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The map label for this gene is ppiD [H]

Identifier: 50084586

GI number: 50084586

Start: 1401702

End: 1403570

Strand: Direct

Name: ppiD [H]

Synonym: ACIAD1409

Alternate gene names: 50084586

Gene position: 1401702-1403570 (Clockwise)

Preceding gene: 50084585

Following gene: 50084588

Centisome position: 38.95

GC content: 38.84

Gene sequence:

>1869_bases
ATGGAATCGTTTCGTAAAGTCATTAAGGGTTGGCTTGGAAAAGTCCTGCTAATTTTGTTTTTGACCCCTTTGGCACTAGT
AGGTATTGAAGGATATTTTGGCGGTGGTAATAAAGCAGATGTTGCAAAAACAGTAAATGGTCAAGATATTTCCAAAAAGG
ATCTAGAGAATCTAACTAAAACTTATAAAGACCAGTATCTCTCGTTAGCCAAAGGCGATGAAACCTTACTCAACCAGTCT
TATATTGAAGAAAATGCGCTCAATACATTAATTGCACGTAGTTTATTGCTACAGCAAGCTGAAAAATTAGGTATTTCTTT
AAGCGATGCGCAAATTGAAAAGATGCTGGCTCAGCAGCCAAGTTTCCAAGAAAATGGAAAATTTTCTGAAACTTTGTATA
GCAACTATCTGCGTTCAGTTGGAATGACAAGTCAGGCACTTATTGCAAGCTTGAGACAAGATCACGCTTTAAAAATGCTT
ACTTCGAGTGTGACTGACACGGCCTTGGTCAGTAAATTTGATCTTCATCAAATTGCGGTCTTGCAGACAGAGCAACGCAC
TATTCATCTTGCCAGTATCAAGCTTGATGATTATAAAAAAAATATCAATGTGACAAATCAAGAAATTGCTGACTATTACA
ATAAGCACAAAAATAAATTTAAACAGGTTGCAAGTGTAGATGTAGATTATATTGTAGTTTCTCCTGCGCAAGTGTCTAGT
GCTCCAGCCGCTGTGACAGAAGCCGAACTCCAACAGGCATATAATGCTTTTGTAGAGACTCAGAAGAAAGATGCAAAACG
ATTGGTCAAGCATATCTTGATTACTGCAGATGGTCGTTCAGATGCAGAAGCGCAAAAAATTGCGAATGACGTATATGCAA
AAATTCAGGCAGGCACTCACTTTTCTGAGGCTGCAAAACAATACTCTGATGACACGAGTTCAAAGAACAATGGTGGTGTG
GTAGATGCATACCAACCAGGGATCTTCTCTAAAGATTTCGATCAAGCTGTTGAGTCATTAAAGAATGGTCAGGTTTCCAA
ACCAGTCAAAACACAATATGGTTATCACATTATTGAAGTTGAAACTGCTCAGGTAAAACTACCATCACTGGAAGCAGAAA
AAGCACGACTCACAGCAGAGATTCAAAAGTCTAAATCTGCAAATGCTTATACTGATACAATTAACCGTTTAAATGAAATG
GTCGTGAGTACTGATGCTTTGGATTCAGTGGCGCAGGAGCTCAAAGGTTTACGTGTTGAATCATTAAATGGCGTGACGCT
GTCAACACAGCATCCGTTACTCAGTGATCCAAATGTAAAAGCTAAATTGTTTAATGATGATGTTAAAAATGGTGATCGTA
ACGCATCAAGTAATATTCAGCTTGCTAATGGTGACACAATTTGGGTAAAAGTACGTAACTATCATGCTGCTGGTGTAAAG
CCTTTAGCGACTGCAACTGCACAGGTACGCGCCAAATTGATTGAAGACAAAGCATTTAATGCAGCCCAAGCTAAAATTCA
AGCTGTATTAAACGACTTTAAAACTCAGCCAGCAGATCAGGTTGTTGCCAAGAGTGGTCTTAAATTTGAAAGTGCAGGTA
CCTTTACTCGTTCACAAGGTTTAAAGCGTGAAATTGAACGTGCAGCGTTCAGTTTAACTGCACCAAAAGCAGGAATGTGG
TCAGTAGCCACCGCAAAATTACCTGATGAACTTGTGGTTGTAGGTGTATCTGATATCAATTCTAAGGCAGCAGATGCGCT
TAACCCTGAACAATTGCAAGAACTAGGTAATTTATATCAGCGTTTCCGTGGTCAGCAGGAACTTGATGATTATACTCAGT
ATTTAAAATCACACGCCAAAATTAAATAA

Upstream 100 bases:

>100_bases
CGCGTTTTTTATTAAAAAGATGGATTACTGAGTGTTTCATACATTCATTCGATAGTGTTTTTCAGTTAAAATCCCTCCGA
AATAAAATATTGGAATACTT

Downstream 100 bases:

>100_bases
TCTTTGACTTTGAAATAAAAAAGCGCCATATTCGGCGCTTTTTTTATCATGATTGCTGGCGATAGTGTTTAGGAGATTGT
TCAAATTGACGTTTAAATGC

Product: peptidyl-prolyl cis-trans isomerase precursor (PPIase)

Products: NA

Alternate protein names: PPIase D; Rotamase D [H]

Number of amino acids: Translated: 622; Mature: 622

Protein sequence:

>622_residues
MESFRKVIKGWLGKVLLILFLTPLALVGIEGYFGGGNKADVAKTVNGQDISKKDLENLTKTYKDQYLSLAKGDETLLNQS
YIEENALNTLIARSLLLQQAEKLGISLSDAQIEKMLAQQPSFQENGKFSETLYSNYLRSVGMTSQALIASLRQDHALKML
TSSVTDTALVSKFDLHQIAVLQTEQRTIHLASIKLDDYKKNINVTNQEIADYYNKHKNKFKQVASVDVDYIVVSPAQVSS
APAAVTEAELQQAYNAFVETQKKDAKRLVKHILITADGRSDAEAQKIANDVYAKIQAGTHFSEAAKQYSDDTSSKNNGGV
VDAYQPGIFSKDFDQAVESLKNGQVSKPVKTQYGYHIIEVETAQVKLPSLEAEKARLTAEIQKSKSANAYTDTINRLNEM
VVSTDALDSVAQELKGLRVESLNGVTLSTQHPLLSDPNVKAKLFNDDVKNGDRNASSNIQLANGDTIWVKVRNYHAAGVK
PLATATAQVRAKLIEDKAFNAAQAKIQAVLNDFKTQPADQVVAKSGLKFESAGTFTRSQGLKREIERAAFSLTAPKAGMW
SVATAKLPDELVVVGVSDINSKAADALNPEQLQELGNLYQRFRGQQELDDYTQYLKSHAKIK

Sequences:

>Translated_622_residues
MESFRKVIKGWLGKVLLILFLTPLALVGIEGYFGGGNKADVAKTVNGQDISKKDLENLTKTYKDQYLSLAKGDETLLNQS
YIEENALNTLIARSLLLQQAEKLGISLSDAQIEKMLAQQPSFQENGKFSETLYSNYLRSVGMTSQALIASLRQDHALKML
TSSVTDTALVSKFDLHQIAVLQTEQRTIHLASIKLDDYKKNINVTNQEIADYYNKHKNKFKQVASVDVDYIVVSPAQVSS
APAAVTEAELQQAYNAFVETQKKDAKRLVKHILITADGRSDAEAQKIANDVYAKIQAGTHFSEAAKQYSDDTSSKNNGGV
VDAYQPGIFSKDFDQAVESLKNGQVSKPVKTQYGYHIIEVETAQVKLPSLEAEKARLTAEIQKSKSANAYTDTINRLNEM
VVSTDALDSVAQELKGLRVESLNGVTLSTQHPLLSDPNVKAKLFNDDVKNGDRNASSNIQLANGDTIWVKVRNYHAAGVK
PLATATAQVRAKLIEDKAFNAAQAKIQAVLNDFKTQPADQVVAKSGLKFESAGTFTRSQGLKREIERAAFSLTAPKAGMW
SVATAKLPDELVVVGVSDINSKAADALNPEQLQELGNLYQRFRGQQELDDYTQYLKSHAKIK
>Mature_622_residues
MESFRKVIKGWLGKVLLILFLTPLALVGIEGYFGGGNKADVAKTVNGQDISKKDLENLTKTYKDQYLSLAKGDETLLNQS
YIEENALNTLIARSLLLQQAEKLGISLSDAQIEKMLAQQPSFQENGKFSETLYSNYLRSVGMTSQALIASLRQDHALKML
TSSVTDTALVSKFDLHQIAVLQTEQRTIHLASIKLDDYKKNINVTNQEIADYYNKHKNKFKQVASVDVDYIVVSPAQVSS
APAAVTEAELQQAYNAFVETQKKDAKRLVKHILITADGRSDAEAQKIANDVYAKIQAGTHFSEAAKQYSDDTSSKNNGGV
VDAYQPGIFSKDFDQAVESLKNGQVSKPVKTQYGYHIIEVETAQVKLPSLEAEKARLTAEIQKSKSANAYTDTINRLNEM
VVSTDALDSVAQELKGLRVESLNGVTLSTQHPLLSDPNVKAKLFNDDVKNGDRNASSNIQLANGDTIWVKVRNYHAAGVK
PLATATAQVRAKLIEDKAFNAAQAKIQAVLNDFKTQPADQVVAKSGLKFESAGTFTRSQGLKREIERAAFSLTAPKAGMW
SVATAKLPDELVVVGVSDINSKAADALNPEQLQELGNLYQRFRGQQELDDYTQYLKSHAKIK

Specific function: PPIases accelerate the folding of proteins. Seems to be involved in the folding of outer membrane proteins [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein; Periplasmic side [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Escherichia coli, GI1786645, Length=585, Percent_Identity=27.6923076923077, Blast_Score=171, Evalue=1e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR015391
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase; PF09312 SurA_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 68358; Mature: 68358

Theoretical pI: Translated: 8.77; Mature: 8.77

Prosite motif: PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESFRKVIKGWLGKVLLILFLTPLALVGIEGYFGGGNKADVAKTVNGQDISKKDLENLTK
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHH
TYKDQYLSLAKGDETLLNQSYIEENALNTLIARSLLLQQAEKLGISLSDAQIEKMLAQQP
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCC
SFQENGKFSETLYSNYLRSVGMTSQALIASLRQDHALKMLTSSVTDTALVSKFDLHQIAV
CCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHE
LQTEQRTIHLASIKLDDYKKNINVTNQEIADYYNKHKNKFKQVASVDVDYIVVSPAQVSS
EEECCCEEEEEEEEEHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHCC
APAAVTEAELQQAYNAFVETQKKDAKRLVKHILITADGRSDAEAQKIANDVYAKIQAGTH
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHCCCC
FSEAAKQYSDDTSSKNNGGVVDAYQPGIFSKDFDQAVESLKNGQVSKPVKTQYGYHIIEV
HHHHHHHHCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHCCCCCCCHHHHCCEEEEEE
ETAQVKLPSLEAEKARLTAEIQKSKSANAYTDTINRLNEMVVSTDALDSVAQELKGLRVE
EEEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEE
SLNGVTLSTQHPLLSDPNVKAKLFNDDVKNGDRNASSNIQLANGDTIWVKVRNYHAAGVK
CCCCEEEECCCCCCCCCCCEEEEECCHHCCCCCCCCCCEEEECCCEEEEEEECCCCCCCC
PLATATAQVRAKLIEDKAFNAAQAKIQAVLNDFKTQPADQVVAKSGLKFESAGTFTRSQG
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCHHHHH
LKREIERAAFSLTAPKAGMWSVATAKLPDELVVVGVSDINSKAADALNPEQLQELGNLYQ
HHHHHHHHHHHCCCCCCCCCEEHHHCCCCCEEEEEECCCCCHHHCCCCHHHHHHHHHHHH
RFRGQQELDDYTQYLKSHAKIK
HHCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MESFRKVIKGWLGKVLLILFLTPLALVGIEGYFGGGNKADVAKTVNGQDISKKDLENLTK
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHH
TYKDQYLSLAKGDETLLNQSYIEENALNTLIARSLLLQQAEKLGISLSDAQIEKMLAQQP
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCC
SFQENGKFSETLYSNYLRSVGMTSQALIASLRQDHALKMLTSSVTDTALVSKFDLHQIAV
CCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHE
LQTEQRTIHLASIKLDDYKKNINVTNQEIADYYNKHKNKFKQVASVDVDYIVVSPAQVSS
EEECCCEEEEEEEEEHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHCC
APAAVTEAELQQAYNAFVETQKKDAKRLVKHILITADGRSDAEAQKIANDVYAKIQAGTH
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHCCCC
FSEAAKQYSDDTSSKNNGGVVDAYQPGIFSKDFDQAVESLKNGQVSKPVKTQYGYHIIEV
HHHHHHHHCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHCCCCCCCHHHHCCEEEEEE
ETAQVKLPSLEAEKARLTAEIQKSKSANAYTDTINRLNEMVVSTDALDSVAQELKGLRVE
EEEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEE
SLNGVTLSTQHPLLSDPNVKAKLFNDDVKNGDRNASSNIQLANGDTIWVKVRNYHAAGVK
CCCCEEEECCCCCCCCCCCEEEEECCHHCCCCCCCCCCEEEECCCEEEEEEECCCCCCCC
PLATATAQVRAKLIEDKAFNAAQAKIQAVLNDFKTQPADQVVAKSGLKFESAGTFTRSQG
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCHHHHH
LKREIERAAFSLTAPKAGMWSVATAKLPDELVVVGVSDINSKAADALNPEQLQELGNLYQ
HHHHHHHHHHHCCCCCCCCCEEHHHCCCCCEEEEEECCCCCHHHCCCCHHHHHHHHHHHH
RFRGQQELDDYTQYLKSHAKIK
HHCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]