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The map label for this gene is rmlA [H]

Identifier: 50083370

GI number: 50083370

Start: 74767

End: 75666

Strand: Direct

Name: rmlA [H]

Synonym: ACIAD0079

Alternate gene names: 50083370

Gene position: 74767-75666 (Clockwise)

Preceding gene: 50083369

Following gene: 50083371

Centisome position: 2.08

GC content: 40.33

Gene sequence:

>900_bases
ATGACAGCATCAAAACAACGTAAAGGTATTATTCTGGCGGGTGGCTCAGGTACACGCTTGTACCCAATTACCATGGGTAC
ATCTAAGCAGTTATTGCCAATCTATGATAAACCAATGATCTATTATCCATTGTCAGTGCTTATGCTGGCAGGGATTCAAG
ATATTTTAATTATTTCAACACCAGAAGACCTACCAAATTTTGAAAAATTATTGGGAACGGGTGAGGAACTGGGTATTCGT
CTCTCTTATAAAGTACAGCCATCACCAGATGGCTTGGCACAAGCGTTTATATTGGGTGAAGAATTTATTGGGCAAGATAA
CGTTACATTAATCTTAGGTGATAATATTTTCTATGGCCAAAGTTTTGGTCAGCAGCTTAAGCGTGCGGCCGAGCAGCAGA
CAGGTGCAACGGTATTTGGTTATTATGTCAATGATCCAGAGCGCTTTGGCGTGGTCGATTTTGATGAAAATGGTAAAGCA
TTAAGTATTGAAGAAAAACCTGAGCAGCCCAAGTCTAACTATGCGGTTACCGGTCTCTATTTTTACGATAACACTGTGGT
TGAAATTGCGAAAAATATCAAACCCTCCCACCGTGGTGAGCTCGAAATTACAGATGTGAATAATGTGTACCTACAGCAAA
ATAATCTCAATGTAGAAGTACTTGGCCGTGGTTTTGCATGGTTAGATACAGGTACACATGACTCACTATTGGAAGCAAGC
CAGTTTGTACAGACCATTGAGCATCGTCAGGGCTTAAAGGTGGCGAGTCTGGAAGAGATTTCATTTAATAATGGCTGGAT
TAACGCAGATCAGCTTAAAGCACGTGGCGAGTTTTTCAAAAAAACAGGCTATGGGCAGTATTTGCTTAAGTTATATAAAG
ACCAGTCAAATAAAGCTTAA

Upstream 100 bases:

>100_bases
CAACTCAAGATTAAATACTCAGAAACTCCAACAAATGTTTGCTTTACACCTTCCTCAATGGCAGCAAGGTGTTGAGCATA
TGATTAAAGAGACCCTATAA

Downstream 100 bases:

>100_bases
CCCTTAAATTGGCAGAAGTGATTTATAATGAAATAAATCACTTCTTGCCGATTATCAATCAGGTAAAAATATGAATATTA
TTGAAACTAAAATCAAAGAT

Product: dTDP-glucose pyrophosphorylase (glucose-1-phosphate thymidylyltransferase)

Products: NA

Alternate protein names: G1P-TT 1; dTDP-glucose pyrophosphorylase 1; dTDP-glucose synthase 1 [H]

Number of amino acids: Translated: 299; Mature: 298

Protein sequence:

>299_residues
MTASKQRKGIILAGGSGTRLYPITMGTSKQLLPIYDKPMIYYPLSVLMLAGIQDILIISTPEDLPNFEKLLGTGEELGIR
LSYKVQPSPDGLAQAFILGEEFIGQDNVTLILGDNIFYGQSFGQQLKRAAEQQTGATVFGYYVNDPERFGVVDFDENGKA
LSIEEKPEQPKSNYAVTGLYFYDNTVVEIAKNIKPSHRGELEITDVNNVYLQQNNLNVEVLGRGFAWLDTGTHDSLLEAS
QFVQTIEHRQGLKVASLEEISFNNGWINADQLKARGEFFKKTGYGQYLLKLYKDQSNKA

Sequences:

>Translated_299_residues
MTASKQRKGIILAGGSGTRLYPITMGTSKQLLPIYDKPMIYYPLSVLMLAGIQDILIISTPEDLPNFEKLLGTGEELGIR
LSYKVQPSPDGLAQAFILGEEFIGQDNVTLILGDNIFYGQSFGQQLKRAAEQQTGATVFGYYVNDPERFGVVDFDENGKA
LSIEEKPEQPKSNYAVTGLYFYDNTVVEIAKNIKPSHRGELEITDVNNVYLQQNNLNVEVLGRGFAWLDTGTHDSLLEAS
QFVQTIEHRQGLKVASLEEISFNNGWINADQLKARGEFFKKTGYGQYLLKLYKDQSNKA
>Mature_298_residues
TASKQRKGIILAGGSGTRLYPITMGTSKQLLPIYDKPMIYYPLSVLMLAGIQDILIISTPEDLPNFEKLLGTGEELGIRL
SYKVQPSPDGLAQAFILGEEFIGQDNVTLILGDNIFYGQSFGQQLKRAAEQQTGATVFGYYVNDPERFGVVDFDENGKAL
SIEEKPEQPKSNYAVTGLYFYDNTVVEIAKNIKPSHRGELEITDVNNVYLQQNNLNVEVLGRGFAWLDTGTHDSLLEASQ
FVQTIEHRQGLKVASLEEISFNNGWINADQLKARGEFFKKTGYGQYLLKLYKDQSNKA

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=257, Percent_Identity=25.2918287937743, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI11761619, Length=257, Percent_Identity=25.2918287937743, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1788351, Length=292, Percent_Identity=67.1232876712329, Blast_Score=421, Evalue=1e-119,
Organism=Escherichia coli, GI1790224, Length=291, Percent_Identity=67.0103092783505, Blast_Score=410, Evalue=1e-116,
Organism=Escherichia coli, GI1787488, Length=250, Percent_Identity=24, Blast_Score=68, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI133931050, Length=183, Percent_Identity=26.2295081967213, Blast_Score=75, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6320148, Length=255, Percent_Identity=27.0588235294118, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21355443, Length=250, Percent_Identity=26.8, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24644084, Length=250, Percent_Identity=26.8, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 33352; Mature: 33221

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASKQRKGIILAGGSGTRLYPITMGTSKQLLPIYDKPMIYYPLSVLMLAGIQDILIIST
CCCCCCCCEEEEECCCCCEEEEEEECCCCCEEEECCCCEEEHHHHHHHHCCCCEEEEEEC
PEDLPNFEKLLGTGEELGIRLSYKVQPSPDGLAQAFILGEEFIGQDNVTLILGDNIFYGQ
CCCCCCHHHHHCCCHHHCEEEEEEECCCCCHHHHHEEECHHHCCCCCEEEEECCCEEECC
SFGQQLKRAAEQQTGATVFGYYVNDPERFGVVDFDENGKALSIEEKPEQPKSNYAVTGLY
HHHHHHHHHHHHHCCCEEEEEEECCCHHCCEEEECCCCCEEEECCCCCCCCCCEEEEEEE
FYDNTVVEIAKNIKPSHRGELEITDVNNVYLQQNNLNVEVLGRGFAWLDTGTHDSLLEAS
EECCHHHHHHHHCCCCCCCCEEEEECCEEEEEECCCEEEEEECCEEEEECCCCHHHHHHH
QFVQTIEHRQGLKVASLEEISFNNGWINADQLKARGEFFKKTGYGQYLLKLYKDQSNKA
HHHHHHHHHCCCEEEEEEEEECCCCEECHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TASKQRKGIILAGGSGTRLYPITMGTSKQLLPIYDKPMIYYPLSVLMLAGIQDILIIST
CCCCCCCEEEEECCCCCEEEEEEECCCCCEEEECCCCEEEHHHHHHHHCCCCEEEEEEC
PEDLPNFEKLLGTGEELGIRLSYKVQPSPDGLAQAFILGEEFIGQDNVTLILGDNIFYGQ
CCCCCCHHHHHCCCHHHCEEEEEEECCCCCHHHHHEEECHHHCCCCCEEEEECCCEEECC
SFGQQLKRAAEQQTGATVFGYYVNDPERFGVVDFDENGKALSIEEKPEQPKSNYAVTGLY
HHHHHHHHHHHHHCCCEEEEEEECCCHHCCEEEECCCCCEEEECCCCCCCCCCEEEEEEE
FYDNTVVEIAKNIKPSHRGELEITDVNNVYLQQNNLNVEVLGRGFAWLDTGTHDSLLEAS
EECCHHHHHHHHCCCCCCCCEEEEECCEEEEEECCCEEEEEECCEEEEECCCCHHHHHHH
QFVQTIEHRQGLKVASLEEISFNNGWINADQLKARGEFFKKTGYGQYLLKLYKDQSNKA
HHHHHHHHHCCCEEEEEEEEECCCCEECHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7517391; 9097040; 9278503; 7517390 [H]