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The map label for this gene is ppiB2 [H]

Identifier: 49475754

GI number: 49475754

Start: 1119457

End: 1120029

Strand: Reverse

Name: ppiB2 [H]

Synonym: BH10100

Alternate gene names: 49475754

Gene position: 1120029-1119457 (Counterclockwise)

Preceding gene: 49475755

Following gene: 49475753

Centisome position: 58.0

GC content: 37.7

Gene sequence:

>573_bases
GTGTCTCTTAGAGTTCTTAGTGTTTTAATATGCTTTTTTTGCTTTTTTTCCTTGAGTGCTGTAGCAGATGATTCTAACGT
TCTTGTTTTATCTCTCAAAAATGGTGATGTAGTTATTCGTCTTCGTTCTGATCTAGCACCAAAGCATGTTGCACAAATCA
AGAAGTTAACTAAGGAAGGTGCTTATAACAATGTTGTATTTCACCGTGTCATTCCTGGTTTTATGGCGCAGACTGGTGAT
GTGCAATTTGGAAAAAAGGGCAGTGTAGATTTTGATCCTAAACGCATTGGTATGGGACGTTCCAATTATCCCAATATACC
GGCGGAATTTTCAAAGGAGCCGTTTAAGCGTGGCACTGTTGGGATGGCACGTTCCCAAGATCCAAATTCCGCTAATTCTC
AATTCTTTATTTGTTTTAGTGATGCTGCTTTTTTAAATGGTCAGTATACTGTTGTGGGAGAGGTGATAAAGGGAATGGAT
GTTGTTGATAAAATTAAAAAAGGTACCACAAGTAATAATGGATCTTTGACAAATCCTGATGTTATTAATGCTGCCACTTT
ACAAGCTAAGTGA

Upstream 100 bases:

>100_bases
CGACAGATTGCCTCTATGGGAGGTGATGTGGCACCTTTTGTGCCTGCGAATGTTGCTAGAGCTTTGCATTTAAAATTTCA
ATCTTCAAGGGGGAGTGATT

Downstream 100 bases:

>100_bases
TGAGCCAAAGGAGTTTAACTATATGGCCGAAATTAAAGATCCAGAAAATACTTTAATTCTTGAAACAACGAAGGGTAGAG
TTGTTATTGAATTTTTTGCT

Product: peptidyl-prolyl cis-trans isomerase b

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 190; Mature: 189

Protein sequence:

>190_residues
MSLRVLSVLICFFCFFSLSAVADDSNVLVLSLKNGDVVIRLRSDLAPKHVAQIKKLTKEGAYNNVVFHRVIPGFMAQTGD
VQFGKKGSVDFDPKRIGMGRSNYPNIPAEFSKEPFKRGTVGMARSQDPNSANSQFFICFSDAAFLNGQYTVVGEVIKGMD
VVDKIKKGTTSNNGSLTNPDVINAATLQAK

Sequences:

>Translated_190_residues
MSLRVLSVLICFFCFFSLSAVADDSNVLVLSLKNGDVVIRLRSDLAPKHVAQIKKLTKEGAYNNVVFHRVIPGFMAQTGD
VQFGKKGSVDFDPKRIGMGRSNYPNIPAEFSKEPFKRGTVGMARSQDPNSANSQFFICFSDAAFLNGQYTVVGEVIKGMD
VVDKIKKGTTSNNGSLTNPDVINAATLQAK
>Mature_189_residues
SLRVLSVLICFFCFFSLSAVADDSNVLVLSLKNGDVVIRLRSDLAPKHVAQIKKLTKEGAYNNVVFHRVIPGFMAQTGDV
QFGKKGSVDFDPKRIGMGRSNYPNIPAEFSKEPFKRGTVGMARSQDPNSANSQFFICFSDAAFLNGQYTVVGEVIKGMDV
VDKIKKGTTSNNGSLTNPDVINAATLQAK

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI5031987, Length=154, Percent_Identity=36.3636363636364, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI19557636, Length=140, Percent_Identity=32.8571428571429, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI4505991, Length=160, Percent_Identity=31.875, Blast_Score=68, Evalue=5e-12,
Organism=Homo sapiens, GI22547212, Length=142, Percent_Identity=31.6901408450704, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI7657473, Length=142, Percent_Identity=31.6901408450704, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI22547215, Length=142, Percent_Identity=31.6901408450704, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1786736, Length=166, Percent_Identity=37.3493975903614, Blast_Score=95, Evalue=2e-21,
Organism=Escherichia coli, GI1789763, Length=184, Percent_Identity=36.4130434782609, Blast_Score=91, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17506311, Length=145, Percent_Identity=35.8620689655172, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71980590, Length=143, Percent_Identity=34.2657342657343, Blast_Score=73, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI71980594, Length=143, Percent_Identity=34.2657342657343, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17539496, Length=161, Percent_Identity=28.5714285714286, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17566266, Length=165, Percent_Identity=30.3030303030303, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17552782, Length=172, Percent_Identity=29.6511627906977, Blast_Score=64, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6320510, Length=213, Percent_Identity=29.1079812206573, Blast_Score=67, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320359, Length=137, Percent_Identity=35.7664233576642, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323562, Length=149, Percent_Identity=35.5704697986577, Blast_Score=66, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322492, Length=170, Percent_Identity=31.1764705882353, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45549139, Length=158, Percent_Identity=36.7088607594937, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI17986117, Length=173, Percent_Identity=30.635838150289, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24664125, Length=139, Percent_Identity=36.6906474820144, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI21357783, Length=139, Percent_Identity=36.6906474820144, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI19922376, Length=141, Percent_Identity=30.4964539007092, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI17647301, Length=141, Percent_Identity=34.7517730496454, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19922912, Length=135, Percent_Identity=35.5555555555556, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 20673; Mature: 20542

Theoretical pI: Translated: 9.95; Mature: 9.95

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLRVLSVLICFFCFFSLSAVADDSNVLVLSLKNGDVVIRLRSDLAPKHVAQIKKLTKEG
CCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHCC
AYNNVVFHRVIPGFMAQTGDVQFGKKGSVDFDPKRIGMGRSNYPNIPAEFSKEPFKRGTV
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCHHCCCCCHHCCCC
GMARSQDPNSANSQFFICFSDAAFLNGQYTVVGEVIKGMDVVDKIKKGTTSNNGSLTNPD
CCCCCCCCCCCCCEEEEEECCCEEECCCEEEHHHHHCCHHHHHHHHCCCCCCCCCCCCCC
VINAATLQAK
CCCCEEECCC
>Mature Secondary Structure 
SLRVLSVLICFFCFFSLSAVADDSNVLVLSLKNGDVVIRLRSDLAPKHVAQIKKLTKEG
CHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHCC
AYNNVVFHRVIPGFMAQTGDVQFGKKGSVDFDPKRIGMGRSNYPNIPAEFSKEPFKRGTV
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCHHCCCCCHHCCCC
GMARSQDPNSANSQFFICFSDAAFLNGQYTVVGEVIKGMDVVDKIKKGTTSNNGSLTNPD
CCCCCCCCCCCCCEEEEEECCCEEECCCEEEHHHHHCCHHHHHHHHCCCCCCCCCCCCCC
VINAATLQAK
CCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA