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The map label for this gene is proC [H]

Identifier: 46446766

GI number: 46446766

Start: 1360259

End: 1361053

Strand: Direct

Name: proC [H]

Synonym: pc1132

Alternate gene names: 46446766

Gene position: 1360259-1361053 (Clockwise)

Preceding gene: 46446765

Following gene: 46446767

Centisome position: 56.34

GC content: 34.47

Gene sequence:

>795_bases
ATGCATATCACAATTATTGGCTGTGGAAATATGGGTTCTGGAATTGCCAAAAGGTTGTCTATGAATCATCAAATTTCTTT
ATATGATCATTATCCTGCCACCGCTGAATCTTTAACTAAACAAATACAAGCAACCGCTTATGCAGATCTTTTTTCAGCTA
TTGAAGAAGCAGACTTAATTCTTGTGGCTGTCAAACCTCAAAATTTAGACGATTTAACGGAACGATTAGCTCCCCTACTC
AAACCCCATCAAACTATTGTAAGTATTTTAGCTGGAATAAATTATAAAACATTAAAACATCGTTTCTCTCAATCGATTGT
TGTAAGAATGATGCCTAATCTAGCTTTAATTCACGGAAAAGGAGTCATTGGATTAGTTGAGAATGATCAATTAACTGATA
AGCTAAAAATGCAGTTAAAAGCTCTTTTTGATCCGTTAGGTTCAGTTTATTGGCTTCCAGAATCTAAAATTGATGCATTA
ACGGCTCTAACTGGATCTGGGCCAGCTTTTATATTTGCTCTTGTTGAATCCATGATTGAAGCTGGAATTTATATGGGATT
TCAAATGACTGACGCAAAGTCCCTCATTTTCCAAATGCTTAAAGGAAGCCTAGCACTCTTAGAAACAACTGATAAACATC
CAGCAGATTTAAAGTGGCAAATTACTTCACCTGCAGGAATGACAATTGAAGGATTAAAAACTTTTGAAGATTACGGTGTT
AGAAGTGGGATCATCCATACTTTTCTTGCTTCTTTCAATAAAATAAAACAAGTTTCTGATTCTTTAAAGAATTAG

Upstream 100 bases:

>100_bases
TTTTAAACCTTCTTTCACCTCTCATAAAATCATCGATGTTTATCAAAATGACTTTTAACTAATTACTTTGCAAATGTCCA
TTAAGATTGAGGAGATAAAA

Downstream 100 bases:

>100_bases
AATAACAATTTAAAAATGAGGGAAAATGAATTTATTCACTTTTACTTTTTTTACACTTTCAACTTTTCTTATTCATACCT
TAACCCCCCTACAAGCTAAA

Product: putative pyrroline-5-carboxylate reductase, proC

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MHITIIGCGNMGSGIAKRLSMNHQISLYDHYPATAESLTKQIQATAYADLFSAIEEADLILVAVKPQNLDDLTERLAPLL
KPHQTIVSILAGINYKTLKHRFSQSIVVRMMPNLALIHGKGVIGLVENDQLTDKLKMQLKALFDPLGSVYWLPESKIDAL
TALTGSGPAFIFALVESMIEAGIYMGFQMTDAKSLIFQMLKGSLALLETTDKHPADLKWQITSPAGMTIEGLKTFEDYGV
RSGIIHTFLASFNKIKQVSDSLKN

Sequences:

>Translated_264_residues
MHITIIGCGNMGSGIAKRLSMNHQISLYDHYPATAESLTKQIQATAYADLFSAIEEADLILVAVKPQNLDDLTERLAPLL
KPHQTIVSILAGINYKTLKHRFSQSIVVRMMPNLALIHGKGVIGLVENDQLTDKLKMQLKALFDPLGSVYWLPESKIDAL
TALTGSGPAFIFALVESMIEAGIYMGFQMTDAKSLIFQMLKGSLALLETTDKHPADLKWQITSPAGMTIEGLKTFEDYGV
RSGIIHTFLASFNKIKQVSDSLKN
>Mature_264_residues
MHITIIGCGNMGSGIAKRLSMNHQISLYDHYPATAESLTKQIQATAYADLFSAIEEADLILVAVKPQNLDDLTERLAPLL
KPHQTIVSILAGINYKTLKHRFSQSIVVRMMPNLALIHGKGVIGLVENDQLTDKLKMQLKALFDPLGSVYWLPESKIDAL
TALTGSGPAFIFALVESMIEAGIYMGFQMTDAKSLIFQMLKGSLALLETTDKHPADLKWQITSPAGMTIEGLKTFEDYGV
RSGIIHTFLASFNKIKQVSDSLKN

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=202, Percent_Identity=29.2079207920792, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI24797097, Length=272, Percent_Identity=27.2058823529412, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI24797095, Length=277, Percent_Identity=26.7148014440433, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI21361454, Length=216, Percent_Identity=28.2407407407407, Blast_Score=93, Evalue=3e-19,
Organism=Escherichia coli, GI1786585, Length=265, Percent_Identity=27.5471698113208, Blast_Score=111, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17569021, Length=267, Percent_Identity=27.3408239700375, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17540664, Length=279, Percent_Identity=24.3727598566308, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320861, Length=268, Percent_Identity=27.9850746268657, Blast_Score=118, Evalue=1e-27,
Organism=Drosophila melanogaster, GI21358587, Length=211, Percent_Identity=29.3838862559242, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24648116, Length=267, Percent_Identity=28.4644194756554, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24647700, Length=173, Percent_Identity=30.635838150289, Blast_Score=96, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 29006; Mature: 29006

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHITIIGCGNMGSGIAKRLSMNHQISLYDHYPATAESLTKQIQATAYADLFSAIEEADLI
CEEEEEECCCCCHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEE
LVAVKPQNLDDLTERLAPLLKPHQTIVSILAGINYKTLKHRFSQSIVVRMMPNLALIHGK
EEEECCCCHHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEECC
GVIGLVENDQLTDKLKMQLKALFDPLGSVYWLPESKIDALTALTGSGPAFIFALVESMIE
CEEEEECCCHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHCCCCCHHHHHHHHHHHHH
AGIYMGFQMTDAKSLIFQMLKGSLALLETTDKHPADLKWQITSPAGMTIEGLKTFEDYGV
HHHHCCEEECHHHHHHHHHHHCCEEEEECCCCCCCCEEEEEECCCCCCHHHHHHHHHCCC
RSGIIHTFLASFNKIKQVSDSLKN
HHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHITIIGCGNMGSGIAKRLSMNHQISLYDHYPATAESLTKQIQATAYADLFSAIEEADLI
CEEEEEECCCCCHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEE
LVAVKPQNLDDLTERLAPLLKPHQTIVSILAGINYKTLKHRFSQSIVVRMMPNLALIHGK
EEEECCCCHHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEECC
GVIGLVENDQLTDKLKMQLKALFDPLGSVYWLPESKIDALTALTGSGPAFIFALVESMIE
CEEEEECCCHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHCCCCCHHHHHHHHHHHHH
AGIYMGFQMTDAKSLIFQMLKGSLALLETTDKHPADLKWQITSPAGMTIEGLKTFEDYGV
HHHHCCEEECHHHHHHHHHHHCCEEEEECCCCCCCCEEEEEECCCCCCHHHHHHHHHCCC
RSGIIHTFLASFNKIKQVSDSLKN
HHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]