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The map label for this gene is ppiB1 [H]

Identifier: 49475753

GI number: 49475753

Start: 1118922

End: 1119434

Strand: Reverse

Name: ppiB1 [H]

Synonym: BH10090

Alternate gene names: 49475753

Gene position: 1119434-1118922 (Counterclockwise)

Preceding gene: 49475754

Following gene: 49475752

Centisome position: 57.97

GC content: 37.43

Gene sequence:

>513_bases
ATGGCCGAAATTAAAGATCCAGAAAATACTTTAATTCTTGAAACAACGAAGGGTAGAGTTGTTATTGAATTTTTTGCTGA
TTTAGCACCTAGTCACGTTGCACGTATTAAAGAGCTTGTACGTGAAGGTGCTTATGATAACGTCATTTTTCACCGTGTTA
TTGATGGTTTTATGGCGCAAACTGGTGATGTGCAATTTGGAAAAAAAGACGGTGAAAAATTTAATTTATCACGTGCAGGT
ATGGGAGGTTCAGAAAAACCTGATTTAACAGCAGAGTTTTCGAATCTTTCTCATAAGCGTGGTACAGTTTCTATGGCACG
CAGTCAGAATCCAGATTCTGCTAATTCGCAATTTTTTATTTGCTTTGCCAATGCTCCTTGGCTTGATCGTCAATATTCTA
TATGGGGACAAGTTATTGAAGGTATGGAAAATATCGATCAAATTAAGCGCGGTGAGCCTGTTGTAGATCCTGATGCAATC
ATTAAAGCTACAATTGCTGCTGATATAGAATAG

Upstream 100 bases:

>100_bases
AAAAAAGGTACCACAAGTAATAATGGATCTTTGACAAATCCTGATGTTATTAATGCTGCCACTTTACAAGCTAAGTGATG
AGCCAAAGGAGTTTAACTAT

Downstream 100 bases:

>100_bases
GGTAAATTATATAGGTTTCTACCGGTAAGCTCACTAAGTAAAGATATTGTTCTCTTGAGCACAATGAAGAAAAATTTTCG
TAACTTTAATCTATAAAAAA

Product: peptidyl prolyl cis-trans isomerase b

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 170; Mature: 169

Protein sequence:

>170_residues
MAEIKDPENTLILETTKGRVVIEFFADLAPSHVARIKELVREGAYDNVIFHRVIDGFMAQTGDVQFGKKDGEKFNLSRAG
MGGSEKPDLTAEFSNLSHKRGTVSMARSQNPDSANSQFFICFANAPWLDRQYSIWGQVIEGMENIDQIKRGEPVVDPDAI
IKATIAADIE

Sequences:

>Translated_170_residues
MAEIKDPENTLILETTKGRVVIEFFADLAPSHVARIKELVREGAYDNVIFHRVIDGFMAQTGDVQFGKKDGEKFNLSRAG
MGGSEKPDLTAEFSNLSHKRGTVSMARSQNPDSANSQFFICFANAPWLDRQYSIWGQVIEGMENIDQIKRGEPVVDPDAI
IKATIAADIE
>Mature_169_residues
AEIKDPENTLILETTKGRVVIEFFADLAPSHVARIKELVREGAYDNVIFHRVIDGFMAQTGDVQFGKKDGEKFNLSRAGM
GGSEKPDLTAEFSNLSHKRGTVSMARSQNPDSANSQFFICFANAPWLDRQYSIWGQVIEGMENIDQIKRGEPVVDPDAII
KATIAADIE

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=142, Percent_Identity=34.5070422535211, Blast_Score=85, Evalue=3e-17,
Organism=Homo sapiens, GI24308049, Length=144, Percent_Identity=34.0277777777778, Blast_Score=74, Evalue=5e-14,
Organism=Homo sapiens, GI7706339, Length=147, Percent_Identity=32.6530612244898, Blast_Score=74, Evalue=6e-14,
Organism=Homo sapiens, GI5031987, Length=136, Percent_Identity=36.0294117647059, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI22547215, Length=142, Percent_Identity=37.3239436619718, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI22547212, Length=141, Percent_Identity=36.1702127659575, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI7657473, Length=141, Percent_Identity=36.1702127659575, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI10863927, Length=139, Percent_Identity=33.8129496402878, Blast_Score=71, Evalue=4e-13,
Organism=Homo sapiens, GI4505991, Length=135, Percent_Identity=34.0740740740741, Blast_Score=68, Evalue=4e-12,
Organism=Homo sapiens, GI27735045, Length=144, Percent_Identity=31.9444444444444, Blast_Score=68, Evalue=5e-12,
Organism=Homo sapiens, GI64276486, Length=135, Percent_Identity=31.8518518518519, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1786736, Length=147, Percent_Identity=34.6938775510204, Blast_Score=89, Evalue=1e-19,
Organism=Escherichia coli, GI1789763, Length=156, Percent_Identity=35.2564102564103, Blast_Score=84, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI71980594, Length=140, Percent_Identity=36.4285714285714, Blast_Score=86, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI71980590, Length=140, Percent_Identity=36.4285714285714, Blast_Score=86, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17539498, Length=158, Percent_Identity=34.8101265822785, Blast_Score=79, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17539496, Length=150, Percent_Identity=33.3333333333333, Blast_Score=74, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17506311, Length=143, Percent_Identity=34.965034965035, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17532641, Length=145, Percent_Identity=33.1034482758621, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17532643, Length=161, Percent_Identity=31.055900621118, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17559074, Length=154, Percent_Identity=28.5714285714286, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17551284, Length=160, Percent_Identity=28.125, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17551282, Length=160, Percent_Identity=28.125, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17506307, Length=138, Percent_Identity=31.8840579710145, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17552780, Length=135, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320359, Length=151, Percent_Identity=32.4503311258278, Blast_Score=71, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6323562, Length=138, Percent_Identity=31.1594202898551, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17986117, Length=183, Percent_Identity=35.5191256830601, Blast_Score=93, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24652460, Length=142, Percent_Identity=33.0985915492958, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI19922912, Length=150, Percent_Identity=36.6666666666667, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17136360, Length=136, Percent_Identity=30.8823529411765, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI45549139, Length=136, Percent_Identity=33.0882352941176, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI19922376, Length=152, Percent_Identity=33.5526315789474, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI17647301, Length=139, Percent_Identity=33.0935251798561, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24664125, Length=135, Percent_Identity=31.1111111111111, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21357783, Length=135, Percent_Identity=31.1111111111111, Blast_Score=68, Evalue=3e-12,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18861; Mature: 18730

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEIKDPENTLILETTKGRVVIEFFADLAPSHVARIKELVREGAYDNVIFHRVIDGFMAQ
CCCCCCCCCEEEEEECCCCEEEEHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHC
TGDVQFGKKDGEKFNLSRAGMGGSEKPDLTAEFSNLSHKRGTVSMARSQNPDSANSQFFI
CCCCEECCCCCCEECCCCCCCCCCCCCCCEEHHHCCCCCCCCEEHHCCCCCCCCCCEEEE
CFANAPWLDRQYSIWGQVIEGMENIDQIKRGEPVVDPDAIIKATIAADIE
EECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHEECCC
>Mature Secondary Structure 
AEIKDPENTLILETTKGRVVIEFFADLAPSHVARIKELVREGAYDNVIFHRVIDGFMAQ
CCCCCCCCEEEEEECCCCEEEEHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHC
TGDVQFGKKDGEKFNLSRAGMGGSEKPDLTAEFSNLSHKRGTVSMARSQNPDSANSQFFI
CCCCEECCCCCCEECCCCCCCCCCCCCCCEEHHHCCCCCCCCEEHHCCCCCCCCCCEEEE
CFANAPWLDRQYSIWGQVIEGMENIDQIKRGEPVVDPDAIIKATIAADIE
EECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA