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The map label for this gene is acsA [H]

Identifier: 50842393

GI number: 50842393

Start: 990927

End: 991595

Strand: Direct

Name: acsA [H]

Synonym: PPA0909

Alternate gene names: 50842393

Gene position: 990927-991595 (Clockwise)

Preceding gene: 50842387

Following gene: 50842394

Centisome position: 38.7

GC content: 56.95

Gene sequence:

>669_bases
ATGGCCAATGTTCTTAAGGTCATGGGCGTGCGCAAGGGCGATGTCGTCACCATTTATCTGCCCCGCATCCCGGAGATCTT
TTTCGCGATGTTGGCCTGCGCCAAGATTGGTGCGGTGCATTCGGTGTTCTCCCCGACCGTCGAGAACGTCATTGTGGTGC
GCAATACGAAGACCGAGGTTTCGATGGACTCGACTCGTGACCACTGGTACGACGAGTTGTGCAAGCTGCCGATCGCTAAA
GGCAAGTGCGAGACCGTCCAGGTGGACACAGAAGACCCACTATTCATTCTGTACACCTCTGGATTCACCGGCAAGCCGAA
GGCCATCGTTCATACCCATGGTGGCTACCAGGTTGGCACCTACATCACCCTCAAGCAGTACTTCGACATTAAGGAAGAGG
ACCGCTGGTGGTGTACTGCTGATCCGGGCTGGATTAACGGACACTCCTACCTCGTCTACGGCCCGCTGCTCAACGGTGCC
ACCGTCTTCATGCATGAGGGCGGTCCGACGTACCCATACCCCGACGGCTGGTGGCAGCTCATTGAGCACTACGGCATCAC
TAGCTTCTACACCGCTCCAACCGCTATTCGCACTCTCATGCGCTTTGGCGACGCCTGGGTGCGCAAACACGATCTGTCCA
GTTTGCGCATACTCGGTTCGGTTGGCTAG

Upstream 100 bases:

>100_bases
GTACCGTCCGCCGCAATAAGCTAGCCCTTATCTGGGTCGGTGAGAACTCTGATGAGGTGCGTACCTTTCCTACTTCGCCT
TCAATCGAGAAGTCGAGCAG

Downstream 100 bases:

>100_bases
CCCATCAACCCGGAGGCTTGGCGCTGCTTCCACGATGTGGTCGGTGACGGCACGTGTCCGATCACCGATACCTGGTGGCA
GACCGAAACTGGCATGTTCC

Product: acetyl-coenzyme A synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 222; Mature: 221

Protein sequence:

>222_residues
MANVLKVMGVRKGDVVTIYLPRIPEIFFAMLACAKIGAVHSVFSPTVENVIVVRNTKTEVSMDSTRDHWYDELCKLPIAK
GKCETVQVDTEDPLFILYTSGFTGKPKAIVHTHGGYQVGTYITLKQYFDIKEEDRWWCTADPGWINGHSYLVYGPLLNGA
TVFMHEGGPTYPYPDGWWQLIEHYGITSFYTAPTAIRTLMRFGDAWVRKHDLSSLRILGSVG

Sequences:

>Translated_222_residues
MANVLKVMGVRKGDVVTIYLPRIPEIFFAMLACAKIGAVHSVFSPTVENVIVVRNTKTEVSMDSTRDHWYDELCKLPIAK
GKCETVQVDTEDPLFILYTSGFTGKPKAIVHTHGGYQVGTYITLKQYFDIKEEDRWWCTADPGWINGHSYLVYGPLLNGA
TVFMHEGGPTYPYPDGWWQLIEHYGITSFYTAPTAIRTLMRFGDAWVRKHDLSSLRILGSVG
>Mature_221_residues
ANVLKVMGVRKGDVVTIYLPRIPEIFFAMLACAKIGAVHSVFSPTVENVIVVRNTKTEVSMDSTRDHWYDELCKLPIAKG
KCETVQVDTEDPLFILYTSGFTGKPKAIVHTHGGYQVGTYITLKQYFDIKEEDRWWCTADPGWINGHSYLVYGPLLNGAT
VFMHEGGPTYPYPDGWWQLIEHYGITSFYTAPTAIRTLMRFGDAWVRKHDLSSLRILGSVG

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI28416953, Length=269, Percent_Identity=41.2639405204461, Blast_Score=189, Evalue=2e-48,
Organism=Homo sapiens, GI253970489, Length=169, Percent_Identity=52.6627218934911, Blast_Score=177, Evalue=4e-45,
Organism=Homo sapiens, GI8923896, Length=164, Percent_Identity=54.2682926829268, Blast_Score=176, Evalue=1e-44,
Organism=Homo sapiens, GI13375727, Length=274, Percent_Identity=31.3868613138686, Blast_Score=138, Evalue=4e-33,
Organism=Homo sapiens, GI42544134, Length=232, Percent_Identity=28.0172413793103, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI42544132, Length=233, Percent_Identity=27.8969957081545, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI31982927, Length=274, Percent_Identity=27.7372262773723, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI38505220, Length=250, Percent_Identity=26.8, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI122937307, Length=248, Percent_Identity=26.2096774193548, Blast_Score=76, Evalue=2e-14,
Organism=Escherichia coli, GI1790505, Length=270, Percent_Identity=42.962962962963, Blast_Score=205, Evalue=2e-54,
Organism=Escherichia coli, GI1786529, Length=264, Percent_Identity=34.0909090909091, Blast_Score=145, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71982997, Length=277, Percent_Identity=36.4620938628159, Blast_Score=167, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI71983001, Length=277, Percent_Identity=36.4620938628159, Blast_Score=167, Evalue=5e-42,
Organism=Saccharomyces cerevisiae, GI6323182, Length=269, Percent_Identity=40.5204460966543, Blast_Score=184, Evalue=8e-48,
Organism=Saccharomyces cerevisiae, GI6319264, Length=263, Percent_Identity=38.4030418250951, Blast_Score=180, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24667955, Length=283, Percent_Identity=42.756183745583, Blast_Score=206, Evalue=1e-53,
Organism=Drosophila melanogaster, GI62472339, Length=283, Percent_Identity=42.756183745583, Blast_Score=206, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24667959, Length=264, Percent_Identity=40.9090909090909, Blast_Score=181, Evalue=4e-46,
Organism=Drosophila melanogaster, GI21355225, Length=276, Percent_Identity=30.7971014492754, Blast_Score=137, Evalue=6e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 25042; Mature: 24911

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANVLKVMGVRKGDVVTIYLPRIPEIFFAMLACAKIGAVHSVFSPTVENVIVVRNTKTEV
CCCCEEHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEE
SMDSTRDHWYDELCKLPIAKGKCETVQVDTEDPLFILYTSGFTGKPKAIVHTHGGYQVGT
ECCCCHHHHHHHHHCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCCEEEEECCCEEEEE
YITLKQYFDIKEEDRWWCTADPGWINGHSYLVYGPLLNGATVFMHEGGPTYPYPDGWWQL
EEEEEECCCCCCCCCEEEECCCCEECCCCEEEEECCCCCEEEEEECCCCCCCCCCHHHHH
IEHYGITSFYTAPTAIRTLMRFGDAWVRKHDLSSLRILGSVG
HHHCCCCEEEECHHHHHHHHHHHHHHHHHCCCCCEEEEECCC
>Mature Secondary Structure 
ANVLKVMGVRKGDVVTIYLPRIPEIFFAMLACAKIGAVHSVFSPTVENVIVVRNTKTEV
CCCEEHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEE
SMDSTRDHWYDELCKLPIAKGKCETVQVDTEDPLFILYTSGFTGKPKAIVHTHGGYQVGT
ECCCCHHHHHHHHHCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCCEEEEECCCEEEEE
YITLKQYFDIKEEDRWWCTADPGWINGHSYLVYGPLLNGATVFMHEGGPTYPYPDGWWQL
EEEEEECCCCCCCCCEEEECCCCEECCCCEEEEECCCCCEEEEEECCCCCCCCCCHHHHH
IEHYGITSFYTAPTAIRTLMRFGDAWVRKHDLSSLRILGSVG
HHHCCCCEEEECHHHHHHHHHHHHHHHHHCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA