| Definition | Bartonella henselae str. Houston-1, complete genome. |
|---|---|
| Accession | NC_005956 |
| Length | 1,931,047 |
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The map label for this gene is murF [H]
Identifier: 49475859
GI number: 49475859
Start: 1244530
End: 1245951
Strand: Reverse
Name: murF [H]
Synonym: BH11280
Alternate gene names: 49475859
Gene position: 1245951-1244530 (Counterclockwise)
Preceding gene: 49475860
Following gene: 49475858
Centisome position: 64.52
GC content: 39.03
Gene sequence:
>1422_bases ATGAAAGCTTTATGGGATAAACAAGCACTTATTACAGCAATTGATGGTTATGCAATTGGGGAAATACCGGAAACTTTTTC CGGTATTTCTATTGATAGTCGTACTCTTATAGAAGGCGATATTTTTTTCTGTATCAAAGGACATCATCTTGATGGTCATG ATTTTGCGGTGCAAGCTTATGAACGAGGTGCAGCTGTTCTTATTGTTGCGGAAAACCGTTTAGCTGATATGGAAAAAATA TCCGCTCCACTTATTGTCGTTTCTGATGTTTTACAAGCTTTAGAAAAACTTGCACAAGCCGCACGCAAGCGCTCAAAGGC TAAAATTATAGCGGTAACAGGATCGGTGGGAAAAACAACGACAAAAGAAGTTCTAAAACAAGTGCTGGCAACTGTTGGGA AGGTTCACGCGAATTCTGCTTCTTTGAATAATCACTGGGGAGTGCCGCTTACCTTGGCGCGAATGCCTGTGGAGAGTAAT TATGGTGTCTTTGAAATTGGTATGAATCATAAAGATGAAATTCGCCCTTTGGTTAAGTTGGTCCATCCACATGTTGTTCT CATTACGCATATTTCTGCAGCACATATGGGTTTCTTCAAAAATCTTGAGGAAATAGCAGACGCAAAAGCTGAAATTTTTG AGGGACTGGATGAGGAGGGTATTGCTGTTTTAAATGCGGATGATGATTTTTTTCCTTATTTAGTTCAAAAAGCAAAACAA TGTAGTGTGAAAAGGATCTTAAGCTTTGGTGAGACTAAAAATTCCGATTATCAGGCGAAAGATATACGTCTTTTAACAGA TTATTCCTCTATGATTGTTAGTATTTCTGGGCAGGATAGGGCAATGAAAATTGGTGCTCCTGGACGACATATTATACAAA ATAGTTTGGCTGTTATTGCTGCTTGTGATGCCATTGGTGTTGATTTAGAACCTGTTTTGCTCTCTTTGAGCTATTTTTCT CCTCAAAAGGGGCGCGGTGTTCGTTATCGATTGTCTTTACCAAGTGGAGGCGAATTTTATTTAATTGATGAAAGCTATAA TGCAAATCCTGCATCTATGCGTGCGGCTCTTGATCTGCTTGCTATAGGGCCAGTCGGTGTGGAGGGAAGGCGAATTGCTA TTTTGGGTGATATGCTGGAATTGGGGGCTTATAGTGAAAAACTCCATCGTGACTTAGTAAAGCCAGTATATCTCTCTGGT GCTAATCCCGTTTTTTTATTTGGTGAGGCAATGAAGTTTTTAGCCACTGATTTGGCTGCATACGTTAAGGTTCATTATGC TGAAAATATTGAAAAAATTTTACCACTTATTTTGGCAGAAATTTCCAATGGGGATCTCCTTATGATTAAATCATCCCATA GTCTTTATTCATCAGATATTGTGAGTGCATTGCTTGATCGCTATAAAGTGGTTTCTCTGTAA
Upstream 100 bases:
>100_bases TTGCTGGAAAAGGTCATGAGAATGGTCAAATTATAGGGCAAAAAACATATCCTTTTTCAGATCGTTTGAAAGCGATTGAA GCTTTACAGGAACGGATTAG
Downstream 100 bases:
>100_bases TTTTAATGGTTTTTTTTATCATGATGCTGTTTTTTTCTTCGCTTAGTGATTGGCTACCAGGTGTGAGTGTGTTTCGTTAC ATTACGTTTCGCACTATAGC
Product: UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6- diaminopimelate-D-alanyl-D-alanine ligase
Products: NA
Alternate protein names: D-alanyl-D-alanine-adding enzyme; UDP-MurNAc-pentapeptide synthetase [H]
Number of amino acids: Translated: 473; Mature: 473
Protein sequence:
>473_residues MKALWDKQALITAIDGYAIGEIPETFSGISIDSRTLIEGDIFFCIKGHHLDGHDFAVQAYERGAAVLIVAENRLADMEKI SAPLIVVSDVLQALEKLAQAARKRSKAKIIAVTGSVGKTTTKEVLKQVLATVGKVHANSASLNNHWGVPLTLARMPVESN YGVFEIGMNHKDEIRPLVKLVHPHVVLITHISAAHMGFFKNLEEIADAKAEIFEGLDEEGIAVLNADDDFFPYLVQKAKQ CSVKRILSFGETKNSDYQAKDIRLLTDYSSMIVSISGQDRAMKIGAPGRHIIQNSLAVIAACDAIGVDLEPVLLSLSYFS PQKGRGVRYRLSLPSGGEFYLIDESYNANPASMRAALDLLAIGPVGVEGRRIAILGDMLELGAYSEKLHRDLVKPVYLSG ANPVFLFGEAMKFLATDLAAYVKVHYAENIEKILPLILAEISNGDLLMIKSSHSLYSSDIVSALLDRYKVVSL
Sequences:
>Translated_473_residues MKALWDKQALITAIDGYAIGEIPETFSGISIDSRTLIEGDIFFCIKGHHLDGHDFAVQAYERGAAVLIVAENRLADMEKI SAPLIVVSDVLQALEKLAQAARKRSKAKIIAVTGSVGKTTTKEVLKQVLATVGKVHANSASLNNHWGVPLTLARMPVESN YGVFEIGMNHKDEIRPLVKLVHPHVVLITHISAAHMGFFKNLEEIADAKAEIFEGLDEEGIAVLNADDDFFPYLVQKAKQ CSVKRILSFGETKNSDYQAKDIRLLTDYSSMIVSISGQDRAMKIGAPGRHIIQNSLAVIAACDAIGVDLEPVLLSLSYFS PQKGRGVRYRLSLPSGGEFYLIDESYNANPASMRAALDLLAIGPVGVEGRRIAILGDMLELGAYSEKLHRDLVKPVYLSG ANPVFLFGEAMKFLATDLAAYVKVHYAENIEKILPLILAEISNGDLLMIKSSHSLYSSDIVSALLDRYKVVSL >Mature_473_residues MKALWDKQALITAIDGYAIGEIPETFSGISIDSRTLIEGDIFFCIKGHHLDGHDFAVQAYERGAAVLIVAENRLADMEKI SAPLIVVSDVLQALEKLAQAARKRSKAKIIAVTGSVGKTTTKEVLKQVLATVGKVHANSASLNNHWGVPLTLARMPVESN YGVFEIGMNHKDEIRPLVKLVHPHVVLITHISAAHMGFFKNLEEIADAKAEIFEGLDEEGIAVLNADDDFFPYLVQKAKQ CSVKRILSFGETKNSDYQAKDIRLLTDYSSMIVSISGQDRAMKIGAPGRHIIQNSLAVIAACDAIGVDLEPVLLSLSYFS PQKGRGVRYRLSLPSGGEFYLIDESYNANPASMRAALDLLAIGPVGVEGRRIAILGDMLELGAYSEKLHRDLVKPVYLSG ANPVFLFGEAMKFLATDLAAYVKVHYAENIEKILPLILAEISNGDLLMIKSSHSLYSSDIVSALLDRYKVVSL
Specific function: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein [H]
COG id: COG0770
COG function: function code M; UDP-N-acetylmuramyl pentapeptide synthase
Gene ontology:
Cell location: Cytoplasm (Probable) [H]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the MurCDEF family [H]
Homologues:
Organism=Escherichia coli, GI1786274, Length=443, Percent_Identity=33.6343115124154, Blast_Score=202, Evalue=3e-53,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR004101 - InterPro: IPR013221 - InterPro: IPR000713 - InterPro: IPR005863 [H]
Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]
EC number: =6.3.2.10 [H]
Molecular weight: Translated: 51616; Mature: 51616
Theoretical pI: Translated: 6.52; Mature: 6.52
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.6 %Cys (Translated Protein) 2.3 %Met (Translated Protein) 3.0 %Cys+Met (Translated Protein) 0.6 %Cys (Mature Protein) 2.3 %Met (Mature Protein) 3.0 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKALWDKQALITAIDGYAIGEIPETFSGISIDSRTLIEGDIFFCIKGHHLDGHDFAVQAY CCCCCCCHHHEEEECCCEECCCCHHHCCCCCCCCEEEECCEEEEEECCCCCCCCCEEEEE ERGAAVLIVAENRLADMEKISAPLIVVSDVLQALEKLAQAARKRSKAKIIAVTGSVGKTT CCCCEEEEEECCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHH TKEVLKQVLATVGKVHANSASLNNHWGVPLTLARMPVESNYGVFEIGMNHKDEIRPLVKL HHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCEEEECCCCHHHHHHHHHH VHPHVVLITHISAAHMGFFKNLEEIADAKAEIFEGLDEEGIAVLNADDDFFPYLVQKAKQ HCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHH CSVKRILSFGETKNSDYQAKDIRLLTDYSSMIVSISGQDRAMKIGAPGRHIIQNSLAVIA HHHHHHHHCCCCCCCCCCCCCEEEEEECCEEEEEECCCCCEEEECCCCHHHHHHCHHEEE ACDAIGVDLEPVLLSLSYFSPQKGRGVRYRLSLPSGGEFYLIDESYNANPASMRAALDLL EHHHCCCCHHHHHHEEECCCCCCCCCEEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHH AIGPVGVEGRRIAILGDMLELGAYSEKLHRDLVKPVYLSGANPVFLFGEAMKFLATDLAA EECCCCCCCCEEEEEHHHHHHCHHHHHHHHHHCCCEEECCCCEEEEHHHHHHHHHHHHHH YVKVHYAENIEKILPLILAEISNGDLLMIKSSHSLYSSDIVSALLDRYKVVSL HHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHEECCC >Mature Secondary Structure MKALWDKQALITAIDGYAIGEIPETFSGISIDSRTLIEGDIFFCIKGHHLDGHDFAVQAY CCCCCCCHHHEEEECCCEECCCCHHHCCCCCCCCEEEECCEEEEEECCCCCCCCCEEEEE ERGAAVLIVAENRLADMEKISAPLIVVSDVLQALEKLAQAARKRSKAKIIAVTGSVGKTT CCCCEEEEEECCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHH TKEVLKQVLATVGKVHANSASLNNHWGVPLTLARMPVESNYGVFEIGMNHKDEIRPLVKL HHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCEEEECCCCHHHHHHHHHH VHPHVVLITHISAAHMGFFKNLEEIADAKAEIFEGLDEEGIAVLNADDDFFPYLVQKAKQ HCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHH CSVKRILSFGETKNSDYQAKDIRLLTDYSSMIVSISGQDRAMKIGAPGRHIIQNSLAVIA HHHHHHHHCCCCCCCCCCCCCEEEEEECCEEEEEECCCCCEEEECCCCHHHHHHCHHEEE ACDAIGVDLEPVLLSLSYFSPQKGRGVRYRLSLPSGGEFYLIDESYNANPASMRAALDLL EHHHCCCCHHHHHHEEECCCCCCCCCEEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHH AIGPVGVEGRRIAILGDMLELGAYSEKLHRDLVKPVYLSGANPVFLFGEAMKFLATDLAA EECCCCCCCCEEEEEHHHHHHCHHHHHHHHHHCCCEEECCCCEEEEHHHHHHHHHHHHHH YVKVHYAENIEKILPLILAEISNGDLLMIKSSHSLYSSDIVSALLDRYKVVSL HHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHEECCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 11557893 [H]