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The map label for this gene is tlyC [H]

Identifier: 49475035

GI number: 49475035

Start: 299518

End: 300537

Strand: Reverse

Name: tlyC [H]

Synonym: BH02230

Alternate gene names: 49475035

Gene position: 300537-299518 (Counterclockwise)

Preceding gene: 49475036

Following gene: 49475034

Centisome position: 15.56

GC content: 40.49

Gene sequence:

>1020_bases
ATGGCAAACAAAGTGAATGCACAAAATAATAGTCAAACACCTTCTCATATTGAAGAACATCCTCCTCAACCAGCGAATCA
TACAGAAAAATACTCCCTGATGAATCATTTGTTTTCGTTCTTACGTGGCCGCAATTCTACGTCACTGCGCAATGATCTTA
CTGTTGCACTCACTGCTGACAATGAAAAGGATACGGCACTCTTCTCACCTGAAGAACGTACTATGCTGCATAATATCTTA
CGTTTGCGCGAAGCACGCATTGATGATGTTATGATTCCACGTTCTGAAATTGAGGCATTAGACATAAATACCTCTCTTGG
AGAAGCACTCAAATGTTTTGCAAAAATTGGACATTCTCGCATACCTGTTTATGCTGAAACCTTAGATGATCCACGAGGAA
TGATTCATATCCGCGATATCCTCAATTATATAACGCGCTTTATTACCAAATCAGCTCAAACCGAGCAAACATCCGATTCA
CTACAGTTAACCTATACAGATTTGCATACCCCTATCGGCGAACTTGATCTTATCCGAACAGTTCTCTTCGTTCCTGGCTC
CATGCTTGCAAGCACATTATTGACCCGTATGCAAACCACACGAACACAAATGGCTTTGGTAATTGATGAACATGGTGGTA
CAGATGGTTTAGTTTCTATGGAAGATATTGTCGAATTAGTCGTTGGTGATATCGAAGATGAACATGATCATGTTGACAAT
GCTATCGTGCGCGAACCCAATAATAAATGGCTTGTTGATGCGAGAACTGAACTAGAAGATGTGGAGAAAGCTCTCGGTCC
TGATTTTATTGTAGGGGAATATGGTGATGAAGTCGATACCATCGGTGGTTTGATTGTTTCTATTCTTGATCGCATTCCCG
CAAAAGGTGAAATCATTGAAGCGGTGCCAGGTTATCGATTCCGTATTTTAGAAGCTGATAAACGTCGGATTAAGCGCTTA
CGTATTTTTCGTATTCCGGAGAATGAAAGTTTTAAACAAAATGTCATCTCCGAAGAGTAA

Upstream 100 bases:

>100_bases
AAAATGATAAAAATTAATTTTTAAAATCAATATCACCATCATAAAATTTAAAATACCCTATGCCTTTCTTACAGAAAAAA
GTTTAGAAGATCTCAAAACC

Downstream 100 bases:

>100_bases
CTTCGTGTTTTTAAACAGTGTCAAGATGTCCTTGTTTTCCCTCACTGGTTGGAAACGGCAAGGGGTGTTGTTTTTATGTG
GTGCATTGACATCCTTTGCA

Product: hemolysin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MANKVNAQNNSQTPSHIEEHPPQPANHTEKYSLMNHLFSFLRGRNSTSLRNDLTVALTADNEKDTALFSPEERTMLHNIL
RLREARIDDVMIPRSEIEALDINTSLGEALKCFAKIGHSRIPVYAETLDDPRGMIHIRDILNYITRFITKSAQTEQTSDS
LQLTYTDLHTPIGELDLIRTVLFVPGSMLASTLLTRMQTTRTQMALVIDEHGGTDGLVSMEDIVELVVGDIEDEHDHVDN
AIVREPNNKWLVDARTELEDVEKALGPDFIVGEYGDEVDTIGGLIVSILDRIPAKGEIIEAVPGYRFRILEADKRRIKRL
RIFRIPENESFKQNVISEE

Sequences:

>Translated_339_residues
MANKVNAQNNSQTPSHIEEHPPQPANHTEKYSLMNHLFSFLRGRNSTSLRNDLTVALTADNEKDTALFSPEERTMLHNIL
RLREARIDDVMIPRSEIEALDINTSLGEALKCFAKIGHSRIPVYAETLDDPRGMIHIRDILNYITRFITKSAQTEQTSDS
LQLTYTDLHTPIGELDLIRTVLFVPGSMLASTLLTRMQTTRTQMALVIDEHGGTDGLVSMEDIVELVVGDIEDEHDHVDN
AIVREPNNKWLVDARTELEDVEKALGPDFIVGEYGDEVDTIGGLIVSILDRIPAKGEIIEAVPGYRFRILEADKRRIKRL
RIFRIPENESFKQNVISEE
>Mature_338_residues
ANKVNAQNNSQTPSHIEEHPPQPANHTEKYSLMNHLFSFLRGRNSTSLRNDLTVALTADNEKDTALFSPEERTMLHNILR
LREARIDDVMIPRSEIEALDINTSLGEALKCFAKIGHSRIPVYAETLDDPRGMIHIRDILNYITRFITKSAQTEQTSDSL
QLTYTDLHTPIGELDLIRTVLFVPGSMLASTLLTRMQTTRTQMALVIDEHGGTDGLVSMEDIVELVVGDIEDEHDHVDNA
IVREPNNKWLVDARTELEDVEKALGPDFIVGEYGDEVDTIGGLIVSILDRIPAKGEIIEAVPGYRFRILEADKRRIKRLR
IFRIPENESFKQNVISEE

Specific function: Unknown

COG id: COG1253

COG function: function code R; Hemolysins and related proteins containing CBS domains

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI310128564, Length=215, Percent_Identity=27.906976744186, Blast_Score=82, Evalue=6e-16,
Organism=Escherichia coli, GI1786879, Length=278, Percent_Identity=33.8129496402878, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI145693175, Length=261, Percent_Identity=26.8199233716475, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI87082033, Length=301, Percent_Identity=24.2524916943522, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1790664, Length=257, Percent_Identity=24.124513618677, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1788119, Length=257, Percent_Identity=24.5136186770428, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR005170 [H]

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC [H]

EC number: NA

Molecular weight: Translated: 38347; Mature: 38216

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANKVNAQNNSQTPSHIEEHPPQPANHTEKYSLMNHLFSFLRGRNSTSLRNDLTVALTAD
CCCCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEC
NEKDTALFSPEERTMLHNILRLREARIDDVMIPRSEIEALDINTSLGEALKCFAKIGHSR
CCCCCEEECCHHHHHHHHHHHHHHHHCCCEECCHHHCCEEECCCHHHHHHHHHHHHCCCC
IPVYAETLDDPRGMIHIRDILNYITRFITKSAQTEQTSDSLQLTYTDLHTPIGELDLIRT
CCEEHCCCCCCCCEEEHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHCCCCCHHHHHHH
VLFVPGSMLASTLLTRMQTTRTQMALVIDEHGGTDGLVSMEDIVELVVGDIEDEHDHVDN
HHHCCHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCHHHHHCC
AIVREPNNKWLVDARTELEDVEKALGPDFIVGEYGDEVDTIGGLIVSILDRIPAKGEIIE
CEEECCCCCEEEECHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHCCCCCCEEE
AVPGYRFRILEADKRRIKRLRIFRIPENESFKQNVISEE
CCCCCEEEEEHHHHHHHHHEEEEECCCCCCHHHHCCCCC
>Mature Secondary Structure 
ANKVNAQNNSQTPSHIEEHPPQPANHTEKYSLMNHLFSFLRGRNSTSLRNDLTVALTAD
CCCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEC
NEKDTALFSPEERTMLHNILRLREARIDDVMIPRSEIEALDINTSLGEALKCFAKIGHSR
CCCCCEEECCHHHHHHHHHHHHHHHHCCCEECCHHHCCEEECCCHHHHHHHHHHHHCCCC
IPVYAETLDDPRGMIHIRDILNYITRFITKSAQTEQTSDSLQLTYTDLHTPIGELDLIRT
CCEEHCCCCCCCCEEEHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHCCCCCHHHHHHH
VLFVPGSMLASTLLTRMQTTRTQMALVIDEHGGTDGLVSMEDIVELVVGDIEDEHDHVDN
HHHCCHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCHHHHHCC
AIVREPNNKWLVDARTELEDVEKALGPDFIVGEYGDEVDTIGGLIVSILDRIPAKGEIIE
CEEECCCCCEEEECHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHCCCCCCEEE
AVPGYRFRILEADKRRIKRLRIFRIPENESFKQNVISEE
CCCCCEEEEEHHHHHHHHHEEEEECCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA