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The map label for this gene is pdxH

Identifier: 49475226

GI number: 49475226

Start: 494469

End: 495092

Strand: Reverse

Name: pdxH

Synonym: BH04290

Alternate gene names: 49475226

Gene position: 495092-494469 (Counterclockwise)

Preceding gene: 49475235

Following gene: 49475224

Centisome position: 25.64

GC content: 42.79

Gene sequence:

>624_bases
ATGGGCAACACCGTACAAACAGACAATGACTTTATGCAAATGCAAAAACCTTTTGCGCTCTTCGCAAAATGGCTTGAAGA
AGCAACAGTGAGCGAAATAAACGATCCTAACGCTATGGCGTTAGCGACAGTTGATAAAACAGGCTTCCCGAATGTTCGTA
TGGTTCTTCTTAAAGACTTCAGTCCCCAAGGTTTTGTCTTCTATACCAACTATGAAAGCCCTAAAGGACAAGAAATTTTA
AAATCAATGAAAGCATCCTTAGTTTTTCATTGGAAATCACTCCGCCGTCAGGTTAGAATTCGAGGAATTGTTGAAAAAGT
CACTCCTCAGGAAGCGGATGCCTATTTCCAATCGCGACCACGTGACAGCAGAATCGGTGCATGGGCTTCTAAACAATCTC
AACCATTAGAAAGCCGTTTTGTCCTAGAAAAAGCCATTGCCCGATATACTACGCGTTATGCAGTAGGCAATATCCCACGC
CCACCTTATTGGTCCGGTTTCCGTGTTAAGCCTCTTTCTATTGAATTTTGGTGTGATCGCCCATTCCGTTTACATGATCG
CCTACTTTTTACACGCGATTCTGTTGAACATGTCGATTGGAAAAGGCAAAAGCTCTATCCCTAA

Upstream 100 bases:

>100_bases
GAAAGGTATTTTTGAAAGAGAAAAATAGCTCTTTAATTTTCAATGATAAAATAAATTAAACCCTAAGCCTCACGCTTTCT
CGTTAATATTCGGAGATAAT

Downstream 100 bases:

>100_bases
TCCTTCAAGCTTTAAAGAATGAAAACTTTGTTTTCTTATAAAGGAGAAAAACAAAACCATCATACTATTTGCCAACTCCT
AATGTTGCTACAACCCTTGC

Product: pyridoxamine 5'-phosphate oxidase

Products: NA

Alternate protein names: PNP/PMP oxidase; PNPOx; Pyridoxal 5'-phosphate synthase

Number of amino acids: Translated: 207; Mature: 206

Protein sequence:

>207_residues
MGNTVQTDNDFMQMQKPFALFAKWLEEATVSEINDPNAMALATVDKTGFPNVRMVLLKDFSPQGFVFYTNYESPKGQEIL
KSMKASLVFHWKSLRRQVRIRGIVEKVTPQEADAYFQSRPRDSRIGAWASKQSQPLESRFVLEKAIARYTTRYAVGNIPR
PPYWSGFRVKPLSIEFWCDRPFRLHDRLLFTRDSVEHVDWKRQKLYP

Sequences:

>Translated_207_residues
MGNTVQTDNDFMQMQKPFALFAKWLEEATVSEINDPNAMALATVDKTGFPNVRMVLLKDFSPQGFVFYTNYESPKGQEIL
KSMKASLVFHWKSLRRQVRIRGIVEKVTPQEADAYFQSRPRDSRIGAWASKQSQPLESRFVLEKAIARYTTRYAVGNIPR
PPYWSGFRVKPLSIEFWCDRPFRLHDRLLFTRDSVEHVDWKRQKLYP
>Mature_206_residues
GNTVQTDNDFMQMQKPFALFAKWLEEATVSEINDPNAMALATVDKTGFPNVRMVLLKDFSPQGFVFYTNYESPKGQEILK
SMKASLVFHWKSLRRQVRIRGIVEKVTPQEADAYFQSRPRDSRIGAWASKQSQPLESRFVLEKAIARYTTRYAVGNIPRP
PYWSGFRVKPLSIEFWCDRPFRLHDRLLFTRDSVEHVDWKRQKLYP

Specific function: Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)

COG id: COG0259

COG function: function code H; Pyridoxamine-phosphate oxidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxamine 5'-phosphate oxidase family

Homologues:

Organism=Homo sapiens, GI8922498, Length=177, Percent_Identity=44.6327683615819, Blast_Score=152, Evalue=3e-37,
Organism=Escherichia coli, GI1787926, Length=191, Percent_Identity=43.979057591623, Blast_Score=167, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17553712, Length=198, Percent_Identity=40.4040404040404, Blast_Score=138, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6319509, Length=205, Percent_Identity=39.0243902439024, Blast_Score=143, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24644901, Length=185, Percent_Identity=43.2432432432432, Blast_Score=143, Evalue=9e-35,
Organism=Drosophila melanogaster, GI45551845, Length=185, Percent_Identity=43.2432432432432, Blast_Score=143, Evalue=9e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXH_BARHE (Q6G4D7)

Other databases:

- EMBL:   BX897699
- RefSeq:   YP_033267.1
- ProteinModelPortal:   Q6G4D7
- SMR:   Q6G4D7
- GeneID:   2865013
- GenomeReviews:   BX897699_GR
- KEGG:   bhe:BH04290
- NMPDR:   fig|283166.1.peg.395
- HOGENOM:   HBG327559
- OMA:   HWSGFRI
- PhylomeDB:   Q6G4D7
- ProtClustDB:   PRK05679
- BioCyc:   BHEN283166:BH04290-MONOMER
- BRENDA:   1.4.3.5
- HAMAP:   MF_01629
- InterPro:   IPR000659
- InterPro:   IPR019740
- InterPro:   IPR019576
- InterPro:   IPR011576
- InterPro:   IPR012349
- InterPro:   IPR009002
- Gene3D:   G3DSA:2.30.110.10
- PANTHER:   PTHR10851
- PIRSF:   PIRSF000190
- TIGRFAMs:   TIGR00558

Pfam domain/function: PF10590 PNPOx_C; PF01243 Pyridox_oxidase; SSF50475 FMN_binding

EC number: =1.4.3.5

Molecular weight: Translated: 24271; Mature: 24140

Theoretical pI: Translated: 10.33; Mature: 10.33

Prosite motif: PS01064 PYRIDOX_OXIDASE

Important sites: BINDING 53-53 BINDING 56-56 BINDING 58-58 BINDING 75-75 BINDING 115-115 BINDING 119-119 BINDING 123-123

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGNTVQTDNDFMQMQKPFALFAKWLEEATVSEINDPNAMALATVDKTGFPNVRMVLLKDF
CCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCEEEEEEECC
SPQGFVFYTNYESPKGQEILKSMKASLVFHWKSLRRQVRIRGIVEKVTPQEADAYFQSRP
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCC
RDSRIGAWASKQSQPLESRFVLEKAIARYTTRYAVGNIPRPPYWSGFRVKPLSIEFWCDR
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEEEECC
PFRLHDRLLFTRDSVEHVDWKRQKLYP
CCHHHHHEEEECCCHHHHCCHHHCCCC
>Mature Secondary Structure 
GNTVQTDNDFMQMQKPFALFAKWLEEATVSEINDPNAMALATVDKTGFPNVRMVLLKDF
CCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCEEEEEEECC
SPQGFVFYTNYESPKGQEILKSMKASLVFHWKSLRRQVRIRGIVEKVTPQEADAYFQSRP
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCC
RDSRIGAWASKQSQPLESRFVLEKAIARYTTRYAVGNIPRPPYWSGFRVKPLSIEFWCDR
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEEEECC
PFRLHDRLLFTRDSVEHVDWKRQKLYP
CCHHHHHEEEECCCHHHHCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA