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The map label for this gene is pncB1 [H]

Identifier: 50843143

GI number: 50843143

Start: 1833164

End: 1834504

Strand: Direct

Name: pncB1 [H]

Synonym: PPA1681

Alternate gene names: 50843143

Gene position: 1833164-1834504 (Clockwise)

Preceding gene: 50843141

Following gene: 50843144

Centisome position: 71.6

GC content: 63.31

Gene sequence:

>1341_bases
ATGTCGACCGCACTGTTCACCGACCACTACGAGCTAACCATGGTCGAAGCCGCCATGGCATCAGGGACTGCCAACCGCCG
CTGTGTCTTTGAATTATTCCCCCGACGTCTGCCCGAAGGCCGCCGCTACGGCGTCGTAGCCGGTACCGGACGCGTCCTTG
ATGCTGTCGAGAACTTCCGATTCACCGACGAGGACGTCTCCTTCCTGGAACGCACCGGGGTAGTCGGCCCGCACATGGCC
GAGTGGCTGTCACACTACCGATTTACCGGATCCATCCACGGTTACGCTGAAGGCGATCTCTACTTTCCTGGTTCCCCGCT
GCTCACCGTCGAGGGCACTTTCGCCGAAGCCTGCGTGCTCGAGACCGTGCTGCTCAGCATCTACAACCACGACTCAGCTA
TCGCCTCCGCCGCATCCCGCATGGTCATGATGGGTGAAGGCCGCTCGATCATCGAAATGGGCTCGCGACGCACCCACGAA
GAGTCCGCCGTCGCTGCCGCCCGTGCCGCGTGGATCGCCGGCTTCGGACCGACCTCTAACTTAGCCGCCGGGATCCGCTA
TGGCGTCCCCACCTCTGGTACCGCTGCCCACGCCTTTACCCTCCTCCATGACACCGAGGAAGAGGCTTTTCGCGCCCAGC
TAGCCGCCTACGGTGAAAAGACAACCCTTCTCGTCGACACCTATGACATTGACAATGCGGTACGCACGGCCATCCGCCTC
ACCGAGGGACGCCTCGGCGCGGTCCGTATCGACTCCGGCGACCTGTCCATCGTCGCTCGTCAAGTCCGCAACTTGCTCGA
CGACCTCGGCGCCCCGAACACTCGCGTCATCGTCACTAGCGACCTTGACGAATGGCAAATCGCCGCCCTGCGCGGTGCCC
CCGTCGATGGATTCGGCGTCGGAACCTCCCTGGTAACCGGTTCGGGAGCTCCAACCTGCTCCTTCGTCTATAAGCTAGTC
GCCCGCGCCACCTCAGACAGCCCCGACGCCGAGTTGCTGCCGGTGGCCAAGAAGTCGTCCCACAAAAACACTGTGGGCGG
GCGAAAGTATGCGGTGCGCCGCATTGGCTCAGGTGGGATCGCCACCGCAGAGGTCGTCGGGGTGGGCCAACCGCCAGCCG
CCGACGCTGACGACCGTAACCTCATCGTCCCGCTCATCGTCAACGGGGAAGTTGTGGGCCGTGAACCGCTGGAGACGGCG
CGTAAACGTCACCAGGCTGCCATCGCTGAACTGCCAATTTCCGGACGACGCATCTCGCGTGGCGACCAGGCCATCCCCAC
AGTCATGGTGAAGCAAGGCAACGACGGCGCTGACACCGTTCTTGGAGCATCCCTCTCCTGA

Upstream 100 bases:

>100_bases
GTGGCTACAGACATGTGCTCATTCTGTCACCCAGGTGAGACACTCAAACTTCACCGACGCAAACATCCTCTAGAGCGCAC
CCCCTCTTAGACTGTGACCC

Downstream 100 bases:

>100_bases
GCACAACCCCAGGGGCACGGCCCAGAGCACGCCAGAAATACGACACGCAAGGTACCTCAGGGCCCGAAATCTGTCCAAAA
GCCCCTTATGACGCGGTTTT

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase pncB1 [H]

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MSTALFTDHYELTMVEAAMASGTANRRCVFELFPRRLPEGRRYGVVAGTGRVLDAVENFRFTDEDVSFLERTGVVGPHMA
EWLSHYRFTGSIHGYAEGDLYFPGSPLLTVEGTFAEACVLETVLLSIYNHDSAIASAASRMVMMGEGRSIIEMGSRRTHE
ESAVAAARAAWIAGFGPTSNLAAGIRYGVPTSGTAAHAFTLLHDTEEEAFRAQLAAYGEKTTLLVDTYDIDNAVRTAIRL
TEGRLGAVRIDSGDLSIVARQVRNLLDDLGAPNTRVIVTSDLDEWQIAALRGAPVDGFGVGTSLVTGSGAPTCSFVYKLV
ARATSDSPDAELLPVAKKSSHKNTVGGRKYAVRRIGSGGIATAEVVGVGQPPAADADDRNLIVPLIVNGEVVGREPLETA
RKRHQAAIAELPISGRRISRGDQAIPTVMVKQGNDGADTVLGASLS

Sequences:

>Translated_446_residues
MSTALFTDHYELTMVEAAMASGTANRRCVFELFPRRLPEGRRYGVVAGTGRVLDAVENFRFTDEDVSFLERTGVVGPHMA
EWLSHYRFTGSIHGYAEGDLYFPGSPLLTVEGTFAEACVLETVLLSIYNHDSAIASAASRMVMMGEGRSIIEMGSRRTHE
ESAVAAARAAWIAGFGPTSNLAAGIRYGVPTSGTAAHAFTLLHDTEEEAFRAQLAAYGEKTTLLVDTYDIDNAVRTAIRL
TEGRLGAVRIDSGDLSIVARQVRNLLDDLGAPNTRVIVTSDLDEWQIAALRGAPVDGFGVGTSLVTGSGAPTCSFVYKLV
ARATSDSPDAELLPVAKKSSHKNTVGGRKYAVRRIGSGGIATAEVVGVGQPPAADADDRNLIVPLIVNGEVVGREPLETA
RKRHQAAIAELPISGRRISRGDQAIPTVMVKQGNDGADTVLGASLS
>Mature_445_residues
STALFTDHYELTMVEAAMASGTANRRCVFELFPRRLPEGRRYGVVAGTGRVLDAVENFRFTDEDVSFLERTGVVGPHMAE
WLSHYRFTGSIHGYAEGDLYFPGSPLLTVEGTFAEACVLETVLLSIYNHDSAIASAASRMVMMGEGRSIIEMGSRRTHEE
SAVAAARAAWIAGFGPTSNLAAGIRYGVPTSGTAAHAFTLLHDTEEEAFRAQLAAYGEKTTLLVDTYDIDNAVRTAIRLT
EGRLGAVRIDSGDLSIVARQVRNLLDDLGAPNTRVIVTSDLDEWQIAALRGAPVDGFGVGTSLVTGSGAPTCSFVYKLVA
RATSDSPDAELLPVAKKSSHKNTVGGRKYAVRRIGSGGIATAEVVGVGQPPAADADDRNLIVPLIVNGEVVGREPLETAR
KRHQAAIAELPISGRRISRGDQAIPTVMVKQGNDGADTVLGASLS

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=449, Percent_Identity=28.9532293986637, Blast_Score=142, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI71997952, Length=470, Percent_Identity=28.2978723404255, Blast_Score=167, Evalue=8e-42,
Organism=Caenorhabditis elegans, GI71997947, Length=470, Percent_Identity=28.2978723404255, Blast_Score=167, Evalue=9e-42,
Organism=Caenorhabditis elegans, GI71997955, Length=204, Percent_Identity=34.8039215686275, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24581587, Length=471, Percent_Identity=26.1146496815287, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI161076680, Length=206, Percent_Identity=29.6116504854369, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24581595, Length=206, Percent_Identity=29.6116504854369, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI28574709, Length=206, Percent_Identity=29.6116504854369, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24581593, Length=206, Percent_Identity=29.6116504854369, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24581591, Length=206, Percent_Identity=29.6116504854369, Blast_Score=89, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 47431; Mature: 47300

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTALFTDHYELTMVEAAMASGTANRRCVFELFPRRLPEGRRYGVVAGTGRVLDAVENFR
CCCEEEECCCEEEEHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHCC
FTDEDVSFLERTGVVGPHMAEWLSHYRFTGSIHGYAEGDLYFPGSPLLTVEGTFAEACVL
CCCHHHHHHHHCCCCCCHHHHHHHHHEEECEECCEECCCEEECCCCEEEEECCHHHHHHH
ETVLLSIYNHDSAIASAASRMVMMGEGRSIIEMGSRRTHEESAVAAARAAWIAGFGPTSN
HHHHHHHHCCCHHHHHHHHCEEEECCCCHHHHHCCCCCCHHHHHHHHHHHHEECCCCCCC
LAAGIRYGVPTSGTAAHAFTLLHDTEEEAFRAQLAAYGEKTTLLVDTYDIDNAVRTAIRL
HHCCEEECCCCCCCHHHEEEEEECCHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHE
TEGRLGAVRIDSGDLSIVARQVRNLLDDLGAPNTRVIVTSDLDEWQIAALRGAPVDGFGV
ECCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEEECCCCCCCCCC
GTSLVTGSGAPTCSFVYKLVARATSDSPDAELLPVAKKSSHKNTVGGRKYAVRRIGSGGI
CCCEEECCCCCHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCHHHEEEECCCCCC
ATAEVVGVGQPPAADADDRNLIVPLIVNGEVVGREPLETARKRHQAAIAELPISGRRISR
EEEEEEECCCCCCCCCCCCCEEEEEEECCEEECCCHHHHHHHHHHHHHHHCCCCCCCCCC
GDQAIPTVMVKQGNDGADTVLGASLS
CCCCCCEEEEECCCCCCCCEECCCCC
>Mature Secondary Structure 
STALFTDHYELTMVEAAMASGTANRRCVFELFPRRLPEGRRYGVVAGTGRVLDAVENFR
CCEEEECCCEEEEHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHCC
FTDEDVSFLERTGVVGPHMAEWLSHYRFTGSIHGYAEGDLYFPGSPLLTVEGTFAEACVL
CCCHHHHHHHHCCCCCCHHHHHHHHHEEECEECCEECCCEEECCCCEEEEECCHHHHHHH
ETVLLSIYNHDSAIASAASRMVMMGEGRSIIEMGSRRTHEESAVAAARAAWIAGFGPTSN
HHHHHHHHCCCHHHHHHHHCEEEECCCCHHHHHCCCCCCHHHHHHHHHHHHEECCCCCCC
LAAGIRYGVPTSGTAAHAFTLLHDTEEEAFRAQLAAYGEKTTLLVDTYDIDNAVRTAIRL
HHCCEEECCCCCCCHHHEEEEEECCHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHE
TEGRLGAVRIDSGDLSIVARQVRNLLDDLGAPNTRVIVTSDLDEWQIAALRGAPVDGFGV
ECCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEEECCCCCCCCCC
GTSLVTGSGAPTCSFVYKLVARATSDSPDAELLPVAKKSSHKNTVGGRKYAVRRIGSGGI
CCCEEECCCCCHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCHHHEEEECCCCCC
ATAEVVGVGQPPAADADDRNLIVPLIVNGEVVGREPLETARKRHQAAIAELPISGRRISR
EEEEEEECCCCCCCCCCCCCEEEEEEECCEEECCCHHHHHHHHHHHHHHHCCCCCCCCCC
GDQAIPTVMVKQGNDGADTVLGASLS
CCCCCCEEEEECCCCCCCCEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]