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The map label for this gene is pgi

Identifier: 50083391

GI number: 50083391

Start: 98305

End: 99978

Strand: Direct

Name: pgi

Synonym: ACIAD0101

Alternate gene names: 50083391

Gene position: 98305-99978 (Clockwise)

Preceding gene: 50083390

Following gene: 50083392

Centisome position: 2.73

GC content: 41.4

Gene sequence:

>1674_bases
ATGAACAAAAATATCGAACAATTTCCAAGGAAAACCACGTTGACACCTCAACAAAAACTTGAACAGCTGATGGAACAGCA
CAAAACAGTTCATTTGACTGAATTGTTTGACAAAGAACAGGATCGTTTCGCCAAGTATTGTGTGGGCTGTGAAGATCTGG
TTTTTGATTTTAGTAAACAGCGCATTAATCAGCCCATTTTAGATGCGCTGGTTCAACTGGCCGAGTCTAAACAATTAAAC
AAATGGATTGATACTTTATTTTCTCAAAACAAGATTAATTACACTGAACAGCGTGAGGCCATGCACTGGGCACTACGTTT
ACCTGCGGATAATCAGGTCTATCCAGAGCTCGCTAAACAAGTCAGTGATCAGTTAGAGCGAATGTATCAACTGGTGAATA
AGATTCATGAAGGACAATACCGTGGTGCAACGGGTGAAGTCATTCAGGATGTTGTGAATATAGGTGTGGGTGGCTCAGAT
TTAGGGCCTTTGATGGTCAGTCATGCGTTATCCGATTTTAAAGTCAAAACAGCAAAGCCTTTAAATATCCGTTTTGTCTC
GACGATGGATGGTAGTCAGCTCTCTGATATTCTGCATCAGTTAAGACCTGAAACCACTCTATTTATTGTCTCATCCAAGT
CATTTAGTACCATTGATACACTTTCTAATGCGCATACTGCTCGAAAATGGTTAGAAAAAGCCTTAGGTCGTGAAAGTAGC
ATACTCAAAAGCCATTTCATTGGCGTTTCAACCAAACCTGATAAAATGACCGAATGGGGTATTCATCCAGATAACCAATT
CTTGCTGTGGGACTGGGTGGGTGGTCGTTATTCTTTGTGGTCATGTATTGGTCTACCTATCGCATTGACGATTGGTGTGG
AAGGTTTCAAAGCCTTTTTGGCAGGTGCACATGGTATCGATGAACACTTTAGAACCACAGAATTTCATCAAAATATTCCA
GTGCTGATGGGGTTGATGGGGATCTGGAATACCAATTATTTAAATTTAAAAACTCATGCAGTTTTGCCTTATGATGGACG
TTTAAAATATTTTACGTCTTATCTGCAACAGCTCGAAATGGAGTCTAATGGCAAGTCTACTCAGCGCAATGGGCAAAAAG
TGGAGAATACCACCTGTCCAATTGTATGGGGTGAGGTTGGACCAAATGCACAGCATGCGTTCTATCAGCTTTTGCATCAA
GGGACACAAAAAGTCAGTTGTGATTTTATCGCACCAATGCACCGCTATAATGCCAATCATTTTACGTATGTTGAAAATGC
AGATGCTTTGATTGATCAGCATTTACTCGCGTTATCCAACTGTTTGGCACAATCACGTTTGCTGGCTTTTGGAAATGATG
CACTCAAGGTAGATCAGCGAGAGCAGCTTCCAGCATATAAACAGTATGAAGGCAATCAGCCAAGTACCACCATGCTTCTG
AAAGAGCTCTCTCCTCGGACGATGGGTAAACTGATTGCGTTGTATGAGCATAAAGTTTTTGTTCAGTCGGTGATTTGGGA
CATTAACCCGTTTGATCAGTGGGGCGTCGAAAAAGGTAAGGAAATTGCCAATGACTTGCTACCTATCTTAAACGGCGAGA
GCAGTGATCTTTCACACCTCGATGACTCGACGCAAGGTTTAATTCAGTTTTTGTTGGGAAAGTCTAATGGCTAA

Upstream 100 bases:

>100_bases
AACAATTGATGGCACACCCGTTTATTTTGGACGGACGTAATGTTTACGATCCAGTTTATATAAAACAGCAAGGGTTTGCC
TATGAGGGTATAGGTCGGTT

Downstream 100 bases:

>100_bases
GATTTTGGTAACAGGTGGGGCAGGCTATATTGGCTCGCACACCTGTGTGGAATTGTTAAATGCGAACCACAGTGTGGTTG
TAGTGGACAATTTATCAAAT

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 557; Mature: 557

Protein sequence:

>557_residues
MNKNIEQFPRKTTLTPQQKLEQLMEQHKTVHLTELFDKEQDRFAKYCVGCEDLVFDFSKQRINQPILDALVQLAESKQLN
KWIDTLFSQNKINYTEQREAMHWALRLPADNQVYPELAKQVSDQLERMYQLVNKIHEGQYRGATGEVIQDVVNIGVGGSD
LGPLMVSHALSDFKVKTAKPLNIRFVSTMDGSQLSDILHQLRPETTLFIVSSKSFSTIDTLSNAHTARKWLEKALGRESS
ILKSHFIGVSTKPDKMTEWGIHPDNQFLLWDWVGGRYSLWSCIGLPIALTIGVEGFKAFLAGAHGIDEHFRTTEFHQNIP
VLMGLMGIWNTNYLNLKTHAVLPYDGRLKYFTSYLQQLEMESNGKSTQRNGQKVENTTCPIVWGEVGPNAQHAFYQLLHQ
GTQKVSCDFIAPMHRYNANHFTYVENADALIDQHLLALSNCLAQSRLLAFGNDALKVDQREQLPAYKQYEGNQPSTTMLL
KELSPRTMGKLIALYEHKVFVQSVIWDINPFDQWGVEKGKEIANDLLPILNGESSDLSHLDDSTQGLIQFLLGKSNG

Sequences:

>Translated_557_residues
MNKNIEQFPRKTTLTPQQKLEQLMEQHKTVHLTELFDKEQDRFAKYCVGCEDLVFDFSKQRINQPILDALVQLAESKQLN
KWIDTLFSQNKINYTEQREAMHWALRLPADNQVYPELAKQVSDQLERMYQLVNKIHEGQYRGATGEVIQDVVNIGVGGSD
LGPLMVSHALSDFKVKTAKPLNIRFVSTMDGSQLSDILHQLRPETTLFIVSSKSFSTIDTLSNAHTARKWLEKALGRESS
ILKSHFIGVSTKPDKMTEWGIHPDNQFLLWDWVGGRYSLWSCIGLPIALTIGVEGFKAFLAGAHGIDEHFRTTEFHQNIP
VLMGLMGIWNTNYLNLKTHAVLPYDGRLKYFTSYLQQLEMESNGKSTQRNGQKVENTTCPIVWGEVGPNAQHAFYQLLHQ
GTQKVSCDFIAPMHRYNANHFTYVENADALIDQHLLALSNCLAQSRLLAFGNDALKVDQREQLPAYKQYEGNQPSTTMLL
KELSPRTMGKLIALYEHKVFVQSVIWDINPFDQWGVEKGKEIANDLLPILNGESSDLSHLDDSTQGLIQFLLGKSNG
>Mature_557_residues
MNKNIEQFPRKTTLTPQQKLEQLMEQHKTVHLTELFDKEQDRFAKYCVGCEDLVFDFSKQRINQPILDALVQLAESKQLN
KWIDTLFSQNKINYTEQREAMHWALRLPADNQVYPELAKQVSDQLERMYQLVNKIHEGQYRGATGEVIQDVVNIGVGGSD
LGPLMVSHALSDFKVKTAKPLNIRFVSTMDGSQLSDILHQLRPETTLFIVSSKSFSTIDTLSNAHTARKWLEKALGRESS
ILKSHFIGVSTKPDKMTEWGIHPDNQFLLWDWVGGRYSLWSCIGLPIALTIGVEGFKAFLAGAHGIDEHFRTTEFHQNIP
VLMGLMGIWNTNYLNLKTHAVLPYDGRLKYFTSYLQQLEMESNGKSTQRNGQKVENTTCPIVWGEVGPNAQHAFYQLLHQ
GTQKVSCDFIAPMHRYNANHFTYVENADALIDQHLLALSNCLAQSRLLAFGNDALKVDQREQLPAYKQYEGNQPSTTMLL
KELSPRTMGKLIALYEHKVFVQSVIWDINPFDQWGVEKGKEIANDLLPILNGESSDLSHLDDSTQGLIQFLLGKSNG

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=553, Percent_Identity=42.1338155515371, Blast_Score=457, Evalue=1e-128,
Organism=Homo sapiens, GI296080693, Length=557, Percent_Identity=40.0359066427289, Blast_Score=407, Evalue=1e-113,
Organism=Escherichia coli, GI1790457, Length=546, Percent_Identity=45.6043956043956, Blast_Score=474, Evalue=1e-135,
Organism=Caenorhabditis elegans, GI71996703, Length=542, Percent_Identity=42.2509225092251, Blast_Score=439, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI71996708, Length=542, Percent_Identity=42.2509225092251, Blast_Score=439, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6319673, Length=559, Percent_Identity=40.0715563506261, Blast_Score=411, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24651916, Length=558, Percent_Identity=44.2652329749104, Blast_Score=463, Evalue=1e-130,
Organism=Drosophila melanogaster, GI24651914, Length=558, Percent_Identity=44.2652329749104, Blast_Score=463, Evalue=1e-130,
Organism=Drosophila melanogaster, GI17737445, Length=558, Percent_Identity=44.2652329749104, Blast_Score=463, Evalue=1e-130,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_ACIAD (Q59088)

Other databases:

- EMBL:   X89900
- EMBL:   CR543861
- PIR:   S58164
- RefSeq:   YP_044901.1
- ProteinModelPortal:   Q59088
- SMR:   Q59088
- STRING:   Q59088
- GeneID:   2879592
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD0101
- NMPDR:   fig|62977.3.peg.16
- eggNOG:   COG0166
- HOGENOM:   HBG352954
- OMA:   SFTTIDT
- PhylomeDB:   Q59088
- ProtClustDB:   PRK00179
- BioCyc:   ASP62977:ACIAD0101-MONOMER
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189
- Gene3D:   G3DSA:1.10.1390.10
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 63281; Mature: 63281

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 361-361 ACT_SITE 392-392 ACT_SITE 520-520

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKNIEQFPRKTTLTPQQKLEQLMEQHKTVHLTELFDKEQDRFAKYCVGCEDLVFDFSKQ
CCCCHHHCCCCCCCCHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
RINQPILDALVQLAESKQLNKWIDTLFSQNKINYTEQREAMHWALRLPADNQVYPELAKQ
HCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHEEECCCCCCHHHHHHHH
VSDQLERMYQLVNKIHEGQYRGATGEVIQDVVNIGVGGSDLGPLMVSHALSDFKVKTAKP
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCEEECCCC
LNIRFVSTMDGSQLSDILHQLRPETTLFIVSSKSFSTIDTLSNAHTARKWLEKALGRESS
CEEEEEECCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCHHH
ILKSHFIGVSTKPDKMTEWGIHPDNQFLLWDWVGGRYSLWSCIGLPIALTIGVEGFKAFL
HHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHCCCEEEEECHHHHHHHH
AGAHGIDEHFRTTEFHQNIPVLMGLMGIWNTNYLNLKTHAVLPYDGRLKYFTSYLQQLEM
HCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHH
ESNGKSTQRNGQKVENTTCPIVWGEVGPNAQHAFYQLLHQGTQKVSCDFIAPMHRYNANH
HCCCCCCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCC
FTYVENADALIDQHLLALSNCLAQSRLLAFGNDALKVDQREQLPAYKQYEGNQPSTTMLL
EEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCHHHCCCCCCHHHHHH
KELSPRTMGKLIALYEHKVFVQSVIWDINPFDQWGVEKGKEIANDLLPILNGESSDLSHL
HHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCHHHHHHHHHHHHHHCCCCCCCHHHC
DDSTQGLIQFLLGKSNG
CCHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNKNIEQFPRKTTLTPQQKLEQLMEQHKTVHLTELFDKEQDRFAKYCVGCEDLVFDFSKQ
CCCCHHHCCCCCCCCHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
RINQPILDALVQLAESKQLNKWIDTLFSQNKINYTEQREAMHWALRLPADNQVYPELAKQ
HCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHEEECCCCCCHHHHHHHH
VSDQLERMYQLVNKIHEGQYRGATGEVIQDVVNIGVGGSDLGPLMVSHALSDFKVKTAKP
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCEEECCCC
LNIRFVSTMDGSQLSDILHQLRPETTLFIVSSKSFSTIDTLSNAHTARKWLEKALGRESS
CEEEEEECCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCHHH
ILKSHFIGVSTKPDKMTEWGIHPDNQFLLWDWVGGRYSLWSCIGLPIALTIGVEGFKAFL
HHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHCCCEEEEECHHHHHHHH
AGAHGIDEHFRTTEFHQNIPVLMGLMGIWNTNYLNLKTHAVLPYDGRLKYFTSYLQQLEM
HCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHH
ESNGKSTQRNGQKVENTTCPIVWGEVGPNAQHAFYQLLHQGTQKVSCDFIAPMHRYNANH
HCCCCCCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCC
FTYVENADALIDQHLLALSNCLAQSRLLAFGNDALKVDQREQLPAYKQYEGNQPSTTMLL
EEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCHHHCCCCCCHHHHHH
KELSPRTMGKLIALYEHKVFVQSVIWDINPFDQWGVEKGKEIANDLLPILNGESSDLSHL
HHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCHHHHHHHHHHHHHHCCCCCCCHHHC
DDSTQGLIQFLLGKSNG
CCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA