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The map label for this gene is bglH [H]

Identifier: 50842625

GI number: 50842625

Start: 1245213

End: 1246643

Strand: Direct

Name: bglH [H]

Synonym: PPA1146

Alternate gene names: 50842625

Gene position: 1245213-1246643 (Clockwise)

Preceding gene: 50842624

Following gene: 50842626

Centisome position: 48.64

GC content: 48.08

Gene sequence:

>1431_bases
ATGAAGCGCATTCTGTGGGGTGGGGCTACCGCGGCCAGTCAATATGAAGGCGGATTCTACGATGGAAAGGGAATGGACAC
CCAAGACTGTCGTCGATGGATTCCACGGCTATCGAATGATACCATACAAACTCCTCTCCTCACCGAGGCTGACGTTCGAA
ACGCAAAGAATTCCCGTTCTGACGACTGCCGGTTCCCGTTCCGTATGGGCTCGCGGGGTTACGAATACTGGGAGTCAGAC
TTGCATTACATTACCAGTCTTGGCCTAGATGTATATCGTCTTTCGATTAGCTGGGCCCGTCTATTTCCCACTGGTTTCGA
GGACCAGTCCAATCCGGAAGGCGTGATGTACTATGACCGGATTATTCGCACCCTTGCACATGCTGGAATTAAAGTCTTCA
TTACGATCAATCACTATGCGATGCCGATTGCTATCGTTGGCAAATACGGAGGTTGGCGACATCGTGACGTCATCGATCTG
TACCTTAAGATGGCGAAATTTGTCGTCTATCGCTGGCAAGAAAATGTAGACTATTGGCTTCCCATAAATGAGATTAATTC
CGGATATTTCAGTCCTTATAATGGACTCGGAATAATAGGATCCATCGATCACTCTTATGATTATCAGGCAGTCTTTAATG
GTCTTCATTACCAAATGATAGCAAGCGCCCTAATAACAAAATACGGTCGCGATATCGGAGTACGAGGAAAATTCGTGTGC
ATGGTGAGCTGTTTCGATTACTATGCGCTCCATCCCACACCTGAGGACAACATGAAGCTCGTTCACGACGAGCAGATCAA
TCAGTGGTGGTGTGCGGATGTACTTGCAACAGGTGAATACGGGTATTACACAGAGAAGTTCTTAGCCGACCACGGGGTAG
TACTCGACGTCACGGACAAGGACCGTGGCATACTCAGGTCGAATACCTGTGATGTCGTGTCATTTTCGTACTATTCATCG
TCGATTTGTAGTGTCGACGAAAAACGTGAAAAAGTCCCCGGAAACCTGGTACCAACATTGAGAAACCCTAGTTTAGAAGC
TACCGAGTGGGGATGGCAGATAGACCCGATGGGTTTGAGGATTGCGGCTCACAAGGTTTACGACCGGTACCGGAAGCCCA
TAATGGTTGCTGAGAATGGATTAGGTGCACGGGATAATATCGACTCTGATGGACGTATCCACGATGACTATAGAATATCA
TATCTCGAGCGCCATATGGAACAGGCTGAGCTTGCCGTGCGGGAGGGTGTAGGTATAGAAGCATATTTCGTTTGGGGCAT
CATTGACATCGTCAGTGCCGGTAGTTGCGAAATGGAGAAAAGGTACGGTGTCGTCTATGTAGACGCAGACAATGAAGGGC
GGGGAACTTATAAACGGTTGCCGAAAGATAGTTTCTATTGGTATCGCGACTTCATCGCCTCTCATAGGTGA

Upstream 100 bases:

>100_bases
GGAATATGACTCCGGACGAGTTGAAGCAGTTGGTCGAGGCTAAGAGTTGTTGGCCTAGACGGTTTAGCGGATCGCACGGT
GTTCATGAGAGGTATGTGAG

Downstream 100 bases:

>100_bases
TTGATACACAATCAAGGAGGATTGGTCATGTCTAATGTTTTACTGGTTTGCTCTGGTGGTATGTCGAGTGGGGTCGTTCT
CAAGAATTTGGAGAAGGAAT

Product: beta-glucosidase

Products: NA

Alternate protein names: 6-phospho-beta-glucosidase [H]

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MKRILWGGATAASQYEGGFYDGKGMDTQDCRRWIPRLSNDTIQTPLLTEADVRNAKNSRSDDCRFPFRMGSRGYEYWESD
LHYITSLGLDVYRLSISWARLFPTGFEDQSNPEGVMYYDRIIRTLAHAGIKVFITINHYAMPIAIVGKYGGWRHRDVIDL
YLKMAKFVVYRWQENVDYWLPINEINSGYFSPYNGLGIIGSIDHSYDYQAVFNGLHYQMIASALITKYGRDIGVRGKFVC
MVSCFDYYALHPTPEDNMKLVHDEQINQWWCADVLATGEYGYYTEKFLADHGVVLDVTDKDRGILRSNTCDVVSFSYYSS
SICSVDEKREKVPGNLVPTLRNPSLEATEWGWQIDPMGLRIAAHKVYDRYRKPIMVAENGLGARDNIDSDGRIHDDYRIS
YLERHMEQAELAVREGVGIEAYFVWGIIDIVSAGSCEMEKRYGVVYVDADNEGRGTYKRLPKDSFYWYRDFIASHR

Sequences:

>Translated_476_residues
MKRILWGGATAASQYEGGFYDGKGMDTQDCRRWIPRLSNDTIQTPLLTEADVRNAKNSRSDDCRFPFRMGSRGYEYWESD
LHYITSLGLDVYRLSISWARLFPTGFEDQSNPEGVMYYDRIIRTLAHAGIKVFITINHYAMPIAIVGKYGGWRHRDVIDL
YLKMAKFVVYRWQENVDYWLPINEINSGYFSPYNGLGIIGSIDHSYDYQAVFNGLHYQMIASALITKYGRDIGVRGKFVC
MVSCFDYYALHPTPEDNMKLVHDEQINQWWCADVLATGEYGYYTEKFLADHGVVLDVTDKDRGILRSNTCDVVSFSYYSS
SICSVDEKREKVPGNLVPTLRNPSLEATEWGWQIDPMGLRIAAHKVYDRYRKPIMVAENGLGARDNIDSDGRIHDDYRIS
YLERHMEQAELAVREGVGIEAYFVWGIIDIVSAGSCEMEKRYGVVYVDADNEGRGTYKRLPKDSFYWYRDFIASHR
>Mature_476_residues
MKRILWGGATAASQYEGGFYDGKGMDTQDCRRWIPRLSNDTIQTPLLTEADVRNAKNSRSDDCRFPFRMGSRGYEYWESD
LHYITSLGLDVYRLSISWARLFPTGFEDQSNPEGVMYYDRIIRTLAHAGIKVFITINHYAMPIAIVGKYGGWRHRDVIDL
YLKMAKFVVYRWQENVDYWLPINEINSGYFSPYNGLGIIGSIDHSYDYQAVFNGLHYQMIASALITKYGRDIGVRGKFVC
MVSCFDYYALHPTPEDNMKLVHDEQINQWWCADVLATGEYGYYTEKFLADHGVVLDVTDKDRGILRSNTCDVVSFSYYSS
SICSVDEKREKVPGNLVPTLRNPSLEATEWGWQIDPMGLRIAAHKVYDRYRKPIMVAENGLGARDNIDSDGRIHDDYRIS
YLERHMEQAELAVREGVGIEAYFVWGIIDIVSAGSCEMEKRYGVVYVDADNEGRGTYKRLPKDSFYWYRDFIASHR

Specific function: Catalyzes the hydrolysis of aryl-phospho-beta-D- glucosides such as 4-methylumbelliferyl-phospho-beta-D- glucopyranoside (MUG-P), phosphoarbutin and phosphosalicin. Plays a major role in the utilization of arbutin or salicin as the sole carbon source. Bgl

COG id: COG2723

COG function: function code G; Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 1 family [H]

Homologues:

Organism=Homo sapiens, GI13273313, Length=483, Percent_Identity=24.4306418219462, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI28376633, Length=480, Percent_Identity=24.375, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI32481206, Length=500, Percent_Identity=24.6, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI110681710, Length=515, Percent_Identity=20.7766990291262, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI24497614, Length=489, Percent_Identity=22.6993865030675, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI2367270, Length=476, Percent_Identity=38.2352941176471, Blast_Score=335, Evalue=5e-93,
Organism=Escherichia coli, GI1789070, Length=477, Percent_Identity=36.8972746331237, Blast_Score=327, Evalue=9e-91,
Organism=Escherichia coli, GI2367174, Length=480, Percent_Identity=34.375, Blast_Score=288, Evalue=4e-79,
Organism=Caenorhabditis elegans, GI17539390, Length=510, Percent_Identity=22.3529411764706, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17552856, Length=186, Percent_Identity=27.9569892473118, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21356577, Length=494, Percent_Identity=22.4696356275304, Blast_Score=82, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001360
- InterPro:   IPR018120
- InterPro:   IPR017853
- InterPro:   IPR013781 [H]

Pfam domain/function: PF00232 Glyco_hydro_1 [H]

EC number: =3.2.1.86 [H]

Molecular weight: Translated: 54921; Mature: 54921

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRILWGGATAASQYEGGFYDGKGMDTQDCRRWIPRLSNDTIQTPLLTEADVRNAKNSRS
CCEEEECCCCCCCCCCCCEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCCCC
DDCRFPFRMGSRGYEYWESDLHYITSLGLDVYRLSISWARLFPTGFEDQSNPEGVMYYDR
CCCCCCHHCCCCCHHHHHHHHHHHHHCCCEEEEEEEEEHHHCCCCCCCCCCCCCCHHHHH
IIRTLAHAGIKVFITINHYAMPIAIVGKYGGWRHRDVIDLYLKMAKFVVYRWQENVDYWL
HHHHHHHCCEEEEEEEECCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEE
PINEINSGYFSPYNGLGIIGSIDHSYDYQAVFNGLHYQMIASALITKYGRDIGVRGKFVC
EHHHCCCCCCCCCCCCEEEECCCCCCCHHHHHCCHHHHHHHHHHHHHHCCCCCCCCEEEE
MVSCFDYYALHPTPEDNMKLVHDEQINQWWCADVLATGEYGYYTEKFLADHGVVLDVTDK
EEEEHHHEEECCCCCCCCEEEEHHHCCHHHHHHHHCCCCCCCHHHHHHHCCCEEEEECCC
DRGILRSNTCDVVSFSYYSSSICSVDEKREKVPGNLVPTLRNPSLEATEWGWQIDPMGLR
CCCCEECCCCCEEEECCCCCCHHCCHHHHHHCCCCCCCCCCCCCCCCCCCCCEECCCCEE
IAAHKVYDRYRKPIMVAENGLGARDNIDSDGRIHDDYRISYLERHMEQAELAVREGVGIE
EHHHHHHHHHCCCEEEECCCCCCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHCCCCEE
AYFVWGIIDIVSAGSCEMEKRYGVVYVDADNEGRGTYKRLPKDSFYWYRDFIASHR
EEHHHHHHHHHCCCCCCHHHCCCEEEEECCCCCCCHHHHCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MKRILWGGATAASQYEGGFYDGKGMDTQDCRRWIPRLSNDTIQTPLLTEADVRNAKNSRS
CCEEEECCCCCCCCCCCCEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCCCC
DDCRFPFRMGSRGYEYWESDLHYITSLGLDVYRLSISWARLFPTGFEDQSNPEGVMYYDR
CCCCCCHHCCCCCHHHHHHHHHHHHHCCCEEEEEEEEEHHHCCCCCCCCCCCCCCHHHHH
IIRTLAHAGIKVFITINHYAMPIAIVGKYGGWRHRDVIDLYLKMAKFVVYRWQENVDYWL
HHHHHHHCCEEEEEEEECCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEE
PINEINSGYFSPYNGLGIIGSIDHSYDYQAVFNGLHYQMIASALITKYGRDIGVRGKFVC
EHHHCCCCCCCCCCCCEEEECCCCCCCHHHHHCCHHHHHHHHHHHHHHCCCCCCCCEEEE
MVSCFDYYALHPTPEDNMKLVHDEQINQWWCADVLATGEYGYYTEKFLADHGVVLDVTDK
EEEEHHHEEECCCCCCCCEEEEHHHCCHHHHHHHHCCCCCCCHHHHHHHCCCEEEEECCC
DRGILRSNTCDVVSFSYYSSSICSVDEKREKVPGNLVPTLRNPSLEATEWGWQIDPMGLR
CCCCEECCCCCEEEECCCCCCHHCCHHHHHHCCCCCCCCCCCCCCCCCCCCCEECCCCEE
IAAHKVYDRYRKPIMVAENGLGARDNIDSDGRIHDDYRISYLERHMEQAELAVREGVGIE
EHHHHHHHHHCCCEEEECCCCCCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHCCCCEE
AYFVWGIIDIVSAGSCEMEKRYGVVYVDADNEGRGTYKRLPKDSFYWYRDFIASHR
EEHHHHHHHHHCCCCCCHHHCCCEEEEECCCCCCCHHHHCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7883710; 7704263; 9384377 [H]