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The map label for this gene is tdk [H]

Identifier: 50365450

GI number: 50365450

Start: 740966

End: 741577

Strand: Reverse

Name: tdk [H]

Synonym: Mfl635

Alternate gene names: 50365450

Gene position: 741577-740966 (Counterclockwise)

Preceding gene: 50365451

Following gene: 50365449

Centisome position: 93.49

GC content: 31.05

Gene sequence:

>612_bases
ATGATACCTAACAGAGATACAATTGAACAAAAACAGTTAGGTTGAGTAGAATTAATAACTGGATGTATGTTTGCTGGTAA
AACAGAAGAGTTTATCAAAAGATTACGTAGACATGCTTTTGCCAAAAGAAATGTAATAGCATTTAAACCAGTCATAGATA
CAAGATATGCTGTTAATGAGGTTGCTTCGCATGCAGGAACTTTATTACCATCAATTCCTGTAAATTCAACAGCTGAATTA
AAAGAAAAACTAGAAGCAAAAATATTAGAAAAAAAAGTAGATGTAGTTGGTATTGATGAAATTCAATTTTTTGATGAAGC
TATTGTTGATTACATTGAAGAATTAGCTGACAGAGGAATAATAGTAATAGTTACAGGTTTAGATAAAGACTTTAGAAGTC
AACCATTTAAAAATGTTGACAGAATACTTCCACTAGCTGAAATGGTAGATAAATTAACAGCCATTTGCCAAAAATGTGGA
AACTTTGCAAATAGAACGCAAAGAATAATTGATGGCAAACCAGCTGATTGAAATTCACCATTAATACTAGTTGATGGTAA
TGATAGTTACGAAGCTAGATGTAGAAATTGCTACCAAATAGAAAAGGGGTAA

Upstream 100 bases:

>100_bases
GACATAAATTAGCAAGTGGATGTAAGTTAAATACACTATCTGATATATCAAAACTTGTTAAAGACTTAGACGCTGTTATA
ACAAAAGGAAACAAATAGTT

Downstream 100 bases:

>100_bases
AAATGAATCCAAAAACTTATGAAGCATTGGAAACAATGCAAAAAAGGGTTGATCAAATAGATAAAGATTTACAATCAGAA
GAAATTGTTTCAGATGTTAA

Product: thymidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 203; Mature: 203

Protein sequence:

>203_residues
MIPNRDTIEQKQLGWVELITGCMFAGKTEEFIKRLRRHAFAKRNVIAFKPVIDTRYAVNEVASHAGTLLPSIPVNSTAEL
KEKLEAKILEKKVDVVGIDEIQFFDEAIVDYIEELADRGIIVIVTGLDKDFRSQPFKNVDRILPLAEMVDKLTAICQKCG
NFANRTQRIIDGKPADWNSPLILVDGNDSYEARCRNCYQIEKG

Sequences:

>Translated_203_residues
MIPNRDTIEQKQLG*VELITGCMFAGKTEEFIKRLRRHAFAKRNVIAFKPVIDTRYAVNEVASHAGTLLPSIPVNSTAEL
KEKLEAKILEKKVDVVGIDEIQFFDEAIVDYIEELADRGIIVIVTGLDKDFRSQPFKNVDRILPLAEMVDKLTAICQKCG
NFANRTQRIIDGKPAD*NSPLILVDGNDSYEARCRNCYQIEKG
>Mature_203_residues
MIPNRDTIEQKQLG*VELITGCMFAGKTEEFIKRLRRHAFAKRNVIAFKPVIDTRYAVNEVASHAGTLLPSIPVNSTAEL
KEKLEAKILEKKVDVVGIDEIQFFDEAIVDYIEELADRGIIVIVTGLDKDFRSQPFKNVDRILPLAEMVDKLTAICQKCG
NFANRTQRIIDGKPAD*NSPLILVDGNDSYEARCRNCYQIEKG

Specific function: Phosphorylates Both Thymidine And Deoxyuridine. [C]

COG id: COG1435

COG function: function code F; Thymidine kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine kinase family [H]

Homologues:

Organism=Homo sapiens, GI164698438, Length=182, Percent_Identity=34.0659340659341, Blast_Score=105, Evalue=3e-23,
Organism=Escherichia coli, GI1787490, Length=178, Percent_Identity=25.8426966292135, Blast_Score=69, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17543396, Length=183, Percent_Identity=35.5191256830601, Blast_Score=110, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001267
- InterPro:   IPR020633
- InterPro:   IPR020634 [H]

Pfam domain/function: PF00265 TK [H]

EC number: =2.7.1.21 [H]

Molecular weight: Translated: 22589; Mature: 22589

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS00603 TK_CELLULAR_TYPE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPNRDTIEQKQLGVELITGCMFAGKTEEFIKRLRRHAFAKRNVIAFKPVIDTRYAVNEV
CCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHH
ASHAGTLLPSIPVNSTAELKEKLEAKILEKKVDVVGIDEIQFFDEAIVDYIEELADRGII
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCEE
VIVTGLDKDFRSQPFKNVDRILPLAEMVDKLTAICQKCGNFANRTQRIIDGKPADNSPLI
EEEECCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCEE
LVDGNDSYEARCRNCYQIEKG
EEECCCCHHHHHHHHHCCCCC
>Mature Secondary Structure
MIPNRDTIEQKQLGVELITGCMFAGKTEEFIKRLRRHAFAKRNVIAFKPVIDTRYAVNEV
CCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHH
ASHAGTLLPSIPVNSTAELKEKLEAKILEKKVDVVGIDEIQFFDEAIVDYIEELADRGII
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCEE
VIVTGLDKDFRSQPFKNVDRILPLAEMVDKLTAICQKCGNFANRTQRIIDGKPADNSPLI
EEEECCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCEE
LVDGNDSYEARCRNCYQIEKG
EEECCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA