Click here to switch to the map view.

The map label for this gene is murC

Identifier: 50086473

GI number: 50086473

Start: 3443462

End: 3444910

Strand: Reverse

Name: murC

Synonym: ACIAD3516

Alternate gene names: 50086473

Gene position: 3444910-3443462 (Counterclockwise)

Preceding gene: 50086474

Following gene: 50086472

Centisome position: 95.73

GC content: 45.96

Gene sequence:

>1449_bases
ATGTCACCAACAACCCCTGCCGATCAAGCAAAAAAACTCATTAAAGTTCCTGAAATGCGCCGTATCAAACACATTTATTT
TGTGGGAATCGGTGGTGCAGGAATGTGTGGCATTGCGGAAGTGTTAAAAAATCAGGGCTACAAAGTATCTGGTTCTGACA
TTAAAGCCTCTAAAACAACAGCACATCTTGAACAAAAAGGCATTAAAGTTTATATCGGTCATACTGCTGATAATTTAAAA
GCAGTCGATGTGCTGGTGGTATCCACTGCGATTGATCCTGAAAATCCTGAAGTCAAGGCCGCAATCGAAAATCGTATCCC
CGTGGTGCGCCGTGCCGAGATGTTGGGCGAGCTCATGCGCTATCGCCATGGAATCGCGGTAGCTGGAACACATGGTAAAA
CCACCACAACCAGTTTGTTAACCACCATGTTGGCCGAAGAAAATATGGACCCAACCTATGTGATTGGCGGGTTGCTCAAC
CGTACGGGTGTCAATGCAGCACTGGGTGCAAGTCGATTTATTGTGGCCGAAGCCGATGAGTCAGATGCCTCATTCTTATA
TCTACAACCGATGGCGGCCATCATTACCAATGTTGATGCCGACCATATGGATACTTATGGCGGTAGCTTCGATAAGCTCA
AAGATACCTTTGTTGAGTTTATTCATCGTTTGCCATTTTATGGTTTGGCTGTGGTCTGTGGTGATGATCATAATGTGCGT
GAAATCATGCCACGTTTTGGCCGTCCAACACTGACCTATGGCTTTAATGAAGATAATGACATTCGCGCTGTAGACGTGGT
GCAAGAGGGGATGCAGTCGCATTTTACCGTACTACGTAAAGATCGTGAACCACTGCGTTTGACTGTTAACCAGCCAGGAC
TGCACAACATTTTAAATGCATTGGCAGCCATTGGTGTGGCCACTGATGAAGGCGTATCTGATGCAGCAATTGCACGTGCA
TTGGAAGGCTTTAGTGGTGTTGGGCGTCGTTTTCAGGTTCAGGGCGAGTTTGAGTTGGGTGAAGGCAGTGTCAAACTAGT
CGATGATTATGGCCATCATCCCAAAGAAGTTGAGGCAACCATTAAAGCTGCCCGTCAGAGTCATCCAGATCGTCGTTTGG
TGATGATGTTTCAGCCTCATCGCTTTAGTCGTACCCGTGACTGTTTTGATGATTTTGTTGAAGTGTTATCGCAGGTCGAT
CAATTATTGTTACTTGAGGTCTACCCTGCAGGTGAGAAGCCCATTGTGGGCGCAGACAGTCGTACATTGGCTCGAAGTAT
TCGTTTGCGTGGTGATGTTGAGCCTATTCTGGTTGATCCAGTGGAAGGCAATTTGCCTAACATCATACAAAAAGTGTTAC
AACCAAATGACTTGTTATTGACGCAGGGTGCAGGTAACGTGGGAGCAATTTCCGTTGATCTTGCCCAGCAGCAATTGTAT
TTGAAATAA

Upstream 100 bases:

>100_bases
TTACTTTCAGAAATGGCTGTAAAAGCCCGTCAACATGCACAACCCAATGCTACCCAACACGTGGTAGACCTTATTCAAAC
TTTGTAAGTTAGAGTGCTCT

Downstream 100 bases:

>100_bases
GTGTATTGCTTGATCATATTTAGTTTGCGATAAAATTTAAGGATAAAAACGTGTCAAATGCTTCAAAATTCGGCAAAGTG
GCGGTGTTGTTTGGTGGGAA

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 482; Mature: 481

Protein sequence:

>482_residues
MSPTTPADQAKKLIKVPEMRRIKHIYFVGIGGAGMCGIAEVLKNQGYKVSGSDIKASKTTAHLEQKGIKVYIGHTADNLK
AVDVLVVSTAIDPENPEVKAAIENRIPVVRRAEMLGELMRYRHGIAVAGTHGKTTTTSLLTTMLAEENMDPTYVIGGLLN
RTGVNAALGASRFIVAEADESDASFLYLQPMAAIITNVDADHMDTYGGSFDKLKDTFVEFIHRLPFYGLAVVCGDDHNVR
EIMPRFGRPTLTYGFNEDNDIRAVDVVQEGMQSHFTVLRKDREPLRLTVNQPGLHNILNALAAIGVATDEGVSDAAIARA
LEGFSGVGRRFQVQGEFELGEGSVKLVDDYGHHPKEVEATIKAARQSHPDRRLVMMFQPHRFSRTRDCFDDFVEVLSQVD
QLLLLEVYPAGEKPIVGADSRTLARSIRLRGDVEPILVDPVEGNLPNIIQKVLQPNDLLLTQGAGNVGAISVDLAQQQLY
LK

Sequences:

>Translated_482_residues
MSPTTPADQAKKLIKVPEMRRIKHIYFVGIGGAGMCGIAEVLKNQGYKVSGSDIKASKTTAHLEQKGIKVYIGHTADNLK
AVDVLVVSTAIDPENPEVKAAIENRIPVVRRAEMLGELMRYRHGIAVAGTHGKTTTTSLLTTMLAEENMDPTYVIGGLLN
RTGVNAALGASRFIVAEADESDASFLYLQPMAAIITNVDADHMDTYGGSFDKLKDTFVEFIHRLPFYGLAVVCGDDHNVR
EIMPRFGRPTLTYGFNEDNDIRAVDVVQEGMQSHFTVLRKDREPLRLTVNQPGLHNILNALAAIGVATDEGVSDAAIARA
LEGFSGVGRRFQVQGEFELGEGSVKLVDDYGHHPKEVEATIKAARQSHPDRRLVMMFQPHRFSRTRDCFDDFVEVLSQVD
QLLLLEVYPAGEKPIVGADSRTLARSIRLRGDVEPILVDPVEGNLPNIIQKVLQPNDLLLTQGAGNVGAISVDLAQQQLY
LK
>Mature_481_residues
SPTTPADQAKKLIKVPEMRRIKHIYFVGIGGAGMCGIAEVLKNQGYKVSGSDIKASKTTAHLEQKGIKVYIGHTADNLKA
VDVLVVSTAIDPENPEVKAAIENRIPVVRRAEMLGELMRYRHGIAVAGTHGKTTTTSLLTTMLAEENMDPTYVIGGLLNR
TGVNAALGASRFIVAEADESDASFLYLQPMAAIITNVDADHMDTYGGSFDKLKDTFVEFIHRLPFYGLAVVCGDDHNVRE
IMPRFGRPTLTYGFNEDNDIRAVDVVQEGMQSHFTVLRKDREPLRLTVNQPGLHNILNALAAIGVATDEGVSDAAIARAL
EGFSGVGRRFQVQGEFELGEGSVKLVDDYGHHPKEVEATIKAARQSHPDRRLVMMFQPHRFSRTRDCFDDFVEVLSQVDQ
LLLLEVYPAGEKPIVGADSRTLARSIRLRGDVEPILVDPVEGNLPNIIQKVLQPNDLLLTQGAGNVGAISVDLAQQQLYL
K

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=469, Percent_Identity=60.3411513859275, Blast_Score=532, Evalue=1e-152,
Organism=Escherichia coli, GI1790680, Length=465, Percent_Identity=29.8924731182796, Blast_Score=167, Evalue=1e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_ACIAD (Q6F704)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_047983.1
- ProteinModelPortal:   Q6F704
- SMR:   Q6F704
- STRING:   Q6F704
- GeneID:   2879155
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD3516
- NMPDR:   fig|62977.3.peg.3176
- eggNOG:   COG0773
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- PhylomeDB:   Q6F704
- ProtClustDB:   PRK00421
- BioCyc:   ASP62977:ACIAD3516-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 52788; Mature: 52657

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPTTPADQAKKLIKVPEMRRIKHIYFVGIGGAGMCGIAEVLKNQGYKVSGSDIKASKTT
CCCCCCHHHHHHHHCCCCHHCEEEEEEEEECCCCHHHHHHHHHCCCEEECCCCCCCCHHH
AHLEQKGIKVYIGHTADNLKAVDVLVVSTAIDPENPEVKAAIENRIPVVRRAEMLGELMR
HHHHHCCCEEEEECCCCCCEEEEEEEEEEECCCCCCCCHHHHHHCCCHHHHHHHHHHHHH
YRHGIAVAGTHGKTTTTSLLTTMLAEENMDPTYVIGGLLNRTGVNAALGASRFIVAEADE
HHCCEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEHHHHHCCCCCHHHCCCEEEEEECCC
SDASFLYLQPMAAIITNVDADHMDTYGGSFDKLKDTFVEFIHRLPFYGLAVVCGDDHNVR
CCCCEEEECHHHHHHHCCCCHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCHH
EIMPRFGRPTLTYGFNEDNDIRAVDVVQEGMQSHFTVLRKDREPLRLTVNQPGLHNILNA
HHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHH
LAAIGVATDEGVSDAAIARALEGFSGVGRRFQVQGEFELGEGSVKLVDDYGHHPKEVEAT
HHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEEEECCCCEEEEECCCCCHHHHHHH
IKAARQSHPDRRLVMMFQPHRFSRTRDCFDDFVEVLSQVDQLLLLEVYPAGEKPIVGADS
HHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCEECCCH
RTLARSIRLRGDVEPILVDPVEGNLPNIIQKVLQPNDLLLTQGAGNVGAISVDLAQQQLY
HHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHCCCCCEEEECCCCCCEEEEEEEHHHHHC
LK
CC
>Mature Secondary Structure 
SPTTPADQAKKLIKVPEMRRIKHIYFVGIGGAGMCGIAEVLKNQGYKVSGSDIKASKTT
CCCCCHHHHHHHHCCCCHHCEEEEEEEEECCCCHHHHHHHHHCCCEEECCCCCCCCHHH
AHLEQKGIKVYIGHTADNLKAVDVLVVSTAIDPENPEVKAAIENRIPVVRRAEMLGELMR
HHHHHCCCEEEEECCCCCCEEEEEEEEEEECCCCCCCCHHHHHHCCCHHHHHHHHHHHHH
YRHGIAVAGTHGKTTTTSLLTTMLAEENMDPTYVIGGLLNRTGVNAALGASRFIVAEADE
HHCCEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEHHHHHCCCCCHHHCCCEEEEEECCC
SDASFLYLQPMAAIITNVDADHMDTYGGSFDKLKDTFVEFIHRLPFYGLAVVCGDDHNVR
CCCCEEEECHHHHHHHCCCCHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCHH
EIMPRFGRPTLTYGFNEDNDIRAVDVVQEGMQSHFTVLRKDREPLRLTVNQPGLHNILNA
HHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHH
LAAIGVATDEGVSDAAIARALEGFSGVGRRFQVQGEFELGEGSVKLVDDYGHHPKEVEAT
HHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEEEECCCCEEEEECCCCCHHHHHHH
IKAARQSHPDRRLVMMFQPHRFSRTRDCFDDFVEVLSQVDQLLLLEVYPAGEKPIVGADS
HHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCEECCCH
RTLARSIRLRGDVEPILVDPVEGNLPNIIQKVLQPNDLLLTQGAGNVGAISVDLAQQQLY
HHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHCCCCCEEEECCCCCCEEEEEEEHHHHHC
LK
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA