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The map label for this gene is sahH

Identifier: 50085382

GI number: 50085382

Start: 2253029

End: 2254432

Strand: Direct

Name: sahH

Synonym: ACIAD2282

Alternate gene names: 50085382

Gene position: 2253029-2254432 (Clockwise)

Preceding gene: 50085380

Following gene: 50085383

Centisome position: 62.61

GC content: 41.74

Gene sequence:

>1404_bases
TTGTTTTTTAAGGAGATCGTGATGAACGCGGTTAATGCTTCATTTACAGATTATAAAGTTGCCGATATTTCTCTTGCAGA
TTATGGCCGTAAAGAAATCAAACTTGCTGAAGCTGAAATGCCAGCTTTAATTGGCTTACGCAAACGCTACGCTGCTGAAA
AACCACTGGCTGGTGCTAAAATTCTTGGCTGTATCCACATGACCATTCAAACAGCCGTTTTAATTGAAACGCTGGTGGAA
CTAGGCGCTGAAGTTCGCTGGACCTCTTGTAATATTTTCTCGACTCAAGATCATGCTGCTGCTGCAATTGCTGCAAGTGG
CGTACCTGTATTTGCCTGGAAAGGCGAAACCGAAGAAGAATATAACTGGTGTCTTGAGCAACAAATTAATGTCAATGGCA
AACCTTGGGATGCCAATATGATTCTGGACGATGGCGGTGACTTGACTGCTCTAGTTCATGAAAAATATCCTACTCTTCTT
GACCATATTCATGGTATTACAGAAGAAACCACAACGGGTGTTCAACGTCTTCTTGAAATGTGGAAAGACGGCTCGCTTAA
AGTGCCTGCAATCAATGTCAATGATTCTGTGACCAAGTCTAAAAATGACAATAAATATGGTTGCCGTCACTCGCTGAATG
ACGCGATCAAACGTGCAACAGACATGTTACTTTCTGGTCGTCGTGCGCTTGTGATCGGTTACGGTGATGTGGGTAAAGGT
TCTGCTCAATCTCTACGCCAAGAAGGTATGATTGTACGTGTCACCGAAGTTGATCCGATTTGTGCCATGCAAGCGTGTAT
GGATGGCTACGAAGTTGTTTCTCCATACAAAAATGGTGTTCAGACTGGTAAAAAAGAAGACATTAATCTTGATCTTCTTA
AAAATACCGACTTAATTGTGACAACAACGGGTAACTACCACGTATGTGATTCAGCTATGCTGGATACACTTAAAGCTGGT
GCTGTAGTATGTAATATCGGTCACTTTGATACAGAGATTGATACCAACTATTTACGTGGTTACAAGTGGGTAGAAGTAAA
ACCTCAAGTTCATCAGGTTTATCGTTCAGAAAATGAAAACGATTACTTGATTCTTCTTTCAGAAGGTCGTTTGGTCAATC
TGGGGAATGCAACAGGTCACCCATCACGTGTCATGGATGGTTCTTTTGCAAACCAAGTATTGGGCCAAATCCATCTGTTC
CAAGAAAAATTTGCTGATTTACCTGCAAGTGAAAAAGCTGCTCAAATTCGTGTCGAAGTTCTTCCGAAAAAACTCGATGA
AGAAGTTGCTGCGGCAATGGTACTTGGATTTGGTGGTGTATTGACCCAACTTACGTCGGTACAAGCAGATTACCTAGGTG
TTCCTGTTGAAGGCCCATTTAAATCTGACGCTTACAAATACTAA

Upstream 100 bases:

>100_bases
TGGTACTAAAAATCAATTTGCCAGGCTCGACGATCGGTTAATCTTTTTAAATACATGGGTTTTAACCAACAACGGCATCC
GCGAACTGAATGATCCATAT

Downstream 100 bases:

>100_bases
GATATGAAGGGCAGCGCTGTAATAGGCTGCCCTTTTCTTAAACATTTTAAGTGATTTTGAAAAGGATTTATAATGTCAAA
ACGTACACCTATTTCATTTG

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MFFKEIVMNAVNASFTDYKVADISLADYGRKEIKLAEAEMPALIGLRKRYAAEKPLAGAKILGCIHMTIQTAVLIETLVE
LGAEVRWTSCNIFSTQDHAAAAIAASGVPVFAWKGETEEEYNWCLEQQINVNGKPWDANMILDDGGDLTALVHEKYPTLL
DHIHGITEETTTGVQRLLEMWKDGSLKVPAINVNDSVTKSKNDNKYGCRHSLNDAIKRATDMLLSGRRALVIGYGDVGKG
SAQSLRQEGMIVRVTEVDPICAMQACMDGYEVVSPYKNGVQTGKKEDINLDLLKNTDLIVTTTGNYHVCDSAMLDTLKAG
AVVCNIGHFDTEIDTNYLRGYKWVEVKPQVHQVYRSENENDYLILLSEGRLVNLGNATGHPSRVMDGSFANQVLGQIHLF
QEKFADLPASEKAAQIRVEVLPKKLDEEVAAAMVLGFGGVLTQLTSVQADYLGVPVEGPFKSDAYKY

Sequences:

>Translated_467_residues
MFFKEIVMNAVNASFTDYKVADISLADYGRKEIKLAEAEMPALIGLRKRYAAEKPLAGAKILGCIHMTIQTAVLIETLVE
LGAEVRWTSCNIFSTQDHAAAAIAASGVPVFAWKGETEEEYNWCLEQQINVNGKPWDANMILDDGGDLTALVHEKYPTLL
DHIHGITEETTTGVQRLLEMWKDGSLKVPAINVNDSVTKSKNDNKYGCRHSLNDAIKRATDMLLSGRRALVIGYGDVGKG
SAQSLRQEGMIVRVTEVDPICAMQACMDGYEVVSPYKNGVQTGKKEDINLDLLKNTDLIVTTTGNYHVCDSAMLDTLKAG
AVVCNIGHFDTEIDTNYLRGYKWVEVKPQVHQVYRSENENDYLILLSEGRLVNLGNATGHPSRVMDGSFANQVLGQIHLF
QEKFADLPASEKAAQIRVEVLPKKLDEEVAAAMVLGFGGVLTQLTSVQADYLGVPVEGPFKSDAYKY
>Mature_467_residues
MFFKEIVMNAVNASFTDYKVADISLADYGRKEIKLAEAEMPALIGLRKRYAAEKPLAGAKILGCIHMTIQTAVLIETLVE
LGAEVRWTSCNIFSTQDHAAAAIAASGVPVFAWKGETEEEYNWCLEQQINVNGKPWDANMILDDGGDLTALVHEKYPTLL
DHIHGITEETTTGVQRLLEMWKDGSLKVPAINVNDSVTKSKNDNKYGCRHSLNDAIKRATDMLLSGRRALVIGYGDVGKG
SAQSLRQEGMIVRVTEVDPICAMQACMDGYEVVSPYKNGVQTGKKEDINLDLLKNTDLIVTTTGNYHVCDSAMLDTLKAG
AVVCNIGHFDTEIDTNYLRGYKWVEVKPQVHQVYRSENENDYLILLSEGRLVNLGNATGHPSRVMDGSFANQVLGQIHLF
QEKFADLPASEKAAQIRVEVLPKKLDEEVAAAMVLGFGGVLTQLTSVQADYLGVPVEGPFKSDAYKY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family

Homologues:

Organism=Homo sapiens, GI9951915, Length=452, Percent_Identity=56.1946902654867, Blast_Score=462, Evalue=1e-130,
Organism=Homo sapiens, GI239937451, Length=430, Percent_Identity=55.8139534883721, Blast_Score=436, Evalue=1e-122,
Organism=Homo sapiens, GI298286489, Length=454, Percent_Identity=48.0176211453744, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI24308043, Length=454, Percent_Identity=48.0176211453744, Blast_Score=421, Evalue=1e-118,
Organism=Homo sapiens, GI195539337, Length=454, Percent_Identity=48.0176211453744, Blast_Score=421, Evalue=1e-118,
Organism=Homo sapiens, GI195539349, Length=454, Percent_Identity=48.0176211453744, Blast_Score=421, Evalue=1e-118,
Organism=Homo sapiens, GI21361647, Length=454, Percent_Identity=47.7973568281938, Blast_Score=404, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI17506425, Length=453, Percent_Identity=57.3951434878587, Blast_Score=481, Evalue=1e-136,
Organism=Saccharomyces cerevisiae, GI6320882, Length=467, Percent_Identity=55.8886509635974, Blast_Score=476, Evalue=1e-135,
Organism=Drosophila melanogaster, GI24642172, Length=457, Percent_Identity=57.5492341356674, Blast_Score=470, Evalue=1e-132,
Organism=Drosophila melanogaster, GI24656245, Length=455, Percent_Identity=48.5714285714286, Blast_Score=425, Evalue=1e-119,
Organism=Drosophila melanogaster, GI45553387, Length=458, Percent_Identity=47.3799126637555, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI45553385, Length=457, Percent_Identity=47.2647702407002, Blast_Score=392, Evalue=1e-109,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SAHH_ACIAD (Q6FA43)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_046892.1
- ProteinModelPortal:   Q6FA43
- STRING:   Q6FA43
- GeneID:   2879932
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD2282
- NMPDR:   fig|62977.3.peg.2179
- eggNOG:   COG0499
- HOGENOM:   HBG352029
- OMA:   VITHDHM
- PhylomeDB:   Q6FA43
- ProtClustDB:   PRK05476
- BioCyc:   ASP62977:ACIAD2282-MONOMER
- GO:   GO:0005737
- GO:   GO:0005488
- HAMAP:   MF_00563
- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082
- PANTHER:   PTHR23420
- PIRSF:   PIRSF001109
- TIGRFAMs:   TIGR00936

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD

EC number: =3.3.1.1

Molecular weight: Translated: 51370; Mature: 51370

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00738 ADOHCYASE_1; PS00739 ADOHCYASE_2

Important sites: BINDING 68-68 BINDING 144-144 BINDING 169-169 BINDING 199-199 BINDING 203-203 BINDING 204-204 BINDING 256-256 BINDING 305-305 BINDING 373-373

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFFKEIVMNAVNASFTDYKVADISLADYGRKEIKLAEAEMPALIGLRKRYAAEKPLAGAK
CCHHHHHHHHHCCCCCCEEEEEEEHHHCCCHHEEEEHHCCCHHHHHHHHHHCCCCCCCHH
ILGCIHMTIQTAVLIETLVELGAEVRWTSCNIFSTQDHAAAAIAASGVPVFAWKGETEEE
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCHHHHHEECCCEEEEECCCCHHH
YNWCLEQQINVNGKPWDANMILDDGGDLTALVHEKYPTLLDHIHGITEETTTGVQRLLEM
HHHHHHHCCCCCCCCCCCEEEEECCCCEEEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHH
WKDGSLKVPAINVNDSVTKSKNDNKYGCRHSLNDAIKRATDMLLSGRRALVIGYGDVGKG
CCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCC
SAQSLRQEGMIVRVTEVDPICAMQACMDGYEVVSPYKNGVQTGKKEDINLDLLKNTDLIV
HHHHHHHCCCEEEEECCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCEEEEEECCCEEE
TTTGNYHVCDSAMLDTLKAGAVVCNIGHFDTEIDTNYLRGYKWVEVKPQVHQVYRSENEN
EECCCEEECCHHHHHHHHCCEEEEECCCCCCCCCHHHHCCEEEEEECHHHHHHHHCCCCC
DYLILLSEGRLVNLGNATGHPSRVMDGSFANQVLGQIHLFQEKFADLPASEKAAQIRVEV
CEEEEECCCCEEEECCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHEEEEEH
LPKKLDEEVAAAMVLGFGGVLTQLTSVQADYLGVPVEGPFKSDAYKY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MFFKEIVMNAVNASFTDYKVADISLADYGRKEIKLAEAEMPALIGLRKRYAAEKPLAGAK
CCHHHHHHHHHCCCCCCEEEEEEEHHHCCCHHEEEEHHCCCHHHHHHHHHHCCCCCCCHH
ILGCIHMTIQTAVLIETLVELGAEVRWTSCNIFSTQDHAAAAIAASGVPVFAWKGETEEE
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCHHHHHEECCCEEEEECCCCHHH
YNWCLEQQINVNGKPWDANMILDDGGDLTALVHEKYPTLLDHIHGITEETTTGVQRLLEM
HHHHHHHCCCCCCCCCCCEEEEECCCCEEEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHH
WKDGSLKVPAINVNDSVTKSKNDNKYGCRHSLNDAIKRATDMLLSGRRALVIGYGDVGKG
CCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCC
SAQSLRQEGMIVRVTEVDPICAMQACMDGYEVVSPYKNGVQTGKKEDINLDLLKNTDLIV
HHHHHHHCCCEEEEECCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCEEEEEECCCEEE
TTTGNYHVCDSAMLDTLKAGAVVCNIGHFDTEIDTNYLRGYKWVEVKPQVHQVYRSENEN
EECCCEEECCHHHHHHHHCCEEEEECCCCCCCCCHHHHCCEEEEEECHHHHHHHHCCCCC
DYLILLSEGRLVNLGNATGHPSRVMDGSFANQVLGQIHLFQEKFADLPASEKAAQIRVEV
CEEEEECCCCEEEECCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHEEEEEH
LPKKLDEEVAAAMVLGFGGVLTQLTSVQADYLGVPVEGPFKSDAYKY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA