BacMap

Definition	Candidatus Protochlamydia amoebophila UWE25, complete genome.
Accession	NC_005861
Length	2,414,465

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The map label for this gene is ppiB [C]

Identifier: 46446767

GI number: 46446767

Start: 1361163

End: 1361642

Strand: Direct

Name: ppiB [C]

Synonym: pc1133

Alternate gene names: 46446767

Gene position: 1361163-1361642 (Clockwise)

Preceding gene: 46446766

Following gene: 46446768

Centisome position: 56.38

GC content: 37.5

Gene sequence:

>480_bases
ATGCCTAATCAACCTATTGCTCAAATTGAAACTACTCAAGGAACAATTGAAGTCGCTTTAAGACCTGATGTTGCTCCTAA
AGCAACAGAAAATTTTATTAAGCACGCGAAAGATGGTTATTACAATGGAGTTATTTTTCATCGAGTAATCAAAGGTTTTA
TGATTCAAGGAGGAGATCCCACAGGAACCGGCCGTGGAGGGGAATCGATTTGGAATAAACCTTTTGAAGATGAGGTTTCT
GATAACGTAAAGTTTGATCGCCCAGGCTTATTAGCAATGGCAAATGCTGGCCCAAAAACTAATGGAAGCCAGTTTTTTAT
TACCACAGCTGCTACACCTTGGTTGAATAAAAAACATACGATCTTTGGAGAGATCATTAAAGGTTATGATGTCGTTCAAA
AAATCGAAAACACCCAAACAGGTCCTGGAGATCGTCCAGTGGAAGAACAAAAAATTATCAATATTACTATTAAAGAGTAA

Upstream 100 bases:

>100_bases
TTAAAAATGAGGGAAAATGAATTTATTCACTTTTACTTTTTTTACACTTTCAACTTTTCTTATTCATACCTTAACCCCCC
TACAAGCTAAAGAGGAATCT

Downstream 100 bases:

>100_bases
ACTTTGTAAAAGGATTCAGCATCGCTTAAATTCTGAGTCGATGCTGAATTAGAATGAATTTTCAACTCATTGATCATGAA
ATTATCTTAAGATAGGAAAT

Product: peptidylprolyl isomerase II (cyclophilin A)

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 159; Mature: 158

Protein sequence:

>159_residues
MPNQPIAQIETTQGTIEVALRPDVAPKATENFIKHAKDGYYNGVIFHRVIKGFMIQGGDPTGTGRGGESIWNKPFEDEVS
DNVKFDRPGLLAMANAGPKTNGSQFFITTAATPWLNKKHTIFGEIIKGYDVVQKIENTQTGPGDRPVEEQKIINITIKE

Sequences:

>Translated_159_residues
MPNQPIAQIETTQGTIEVALRPDVAPKATENFIKHAKDGYYNGVIFHRVIKGFMIQGGDPTGTGRGGESIWNKPFEDEVS
DNVKFDRPGLLAMANAGPKTNGSQFFITTAATPWLNKKHTIFGEIIKGYDVVQKIENTQTGPGDRPVEEQKIINITIKE
>Mature_158_residues
PNQPIAQIETTQGTIEVALRPDVAPKATENFIKHAKDGYYNGVIFHRVIKGFMIQGGDPTGTGRGGESIWNKPFEDEVSD
NVKFDRPGLLAMANAGPKTNGSQFFITTAATPWLNKKHTIFGEIIKGYDVVQKIENTQTGPGDRPVEEQKIINITIKE

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI24308049, Length=153, Percent_Identity=58.1699346405229, Blast_Score=188, Evalue=2e-48,
Organism=Homo sapiens, GI7706339, Length=149, Percent_Identity=55.7046979865772, Blast_Score=170, Evalue=6e-43,
Organism=Homo sapiens, GI19557636, Length=150, Percent_Identity=48, Blast_Score=147, Evalue=5e-36,
Organism=Homo sapiens, GI64276486, Length=117, Percent_Identity=54.7008547008547, Blast_Score=141, Evalue=3e-34,
Organism=Homo sapiens, GI22547215, Length=151, Percent_Identity=50.3311258278146, Blast_Score=140, Evalue=5e-34,
Organism=Homo sapiens, GI22547212, Length=151, Percent_Identity=50.3311258278146, Blast_Score=140, Evalue=5e-34,
Organism=Homo sapiens, GI7657473, Length=151, Percent_Identity=50.3311258278146, Blast_Score=140, Evalue=5e-34,
Organism=Homo sapiens, GI5454154, Length=142, Percent_Identity=50, Blast_Score=130, Evalue=7e-31,
Organism=Homo sapiens, GI4505991, Length=147, Percent_Identity=50.3401360544218, Blast_Score=121, Evalue=3e-28,
Organism=Homo sapiens, GI4826932, Length=147, Percent_Identity=48.2993197278912, Blast_Score=120, Evalue=3e-28,
Organism=Homo sapiens, GI5174637, Length=144, Percent_Identity=47.9166666666667, Blast_Score=120, Evalue=4e-28,
Organism=Homo sapiens, GI45439316, Length=130, Percent_Identity=49.2307692307692, Blast_Score=120, Evalue=4e-28,
Organism=Homo sapiens, GI303305009, Length=127, Percent_Identity=50.3937007874016, Blast_Score=120, Evalue=5e-28,
Organism=Homo sapiens, GI4758950, Length=146, Percent_Identity=45.8904109589041, Blast_Score=119, Evalue=8e-28,
Organism=Homo sapiens, GI42560244, Length=153, Percent_Identity=45.7516339869281, Blast_Score=117, Evalue=4e-27,
Organism=Homo sapiens, GI6631100, Length=153, Percent_Identity=43.7908496732026, Blast_Score=116, Evalue=1e-26,
Organism=Homo sapiens, GI5031987, Length=128, Percent_Identity=50, Blast_Score=115, Evalue=1e-26,
Organism=Homo sapiens, GI10863927, Length=127, Percent_Identity=48.8188976377953, Blast_Score=115, Evalue=1e-26,
Organism=Homo sapiens, GI310129267, Length=128, Percent_Identity=46.09375, Blast_Score=107, Evalue=4e-24,
Organism=Homo sapiens, GI310120620, Length=128, Percent_Identity=46.09375, Blast_Score=107, Evalue=4e-24,
Organism=Homo sapiens, GI20911035, Length=157, Percent_Identity=38.2165605095541, Blast_Score=107, Evalue=5e-24,
Organism=Homo sapiens, GI310127646, Length=127, Percent_Identity=44.0944881889764, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI310110104, Length=128, Percent_Identity=45.3125, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI310114371, Length=127, Percent_Identity=44.0944881889764, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI310119221, Length=127, Percent_Identity=44.0944881889764, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI169164185, Length=127, Percent_Identity=44.8818897637795, Blast_Score=104, Evalue=3e-23,
Organism=Homo sapiens, GI169163623, Length=127, Percent_Identity=44.8818897637795, Blast_Score=104, Evalue=3e-23,
Organism=Homo sapiens, GI169163387, Length=127, Percent_Identity=44.8818897637795, Blast_Score=104, Evalue=4e-23,
Organism=Homo sapiens, GI256017253, Length=130, Percent_Identity=45.3846153846154, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI221139811, Length=130, Percent_Identity=45.3846153846154, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI256017251, Length=130, Percent_Identity=45.3846153846154, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI178057341, Length=130, Percent_Identity=45.3846153846154, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI209417936, Length=130, Percent_Identity=44.6153846153846, Blast_Score=100, Evalue=8e-22,
Organism=Homo sapiens, GI30102944, Length=130, Percent_Identity=44.6153846153846, Blast_Score=100, Evalue=8e-22,
Organism=Homo sapiens, GI219842199, Length=130, Percent_Identity=44.6153846153846, Blast_Score=100, Evalue=8e-22,
Organism=Homo sapiens, GI27735045, Length=152, Percent_Identity=38.8157894736842, Blast_Score=97, Evalue=5e-21,
Organism=Homo sapiens, GI310132444, Length=127, Percent_Identity=41.7322834645669, Blast_Score=95, Evalue=3e-20,
Organism=Homo sapiens, GI310113152, Length=127, Percent_Identity=41.7322834645669, Blast_Score=95, Evalue=3e-20,
Organism=Homo sapiens, GI150418007, Length=128, Percent_Identity=45.3125, Blast_Score=94, Evalue=4e-20,
Organism=Homo sapiens, GI239751853, Length=127, Percent_Identity=42.5196850393701, Blast_Score=94, Evalue=5e-20,
Organism=Homo sapiens, GI113428306, Length=127, Percent_Identity=42.5196850393701, Blast_Score=94, Evalue=5e-20,
Organism=Homo sapiens, GI169214050, Length=127, Percent_Identity=42.5196850393701, Blast_Score=94, Evalue=7e-20,
Organism=Homo sapiens, GI310114540, Length=124, Percent_Identity=43.5483870967742, Blast_Score=90, Evalue=8e-19,
Organism=Homo sapiens, GI310127745, Length=124, Percent_Identity=43.5483870967742, Blast_Score=90, Evalue=9e-19,
Organism=Homo sapiens, GI310119290, Length=124, Percent_Identity=43.5483870967742, Blast_Score=90, Evalue=9e-19,
Organism=Homo sapiens, GI14277126, Length=96, Percent_Identity=46.875, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI289803023, Length=177, Percent_Identity=32.2033898305085, Blast_Score=84, Evalue=4e-17,
Organism=Escherichia coli, GI1786736, Length=169, Percent_Identity=33.7278106508876, Blast_Score=87, Evalue=5e-19,
Organism=Escherichia coli, GI1789763, Length=142, Percent_Identity=35.9154929577465, Blast_Score=83, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI71980594, Length=149, Percent_Identity=51.006711409396, Blast_Score=161, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI71980590, Length=143, Percent_Identity=50.3496503496504, Blast_Score=154, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17506311, Length=154, Percent_Identity=50.6493506493506, Blast_Score=153, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17539496, Length=149, Percent_Identity=51.006711409396, Blast_Score=153, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17532641, Length=138, Percent_Identity=51.4492753623188, Blast_Score=151, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI71997782, Length=163, Percent_Identity=47.8527607361963, Blast_Score=142, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17552780, Length=147, Percent_Identity=53.0612244897959, Blast_Score=137, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17551282, Length=144, Percent_Identity=50, Blast_Score=129, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17551284, Length=144, Percent_Identity=50, Blast_Score=129, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17506307, Length=141, Percent_Identity=52.4822695035461, Blast_Score=127, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17532643, Length=159, Percent_Identity=46.5408805031447, Blast_Score=124, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17552784, Length=162, Percent_Identity=43.8271604938272, Blast_Score=120, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17539498, Length=144, Percent_Identity=45.1388888888889, Blast_Score=118, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17559074, Length=155, Percent_Identity=43.8709677419355, Blast_Score=117, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17566266, Length=141, Percent_Identity=46.0992907801418, Blast_Score=117, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17565860, Length=145, Percent_Identity=46.2068965517241, Blast_Score=114, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17552782, Length=135, Percent_Identity=45.9259259259259, Blast_Score=109, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI32563659, Length=152, Percent_Identity=34.8684210526316, Blast_Score=100, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI115533296, Length=151, Percent_Identity=35.0993377483444, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323246, Length=154, Percent_Identity=48.0519480519481, Blast_Score=129, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6320359, Length=130, Percent_Identity=53.8461538461538, Blast_Score=128, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6320510, Length=146, Percent_Identity=50.6849315068493, Blast_Score=128, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6323562, Length=137, Percent_Identity=52.5547445255474, Blast_Score=125, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6321848, Length=150, Percent_Identity=46.6666666666667, Blast_Score=118, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6322492, Length=183, Percent_Identity=38.7978142076503, Blast_Score=93, Evalue=2e-20,
Organism=Drosophila melanogaster, GI19922376, Length=142, Percent_Identity=52.112676056338, Blast_Score=165, Evalue=9e-42,
Organism=Drosophila melanogaster, GI17986117, Length=151, Percent_Identity=50.3311258278146, Blast_Score=160, Evalue=2e-40,
Organism=Drosophila melanogaster, GI19922912, Length=150, Percent_Identity=56, Blast_Score=154, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24652460, Length=150, Percent_Identity=44, Blast_Score=141, Evalue=2e-34,
Organism=Drosophila melanogaster, GI20130249, Length=146, Percent_Identity=50.6849315068493, Blast_Score=128, Evalue=2e-30,
Organism=Drosophila melanogaster, GI21357249, Length=158, Percent_Identity=41.1392405063291, Blast_Score=127, Evalue=3e-30,
Organism=Drosophila melanogaster, GI45549139, Length=140, Percent_Identity=49.2857142857143, Blast_Score=126, Evalue=7e-30,
Organism=Drosophila melanogaster, GI17647301, Length=150, Percent_Identity=46.6666666666667, Blast_Score=121, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24586038, Length=158, Percent_Identity=43.0379746835443, Blast_Score=120, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24664125, Length=140, Percent_Identity=48.5714285714286, Blast_Score=119, Evalue=1e-27,
Organism=Drosophila melanogaster, GI21357783, Length=140, Percent_Identity=48.5714285714286, Blast_Score=119, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24650807, Length=153, Percent_Identity=46.4052287581699, Blast_Score=117, Evalue=3e-27,
Organism=Drosophila melanogaster, GI17136360, Length=148, Percent_Identity=42.5675675675676, Blast_Score=110, Evalue=5e-25,
Organism=Drosophila melanogaster, GI21355677, Length=159, Percent_Identity=34.5911949685535, Blast_Score=96, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24661775, Length=143, Percent_Identity=34.2657342657343, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21355237, Length=143, Percent_Identity=34.2657342657343, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24661771, Length=143, Percent_Identity=34.2657342657343, Blast_Score=82, Evalue=2e-16,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 17511; Mature: 17380

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNQPIAQIETTQGTIEVALRPDVAPKATENFIKHAKDGYYNGVIFHRVIKGFMIQGGDP
CCCCCCCEEEECCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHEEECCCC
TGTGRGGESIWNKPFEDEVSDNVKFDRPGLLAMANAGPKTNGSQFFITTAATPWLNKKHT
CCCCCCCHHHCCCCCCCCCCCCCEECCCCEEEEECCCCCCCCCEEEEEECCCCCCCCCHH
IFGEIIKGYDVVQKIENTQTGPGDRPVEEQKIINITIKE
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECC
>Mature Secondary Structure 
PNQPIAQIETTQGTIEVALRPDVAPKATENFIKHAKDGYYNGVIFHRVIKGFMIQGGDP
CCCCCCEEEECCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHEEECCCC
TGTGRGGESIWNKPFEDEVSDNVKFDRPGLLAMANAGPKTNGSQFFITTAATPWLNKKHT
CCCCCCCHHHCCCCCCCCCCCCCEECCCCEEEEECCCCCCCCCEEEEEECCCCCCCCCHH
IFGEIIKGYDVVQKIENTQTGPGDRPVEEQKIINITIKE
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA