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The map label for this gene is gltR [H]

Identifier: 50085601

GI number: 50085601

Start: 2479003

End: 2479932

Strand: Reverse

Name: gltR [H]

Synonym: ACIAD2522

Alternate gene names: 50085601

Gene position: 2479932-2479003 (Counterclockwise)

Preceding gene: 50085603

Following gene: 50085600

Centisome position: 68.91

GC content: 37.85

Gene sequence:

>930_bases
ATGAATTTTAAAAGTATCGAAAATTTTTATTGGGTGGCACGTTTAAATAGTTTTAATAAGGCTGCGGTCAAGTTAAATAC
AACCCAACCAGCAGTTTCCCAGCGTTTGAACAGTTTTGAACAAGAACTGGGGGTGAAATTATTGGAACGTACATCTCGAA
GCCTGCAACTGACTGACAAAGGCAAAGTGGTATATGAATATGCTGAAAAATATATTCAACTGAATCAGGATTTGTTAAAG
GCCTTGTCTGAAAATAAAGCGATTCAAGCCACGATTCGTCTTGGGGTTGCAGAAACGATTGTACATACTTGGCTGGTTGA
TTTTATAGAACAAGTTCAACTGGAATTTCCGCAAGTCACCATTGATATTGTGATTAATATTACGCCAGTATTGAAGCAGG
CAGTCCAATCGGGTGAGCTTGATATGGCCTTTTTACTCGAATCTGGCTGTGATTTTGATTGTATAGAATTGCCCTTATGT
GAATTCCAGCATAGTTTTTTAATCGCACCTCGTTTTCATAAACGATTTATGTCAAGGCAGCTTTCACTCAAAGATATTTC
TCAAACGACAATTTTGACTTACCCTAAAACCACGTATCCCTATGTCGATTTAAAAAAACAGCTCACTTTACATCAGTTTA
AAGAGCCAAAAACCATTACCAGTTACTCATTGGCCACCTTAATTAAGATGACAGAAGAAGGGATGGGGATTGGTATTATT
CCGCACTTGTCTGTTATTCATGAATTGCGAGAGCGACGCTTACAAATTTTACCTGCCGAACTCACTCTCAAGCCTTTTCG
TTTTTCCTGTATCTATGTCGCGGGTAAAGATGATTTGGTCAAGCAGCAGCTTTCTAAAATGGCTTATCAGATTGCTCAGC
AATCTTTACGCAAATTGAATAATCAATTTGATGGTGATCATTATGTATAG

Upstream 100 bases:

>100_bases
GTTGACGTTATAGCGTTTTGGCACAATTTTAGATAAGGGATAGATATTTTAGATCCAGCCAGAAGCGATCAGTGACATAA
GGATATAATGGTTTTACGTC

Downstream 100 bases:

>100_bases
CAAATAAATCCCTCTACTTCTCAATCTTGCTTTTTAAATTTAAGCAGGATATTGGTGCAATATATGCCCAGTATTTGTGC
ATGATGCACCAATAACATAT

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MNFKSIENFYWVARLNSFNKAAVKLNTTQPAVSQRLNSFEQELGVKLLERTSRSLQLTDKGKVVYEYAEKYIQLNQDLLK
ALSENKAIQATIRLGVAETIVHTWLVDFIEQVQLEFPQVTIDIVINITPVLKQAVQSGELDMAFLLESGCDFDCIELPLC
EFQHSFLIAPRFHKRFMSRQLSLKDISQTTILTYPKTTYPYVDLKKQLTLHQFKEPKTITSYSLATLIKMTEEGMGIGII
PHLSVIHELRERRLQILPAELTLKPFRFSCIYVAGKDDLVKQQLSKMAYQIAQQSLRKLNNQFDGDHYV

Sequences:

>Translated_309_residues
MNFKSIENFYWVARLNSFNKAAVKLNTTQPAVSQRLNSFEQELGVKLLERTSRSLQLTDKGKVVYEYAEKYIQLNQDLLK
ALSENKAIQATIRLGVAETIVHTWLVDFIEQVQLEFPQVTIDIVINITPVLKQAVQSGELDMAFLLESGCDFDCIELPLC
EFQHSFLIAPRFHKRFMSRQLSLKDISQTTILTYPKTTYPYVDLKKQLTLHQFKEPKTITSYSLATLIKMTEEGMGIGII
PHLSVIHELRERRLQILPAELTLKPFRFSCIYVAGKDDLVKQQLSKMAYQIAQQSLRKLNNQFDGDHYV
>Mature_309_residues
MNFKSIENFYWVARLNSFNKAAVKLNTTQPAVSQRLNSFEQELGVKLLERTSRSLQLTDKGKVVYEYAEKYIQLNQDLLK
ALSENKAIQATIRLGVAETIVHTWLVDFIEQVQLEFPQVTIDIVINITPVLKQAVQSGELDMAFLLESGCDFDCIELPLC
EFQHSFLIAPRFHKRFMSRQLSLKDISQTTILTYPKTTYPYVDLKKQLTLHQFKEPKTITSYSLATLIKMTEEGMGIGII
PHLSVIHELRERRLQILPAELTLKPFRFSCIYVAGKDDLVKQQLSKMAYQIAQQSLRKLNNQFDGDHYV

Specific function: Positive regulator of glutamate biosynthesis (gltAB genes). Negatively regulates its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790262, Length=281, Percent_Identity=27.4021352313167, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1788297, Length=243, Percent_Identity=25.1028806584362, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1789204, Length=250, Percent_Identity=24.8, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1790783, Length=269, Percent_Identity=24.5353159851301, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1789639, Length=260, Percent_Identity=24.2307692307692, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI145693105, Length=251, Percent_Identity=25.8964143426295, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1790399, Length=312, Percent_Identity=24.6794871794872, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI157672245, Length=124, Percent_Identity=29.0322580645161, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788706, Length=164, Percent_Identity=29.2682926829268, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1786401, Length=286, Percent_Identity=24.4755244755245, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI87081904, Length=266, Percent_Identity=21.8045112781955, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1788748, Length=259, Percent_Identity=23.5521235521236, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 35624; Mature: 35624

Theoretical pI: Translated: 8.56; Mature: 8.56

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFKSIENFYWVARLNSFNKAAVKLNTTQPAVSQRLNSFEQELGVKLLERTSRSLQLTDK
CCCCHHHHEEEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCC
GKVVYEYAEKYIQLNQDLLKALSENKAIQATIRLGVAETIVHTWLVDFIEQVQLEFPQVT
CCHHHHHHHHHHHHCHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEE
IDIVINITPVLKQAVQSGELDMAFLLESGCDFDCIELPLCEFQHSFLIAPRFHKRFMSRQ
EEEEEECCHHHHHHHHCCCCCHHHHHHCCCCCCHHCCCHHHHCCCEEECHHHHHHHHHHC
LSLKDISQTTILTYPKTTYPYVDLKKQLTLHQFKEPKTITSYSLATLIKMTEEGMGIGII
CCHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEECH
PHLSVIHELRERRLQILPAELTLKPFRFSCIYVAGKDDLVKQQLSKMAYQIAQQSLRKLN
HHHHHHHHHHHHHHHCCCHHHEECCEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHH
NQFDGDHYV
HCCCCCCCC
>Mature Secondary Structure
MNFKSIENFYWVARLNSFNKAAVKLNTTQPAVSQRLNSFEQELGVKLLERTSRSLQLTDK
CCCCHHHHEEEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCC
GKVVYEYAEKYIQLNQDLLKALSENKAIQATIRLGVAETIVHTWLVDFIEQVQLEFPQVT
CCHHHHHHHHHHHHCHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEE
IDIVINITPVLKQAVQSGELDMAFLLESGCDFDCIELPLCEFQHSFLIAPRFHKRFMSRQ
EEEEEECCHHHHHHHHCCCCCHHHHHHCCCCCCHHCCCHHHHCCCEEECHHHHHHHHHHC
LSLKDISQTTILTYPKTTYPYVDLKKQLTLHQFKEPKTITSYSLATLIKMTEEGMGIGII
CCHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEECH
PHLSVIHELRERRLQILPAELTLKPFRFSCIYVAGKDDLVKQQLSKMAYQIAQQSLRKLN
HHHHHHHHHHHHHHHCCCHHHEECCEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHH
NQFDGDHYV
HCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9023181; 9308178; 9384377 [H]