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The map label for this gene is rmlD [H]

Identifier: 50083369

GI number: 50083369

Start: 73858

End: 74766

Strand: Direct

Name: rmlD [H]

Synonym: ACIAD0078

Alternate gene names: 50083369

Gene position: 73858-74766 (Clockwise)

Preceding gene: 50083368

Following gene: 50083370

Centisome position: 2.05

GC content: 40.15

Gene sequence:

>909_bases
ATGAAAATACTGATATTGGGCAAAAATGGACAAGTCGGCTGGGAATTACAACGATCGCTTCAGCCCTTAGGTGAAGTTAT
TGCTTTAGATCGATATGAAGATGTTGAGCATGGCTTTAGTGGTGATATCACAAATTTTGAAGCCATTGAAAAAGTGATAC
AAACATTCCAACCTGATATTGTGCTCAATGCAACTGCATATACGGCGGTTGATAAAGCAGAGTCAGAGGTTGAACAGGCC
GATTTGGTCAATCATATTGCTGTGAAGCATTTGGCCGAGCAATGCAAAGCAATAGATGCTTTACTCATACATTATTCTAC
AGATTATGTATTTAATGGGCAGGGCACAGCAGCTTGGCAGGAAGATGATACGACAGAACCTCAAAATGCGTATGGAAAAA
CCAAACGAAATGGTGAGATTGCGCTTGAACAAAGTCAGGTAAAGTTTATCAATTTACGTACAAGCTGGGTGTATGCTTCA
CGTGGTCATAACTTTATAAAAACCATGCTTAAGCTGGCTCAAAGTAAAGATGAACTTAGCATTATTGATGATCAGATTGG
TGCACCTACTGGCGCAGCTTTAATTGCAGATGTGACAGCACAAATTGTTCGTTATTATGCTTTGCAGCCACAACTTCAGC
AAAAGCATTTGCTCGGTCATTATCATTTGGCCGCTCAGGGTGAGACATCTTGGTATGCTTATGCAAATTATATCTTTGAT
GTTGCCAAAGCACATGGATTAGCACTTCAGCTTAAAACAGTGAAGCCAATATCGACAGTTGATTATCCTACACCAGCAGT
TCGACCGCTCAACTCAAGATTAAATACTCAGAAACTCCAACAAATGTTTGCTTTACACCTTCCTCAATGGCAGCAAGGTG
TTGAGCATATGATTAAAGAGACCCTATAA

Upstream 100 bases:

>100_bases
GTATCTGGCAAATCAGGAATGGGTAAAGCATGTGCAAAGCGGCGAGTACCAAAACTGGGTACAAAACCAATACCAAGCCT
AGGTGAAAGAGATGGGTCAC

Downstream 100 bases:

>100_bases
ATGACAGCATCAAAACAACGTAAAGGTATTATTCTGGCGGGTGGCTCAGGTACACGCTTGTACCCAATTACCATGGGTAC
ATCTAAGCAGTTATTGCCAA

Product: dTDP-4-dehydrorhamnose reductase (dTDP-4-keto-L-rhamnose reductase) (dTDP-6-deoxy-L-mannose dehydrogenase) (dTDP-L-rhamnose synthetase)

Products: NA

Alternate protein names: dTDP-4-keto-L-rhamnose reductase; dTDP-6-deoxy-L-lyxo-4-hexulose reductase; dTDP-6-deoxy-L-mannose dehydrogenase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MKILILGKNGQVGWELQRSLQPLGEVIALDRYEDVEHGFSGDITNFEAIEKVIQTFQPDIVLNATAYTAVDKAESEVEQA
DLVNHIAVKHLAEQCKAIDALLIHYSTDYVFNGQGTAAWQEDDTTEPQNAYGKTKRNGEIALEQSQVKFINLRTSWVYAS
RGHNFIKTMLKLAQSKDELSIIDDQIGAPTGAALIADVTAQIVRYYALQPQLQQKHLLGHYHLAAQGETSWYAYANYIFD
VAKAHGLALQLKTVKPISTVDYPTPAVRPLNSRLNTQKLQQMFALHLPQWQQGVEHMIKETL

Sequences:

>Translated_302_residues
MKILILGKNGQVGWELQRSLQPLGEVIALDRYEDVEHGFSGDITNFEAIEKVIQTFQPDIVLNATAYTAVDKAESEVEQA
DLVNHIAVKHLAEQCKAIDALLIHYSTDYVFNGQGTAAWQEDDTTEPQNAYGKTKRNGEIALEQSQVKFINLRTSWVYAS
RGHNFIKTMLKLAQSKDELSIIDDQIGAPTGAALIADVTAQIVRYYALQPQLQQKHLLGHYHLAAQGETSWYAYANYIFD
VAKAHGLALQLKTVKPISTVDYPTPAVRPLNSRLNTQKLQQMFALHLPQWQQGVEHMIKETL
>Mature_302_residues
MKILILGKNGQVGWELQRSLQPLGEVIALDRYEDVEHGFSGDITNFEAIEKVIQTFQPDIVLNATAYTAVDKAESEVEQA
DLVNHIAVKHLAEQCKAIDALLIHYSTDYVFNGQGTAAWQEDDTTEPQNAYGKTKRNGEIALEQSQVKFINLRTSWVYAS
RGHNFIKTMLKLAQSKDELSIIDDQIGAPTGAALIADVTAQIVRYYALQPQLQQKHLLGHYHLAAQGETSWYAYANYIFD
VAKAHGLALQLKTVKPISTVDYPTPAVRPLNSRLNTQKLQQMFALHLPQWQQGVEHMIKETL

Specific function: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose. RmlD uses NADH and NADPH nearly equally well [H]

COG id: COG1091

COG function: function code M; dTDP-4-dehydrorhamnose reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose reductase family [H]

Homologues:

Organism=Homo sapiens, GI11034825, Length=294, Percent_Identity=26.1904761904762, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI33519455, Length=294, Percent_Identity=26.1904761904762, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1788352, Length=300, Percent_Identity=50.3333333333333, Blast_Score=310, Evalue=5e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005913
- InterPro:   IPR016040 [H]

Pfam domain/function: PF04321 RmlD_sub_bind [H]

EC number: =1.1.1.133 [H]

Molecular weight: Translated: 33885; Mature: 33885

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILILGKNGQVGWELQRSLQPLGEVIALDRYEDVEHGFSGDITNFEAIEKVIQTFQPDI
CEEEEECCCCCCCHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCHHHHHHHHHHCCCCE
VLNATAYTAVDKAESEVEQADLVNHIAVKHLAEQCKAIDALLIHYSTDYVFNGQGTAAWQ
EEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCEEECCCCCCCCC
EDDTTEPQNAYGKTKRNGEIALEQSQVKFINLRTSWVYASRGHNFIKTMLKLAQSKDELS
CCCCCCCHHHCCCCCCCCCEEEEECCEEEEEEEEEEEEECCCCHHHHHHHHHHCCCCCHH
IIDDQIGAPTGAALIADVTAQIVRYYALQPQLQQKHLLGHYHLAAQGETSWYAYANYIFD
HHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHEEEEECCCCCHHHHHHHHHH
VAKAHGLALQLKTVKPISTVDYPTPAVRPLNSRLNTQKLQQMFALHLPQWQQGVEHMIKE
HHHHCCEEEEEEECCCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHH
TL
CC
>Mature Secondary Structure
MKILILGKNGQVGWELQRSLQPLGEVIALDRYEDVEHGFSGDITNFEAIEKVIQTFQPDI
CEEEEECCCCCCCHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCHHHHHHHHHHCCCCE
VLNATAYTAVDKAESEVEQADLVNHIAVKHLAEQCKAIDALLIHYSTDYVFNGQGTAAWQ
EEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCEEECCCCCCCCC
EDDTTEPQNAYGKTKRNGEIALEQSQVKFINLRTSWVYASRGHNFIKTMLKLAQSKDELS
CCCCCCCHHHCCCCCCCCCEEEEECCEEEEEEEEEEEEECCCCHHHHHHHHHHCCCCCHH
IIDDQIGAPTGAALIADVTAQIVRYYALQPQLQQKHLLGHYHLAAQGETSWYAYANYIFD
HHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHEEEEECCCCCHHHHHHHHHH
VAKAHGLALQLKTVKPISTVDYPTPAVRPLNSRLNTQKLQQMFALHLPQWQQGVEHMIKE
HHHHCCEEEEEEECCCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHH
TL
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1710759; 11677609 [H]