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The map label for this gene is nudH

Identifier: 50083703

GI number: 50083703

Start: 453598

End: 454098

Strand: Reverse

Name: nudH

Synonym: ACIAD0455

Alternate gene names: 50083703

Gene position: 454098-453598 (Counterclockwise)

Preceding gene: 50083705

Following gene: 50083702

Centisome position: 12.62

GC content: 45.71

Gene sequence:

>501_bases
ATGATCGACTCAGAAGGTTTCCGACCCAACGTCGGGATCATTTTGGCAAATGATAACGGACAAGTTTTATGGGCAAAACG
CATTGGTCACAATGCTTGGCAATTTCCACAAGGAGGAATCCATTTTGGAGAAACCCCCGAGCAGGCACTTTATCGTGAAC
TGAGAGAAGAAGTCGGCTTATTGCCAGAACACGTCCAGATTATTGCGCAGACCAAAGGATGGCTGCGTTATCGTTTGCCA
CATCGGTACATCCGGCCAGATTCTGACCCGGTATGTATTGGACAGAAACAAAAATGGTTTTTATTGAAGCTCACCGCATC
GACACGGCATATTCAATTAAACCTATCCGACCCGCCCGAATTTGACGAATGGCAGTGGGTCAGTTATTGGTATCCATTAG
GCCAAGTCGTCAATTTTAAGCGAGATGTATACCGTAAAGCCATGATGGAGCTGTGTATGCTCTTGCCACAACAACAAACG
TTCGAAAAATCATCTCTCTAG

Upstream 100 bases:

>100_bases
AATTTTAATGCATTTTACTTTGATCTTTTCGAGCTGGGCATTTAAGAGTGACCGCCCCCGATTTCAAAGTCAACGATATT
GATAAATTTTAGGTAGCCAA

Downstream 100 bases:

>100_bases
CAAATGATTTTTCGGTCGAGTGCTGTTATAACATCACTATGAAAAATTAAAAATTTTGGAGTATGCATCCATGTCAAACA
TGCAACTTGACACTTTGAGA

Product: dinucleoside polyphosphate hydrolase

Products: NA

Alternate protein names: (Di)nucleoside polyphosphate hydrolase

Number of amino acids: Translated: 166; Mature: 166

Protein sequence:

>166_residues
MIDSEGFRPNVGIILANDNGQVLWAKRIGHNAWQFPQGGIHFGETPEQALYRELREEVGLLPEHVQIIAQTKGWLRYRLP
HRYIRPDSDPVCIGQKQKWFLLKLTASTRHIQLNLSDPPEFDEWQWVSYWYPLGQVVNFKRDVYRKAMMELCMLLPQQQT
FEKSSL

Sequences:

>Translated_166_residues
MIDSEGFRPNVGIILANDNGQVLWAKRIGHNAWQFPQGGIHFGETPEQALYRELREEVGLLPEHVQIIAQTKGWLRYRLP
HRYIRPDSDPVCIGQKQKWFLLKLTASTRHIQLNLSDPPEFDEWQWVSYWYPLGQVVNFKRDVYRKAMMELCMLLPQQQT
FEKSSL
>Mature_166_residues
MIDSEGFRPNVGIILANDNGQVLWAKRIGHNAWQFPQGGIHFGETPEQALYRELREEVGLLPEHVQIIAQTKGWLRYRLP
HRYIRPDSDPVCIGQKQKWFLLKLTASTRHIQLNLSDPPEFDEWQWVSYWYPLGQVVNFKRDVYRKAMMELCMLLPQQQT
FEKSSL

Specific function: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain

Homologues:

Organism=Escherichia coli, GI1789194, Length=155, Percent_Identity=60, Blast_Score=209, Evalue=7e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RPPH_ACIAD (Q6FEW7)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_045213.1
- ProteinModelPortal:   Q6FEW7
- SMR:   Q6FEW7
- STRING:   Q6FEW7
- GeneID:   2879579
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD0455
- NMPDR:   fig|62977.3.peg.1112
- eggNOG:   COG0494
- HOGENOM:   HBG302451
- OMA:   GQKQIWY
- PhylomeDB:   Q6FEW7
- ProtClustDB:   PRK00714
- BioCyc:   ASP62977:ACIAD0455-MONOMER
- HAMAP:   MF_00298
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797
- InterPro:   IPR022927
- Gene3D:   G3DSA:3.90.79.10
- PRINTS:   PR00502

Pfam domain/function: PF00293 NUDIX; SSF55811 NUDIX_hydrolase

EC number: 3.6.1.- [C]

Molecular weight: Translated: 19565; Mature: 19565

Theoretical pI: Translated: 8.23; Mature: 8.23

Prosite motif: PS51462 NUDIX; PS00893 NUDIX_BOX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDSEGFRPNVGIILANDNGQVLWAKRIGHNAWQFPQGGIHFGETPEQALYRELREEVGL
CCCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
LPEHVQIIAQTKGWLRYRLPHRYIRPDSDPVCIGQKQKWFLLKLTASTRHIQLNLSDPPE
CHHHHHHHHHCCCEEEECCCCCCCCCCCCCEEECCCCCEEEEEEECCCEEEEEECCCCCC
FDEWQWVSYWYPLGQVVNFKRDVYRKAMMELCMLLPQQQTFEKSSL
CCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCC
>Mature Secondary Structure
MIDSEGFRPNVGIILANDNGQVLWAKRIGHNAWQFPQGGIHFGETPEQALYRELREEVGL
CCCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
LPEHVQIIAQTKGWLRYRLPHRYIRPDSDPVCIGQKQKWFLLKLTASTRHIQLNLSDPPE
CHHHHHHHHHCCCEEEECCCCCCCCCCCCCEEECCCCCEEEEEEECCCEEEEEECCCCCC
FDEWQWVSYWYPLGQVVNFKRDVYRKAMMELCMLLPQQQTFEKSSL
CCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA