Click here to switch to the map view.

The map label for this gene is bioF [C]

Identifier: 50084069

GI number: 50084069

Start: 844449

End: 845606

Strand: Direct

Name: bioF [C]

Synonym: ACIAD0857

Alternate gene names: 50084069

Gene position: 844449-845606 (Clockwise)

Preceding gene: 50084068

Following gene: 50084070

Centisome position: 23.47

GC content: 41.19

Gene sequence:

>1158_bases
ATGGCATTGCTTGATCATTATGCACAACAGCTTGATCAATTAAAACAATCTGGAAATTTACGCCAGTTTGTTGCGAATCA
ACAACAAGGTGCGACCATCCAGATCACAGGCCAGCAGATGTTAAATCTATCGTCCAATGATTATTTGGGGTTGGCTGCCA
ATGTGGAATTACGTGAGGAGTTTTTGCAACAACAGCCTGTTGAACGTTGTTATTTTAGTTCGTCATCTTCACGTTTACTC
ACAGGTAACTATGAAGAATATGAGCAACTTGAAGCAAGTTTAAGCCAGGCATTTTATGGTCGTTCGGCACTCCTATTCAA
TAGTGGCTATCATATGAATATTGGTATTTTGCCTGCGATTTGTGATTCACGTACATTAATTCTGGCGGACAAACTGGTTC
ATGCCAGTATGATTGATGGTATTCGTCTATCTGTAGCAAAATACGTGCGATATCGTCATAACGACTTACAGCATCTTGAA
CAGCTTTTATTAAAATATCATGCCAATGATGACATTGAACGCATCGTCGTGGTGACCGAAAGTATTTTTAGTATGGATGG
TGATGAAACTGATCTGGATGCACTGGTTCAAATCAAACGTCGTTTTGGCAAGGTCATGCTCTATGTTGATGAAGCCCATG
CGATTGGGGTTCGTGGTGAACAGGGGTTGGGCTGTGCAGAACAGTATCAAGTGATCAATGAGATTGATTTCTTGGTCGGT
ACGTTTGGAAAAGCAGTTGCATCGATTGGTGGATACTTGATTTGCGATCCGATTATTCGTTCATATCTGATTAATACCAT
GCGCCCACTGATTTTCAGTACGGCTTTGCCACCGCTTAGTATTGCATGGACAAATTTTATCTGGAAAAAGATGCTGACTG
CACAAAAGCAGCGTCAGCATTTGCAGCAAATTAGCAATTATTTGCAAAATTCAATCATTCAAAAAGGTTACAGTAGCCCA
TCAACAAGCCATATCGTCCCTGTCATTATTGGTGAAAGCCAGGCTGCCGTAAATATGTCCAAATATGTACAGACCAATGG
CTTTTATGCAATGCCCGTTCGTCCACCGACAGTGCCACAGCATAGCGCTCGTTTAAGAATTTCATTAACATCACTCATTC
AAATAGATGAACTAGATCGGTTGGTGGCTTGTTTGTGA

Upstream 100 bases:

>100_bases
GTTTATGTAATGCCACCCTATATCATTTCCAATGATGAACTTGATGAATTAATCCAAAAAATGATGAACGTGGTTCGTCA
ACTTTCTTGTGAGGCGCAGC

Downstream 100 bases:

>100_bases
ATCTGAATAAATCACTCATTGCTCAGCGTTTTGCGAAGGCGCGACAAAGTTATGTAGAAAATGCCATTGCGCAGAAAAAA
ATCAGTCATCATTTGTGCCA

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 385; Mature: 384

Protein sequence:

>385_residues
MALLDHYAQQLDQLKQSGNLRQFVANQQQGATIQITGQQMLNLSSNDYLGLAANVELREEFLQQQPVERCYFSSSSSRLL
TGNYEEYEQLEASLSQAFYGRSALLFNSGYHMNIGILPAICDSRTLILADKLVHASMIDGIRLSVAKYVRYRHNDLQHLE
QLLLKYHANDDIERIVVVTESIFSMDGDETDLDALVQIKRRFGKVMLYVDEAHAIGVRGEQGLGCAEQYQVINEIDFLVG
TFGKAVASIGGYLICDPIIRSYLINTMRPLIFSTALPPLSIAWTNFIWKKMLTAQKQRQHLQQISNYLQNSIIQKGYSSP
STSHIVPVIIGESQAAVNMSKYVQTNGFYAMPVRPPTVPQHSARLRISLTSLIQIDELDRLVACL

Sequences:

>Translated_385_residues
MALLDHYAQQLDQLKQSGNLRQFVANQQQGATIQITGQQMLNLSSNDYLGLAANVELREEFLQQQPVERCYFSSSSSRLL
TGNYEEYEQLEASLSQAFYGRSALLFNSGYHMNIGILPAICDSRTLILADKLVHASMIDGIRLSVAKYVRYRHNDLQHLE
QLLLKYHANDDIERIVVVTESIFSMDGDETDLDALVQIKRRFGKVMLYVDEAHAIGVRGEQGLGCAEQYQVINEIDFLVG
TFGKAVASIGGYLICDPIIRSYLINTMRPLIFSTALPPLSIAWTNFIWKKMLTAQKQRQHLQQISNYLQNSIIQKGYSSP
STSHIVPVIIGESQAAVNMSKYVQTNGFYAMPVRPPTVPQHSARLRISLTSLIQIDELDRLVACL
>Mature_384_residues
ALLDHYAQQLDQLKQSGNLRQFVANQQQGATIQITGQQMLNLSSNDYLGLAANVELREEFLQQQPVERCYFSSSSSRLLT
GNYEEYEQLEASLSQAFYGRSALLFNSGYHMNIGILPAICDSRTLILADKLVHASMIDGIRLSVAKYVRYRHNDLQHLEQ
LLLKYHANDDIERIVVVTESIFSMDGDETDLDALVQIKRRFGKVMLYVDEAHAIGVRGEQGLGCAEQYQVINEIDFLVGT
FGKAVASIGGYLICDPIIRSYLINTMRPLIFSTALPPLSIAWTNFIWKKMLTAQKQRQHLQQISNYLQNSIIQKGYSSPS
TSHIVPVIIGESQAAVNMSKYVQTNGFYAMPVRPPTVPQHSARLRISLTSLIQIDELDRLVACL

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=379, Percent_Identity=29.287598944591, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI284448556, Length=346, Percent_Identity=30.0578034682081, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI83977442, Length=342, Percent_Identity=33.0409356725146, Blast_Score=148, Evalue=9e-36,
Organism=Homo sapiens, GI83977440, Length=341, Percent_Identity=32.5513196480938, Blast_Score=148, Evalue=9e-36,
Organism=Homo sapiens, GI83977444, Length=341, Percent_Identity=32.5513196480938, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI4502025, Length=348, Percent_Identity=29.8850574712644, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI40316939, Length=348, Percent_Identity=29.8850574712644, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI119220554, Length=373, Percent_Identity=26.0053619302949, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI4758668, Length=374, Percent_Identity=25.9358288770053, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI5454084, Length=256, Percent_Identity=25.390625, Blast_Score=93, Evalue=3e-19,
Organism=Escherichia coli, GI1786993, Length=351, Percent_Identity=32.7635327635328, Blast_Score=171, Evalue=9e-44,
Organism=Escherichia coli, GI1790046, Length=364, Percent_Identity=28.2967032967033, Blast_Score=167, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI71994529, Length=384, Percent_Identity=28.90625, Blast_Score=169, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI32566772, Length=377, Percent_Identity=27.3209549071618, Blast_Score=131, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI17560914, Length=362, Percent_Identity=25.1381215469613, Blast_Score=111, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17560912, Length=362, Percent_Identity=25.1381215469613, Blast_Score=111, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI71982617, Length=267, Percent_Identity=25.8426966292135, Blast_Score=104, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI71982625, Length=267, Percent_Identity=25.8426966292135, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6320438, Length=352, Percent_Identity=28.125, Blast_Score=136, Evalue=7e-33,
Organism=Saccharomyces cerevisiae, GI6320267, Length=359, Percent_Identity=27.0194986072423, Blast_Score=126, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6323954, Length=281, Percent_Identity=27.0462633451957, Blast_Score=108, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24662918, Length=379, Percent_Identity=32.7176781002639, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI17137420, Length=356, Percent_Identity=32.0224719101124, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI17136286, Length=379, Percent_Identity=26.6490765171504, Blast_Score=131, Evalue=9e-31,
Organism=Drosophila melanogaster, GI24653280, Length=264, Percent_Identity=26.1363636363636, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24653276, Length=264, Percent_Identity=26.1363636363636, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24653278, Length=264, Percent_Identity=26.1363636363636, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 43339; Mature: 43208

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS00599 AA_TRANSFER_CLASS_2 ; PS00139 THIOL_PROTEASE_CYS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALLDHYAQQLDQLKQSGNLRQFVANQQQGATIQITGQQMLNLSSNDYLGLAANVELREE
CCHHHHHHHHHHHHHHCCCHHHHHCCCCCCCEEEEEHHHHHCCCCCCCEEEECCHHHHHH
FLQQQPVERCYFSSSSSRLLTGNYEEYEQLEASLSQAFYGRSALLFNSGYHMNIGILPAI
HHHHCCHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHCCEEEEEECCCEEEEECHHHH
CDSRTLILADKLVHASMIDGIRLSVAKYVRYRHNDLQHLEQLLLKYHANDDIERIVVVTE
CCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHEEEEHH
SIFSMDGDETDLDALVQIKRRFGKVMLYVDEAHAIGVRGEQGLGCAEQYQVINEIDFLVG
HHHHCCCCCCHHHHHHHHHHHHCEEEEEEECCEEECCCCCCCCCHHHHHHHHHHHHHHHH
TFGKAVASIGGYLICDPIIRSYLINTMRPLIFSTALPPLSIAWTNFIWKKMLTAQKQRQH
HHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
LQQISNYLQNSIIQKGYSSPSTSHIVPVIIGESQAAVNMSKYVQTNGFYAMPVRPPTVPQ
HHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCEEEECCCCCCCCC
HSARLRISLTSLIQIDELDRLVACL
CCCEEEEEHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ALLDHYAQQLDQLKQSGNLRQFVANQQQGATIQITGQQMLNLSSNDYLGLAANVELREE
CHHHHHHHHHHHHHHCCCHHHHHCCCCCCCEEEEEHHHHHCCCCCCCEEEECCHHHHHH
FLQQQPVERCYFSSSSSRLLTGNYEEYEQLEASLSQAFYGRSALLFNSGYHMNIGILPAI
HHHHCCHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHCCEEEEEECCCEEEEECHHHH
CDSRTLILADKLVHASMIDGIRLSVAKYVRYRHNDLQHLEQLLLKYHANDDIERIVVVTE
CCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHEEEEHH
SIFSMDGDETDLDALVQIKRRFGKVMLYVDEAHAIGVRGEQGLGCAEQYQVINEIDFLVG
HHHHCCCCCCHHHHHHHHHHHHCEEEEEEECCEEECCCCCCCCCHHHHHHHHHHHHHHHH
TFGKAVASIGGYLICDPIIRSYLINTMRPLIFSTALPPLSIAWTNFIWKKMLTAQKQRQH
HHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
LQQISNYLQNSIIQKGYSSPSTSHIVPVIIGESQAAVNMSKYVQTNGFYAMPVRPPTVPQ
HHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCEEEECCCCCCCCC
HSARLRISLTSLIQIDELDRLVACL
CCCEEEEEHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]