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The map label for this gene is galE [H]

Identifier: 50083392

GI number: 50083392

Start: 99971

End: 100990

Strand: Direct

Name: galE [H]

Synonym: ACIAD0102

Alternate gene names: 50083392

Gene position: 99971-100990 (Clockwise)

Preceding gene: 50083391

Following gene: 50083393

Centisome position: 2.78

GC content: 44.12

Gene sequence:

>1020_bases
ATGGCTAAGATTTTGGTAACAGGTGGGGCAGGCTATATTGGCTCGCACACCTGTGTGGAATTGTTAAATGCGAACCACAG
TGTGGTTGTAGTGGACAATTTATCAAATAGCTCAGAAGAAGCGTTGTTTCGCGTGCAACAGTTGACTGGGAAAAGTCTGG
ATTTTGTACAAGGTGATATTCGTGATAGCACATTGCTGGATCAGGTCTTTGCACAATATTCAATTGATGCAGTGATTCAT
TTTGCAGGTTTGAAGGCGGTCGGTGAAAGCCAGCAGATTCCACTTGCCTACTTTGATAATAATATTGCAGGCAGTATTAG
TCTGGTCAAAGCCATGGAGCGTGCAGGTGTATTTAAGTTGGTGTTTAGTTCATCTGCGACCGTGTATGATGAAGCCAATA
CTTCTCCACTGAATGAAGATATGCCAACAGGTATGCCATCCAACAACTATGGCTATACCAAGTTAATTGTTGAGCAAATG
CTGGAAAAACTGGCAATTGCAGATACACGTTGGTCAATTGCCTTATTGCGTTATTTCAATCCTGTGGGTGCACATCAAAG
TGGACAAATAGGCGAAGATCCACAAGGTATTCCAAATAACTTAATGCCATATGTGACTCAGGTTGCAGTGGGACGCCGTC
AAAAACTGTCGATCTTTGGCGATGACTATGACACCATCGATGGAACAGGCGTGCGAGATTATATCCATGTGGTCGATTTA
GCCAATGCACATTTGTGTGCTCTGAATAATCGTCTGAATGCAGTAGGTTGTCGTGCCTGGAATATTGGCACAGGAAATGG
TTCGTCGGTATTACAGGTCAAAGATACTTTTGAACAGGTCAATGGTGTCGCCATTGCTTTTGAGTTTGCACCGCGCCGTT
TGGGTGATGTTGCAACTTCATTTGCCGATAATCAGCGCGCGCTTGATGAACTCGGATGGGTACCACGCTACACTCTTGAA
GACATGCTGAAAGATAGCTGGAACTGGCAAAAACAGAATCCACAAGGGTATTCGAACTAA

Upstream 100 bases:

>100_bases
GCCAATGACTTGCTACCTATCTTAAACGGCGAGAGCAGTGATCTTTCACACCTCGATGACTCGACGCAAGGTTTAATTCA
GTTTTTGTTGGGAAAGTCTA

Downstream 100 bases:

>100_bases
TTATTTATCGATTTAACGGGAAACAGTCAGAAAGGTGTGGCTGGTTCCCCGCGTGTGTATAATAGCCAGCATTGTGGATT
TTCAGTGGCCGTTATGCGCT

Product: UDP-glucose 4-epimerase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MAKILVTGGAGYIGSHTCVELLNANHSVVVVDNLSNSSEEALFRVQQLTGKSLDFVQGDIRDSTLLDQVFAQYSIDAVIH
FAGLKAVGESQQIPLAYFDNNIAGSISLVKAMERAGVFKLVFSSSATVYDEANTSPLNEDMPTGMPSNNYGYTKLIVEQM
LEKLAIADTRWSIALLRYFNPVGAHQSGQIGEDPQGIPNNLMPYVTQVAVGRRQKLSIFGDDYDTIDGTGVRDYIHVVDL
ANAHLCALNNRLNAVGCRAWNIGTGNGSSVLQVKDTFEQVNGVAIAFEFAPRRLGDVATSFADNQRALDELGWVPRYTLE
DMLKDSWNWQKQNPQGYSN

Sequences:

>Translated_339_residues
MAKILVTGGAGYIGSHTCVELLNANHSVVVVDNLSNSSEEALFRVQQLTGKSLDFVQGDIRDSTLLDQVFAQYSIDAVIH
FAGLKAVGESQQIPLAYFDNNIAGSISLVKAMERAGVFKLVFSSSATVYDEANTSPLNEDMPTGMPSNNYGYTKLIVEQM
LEKLAIADTRWSIALLRYFNPVGAHQSGQIGEDPQGIPNNLMPYVTQVAVGRRQKLSIFGDDYDTIDGTGVRDYIHVVDL
ANAHLCALNNRLNAVGCRAWNIGTGNGSSVLQVKDTFEQVNGVAIAFEFAPRRLGDVATSFADNQRALDELGWVPRYTLE
DMLKDSWNWQKQNPQGYSN
>Mature_338_residues
AKILVTGGAGYIGSHTCVELLNANHSVVVVDNLSNSSEEALFRVQQLTGKSLDFVQGDIRDSTLLDQVFAQYSIDAVIHF
AGLKAVGESQQIPLAYFDNNIAGSISLVKAMERAGVFKLVFSSSATVYDEANTSPLNEDMPTGMPSNNYGYTKLIVEQML
EKLAIADTRWSIALLRYFNPVGAHQSGQIGEDPQGIPNNLMPYVTQVAVGRRQKLSIFGDDYDTIDGTGVRDYIHVVDLA
NAHLCALNNRLNAVGCRAWNIGTGNGSSVLQVKDTFEQVNGVAIAFEFAPRRLGDVATSFADNQRALDELGWVPRYTLED
MLKDSWNWQKQNPQGYSN

Specific function: Galactose metabolism; third step. [C]

COG id: COG1087

COG function: function code M; UDP-glucose 4-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI56237023, Length=341, Percent_Identity=55.425219941349, Blast_Score=382, Evalue=1e-106,
Organism=Homo sapiens, GI56118217, Length=341, Percent_Identity=55.425219941349, Blast_Score=382, Evalue=1e-106,
Organism=Homo sapiens, GI189083684, Length=341, Percent_Identity=55.425219941349, Blast_Score=382, Evalue=1e-106,
Organism=Homo sapiens, GI7657641, Length=346, Percent_Identity=25.1445086705202, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI42516563, Length=336, Percent_Identity=22.0238095238095, Blast_Score=76, Evalue=6e-14,
Organism=Escherichia coli, GI1786974, Length=337, Percent_Identity=54.3026706231454, Blast_Score=388, Evalue=1e-109,
Organism=Escherichia coli, GI48994969, Length=358, Percent_Identity=26.536312849162, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1788353, Length=367, Percent_Identity=25.8855585831063, Blast_Score=82, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71982035, Length=344, Percent_Identity=48.8372093023256, Blast_Score=332, Evalue=2e-91,
Organism=Caenorhabditis elegans, GI71982038, Length=346, Percent_Identity=48.2658959537572, Blast_Score=330, Evalue=8e-91,
Organism=Caenorhabditis elegans, GI17568069, Length=270, Percent_Identity=26.2962962962963, Blast_Score=68, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6319493, Length=344, Percent_Identity=52.3255813953488, Blast_Score=355, Evalue=6e-99,
Organism=Drosophila melanogaster, GI19923002, Length=344, Percent_Identity=52.3255813953488, Blast_Score=363, Evalue=1e-101,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR005886
- InterPro:   IPR016040
- InterPro:   IPR008089 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 37120; Mature: 36989

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKILVTGGAGYIGSHTCVELLNANHSVVVVDNLSNSSEEALFRVQQLTGKSLDFVQGDI
CCEEEEECCCCCCCHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCHHHHCCC
RDSTLLDQVFAQYSIDAVIHFAGLKAVGESQQIPLAYFDNNIAGSISLVKAMERAGVFKL
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHCCEEEE
VFSSSATVYDEANTSPLNEDMPTGMPSNNYGYTKLIVEQMLEKLAIADTRWSIALLRYFN
EECCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
PVGAHQSGQIGEDPQGIPNNLMPYVTQVAVGRRQKLSIFGDDYDTIDGTGVRDYIHVVDL
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHH
ANAHLCALNNRLNAVGCRAWNIGTGNGSSVLQVKDTFEQVNGVAIAFEFAPRRLGDVATS
CCCEEEEECCCCCEEEEEEEECCCCCCCCEEEEHHHHHHCCCEEEEEECCCHHHHHHHHH
FADNQRALDELGWVPRYTLEDMLKDSWNWQKQNPQGYSN
HHCCHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AKILVTGGAGYIGSHTCVELLNANHSVVVVDNLSNSSEEALFRVQQLTGKSLDFVQGDI
CEEEEECCCCCCCHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCHHHHCCC
RDSTLLDQVFAQYSIDAVIHFAGLKAVGESQQIPLAYFDNNIAGSISLVKAMERAGVFKL
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHCCEEEE
VFSSSATVYDEANTSPLNEDMPTGMPSNNYGYTKLIVEQMLEKLAIADTRWSIALLRYFN
EECCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
PVGAHQSGQIGEDPQGIPNNLMPYVTQVAVGRRQKLSIFGDDYDTIDGTGVRDYIHVVDL
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHH
ANAHLCALNNRLNAVGCRAWNIGTGNGSSVLQVKDTFEQVNGVAIAFEFAPRRLGDVATS
CCCEEEEECCCCCEEEEEEEECCCCCCCCEEEEHHHHHHCCCEEEEEECCCHHHHHHHHH
FADNQRALDELGWVPRYTLEDMLKDSWNWQKQNPQGYSN
HHCCHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8978088; 8969509; 9384377 [H]