAATGCGTCGTGCGGGGCTACCTCAC
CGGTTCAGGGTGGGCCGAGTATCAGCGCAACCGGGCCGTGTGCGGAATCCGCCTTCCCGAGGGGCTGCAGAATGGGTCCC
GGCTCGAAGAGCCCATTTTCACCCCGGCAATTAAGGCCCCGCAGGGAGAACATGACGAGAACATCGACTATCTACGCCTG
GTAGAACTCGTCGGTCCCGATGTTGCAGCGCAGCTGCATGACCTTTCGCTGCGGGTCTACCAGCGTGCAGAGGAGATCGC
TCGGAAGCGAGGCATCCTCCTGGCCGATACCAAGTTTGAATTCGGGCGTCGTGCCGACGGCACCATCGTGCTAGCTGACG
AGGTGCTTACCCCTGATTCTTCGCGATTCTGGGACGCTGAGACGTGGCAGCCCGGCAAGGGGGCAGATTCCTTCGATAAG
CAATATGTGCGCGATTGGCTCACGAATGAGTCCGGTTGGGATCGCGCTAGTGACCAGGAGCCGCCTGCCCTCCCGGAGGA
GGTCGTCAAGGCCACCAGTCGGCGTTATGAGGAGGCCTGGGCACGTCTGACTGGCGGGCACGTGTCTGATGAGGTCAGCG
ATGAGACGCCTCACAATGAGGCCGACGATGACAAGCACGTGAGGGCTTCGCGGATGGATGGCGTTTCCGGGGAGTCCGGG
GACGCTGCACCGGTGGCCCTCGACGTTCCTGGCGAGTCGGAGTCCTGTAGTGCCGATAAGATCGGGGCTATGTCACGTGT
AGTGGTGGAGGTCATGCCGAAACCCGAAATCTTGGATCCCCAGGGCAAGGCCATCACGTCGGTGCTCGCTCGGCTTGGCC
ATGACGGCTTGACGGTGCGCCAGGGTAAGCGTTTCGAGATCACTGGTGAGGGTTTGGAAGATCGTCTCGACGAGATCCGT
CAGGTGGCCTCTGGGCTGTTGGCCAACACCGTCATTGAATCCTTCGACGTGCATGTGGAGGACTGA

Upstream 100 bases:

>100_bases
AGGCTATCACTAAACCAGCATCTATAGTCAATAGCTATAAAGATCATGAACTCGGGACTCTCTGTGTCGCCAGGGCCCGC
ACCCGTGGCATGATGCCCCC

Downstream 100 bases:

>100_bases
CGATGGTGCGCATTGGAGTCGTCACCTTCCCTGGCACTCTCGACGACCAGGATGCAGCGCGGGCCGTTCGCCTGGCCGGG
GCTGAGCCTGTGTCGTTGTG

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MVTSHLDLPLLAEGKVRRLYRLPDQPGCLLMVATDRISAYDHVLTPDVPGKGAILTNMSLWWFDLLADIVDNHLVSVDVP
AEVAGRAMVVEELDMFPVECVVRGYLTGSGWAEYQRNRAVCGIRLPEGLQNGSRLEEPIFTPAIKAPQGEHDENIDYLRL
VELVGPDVAAQLHDLSLRVYQRAEEIARKRGILLADTKFEFGRRADGTIVLADEVLTPDSSRFWDAETWQPGKGADSFDK
QYVRDWLTNESGWDRASDQEPPALPEEVVKATSRRYEEAWARLTGGHVSDEVSDETPHNEADDDKHVRASRMDGVSGESG
DAAPVALDVPGESESCSADKIGAMSRVVVEVMPKPEILDPQGKAITSVLARLGHDGLTVRQGKRFEITGEGLEDRLDEIR
QVASGLLANTVIESFDVHVED

Sequences:

>Translated_421_residues
MVTSHLDLPLLAEGKVRRLYRLPDQPGCLLMVATDRISAYDHVLTPDVPGKGAILTNMSLWWFDLLADIVDNHLVSVDVP
AEVAGRAMVVEELDMFPVECVVRGYLTGSGWAEYQRNRAVCGIRLPEGLQNGSRLEEPIFTPAIKAPQGEHDENIDYLRL
VELVGPDVAAQLHDLSLRVYQRAEEIARKRGILLADTKFEFGRRADGTIVLADEVLTPDSSRFWDAETWQPGKGADSFDK
QYVRDWLTNESGWDRASDQEPPALPEEVVKATSRRYEEAWARLTGGHVSDEVSDETPHNEADDDKHVRASRMDGVSGESG
DAAPVALDVPGESESCSADKIGAMSRVVVEVMPKPEILDPQGKAITSVLARLGHDGLTVRQGKRFEITGEGLEDRLDEIR
QVASGLLANTVIESFDVHVED
>Mature_421_residues
MVTSHLDLPLLAEGKVRRLYRLPDQPGCLLMVATDRISAYDHVLTPDVPGKGAILTNMSLWWFDLLADIVDNHLVSVDVP
AEVAGRAMVVEELDMFPVECVVRGYLTGSGWAEYQRNRAVCGIRLPEGLQNGSRLEEPIFTPAIKAPQGEHDENIDYLRL
VELVGPDVAAQLHDLSLRVYQRAEEIARKRGILLADTKFEFGRRADGTIVLADEVLTPDSSRFWDAETWQPGKGADSFDK
QYVRDWLTNESGWDRASDQEPPALPEEVVKATSRRYEEAWARLTGGHVSDEVSDETPHNEADDDKHVRASRMDGVSGESG
DAAPVALDVPGESESCSADKIGAMSRVVVEVMPKPEILDPQGKAITSVLARLGHDGLTVRQGKRFEITGEGLEDRLDEIR
QVASGLLANTVIESFDVHVED

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Escherichia coli, GI1788820, Length=226, Percent_Identity=26.9911504424779, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6319326, Length=300, Percent_Identity=42, Blast_Score=248, Evalue=9e-67,
Organism=Drosophila melanogaster, GI18860083, Length=239, Percent_Identity=30.9623430962343, Blast_Score=82, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24583917, Length=220, Percent_Identity=29.5454545454545, Blast_Score=75, Evalue=8e-14,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 46454; Mature: 46454

Theoretical pI: Translated: 4.39; Mature: 4.39

Prosite motif: PS01057 SAICAR_SYNTHETASE_1 ; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTSHLDLPLLAEGKVRRLYRLPDQPGCLLMVATDRISAYDHVLTPDVPGKGAILTNMSL
CCCCCCCCCEECCCHHHHHHCCCCCCCEEEEEECCCCCHHCCCCCCCCCCCCEEEECCHH
WWFDLLADIVDNHLVSVDVPAEVAGRAMVVEELDMFPVECVVRGYLTGSGWAEYQRNRAV
HHHHHHHHHHCCCEEEEECCHHHHCCCCEEHHHCCCHHHHHHHHHCCCCCHHHHHCCCCE
CGIRLPEGLQNGSRLEEPIFTPAIKAPQGEHDENIDYLRLVELVGPDVAAQLHDLSLRVY
EEEECCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHH
QRAEEIARKRGILLADTKFEFGRRADGTIVLADEVLTPDSSRFWDAETWQPGKGADSFDK
HHHHHHHHHCCCEEEECCCCCCCCCCCEEEEECCEECCCCCCCCCCCCCCCCCCCCHHHH
QYVRDWLTNESGWDRASDQEPPALPEEVVKATSRRYEEAWARLTGGHVSDEVSDETPHNE
HHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
ADDDKHVRASRMDGVSGESGDAAPVALDVPGESESCSADKIGAMSRVVVEVMPKPEILDP
CCCCHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
QGKAITSVLARLGHDGLTVRQGKRFEITGEGLEDRLDEIRQVASGLLANTVIESFDVHVE
CCHHHHHHHHHHCCCCCEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEC
D
C
>Mature Secondary Structure
MVTSHLDLPLLAEGKVRRLYRLPDQPGCLLMVATDRISAYDHVLTPDVPGKGAILTNMSL
CCCCCCCCCEECCCHHHHHHCCCCCCCEEEEEECCCCCHHCCCCCCCCCCCCEEEECCHH
WWFDLLADIVDNHLVSVDVPAEVAGRAMVVEELDMFPVECVVRGYLTGSGWAEYQRNRAV
HHHHHHHHHHCCCEEEEECCHHHHCCCCEEHHHCCCHHHHHHHHHCCCCCHHHHHCCCCE
CGIRLPEGLQNGSRLEEPIFTPAIKAPQGEHDENIDYLRLVELVGPDVAAQLHDLSLRVY
EEEECCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHH
QRAEEIARKRGILLADTKFEFGRRADGTIVLADEVLTPDSSRFWDAETWQPGKGADSFDK
HHHHHHHHHCCCEEEECCCCCCCCCCCEEEEECCEECCCCCCCCCCCCCCCCCCCCHHHH
QYVRDWLTNESGWDRASDQEPPALPEEVVKATSRRYEEAWARLTGGHVSDEVSDETPHNE
HHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
ADDDKHVRASRMDGVSGESGDAAPVALDVPGESESCSADKIGAMSRVVVEVMPKPEILDP
CCCCHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
QGKAITSVLARLGHDGLTVRQGKRFEITGEGLEDRLDEIRQVASGLLANTVIESFDVHVE
CCHHHHHHHHHHCCCCCEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEC
D
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA