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The map label for this gene is mraY

Identifier: 49475858

GI number: 49475858

Start: 1243439

End: 1244509

Strand: Reverse

Name: mraY

Synonym: BH11270

Alternate gene names: 49475858

Gene position: 1244509-1243439 (Counterclockwise)

Preceding gene: 49475859

Following gene: 49475857

Centisome position: 64.45

GC content: 40.34

Gene sequence:

>1071_bases
ATGATGCTGTTTTTTTCTTCGCTTAGTGATTGGCTACCAGGTGTGAGTGTGTTTCGTTACATTACGTTTCGCACTATAGC
AGCTATGCTCACATCGGGGCTTATTGTCTTTTTGTTTGGTCCTAGCATTATTATCTCTCTTAAATTGCGACAGGGAAAAG
GGCAGCCAATTCGCGCTGATGGTCCTCAAACACATTTTAAAAAGGCTGGAACACCTACTATGGGTGGTTTGATGATTTTA
AGCGGCATTGTAGTCTCAGCGTTTTTGTGGTGTAATTTATCCAATATTTATTTTTGGGTATCCTTATTTGTTATGCTTTC
TTTTGGGATGATTGGTTTTTACGATGATTATCTTAAGGTTACCAAACAAACGGAGAAAGGATTTTCTGGTAAAGCACGAT
TAAGCTTGGAGTTTTTGGTTGCGGCAATTGCTGCTTTTGTTTTTTTACAAGTTGGCTCGCCTGGGTTAGCTTTGCCCTTT
GTGAAAGATTACTTTATCAATTTGAGCTGGTTTTTTATTCCTTTCTCTGCTTTTGTTATTGTCGCTACTGGGAATGCGGT
TAATTTGACTGATGGTCTTGATGGGTTGGCTATTGTTCCTGTGATGGTTGCTGCTTTGTCTTTTGCTCTAATTGCTTACC
TTTCTGGTAATATCAATTTTGCTGATTATCTCCAAATCCATTATGTATCGGGGACGGGTGAATTAGCTGTTTTATTAGGA
GCTGTTGTTGGTGCAGGGCTTGGTTTTTTATGGTTTAATGCACCGCCGGCGGCTATTTTTATGGGGGATACTGGTTCGTT
GGCGCTTGGAGGGCTATTGGGTAGTGTTGCTGTAGCAACCAAGCATGAAATTGTTTTGGCTCTTATTGGAGGGCTTTTTG
CTCTTGAAGGATTCTCGGTTGTTATCCAGGTTGGTTATTTCAAATTAACAAAAAAGCGTGCGTTCCTTATGGCACCGATA
CACCATCATTTTGAGAAAAAAGGCTGGACTGAAAGTCAAGTCGTGATACGCTTTTGGATTATTTCGATTGTTCTTGCTCT
CATTGGTCTTTCAACACTTAAATTGCGGTGA

Upstream 100 bases:

>100_bases
TGATTAAATCATCCCATAGTCTTTATTCATCAGATATTGTGAGTGCATTGCTTGATCGCTATAAAGTGGTTTCTCTGTAA
TTTTAATGGTTTTTTTTATC

Downstream 100 bases:

>100_bases
AATTTTGATTTCTATTGCGTTTTATAAGGGGAAAAAAGTTGCTCTGTTTGGATTAGGAAAATCCGGATTAGCTACTGCAC
AAGCATTGATAAGTGGTGGT

Product: phospho-N-acetylmuramoyl-pentapeptide- transferase

Products: NA

Alternate protein names: UDP-MurNAc-pentapeptide phosphotransferase

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MMLFFSSLSDWLPGVSVFRYITFRTIAAMLTSGLIVFLFGPSIIISLKLRQGKGQPIRADGPQTHFKKAGTPTMGGLMIL
SGIVVSAFLWCNLSNIYFWVSLFVMLSFGMIGFYDDYLKVTKQTEKGFSGKARLSLEFLVAAIAAFVFLQVGSPGLALPF
VKDYFINLSWFFIPFSAFVIVATGNAVNLTDGLDGLAIVPVMVAALSFALIAYLSGNINFADYLQIHYVSGTGELAVLLG
AVVGAGLGFLWFNAPPAAIFMGDTGSLALGGLLGSVAVATKHEIVLALIGGLFALEGFSVVIQVGYFKLTKKRAFLMAPI
HHHFEKKGWTESQVVIRFWIISIVLALIGLSTLKLR

Sequences:

>Translated_356_residues
MMLFFSSLSDWLPGVSVFRYITFRTIAAMLTSGLIVFLFGPSIIISLKLRQGKGQPIRADGPQTHFKKAGTPTMGGLMIL
SGIVVSAFLWCNLSNIYFWVSLFVMLSFGMIGFYDDYLKVTKQTEKGFSGKARLSLEFLVAAIAAFVFLQVGSPGLALPF
VKDYFINLSWFFIPFSAFVIVATGNAVNLTDGLDGLAIVPVMVAALSFALIAYLSGNINFADYLQIHYVSGTGELAVLLG
AVVGAGLGFLWFNAPPAAIFMGDTGSLALGGLLGSVAVATKHEIVLALIGGLFALEGFSVVIQVGYFKLTKKRAFLMAPI
HHHFEKKGWTESQVVIRFWIISIVLALIGLSTLKLR
>Mature_356_residues
MMLFFSSLSDWLPGVSVFRYITFRTIAAMLTSGLIVFLFGPSIIISLKLRQGKGQPIRADGPQTHFKKAGTPTMGGLMIL
SGIVVSAFLWCNLSNIYFWVSLFVMLSFGMIGFYDDYLKVTKQTEKGFSGKARLSLEFLVAAIAAFVFLQVGSPGLALPF
VKDYFINLSWFFIPFSAFVIVATGNAVNLTDGLDGLAIVPVMVAALSFALIAYLSGNINFADYLQIHYVSGTGELAVLLG
AVVGAGLGFLWFNAPPAAIFMGDTGSLALGGLLGSVAVATKHEIVLALIGGLFALEGFSVVIQVGYFKLTKKRAFLMAPI
HHHFEKKGWTESQVVIRFWIISIVLALIGLSTLKLR

Specific function: First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. MraY subfamily

Homologues:

Organism=Escherichia coli, GI1786275, Length=355, Percent_Identity=50.9859154929577, Blast_Score=338, Evalue=3e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MRAY_BARHE (Q6G2Q2)

Other databases:

- EMBL:   BX897699
- RefSeq:   YP_033899.1
- GeneID:   2865625
- GenomeReviews:   BX897699_GR
- KEGG:   bhe:BH11270
- NMPDR:   fig|283166.1.peg.1027
- HOGENOM:   HBG708263
- OMA:   LRQGKGQ
- PhylomeDB:   Q6G2Q2
- ProtClustDB:   PRK00108
- BioCyc:   BHEN283166:BH11270-MONOMER
- BRENDA:   2.7.8.13
- HAMAP:   MF_00038
- InterPro:   IPR000715
- InterPro:   IPR003524
- InterPro:   IPR018480
- PANTHER:   PTHR22926
- PANTHER:   PTHR22926:SF3
- TIGRFAMs:   TIGR00445

Pfam domain/function: PF00953 Glycos_transf_4; PF10555 MraY_sig1

EC number: =2.7.8.13

Molecular weight: Translated: 38537; Mature: 38537

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: PS01347 MRAY_1; PS01348 MRAY_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x24a6eb50)-; HASH(0x24f10c84)-; HASH(0x24f0f3e8)-; HASH(0x24f0e620)-; HASH(0x24f0e668)-; HASH(0x24f0f454)-; HASH(0x24f0cbec)-; HASH(0x24b5d6d4)-; HASH(0x24f0cc04)-; HASH(0x24f0d8d0)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMLFFSSLSDWLPGVSVFRYITFRTIAAMLTSGLIVFLFGPSIIISLKLRQGKGQPIRAD
CEEEHHHHHHHCCHHHHHHHHHHHHHHHHHHCCEEEEEECCEEEEEEEEECCCCCCCCCC
GPQTHFKKAGTPTMGGLMILSGIVVSAFLWCNLSNIYFWVSLFVMLSFGMIGFYDDYLKV
CCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCHHHHHHHHHHH
TKQTEKGFSGKARLSLEFLVAAIAAFVFLQVGSPGLALPFVKDYFINLSWFFIPFSAFVI
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHEEEEHEEEEE
VATGNAVNLTDGLDGLAIVPVMVAALSFALIAYLSGNINFADYLQIHYVSGTGELAVLLG
EEECCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCHHHHHHH
AVVGAGLGFLWFNAPPAAIFMGDTGSLALGGLLGSVAVATKHEIVLALIGGLFALEGFSV
HHHHCCCCEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHE
VIQVGYFKLTKKRAFLMAPIHHHFEKKGWTESQVVIRFWIISIVLALIGLSTLKLR
EEEEHHHEEECCCCEEECHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHCCH
>Mature Secondary Structure
MMLFFSSLSDWLPGVSVFRYITFRTIAAMLTSGLIVFLFGPSIIISLKLRQGKGQPIRAD
CEEEHHHHHHHCCHHHHHHHHHHHHHHHHHHCCEEEEEECCEEEEEEEEECCCCCCCCCC
GPQTHFKKAGTPTMGGLMILSGIVVSAFLWCNLSNIYFWVSLFVMLSFGMIGFYDDYLKV
CCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCHHHHHHHHHHH
TKQTEKGFSGKARLSLEFLVAAIAAFVFLQVGSPGLALPFVKDYFINLSWFFIPFSAFVI
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHEEEEHEEEEE
VATGNAVNLTDGLDGLAIVPVMVAALSFALIAYLSGNINFADYLQIHYVSGTGELAVLLG
EEECCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCHHHHHHH
AVVGAGLGFLWFNAPPAAIFMGDTGSLALGGLLGSVAVATKHEIVLALIGGLFALEGFSV
HHHHCCCCEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHE
VIQVGYFKLTKKRAFLMAPIHHHFEKKGWTESQVVIRFWIISIVLALIGLSTLKLR
EEEEHHHEEECCCCEEECHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA