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The map label for this gene is folK [H]

Identifier: 50086074

GI number: 50086074

Start: 2988627

End: 2989115

Strand: Reverse

Name: folK [H]

Synonym: ACIAD3062

Alternate gene names: 50086074

Gene position: 2989115-2988627 (Counterclockwise)

Preceding gene: 50086075

Following gene: 50086073

Centisome position: 83.06

GC content: 44.17

Gene sequence:

>489_bases
ATGAGCATAACCACCTATATCGGAATGGGAAGTAATCTGGGAGATTCGCGCCAGTTGCTTCAACAAGCAGTTCGACAGTT
GCAAACATTGGGACAGGTACAAGTTTCGAGGCTTTACCAGAGTCCGCCTATGGGGCCTCAGGATCAGCCACATTATTTGA
ATGCAGTGGTACAACTGAAAACAGATCTGGACCCGCTGATATTGCTTGATGTACTGCAACAGTTTGAACACGATGCAGGA
CGTGTACGTCTACGTCGCTGGGGTGAGCGGACGCTTGATCTTGATTTGCTGTTGTATGCAGATCAAAACATTCATCATGA
ACGTTTAACTGTACCGCATATTGGCTTGCTGGAACGAGATTTTGTGGTCATTCCTTTACTGGATATTGATCCTACACTGG
TTGTCAAAGGCCAAAAACTCAAAGATTTAACACTCATACACGATCCATCACTTACTGTGATTGAGGATCAAAACTGGGTT
GAAAAATAA

Upstream 100 bases:

>100_bases
CATCTCAAGGCTCGGAATCTCATTTTGGCGCAGATCATCCTATTCTAAAACGTAAACGCGTGAAAAGAGATCTGGCACAG
GTGGTCTTTGGACCAACCCA

Downstream 100 bases:

>100_bases
CGCGCTGTTGTGGGTAGCGTTGATAGAGGACATCACGATGATTAGTCTAAGTGACTTAAGAAAGTTTAAAACTGAAGGAC
GCAAATTTTCCTGCTTGACT

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 162; Mature: 161

Protein sequence:

>162_residues
MSITTYIGMGSNLGDSRQLLQQAVRQLQTLGQVQVSRLYQSPPMGPQDQPHYLNAVVQLKTDLDPLILLDVLQQFEHDAG
RVRLRRWGERTLDLDLLLYADQNIHHERLTVPHIGLLERDFVVIPLLDIDPTLVVKGQKLKDLTLIHDPSLTVIEDQNWV
EK

Sequences:

>Translated_162_residues
MSITTYIGMGSNLGDSRQLLQQAVRQLQTLGQVQVSRLYQSPPMGPQDQPHYLNAVVQLKTDLDPLILLDVLQQFEHDAG
RVRLRRWGERTLDLDLLLYADQNIHHERLTVPHIGLLERDFVVIPLLDIDPTLVVKGQKLKDLTLIHDPSLTVIEDQNWV
EK
>Mature_161_residues
SITTYIGMGSNLGDSRQLLQQAVRQLQTLGQVQVSRLYQSPPMGPQDQPHYLNAVVQLKTDLDPLILLDVLQQFEHDAGR
VRLRRWGERTLDLDLLLYADQNIHHERLTVPHIGLLERDFVVIPLLDIDPTLVVKGQKLKDLTLIHDPSLTVIEDQNWVE
K

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=147, Percent_Identity=45.578231292517, Blast_Score=118, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6324073, Length=133, Percent_Identity=31.5789473684211, Blast_Score=69, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 18557; Mature: 18426

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSITTYIGMGSNLGDSRQLLQQAVRQLQTLGQVQVSRLYQSPPMGPQDQPHYLNAVVQLK
CCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHEEEEC
TDLDPLILLDVLQQFEHDAGRVRLRRWGERTLDLDLLLYADQNIHHERLTVPHIGLLERD
CCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEEEEEECCCCCCCEECCCCCCCCCCC
FVVIPLLDIDPTLVVKGQKLKDLTLIHDPSLTVIEDQNWVEK
EEEEEEECCCCEEEEECCCCCEEEEEECCCEEEEECCCCCCC
>Mature Secondary Structure 
SITTYIGMGSNLGDSRQLLQQAVRQLQTLGQVQVSRLYQSPPMGPQDQPHYLNAVVQLK
CEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHEEEEC
TDLDPLILLDVLQQFEHDAGRVRLRRWGERTLDLDLLLYADQNIHHERLTVPHIGLLERD
CCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEEEEEECCCCCCCEECCCCCCCCCCC
FVVIPLLDIDPTLVVKGQKLKDLTLIHDPSLTVIEDQNWVEK
EEEEEEECCCCEEEEECCCCCEEEEEECCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10080886 [H]