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The map label for this gene is tktA [H]

Identifier: 49476166

GI number: 49476166

Start: 1731125

End: 1733131

Strand: Reverse

Name: tktA [H]

Synonym: BH15090

Alternate gene names: 49476166

Gene position: 1733131-1731125 (Counterclockwise)

Preceding gene: 49476169

Following gene: 49476165

Centisome position: 89.75

GC content: 45.19

Gene sequence:

>2007_bases
ATGACAAATACCGAAACAAAGAAACAGATGGCCAATGCTATCCGTTTTCTTGCGATTGATGCGATTGAAAAAGCAAATTC
TGGTCATCCCGGGTTACCAATGGGGGCAGCCGATATTGCCACCGTCCTTTATACAAAATTCCTTGCCCATGATCCCAAAA
ATCCTCATTGGCCTAACCGTGATCGTTTTGTGTTGTCCGCTGGTCATGGCTCTATGTTGCTTTATGCCCTCTTGTATCTT
TCTGGTTATGAAGATATTTCCCTTGAAGATCTCAAAAACTTCCGCCAAATAGGCTCTAAGGTTGCCGGGCATCCAGAATA
TGGGCATGCTGCTGGAATCGAAACAACCACTGGACCACTCGGACAGGGGATAGCTAATGCTGTGGGAATGGCTCTGGGGG
AGCGCCTGCTCAATGCACGCTTTGGTGATCTCATCAACCATTATACTTACGCGCTGGTTGGGGATGGGTGCCTCATGGAA
GGGATTTCACAAGAAGCTCTTTCCCTTGCTGGACATTTAAAACTCAATAAGCTTATCGTATTGTGGGACGATAATAACAT
TTCCATCGATGGAGAAATTTCCCTTGCTGATAGTACTGACCAAATAGCCCGTTTTAAAGCGTCTGGTTGGAATACACACA
AAGTTGATGGACATGATCAAGCAGCAATCGCACGGGCTATTGAGGCTGCAAGAAATTCCGATAAACCAACTTTGATCGCT
TGTAAAACAACCATTGGTTTTGGAGCTCCCAATAAAGCTGGGACCAATAAAATTCATGGGGCACCTTTAGGTGCATCCGA
AATTGCTGAAACCCGTATCGCTTTGGGATGGGAGGCAGAGCCTTTCGTTATTCCAGCCGATATCCTCGATAATTGGCGCT
TGGCTGGTCTTAATGCCGCTAAAAAACGACAAAAATGGAAAGAAAAATTTGCCGCTCTTCCACTCTCAGAACGGATAGAG
TTTGAAAGATTGATGCGTGGCGATCTCGTGGGCGGATTTGATGGTGCTATCGATGTTTATAAAAAGAAATTGGTTGAGGA
TTGTCCGTGTGTTGCCACCCGTAAAGCTTCGGAAATGGCTCTTGAAGTGATCAATGAAGTCGTTCTTGAAACCATTGGTG
GTTCTGCTGACTTAACCGGATCAAATAATACCAAAAGCAGTCAGATGAAAACTATCTCTGCTGAGGATTTTTCAGGGCGT
TATTTGCATTATGGAGTTCGTGAACATGCTATGGGAGCCGTGATGAATGGTCTTGCCCTTTATGGAGGTTTTATTCCTTA
TGGCGGAACCTTTTTATGTTTTTCCGACTATATGCGTCCCGCAATGCGTTTGTCTTCTCTCATGGGGTTGCGGGTCATTT
ATGTCATGACCCATGATTCCATTGGTCTTGGTGAGGATGGACCTACTCATCAGCCGGTGGAGCATTTGGCTTCTTTGCGT
ACACTTCCTAATCATCTTGTTTTCCGTCCTGCTGACGCTATGGAGACTGTCGAGTGTTGGCAATTGGCTTTGAAAACGCG
AGGGACACCTTCTACTTTGGCTTTGAGTAGACAAAATTTACCACTTTTGCGTCGGGAATATGAAGAAGAAAATCTTTGTA
TGCTCGGTGCTTATGAATTACTCACCGCCAGTGATGATGCGCAAGTGACCCTGTTTGCTTCCGGTTCAGAATTGCAGATT
GCCGTACATGCACATGCAGTCTTAGAAGAAAAGGGAATCCCAACGCGTGTGGTTTCTGTACCTTGTTTTGAACTCTTTAC
ACAGCAATCTCCCTCCTATCAGAGGGCTCTCATTGGTGATGCACCGATTAAAATTGCCATTGAAGCTGCACTCCGGCAAG
GTTGGGACTATTTTATCGGCACTAATGGGGTGTTTATTGGCATGCAAGGATTTGGTGCCAGTGGGACCATCGATGCGCTT
TATGCGCACTTTGGCATCACTTGTGAAAATGTGGTCGCTGCCGTTGAAAAAAAACTTGAAGACATCCATAAGGAAAATGT
GAAATAA

Upstream 100 bases:

>100_bases
ACGCTGACGATTAAAATAAACTGAAAAATATTTCTCAAATAATTTAAGAGAATATGAAAGAACAACAAAACAACGCGTTT
AACAAAGTGGTTTATCATTT

Downstream 100 bases:

>100_bases
ATGCTCATGGTGCTATGAACCATTTTGATCATCGTGGGTGCGATCGTTTTTATGCCATCGTAGAAAGTTAATAAGTGATT
CTTTATGATTTGGAAATCAT

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 668; Mature: 667

Protein sequence:

>668_residues
MTNTETKKQMANAIRFLAIDAIEKANSGHPGLPMGAADIATVLYTKFLAHDPKNPHWPNRDRFVLSAGHGSMLLYALLYL
SGYEDISLEDLKNFRQIGSKVAGHPEYGHAAGIETTTGPLGQGIANAVGMALGERLLNARFGDLINHYTYALVGDGCLME
GISQEALSLAGHLKLNKLIVLWDDNNISIDGEISLADSTDQIARFKASGWNTHKVDGHDQAAIARAIEAARNSDKPTLIA
CKTTIGFGAPNKAGTNKIHGAPLGASEIAETRIALGWEAEPFVIPADILDNWRLAGLNAAKKRQKWKEKFAALPLSERIE
FERLMRGDLVGGFDGAIDVYKKKLVEDCPCVATRKASEMALEVINEVVLETIGGSADLTGSNNTKSSQMKTISAEDFSGR
YLHYGVREHAMGAVMNGLALYGGFIPYGGTFLCFSDYMRPAMRLSSLMGLRVIYVMTHDSIGLGEDGPTHQPVEHLASLR
TLPNHLVFRPADAMETVECWQLALKTRGTPSTLALSRQNLPLLRREYEEENLCMLGAYELLTASDDAQVTLFASGSELQI
AVHAHAVLEEKGIPTRVVSVPCFELFTQQSPSYQRALIGDAPIKIAIEAALRQGWDYFIGTNGVFIGMQGFGASGTIDAL
YAHFGITCENVVAAVEKKLEDIHKENVK

Sequences:

>Translated_668_residues
MTNTETKKQMANAIRFLAIDAIEKANSGHPGLPMGAADIATVLYTKFLAHDPKNPHWPNRDRFVLSAGHGSMLLYALLYL
SGYEDISLEDLKNFRQIGSKVAGHPEYGHAAGIETTTGPLGQGIANAVGMALGERLLNARFGDLINHYTYALVGDGCLME
GISQEALSLAGHLKLNKLIVLWDDNNISIDGEISLADSTDQIARFKASGWNTHKVDGHDQAAIARAIEAARNSDKPTLIA
CKTTIGFGAPNKAGTNKIHGAPLGASEIAETRIALGWEAEPFVIPADILDNWRLAGLNAAKKRQKWKEKFAALPLSERIE
FERLMRGDLVGGFDGAIDVYKKKLVEDCPCVATRKASEMALEVINEVVLETIGGSADLTGSNNTKSSQMKTISAEDFSGR
YLHYGVREHAMGAVMNGLALYGGFIPYGGTFLCFSDYMRPAMRLSSLMGLRVIYVMTHDSIGLGEDGPTHQPVEHLASLR
TLPNHLVFRPADAMETVECWQLALKTRGTPSTLALSRQNLPLLRREYEEENLCMLGAYELLTASDDAQVTLFASGSELQI
AVHAHAVLEEKGIPTRVVSVPCFELFTQQSPSYQRALIGDAPIKIAIEAALRQGWDYFIGTNGVFIGMQGFGASGTIDAL
YAHFGITCENVVAAVEKKLEDIHKENVK
>Mature_667_residues
TNTETKKQMANAIRFLAIDAIEKANSGHPGLPMGAADIATVLYTKFLAHDPKNPHWPNRDRFVLSAGHGSMLLYALLYLS
GYEDISLEDLKNFRQIGSKVAGHPEYGHAAGIETTTGPLGQGIANAVGMALGERLLNARFGDLINHYTYALVGDGCLMEG
ISQEALSLAGHLKLNKLIVLWDDNNISIDGEISLADSTDQIARFKASGWNTHKVDGHDQAAIARAIEAARNSDKPTLIAC
KTTIGFGAPNKAGTNKIHGAPLGASEIAETRIALGWEAEPFVIPADILDNWRLAGLNAAKKRQKWKEKFAALPLSERIEF
ERLMRGDLVGGFDGAIDVYKKKLVEDCPCVATRKASEMALEVINEVVLETIGGSADLTGSNNTKSSQMKTISAEDFSGRY
LHYGVREHAMGAVMNGLALYGGFIPYGGTFLCFSDYMRPAMRLSSLMGLRVIYVMTHDSIGLGEDGPTHQPVEHLASLRT
LPNHLVFRPADAMETVECWQLALKTRGTPSTLALSRQNLPLLRREYEEENLCMLGAYELLTASDDAQVTLFASGSELQIA
VHAHAVLEEKGIPTRVVSVPCFELFTQQSPSYQRALIGDAPIKIAIEAALRQGWDYFIGTNGVFIGMQGFGASGTIDALY
AHFGITCENVVAAVEKKLEDIHKENVK

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=575, Percent_Identity=28.3478260869565, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI4507521, Length=575, Percent_Identity=28.3478260869565, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI133778974, Length=670, Percent_Identity=26.7164179104478, Blast_Score=177, Evalue=4e-44,
Organism=Homo sapiens, GI225637459, Length=586, Percent_Identity=23.8907849829352, Blast_Score=117, Evalue=4e-26,
Organism=Homo sapiens, GI225637461, Length=556, Percent_Identity=23.5611510791367, Blast_Score=103, Evalue=6e-22,
Organism=Homo sapiens, GI225637463, Length=517, Percent_Identity=24.5647969052224, Blast_Score=103, Evalue=7e-22,
Organism=Escherichia coli, GI48994911, Length=664, Percent_Identity=49.5481927710843, Blast_Score=644, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=666, Percent_Identity=47.8978978978979, Blast_Score=600, Evalue=1e-172,
Organism=Caenorhabditis elegans, GI17539652, Length=663, Percent_Identity=26.9984917043741, Blast_Score=172, Evalue=4e-43,
Organism=Saccharomyces cerevisiae, GI6325331, Length=678, Percent_Identity=43.5103244837758, Blast_Score=506, Evalue=1e-144,
Organism=Saccharomyces cerevisiae, GI6319593, Length=676, Percent_Identity=41.2721893491124, Blast_Score=488, Evalue=1e-138,
Organism=Drosophila melanogaster, GI45551847, Length=579, Percent_Identity=29.706390328152, Blast_Score=189, Evalue=5e-48,
Organism=Drosophila melanogaster, GI45550715, Length=579, Percent_Identity=29.706390328152, Blast_Score=189, Evalue=5e-48,
Organism=Drosophila melanogaster, GI24645119, Length=548, Percent_Identity=29.1970802919708, Blast_Score=174, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24666278, Length=262, Percent_Identity=35.8778625954198, Blast_Score=136, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 72585; Mature: 72454

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNTETKKQMANAIRFLAIDAIEKANSGHPGLPMGAADIATVLYTKFLAHDPKNPHWPNR
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
DRFVLSAGHGSMLLYALLYLSGYEDISLEDLKNFRQIGSKVAGHPEYGHAAGIETTTGPL
CEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCH
GQGIANAVGMALGERLLNARFGDLINHYTYALVGDGCLMEGISQEALSLAGHLKLNKLIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHCEEEEEEEE
LWDDNNISIDGEISLADSTDQIARFKASGWNTHKVDGHDQAAIARAIEAARNSDKPTLIA
EECCCCEEECCEEEECCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEE
CKTTIGFGAPNKAGTNKIHGAPLGASEIAETRIALGWEAEPFVIPADILDNWRLAGLNAA
EEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHEECCCCCCCEEEHHHHCCCEEECCCHH
KKRQKWKEKFAALPLSERIEFERLMRGDLVGGFDGAIDVYKKKLVEDCPCVATRKASEMA
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHCHHHHHH
LEVINEVVLETIGGSADLTGSNNTKSSQMKTISAEDFSGRYLHYGVREHAMGAVMNGLAL
HHHHHHHHHHHCCCCCCCCCCCCCCHHHEEEEECCCCCCCEEECCHHHHHHHHHHHHHHH
YGGFIPYGGTFLCFSDYMRPAMRLSSLMGLRVIYVMTHDSIGLGEDGPTHQPVEHLASLR
HCCCCCCCCEEEHHHHHHHHHHHHHHHHCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHH
TLPNHLVFRPADAMETVECWQLALKTRGTPSTLALSRQNLPLLRREYEEENLCMLGAYEL
HCCHHEEECCCHHHHHHHHHHHHHHCCCCCHHEEECCCCCCHHHHHCCCCCEEEEEEEHH
LTASDDAQVTLFASGSELQIAVHAHAVLEEKGIPTRVVSVPCFELFTQQSPSYQRALIGD
EECCCCCEEEEEECCCEEEEEEEHHHHHHHCCCCEEEEECHHHHHHHCCCCCHHHHHCCC
APIKIAIEAALRQGWDYFIGTNGVFIGMQGFGASGTIDALYAHFGITCENVVAAVEKKLE
CCHHHHHHHHHHCCCCEEEECCEEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHH
DIHKENVK
HHHHHCCC
>Mature Secondary Structure 
TNTETKKQMANAIRFLAIDAIEKANSGHPGLPMGAADIATVLYTKFLAHDPKNPHWPNR
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
DRFVLSAGHGSMLLYALLYLSGYEDISLEDLKNFRQIGSKVAGHPEYGHAAGIETTTGPL
CEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCH
GQGIANAVGMALGERLLNARFGDLINHYTYALVGDGCLMEGISQEALSLAGHLKLNKLIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHCEEEEEEEE
LWDDNNISIDGEISLADSTDQIARFKASGWNTHKVDGHDQAAIARAIEAARNSDKPTLIA
EECCCCEEECCEEEECCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEE
CKTTIGFGAPNKAGTNKIHGAPLGASEIAETRIALGWEAEPFVIPADILDNWRLAGLNAA
EEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHEECCCCCCCEEEHHHHCCCEEECCCHH
KKRQKWKEKFAALPLSERIEFERLMRGDLVGGFDGAIDVYKKKLVEDCPCVATRKASEMA
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHCHHHHHH
LEVINEVVLETIGGSADLTGSNNTKSSQMKTISAEDFSGRYLHYGVREHAMGAVMNGLAL
HHHHHHHHHHHCCCCCCCCCCCCCCHHHEEEEECCCCCCCEEECCHHHHHHHHHHHHHHH
YGGFIPYGGTFLCFSDYMRPAMRLSSLMGLRVIYVMTHDSIGLGEDGPTHQPVEHLASLR
HCCCCCCCCEEEHHHHHHHHHHHHHHHHCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHH
TLPNHLVFRPADAMETVECWQLALKTRGTPSTLALSRQNLPLLRREYEEENLCMLGAYEL
HCCHHEEECCCHHHHHHHHHHHHHHCCCCCHHEEECCCCCCHHHHHCCCCCEEEEEEEHH
LTASDDAQVTLFASGSELQIAVHAHAVLEEKGIPTRVVSVPCFELFTQQSPSYQRALIGD
EECCCCCEEEEEECCCEEEEEEEHHHHHHHCCCCEEEEECHHHHHHHCCCCCHHHHHCCC
APIKIAIEAALRQGWDYFIGTNGVFIGMQGFGASGTIDALYAHFGITCENVVAAVEKKLE
CCHHHHHHHHHHCCCCEEEECCEEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHH
DIHKENVK
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7928974 [H]