Click here to switch to the map view.

The map label for this gene is gudP [H]

Identifier: 50083416

GI number: 50083416

Start: 130553

End: 131836

Strand: Reverse

Name: gudP [H]

Synonym: ACIAD0127

Alternate gene names: 50083416

Gene position: 131836-130553 (Counterclockwise)

Preceding gene: 50083421

Following gene: 50083415

Centisome position: 3.66

GC content: 39.41

Gene sequence:

>1284_bases
ATGATTTTTCTAGTTACAGCTTTAAACTACGGTGACCGAGCAACCATCTCCATGGCTGCAACGCCAATGTCACAAGAATT
AGGGCTGACTTCCGTCACTATGGGTTATATTTTTTCCGCATTTGGATGGGCCTATGTCATTGGACAGGTGCCTGGCGGTT
GGCTACTGGATAAATTCGGTGCACGGAAAGTTTACTTCTGGAGTATTTTACTCTGGTCTATTTTTACAGTATTACTTGGT
TTTGTTGATATTTTTGGTTCTATCCCTCTGATCATCGCTTCATTATTTATCCTCCGTTTTTTAGTCGGCTTATCAGAAAG
CCCAGCCTTTCCTGGTAACAGCCAAATTGTTGCAGCTTGGTTTCCCACTAAAGAGCGTGGTACAGCAGCAGCAAGTTTTA
ATTCAGCACAATATTTTGCAACCGTCATATTTGCGCCATTTATGGGTTGGCTAGTCACACATATTCATTGGCAATCTGTC
TTCTGGATTATGGGTGCAATCGGTATCGTCATTGCGTTTATATGGTTAAAAGTAATTTATAGCCCAGAAAAACATCCTAG
AATTAATAAAGAAGAATTAACCTATTTACAGGGAAATGGTGCCATCACATCGATGGGAGAAAACAAATCAAAAACTCTAG
ATCAAAAAAATAAAATGAGTTGGTCTAATGTCAAAAAACTTCTTTCTTCACGTATGCTCCTTGGTATTTTTATCGCGCAA
TATTGTATCACCTGTCTGACCTATTTTTTCCTCACCTGGTTCCCGGTTTATCTGGTGAAAGAACGTCATATGACGATCTT
ACAAGCTGGTTTTGCTGCAGTTTTACCTGCGCTGTGTGGATTTATTGGAGGTATTCTTGGTGGAATTATTTCTGATCGAC
TTATTCGCATGAATAAATCCCTCAGCTTCTCACGCAAATTCCCGATTGTACTTGGCATGTTACTTTCAACCAGCATTATT
GTTTGCAACTATGTTGATTCACAAACAGCGATTGTTTTCTTTATGTCTTTAGCATTTTTTGGTAAAGGATTTGGAGCACT
CGGTTGGGCGGTGATGTCTGATGTCGCACCAAAAGAAATGATCGGCTTATCTGGTGGGTTATTCAATACTTTTGGTAATA
CCGCTGGAATTATCATCCCTATTGCAATTGGCTATATTGTTGCATCAACAGGCTCATTTAATGGTGCACTGGTGTTTGTA
GGCATCCATGCCATCATCGCCATACTTTGCTATTTATTCGTTGTAGGAAAAATTGAACGCTTTGAACTCAAAAAAGTCAT
ATAA

Upstream 100 bases:

>100_bases
TATTAAAAGAGTTTGTATTATGGACAATTTGCAAACAAGTGCTGTCTCTATCTCAAAAGTTAGAGTGACTCACAATAAAA
CTCGCTACTATATTCTAGCG

Downstream 100 bases:

>100_bases
GTGATTTTGACCAGAAAGCTTAGGACGCAAGCTTTCTGGTTCTCTTAGTTTTTTCAAGGAAGATCATTATGTTAAAGCCA
ATTCTAATTCAAATTAATCC

Product: major facilitator superfamily D-glucarate/D-galactarate permease

Products: NA

Alternate protein names: D-glucarate permease [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MIFLVTALNYGDRATISMAATPMSQELGLTSVTMGYIFSAFGWAYVIGQVPGGWLLDKFGARKVYFWSILLWSIFTVLLG
FVDIFGSIPLIIASLFILRFLVGLSESPAFPGNSQIVAAWFPTKERGTAAASFNSAQYFATVIFAPFMGWLVTHIHWQSV
FWIMGAIGIVIAFIWLKVIYSPEKHPRINKEELTYLQGNGAITSMGENKSKTLDQKNKMSWSNVKKLLSSRMLLGIFIAQ
YCITCLTYFFLTWFPVYLVKERHMTILQAGFAAVLPALCGFIGGILGGIISDRLIRMNKSLSFSRKFPIVLGMLLSTSII
VCNYVDSQTAIVFFMSLAFFGKGFGALGWAVMSDVAPKEMIGLSGGLFNTFGNTAGIIIPIAIGYIVASTGSFNGALVFV
GIHAIIAILCYLFVVGKIERFELKKVI

Sequences:

>Translated_427_residues
MIFLVTALNYGDRATISMAATPMSQELGLTSVTMGYIFSAFGWAYVIGQVPGGWLLDKFGARKVYFWSILLWSIFTVLLG
FVDIFGSIPLIIASLFILRFLVGLSESPAFPGNSQIVAAWFPTKERGTAAASFNSAQYFATVIFAPFMGWLVTHIHWQSV
FWIMGAIGIVIAFIWLKVIYSPEKHPRINKEELTYLQGNGAITSMGENKSKTLDQKNKMSWSNVKKLLSSRMLLGIFIAQ
YCITCLTYFFLTWFPVYLVKERHMTILQAGFAAVLPALCGFIGGILGGIISDRLIRMNKSLSFSRKFPIVLGMLLSTSII
VCNYVDSQTAIVFFMSLAFFGKGFGALGWAVMSDVAPKEMIGLSGGLFNTFGNTAGIIIPIAIGYIVASTGSFNGALVFV
GIHAIIAILCYLFVVGKIERFELKKVI
>Mature_427_residues
MIFLVTALNYGDRATISMAATPMSQELGLTSVTMGYIFSAFGWAYVIGQVPGGWLLDKFGARKVYFWSILLWSIFTVLLG
FVDIFGSIPLIIASLFILRFLVGLSESPAFPGNSQIVAAWFPTKERGTAAASFNSAQYFATVIFAPFMGWLVTHIHWQSV
FWIMGAIGIVIAFIWLKVIYSPEKHPRINKEELTYLQGNGAITSMGENKSKTLDQKNKMSWSNVKKLLSSRMLLGIFIAQ
YCITCLTYFFLTWFPVYLVKERHMTILQAGFAAVLPALCGFIGGILGGIISDRLIRMNKSLSFSRKFPIVLGMLLSTSII
VCNYVDSQTAIVFFMSLAFFGKGFGALGWAVMSDVAPKEMIGLSGGLFNTFGNTAGIIIPIAIGYIVASTGSFNGALVFV
GIHAIIAILCYLFVVGKIERFELKKVI

Specific function: Uptake of D-glucarate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Phthalate permease family [H]

Homologues:

Organism=Homo sapiens, GI9966811, Length=377, Percent_Identity=29.4429708222812, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI9945322, Length=360, Percent_Identity=29.1666666666667, Blast_Score=125, Evalue=8e-29,
Organism=Homo sapiens, GI21322234, Length=383, Percent_Identity=27.4151436031332, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI6912666, Length=424, Percent_Identity=26.1792452830189, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI154350196, Length=419, Percent_Identity=24.1050119331742, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI4885441, Length=399, Percent_Identity=25.8145363408521, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI148743791, Length=385, Percent_Identity=25.4545454545455, Blast_Score=96, Evalue=9e-20,
Organism=Homo sapiens, GI223718438, Length=199, Percent_Identity=31.1557788944724, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI5031955, Length=267, Percent_Identity=26.5917602996255, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI148728191, Length=324, Percent_Identity=25, Blast_Score=73, Evalue=5e-13,
Organism=Escherichia coli, GI1789152, Length=426, Percent_Identity=63.1455399061033, Blast_Score=571, Evalue=1e-164,
Organism=Escherichia coli, GI1789515, Length=428, Percent_Identity=56.7757009345794, Blast_Score=513, Evalue=1e-147,
Organism=Escherichia coli, GI87082320, Length=421, Percent_Identity=38.479809976247, Blast_Score=315, Evalue=3e-87,
Organism=Escherichia coli, GI2367379, Length=420, Percent_Identity=27.3809523809524, Blast_Score=161, Evalue=7e-41,
Organism=Escherichia coli, GI2367193, Length=316, Percent_Identity=26.8987341772152, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1788573, Length=434, Percent_Identity=23.2718894009217, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI115533554, Length=368, Percent_Identity=27.7173913043478, Blast_Score=118, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI115533556, Length=368, Percent_Identity=27.7173913043478, Blast_Score=118, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI17554148, Length=390, Percent_Identity=24.3589743589744, Blast_Score=91, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI71997452, Length=364, Percent_Identity=24.4505494505494, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71991453, Length=407, Percent_Identity=24.8157248157248, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17535049, Length=418, Percent_Identity=23.2057416267943, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71991448, Length=407, Percent_Identity=24.8157248157248, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI193205400, Length=291, Percent_Identity=24.7422680412371, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17560030, Length=408, Percent_Identity=25, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI32565916, Length=271, Percent_Identity=24.7232472324723, Blast_Score=82, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI32565914, Length=267, Percent_Identity=24.7191011235955, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17554962, Length=371, Percent_Identity=23.1805929919137, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17552542, Length=399, Percent_Identity=23.3082706766917, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17532009, Length=357, Percent_Identity=22.4089635854342, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17563054, Length=300, Percent_Identity=24.3333333333333, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17562692, Length=348, Percent_Identity=24.1379310344828, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71983953, Length=351, Percent_Identity=23.9316239316239, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71989129, Length=261, Percent_Identity=26.4367816091954, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI25145964, Length=262, Percent_Identity=22.9007633587786, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17537329, Length=279, Percent_Identity=26.8817204301075, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI45550460, Length=406, Percent_Identity=26.1083743842365, Blast_Score=114, Evalue=9e-26,
Organism=Drosophila melanogaster, GI24655255, Length=383, Percent_Identity=26.6318537859008, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24641682, Length=396, Percent_Identity=27.7777777777778, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI62484226, Length=395, Percent_Identity=25.5696202531646, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24639764, Length=368, Percent_Identity=25, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24584153, Length=400, Percent_Identity=23.75, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI28573708, Length=404, Percent_Identity=26.4851485148515, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI28573707, Length=404, Percent_Identity=26.4851485148515, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI19922400, Length=398, Percent_Identity=24.8743718592965, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24654215, Length=398, Percent_Identity=24.8743718592965, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24648416, Length=408, Percent_Identity=24.5098039215686, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI21356189, Length=408, Percent_Identity=24.5098039215686, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24583789, Length=405, Percent_Identity=24.6913580246914, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24655271, Length=410, Percent_Identity=25.8536585365854, Blast_Score=96, Evalue=7e-20,
Organism=Drosophila melanogaster, GI20130135, Length=410, Percent_Identity=25.8536585365854, Blast_Score=96, Evalue=7e-20,
Organism=Drosophila melanogaster, GI20130167, Length=455, Percent_Identity=25.0549450549451, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI28573299, Length=405, Percent_Identity=25.1851851851852, Blast_Score=88, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24653727, Length=370, Percent_Identity=24.3243243243243, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI20129235, Length=404, Percent_Identity=25, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24580790, Length=388, Percent_Identity=22.680412371134, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24658658, Length=434, Percent_Identity=22.8110599078341, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24658666, Length=380, Percent_Identity=23.6842105263158, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI221474708, Length=168, Percent_Identity=29.1666666666667, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24658674, Length=386, Percent_Identity=22.5388601036269, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI281361682, Length=384, Percent_Identity=22.65625, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004744
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 47002; Mature: 47002

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFLVTALNYGDRATISMAATPMSQELGLTSVTMGYIFSAFGWAYVIGQVPGGWLLDKFG
CEEEEEEECCCCCCEEEEEECCCHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHC
ARKVYFWSILLWSIFTVLLGFVDIFGSIPLIIASLFILRFLVGLSESPAFPGNSQIVAAW
CCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEE
FPTKERGTAAASFNSAQYFATVIFAPFMGWLVTHIHWQSVFWIMGAIGIVIAFIWLKVIY
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SPEKHPRINKEELTYLQGNGAITSMGENKSKTLDQKNKMSWSNVKKLLSSRMLLGIFIAQ
CCCCCCCCCHHHEEEEECCCCEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
YCITCLTYFFLTWFPVYLVKERHMTILQAGFAAVLPALCGFIGGILGGIISDRLIRMNKS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LSFSRKFPIVLGMLLSTSIIVCNYVDSQTAIVFFMSLAFFGKGFGALGWAVMSDVAPKEM
CCCCCCHHHHHHHHHHHHEEEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHH
IGLSGGLFNTFGNTAGIIIPIAIGYIVASTGSFNGALVFVGIHAIIAILCYLFVVGKIER
HHCCCCHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHH
FELKKVI
HHHHHCC
>Mature Secondary Structure
MIFLVTALNYGDRATISMAATPMSQELGLTSVTMGYIFSAFGWAYVIGQVPGGWLLDKFG
CEEEEEEECCCCCCEEEEEECCCHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHC
ARKVYFWSILLWSIFTVLLGFVDIFGSIPLIIASLFILRFLVGLSESPAFPGNSQIVAAW
CCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEE
FPTKERGTAAASFNSAQYFATVIFAPFMGWLVTHIHWQSVFWIMGAIGIVIAFIWLKVIY
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SPEKHPRINKEELTYLQGNGAITSMGENKSKTLDQKNKMSWSNVKKLLSSRMLLGIFIAQ
CCCCCCCCCHHHEEEEECCCCEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
YCITCLTYFFLTWFPVYLVKERHMTILQAGFAAVLPALCGFIGGILGGIISDRLIRMNKS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LSFSRKFPIVLGMLLSTSIIVCNYVDSQTAIVFFMSLAFFGKGFGALGWAVMSDVAPKEM
CCCCCCHHHHHHHHHHHHEEEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHH
IGLSGGLFNTFGNTAGIIIPIAIGYIVASTGSFNGALVFVGIHAIIAILCYLFVVGKIER
HHCCCCHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHH
FELKKVI
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503; 9772162; 10762278 [H]