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The map label for this gene is pepA

Identifier: 50083531

GI number: 50083531

Start: 251200

End: 252648

Strand: Reverse

Name: pepA

Synonym: ACIAD0253

Alternate gene names: 50083531

Gene position: 252648-251200 (Counterclockwise)

Preceding gene: 50083536

Following gene: 50083530

Centisome position: 7.02

GC content: 44.03

Gene sequence:

>1449_bases
ATGAAATTTACTCTACAATCTACTGCACCCCAATCTGCACAGCATGAATATTTGCTGGTATTGGTCACTGAACAACAATT
GAAAAATACAGCAGATACCTACAAAATCAATACATTAGATACCATTACACATACCAGTCAGTTCAAATCTGGTTTTAACG
AAGTCCTCACGCTCATTGGACAGGCAGAGACTTGTTCTTATCTGAATCTGGTTGGTCTTGGTGATTTAAAAGACCTACAA
CCTGCCAAAATCGCAAAACTTGCACAAACCATTATCAAACTGGTTCAAACTAAATTCAAACAAATTCATCTAGATATCTC
CGCATTACCAATCGAGCTGCATTATTTATTTGCACTTAATCTTACACAAGCCAATTATGTTTTTGATGAATTTAAGTCTA
AAAAAAGTGAAGCACAGCTTGAACAGATTCACCTGATTACAGCTCAAACTGGACTCACGACGCAACAGCTTGATTTAATT
CAAGCGATTGCATCTGGACAAGATTTGGCACGTGACTTGGGTAATCGTCCTGGTAACATCTGCTTCCCAGAATATTTAGC
CGATCAAGCCAAAGCATTGGCTCATGAGTTTCCAGAGTTGCTCAAAGTGACCATTCTGGATGAGCAGCAAATGGCTGATC
TTGGCATGAATGCTTTCCTTGCTGTGAGTCAGGGTTCAGATCGTCCAGGCCGTATCATCACACTTGAATATAATGCACAG
CTTGAACAGGCGCCTGTTGTACTGGTAGGTAAAGGGGTAACATTTGATACTGGTGGTATTTCAATCAAACCTGCTCAAGG
CATGGATGAAATGAAATTCGATATGTGTGGTGCAGCCTCGGTTCTTGGTACAATACGTACCCTATGCGAAGCTCGTTTAC
CCATTCATGTGGTGGGAGCCGTTGCAGCCGCAGAGAATATGCCTTCAGGGCAAGCGACTCGCCCAGGTGATATTGTCACC
ACCATGAGTGGCCAAACCGTTGAGATTCTGAATACCGATGCAGAAGGTCGTCTGGTTTTATGCGACACCCTAACCTACAT
CAAACGTTTTAATCCAAGTCTGGTCATTGATATTGCGACATTGACAGGCGCCTGTGTAGTGGCTCTTGGCAAGGTGGTCA
GTGGTCTTTTCTCTCCAGATGATGCACTTGCACAAGAATTACAGCAGGCAGGCGAACAATCCTTTGACCGTGTTTGGCGC
TTACCTGTCATGGATGACTATCAGGAATTACTCGATTCTCCTTTTGCAGACATTGCCAATATTGGTGGACCCTATGGCGG
TGCAATTACGGCGGCGTGCTTCCTGCAACGTTTTACACGCGACTATCGCTGGGCGCATCTCGATATTGCAGGAACAGCTT
GGCTCTCAGGAACAGCAAAAGGTGCAACAGGTCGTCCTGTACCACTTTTAGTTCAGTTTTTAGCAAATCGTGTAGGTACG
AATGACTAA

Upstream 100 bases:

>100_bases
AAATATAAAACCTATCGATGTGTTGCACATTGAAACTCGCGCAAAGAAAATGTTTCAATGTCATTATTTGAAAACACACA
TACAGGCAGTTTAAATCAAT

Downstream 100 bases:

>100_bases
AATCAGTTTCTATTTATTTGAAACCAGTCAGGAACGGCAAGTCGAAAGTGCTTGCCGTTTATGCCGAAAACTCGTGAAAC
AACAACAAAAGCTATGGTGG

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 482; Mature: 482

Protein sequence:

>482_residues
MKFTLQSTAPQSAQHEYLLVLVTEQQLKNTADTYKINTLDTITHTSQFKSGFNEVLTLIGQAETCSYLNLVGLGDLKDLQ
PAKIAKLAQTIIKLVQTKFKQIHLDISALPIELHYLFALNLTQANYVFDEFKSKKSEAQLEQIHLITAQTGLTTQQLDLI
QAIASGQDLARDLGNRPGNICFPEYLADQAKALAHEFPELLKVTILDEQQMADLGMNAFLAVSQGSDRPGRIITLEYNAQ
LEQAPVVLVGKGVTFDTGGISIKPAQGMDEMKFDMCGAASVLGTIRTLCEARLPIHVVGAVAAAENMPSGQATRPGDIVT
TMSGQTVEILNTDAEGRLVLCDTLTYIKRFNPSLVIDIATLTGACVVALGKVVSGLFSPDDALAQELQQAGEQSFDRVWR
LPVMDDYQELLDSPFADIANIGGPYGGAITAACFLQRFTRDYRWAHLDIAGTAWLSGTAKGATGRPVPLLVQFLANRVGT
ND

Sequences:

>Translated_482_residues
MKFTLQSTAPQSAQHEYLLVLVTEQQLKNTADTYKINTLDTITHTSQFKSGFNEVLTLIGQAETCSYLNLVGLGDLKDLQ
PAKIAKLAQTIIKLVQTKFKQIHLDISALPIELHYLFALNLTQANYVFDEFKSKKSEAQLEQIHLITAQTGLTTQQLDLI
QAIASGQDLARDLGNRPGNICFPEYLADQAKALAHEFPELLKVTILDEQQMADLGMNAFLAVSQGSDRPGRIITLEYNAQ
LEQAPVVLVGKGVTFDTGGISIKPAQGMDEMKFDMCGAASVLGTIRTLCEARLPIHVVGAVAAAENMPSGQATRPGDIVT
TMSGQTVEILNTDAEGRLVLCDTLTYIKRFNPSLVIDIATLTGACVVALGKVVSGLFSPDDALAQELQQAGEQSFDRVWR
LPVMDDYQELLDSPFADIANIGGPYGGAITAACFLQRFTRDYRWAHLDIAGTAWLSGTAKGATGRPVPLLVQFLANRVGT
ND
>Mature_482_residues
MKFTLQSTAPQSAQHEYLLVLVTEQQLKNTADTYKINTLDTITHTSQFKSGFNEVLTLIGQAETCSYLNLVGLGDLKDLQ
PAKIAKLAQTIIKLVQTKFKQIHLDISALPIELHYLFALNLTQANYVFDEFKSKKSEAQLEQIHLITAQTGLTTQQLDLI
QAIASGQDLARDLGNRPGNICFPEYLADQAKALAHEFPELLKVTILDEQQMADLGMNAFLAVSQGSDRPGRIITLEYNAQ
LEQAPVVLVGKGVTFDTGGISIKPAQGMDEMKFDMCGAASVLGTIRTLCEARLPIHVVGAVAAAENMPSGQATRPGDIVT
TMSGQTVEILNTDAEGRLVLCDTLTYIKRFNPSLVIDIATLTGACVVALGKVVSGLFSPDDALAQELQQAGEQSFDRVWR
LPVMDDYQELLDSPFADIANIGGPYGGAITAACFLQRFTRDYRWAHLDIAGTAWLSGTAKGATGRPVPLLVQFLANRVGT
ND

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=357, Percent_Identity=39.2156862745098, Blast_Score=248, Evalue=1e-65,
Organism=Homo sapiens, GI47155554, Length=254, Percent_Identity=33.0708661417323, Blast_Score=112, Evalue=8e-25,
Organism=Escherichia coli, GI1790710, Length=507, Percent_Identity=46.1538461538462, Blast_Score=426, Evalue=1e-120,
Organism=Escherichia coli, GI87082123, Length=318, Percent_Identity=38.9937106918239, Blast_Score=179, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI17556903, Length=365, Percent_Identity=29.8630136986301, Blast_Score=131, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI17565172, Length=253, Percent_Identity=30.8300395256917, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI20129969, Length=321, Percent_Identity=35.8255451713396, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24661038, Length=369, Percent_Identity=32.2493224932249, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI21355725, Length=328, Percent_Identity=33.5365853658537, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24662227, Length=321, Percent_Identity=34.2679127725857, Blast_Score=178, Evalue=6e-45,
Organism=Drosophila melanogaster, GI21355645, Length=361, Percent_Identity=30.7479224376731, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24662223, Length=361, Percent_Identity=30.7479224376731, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI161077148, Length=322, Percent_Identity=32.9192546583851, Blast_Score=174, Evalue=2e-43,
Organism=Drosophila melanogaster, GI20130057, Length=322, Percent_Identity=32.9192546583851, Blast_Score=174, Evalue=2e-43,
Organism=Drosophila melanogaster, GI19922386, Length=322, Percent_Identity=33.5403726708075, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI20129963, Length=322, Percent_Identity=32.2981366459627, Blast_Score=155, Evalue=6e-38,
Organism=Drosophila melanogaster, GI21357381, Length=283, Percent_Identity=33.9222614840989, Blast_Score=125, Evalue=8e-29,
Organism=Drosophila melanogaster, GI221379063, Length=283, Percent_Identity=33.9222614840989, Blast_Score=125, Evalue=9e-29,
Organism=Drosophila melanogaster, GI221379062, Length=283, Percent_Identity=33.9222614840989, Blast_Score=125, Evalue=9e-29,
Organism=Drosophila melanogaster, GI24646701, Length=332, Percent_Identity=28.0120481927711, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24646703, Length=332, Percent_Identity=28.0120481927711, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI21358201, Length=332, Percent_Identity=28.0120481927711, Blast_Score=99, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_ACIAD (Q6FFD8)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_045041.1
- ProteinModelPortal:   Q6FFD8
- SMR:   Q6FFD8
- STRING:   Q6FFD8
- MEROPS:   M17.003
- GeneID:   2878301
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD0253
- NMPDR:   fig|62977.3.peg.526
- eggNOG:   COG0260
- HOGENOM:   HBG742580
- OMA:   LGHHISG
- PhylomeDB:   Q6FFD8
- ProtClustDB:   PRK00913
- BioCyc:   ASP62977:ACIAD0253-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 52318; Mature: 52318

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 263-263 ACT_SITE 337-337

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFTLQSTAPQSAQHEYLLVLVTEQQLKNTADTYKINTLDTITHTSQFKSGFNEVLTLIG
CEEEECCCCCCCCCCCEEEEEEEHHHHCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHC
QAETCSYLNLVGLGDLKDLQPAKIAKLAQTIIKLVQTKFKQIHLDISALPIELHYLFALN
CCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEECEEEEEEEEEEE
LTQANYVFDEFKSKKSEAQLEQIHLITAQTGLTTQQLDLIQAIASGQDLARDLGNRPGNI
ECHHHHHHHHHHCHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHCCHHHHHHHCCCCCCC
CFPEYLADQAKALAHEFPELLKVTILDEQQMADLGMNAFLAVSQGSDRPGRIITLEYNAQ
CCHHHHHHHHHHHHHHHHHHHEEEECCHHHHHHCCCCEEEEEECCCCCCCEEEEEEECCC
LEQAPVVLVGKGVTFDTGGISIKPAQGMDEMKFDMCGAASVLGTIRTLCEARLPIHVVGA
CCCCCEEEEECCEEEECCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHH
VAAAENMPSGQATRPGDIVTTMSGQTVEILNTDAEGRLVLCDTLTYIKRFNPSLVIDIAT
HHHHCCCCCCCCCCCCCEEEECCCCEEEEEECCCCCCEEEEHHHHHHHHCCCCEEEEHHH
LTGACVVALGKVVSGLFSPDDALAQELQQAGEQSFDRVWRLPVMDDYQELLDSPFADIAN
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHH
IGGPYGGAITAACFLQRFTRDYRWAHLDIAGTAWLSGTAKGATGRPVPLLVQFLANRVGT
CCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCEECCCCCCCCCCCHHHHHHHHHHHCCC
ND
CC
>Mature Secondary Structure
MKFTLQSTAPQSAQHEYLLVLVTEQQLKNTADTYKINTLDTITHTSQFKSGFNEVLTLIG
CEEEECCCCCCCCCCCEEEEEEEHHHHCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHC
QAETCSYLNLVGLGDLKDLQPAKIAKLAQTIIKLVQTKFKQIHLDISALPIELHYLFALN
CCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEECEEEEEEEEEEE
LTQANYVFDEFKSKKSEAQLEQIHLITAQTGLTTQQLDLIQAIASGQDLARDLGNRPGNI
ECHHHHHHHHHHCHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHCCHHHHHHHCCCCCCC
CFPEYLADQAKALAHEFPELLKVTILDEQQMADLGMNAFLAVSQGSDRPGRIITLEYNAQ
CCHHHHHHHHHHHHHHHHHHHEEEECCHHHHHHCCCCEEEEEECCCCCCCEEEEEEECCC
LEQAPVVLVGKGVTFDTGGISIKPAQGMDEMKFDMCGAASVLGTIRTLCEARLPIHVVGA
CCCCCEEEEECCEEEECCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHH
VAAAENMPSGQATRPGDIVTTMSGQTVEILNTDAEGRLVLCDTLTYIKRFNPSLVIDIAT
HHHHCCCCCCCCCCCCCEEEECCCCEEEEEECCCCCCEEEEHHHHHHHHCCCCEEEEHHH
LTGACVVALGKVVSGLFSPDDALAQELQQAGEQSFDRVWRLPVMDDYQELLDSPFADIAN
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHH
IGGPYGGAITAACFLQRFTRDYRWAHLDIAGTAWLSGTAKGATGRPVPLLVQFLANRVGT
CCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCEECCCCCCCCCCCHHHHHHHHHHHCCC
ND
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA