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The map label for this gene is lpxA [H]

Identifier: 50084560

GI number: 50084560

Start: 1378068

End: 1378856

Strand: Direct

Name: lpxA [H]

Synonym: ACIAD1382

Alternate gene names: 50084560

Gene position: 1378068-1378856 (Clockwise)

Preceding gene: 50084559

Following gene: 50084565

Centisome position: 38.29

GC content: 39.04

Gene sequence:

>789_bases
ATGAGCAATAACGACCTAATTCATTCTACCGCTATTATTGATACATCTGCAGTGATTGCTGCAGATGTTCAGATTGGGCC
GTATTGTGTAATTGGTCCCAACGTGACAATTGGGGCTGGCACTAAACTACATTCACATGTTGTTGTTGGTGGTTATACTC
GAATTGGTGAGCATAACGAGATTTTTCAGTTTGCTAGTGTTGGGGAGATTTGTCAGGATCTCAAATACAAAGGTGAAGAG
ACCTGGTTAGAGATTGGAGACTATAATCTTATTCGTGAACATTGCAGTTTGCATCGTGGGACGATACAAGATAACAGTTT
AACCAAAATCGGTAGCCATAACTTACTGATGGTCAATACTCATATTGCACATGATTGTGTGATTGGTGATCATAATGTTT
TTGCAAATAACGTTGGTATTGCAGGACATGTTCACATTGGTAGCCATGTTGTTGTTGGTGGTAACTCTGGAATTCATCAA
TTTTGTAAAATAGACTCCTATAGTATGGTTGGTGGCGCTTCTTTAATTTTAAAAGACGTACCAGCCTATGTCATGGTGTC
TGGTAATCCTGCACACGCATTTGGTATGAATGTTGAGGGTATGCGTCGTAAAGGCTGGTCGAAAAATGTGATTCAGGCAT
TACGTGAGGCATATAAGTTAATTTATAAGTCTGGACTTACGACTGAACAGTCGATTCAAAAGATACGTAATGAGATTTTA
CCGGATATACCTGAAGTTCAATTGTTAATTGATTCTGTTGAACAGTCACAACGTGGAATTGTGCGTTAA

Upstream 100 bases:

>100_bases
AAAAACGTGGTATCTACAAATACAATTGTACTGCTACGGTTGATGGTAAAGTCGCTACAACCGCTGAAATTATAGTTTCG
CATTTAAGAACAGAGCAGGC

Downstream 100 bases:

>100_bases
ATACCTCATAATTAATAAAAAAAGACACCATTTAGGTGTCTTTTTTTGTAGATTAAAATTTATTTAAAGTATTTTACTTC
TTCAGATTGAGGATAGGTTT

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase [H]

Number of amino acids: Translated: 262; Mature: 261

Protein sequence:

>262_residues
MSNNDLIHSTAIIDTSAVIAADVQIGPYCVIGPNVTIGAGTKLHSHVVVGGYTRIGEHNEIFQFASVGEICQDLKYKGEE
TWLEIGDYNLIREHCSLHRGTIQDNSLTKIGSHNLLMVNTHIAHDCVIGDHNVFANNVGIAGHVHIGSHVVVGGNSGIHQ
FCKIDSYSMVGGASLILKDVPAYVMVSGNPAHAFGMNVEGMRRKGWSKNVIQALREAYKLIYKSGLTTEQSIQKIRNEIL
PDIPEVQLLIDSVEQSQRGIVR

Sequences:

>Translated_262_residues
MSNNDLIHSTAIIDTSAVIAADVQIGPYCVIGPNVTIGAGTKLHSHVVVGGYTRIGEHNEIFQFASVGEICQDLKYKGEE
TWLEIGDYNLIREHCSLHRGTIQDNSLTKIGSHNLLMVNTHIAHDCVIGDHNVFANNVGIAGHVHIGSHVVVGGNSGIHQ
FCKIDSYSMVGGASLILKDVPAYVMVSGNPAHAFGMNVEGMRRKGWSKNVIQALREAYKLIYKSGLTTEQSIQKIRNEIL
PDIPEVQLLIDSVEQSQRGIVR
>Mature_261_residues
SNNDLIHSTAIIDTSAVIAADVQIGPYCVIGPNVTIGAGTKLHSHVVVGGYTRIGEHNEIFQFASVGEICQDLKYKGEET
WLEIGDYNLIREHCSLHRGTIQDNSLTKIGSHNLLMVNTHIAHDCVIGDHNVFANNVGIAGHVHIGSHVVVGGNSGIHQF
CKIDSYSMVGGASLILKDVPAYVMVSGNPAHAFGMNVEGMRRKGWSKNVIQALREAYKLIYKSGLTTEQSIQKIRNEILP
DIPEVQLLIDSVEQSQRGIVR

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786378, Length=262, Percent_Identity=50.381679389313, Blast_Score=283, Evalue=6e-78,
Organism=Escherichia coli, GI1786376, Length=223, Percent_Identity=27.8026905829596, Blast_Score=66, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018357
- InterPro:   IPR010137
- InterPro:   IPR011004 [H]

Pfam domain/function: NA

EC number: =2.3.1.129 [H]

Molecular weight: Translated: 28542; Mature: 28411

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNNDLIHSTAIIDTSAVIAADVQIGPYCVIGPNVTIGAGTKLHSHVVVGGYTRIGEHNE
CCCCCEEEEEEEEECCEEEEEEEEECCEEEECCCEEECCCCEEECEEEEECEEECCCCCH
IFQFASVGEICQDLKYKGEETWLEIGDYNLIREHCSLHRGTIQDNSLTKIGSHNLLMVNT
HHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHCCCCCCCCCEEEECCCCEEEEEE
HIAHDCVIGDHNVFANNVGIAGHVHIGSHVVVGGNSGIHQFCKIDSYSMVGGASLILKDV
CCCEEEEECCCCEEECCCCEEEEEEECCEEEECCCCCHHHHHCCCCCCCCCCHHHEEECC
PAYVMVSGNPAHAFGMNVEGMRRKGWSKNVIQALREAYKLIYKSGLTTEQSIQKIRNEIL
CEEEEEECCCCEEECCCCCHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHC
PDIPEVQLLIDSVEQSQRGIVR
CCCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SNNDLIHSTAIIDTSAVIAADVQIGPYCVIGPNVTIGAGTKLHSHVVVGGYTRIGEHNE
CCCCEEEEEEEEECCEEEEEEEEECCEEEECCCEEECCCCEEECEEEEECEEECCCCCH
IFQFASVGEICQDLKYKGEETWLEIGDYNLIREHCSLHRGTIQDNSLTKIGSHNLLMVNT
HHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHCCCCCCCCCEEEECCCCEEEEEE
HIAHDCVIGDHNVFANNVGIAGHVHIGSHVVVGGNSGIHQFCKIDSYSMVGGASLILKDV
CCCEEEEECCCCEEECCCCEEEEEEECCEEEECCCCCHHHHHCCCCCCCCCCHHHEEECC
PAYVMVSGNPAHAFGMNVEGMRRKGWSKNVIQALREAYKLIYKSGLTTEQSIQKIRNEIL
CEEEEEECCCCEEECCCCCHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHC
PDIPEVQLLIDSVEQSQRGIVR
CCCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA