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The map label for this gene is pyrG [H]

Identifier: 46446458

GI number: 46446458

Start: 1008693

End: 1010327

Strand: Reverse

Name: pyrG [H]

Synonym: pc0824

Alternate gene names: 46446458

Gene position: 1010327-1008693 (Counterclockwise)

Preceding gene: 46446459

Following gene: 46446457

Centisome position: 41.84

GC content: 35.78

Gene sequence:

>1635_bases
ATGGCTATGCAAACAAAATACATTTTTATAACAGGCGGTGTCTGTTCCTCTTTGGGAAAAGGACTCACTTCTGCAGCAAT
TGGGTTATTACTCGAAAAAAAAGGGTTAAGAGTGTCAATGCTTAAATTAGATCCTTACTTGAATGTTGATCCAGGTACGA
TGAGCCCCTTTCAACATGGCGAGGTTTATGTGACAGATGATGGCGCTGAAACAGATTTAGATTTAGGTCATTACTACCGT
TATACAAATTCTTTTTTATCAAAAGCTTCTAACGCTACTTCTGGTCAAATTTACAATACAGTAATTAAAAGAGAGCGACA
TGGCGACTATCTAGGAAAAACGGTTCAAGTTATTCCTCATATTACGAATGAGATTAAACAACGCATTGTGAACTGTGGAA
AACAACAAGAAAATATTGATGTTGTTTTGGTCGAAATAGGAGGAACTGCCGGAGATATTGAATCACTTCCCTTTTTAGAA
GCCATTCGCCAATTTACTTACGATCATCGCAATAATTGTTTAAATATACACTTGACATATGTTCCATATTTGAAAGCAGC
AGGAGAGGTAAAAACTAAACCTTCTCAGCATTCCGTACAAGTTTTAAGAGGAATTGGGATTTTTCCAGATATTATTGTTT
GCCGTTGCGAAGTGAATTTATCTGATGAAGTTAAAGATAAAATTAGCCTTTTTTGTAATGTCAACAGACGTGCTGTCATC
GAAGAAAAAGATGTCGAACATAGTATTTATGAAGTCCCTTTAGATTTGCATAAGCAAGGAATTGATGCTTTAATTTGTGA
ACTTTTACATCTTCCTAATCCCTCAATCAATTTATCAGAATGGGAAAAAATACTTGAAACGATAAAAAATCCTAAAGGAA
CTGTAACTGTAGGCATCGTTGGAAAATATGTTCAACATCAAGATGCTTATAAATCGGTTTTCGAATCTTTGACGCATGGA
GCATTAGCTGCAGGATATAAACTTCAAATTAAACGATTTGAAGCAGATAAACTTCCGTTAGATGATAACCAATTAGCTAA
AACAATTGAAGGTTGTGATGGCTATTTAGTTCCTGGAGGATTTGGAGAAAGAGGGTGGCTTGGCAAAATTCACACAGCTA
AATTATGTAGGGAGAAAAAAATTCCTTACTTTGGAATCTGCTTAGGAATGCAGGTCATGGCAGTCGAATTCGCTAGACAT
GTGGTCGGACTCAATGAAGCTAATTCAACAGAGTTTGATCCTGATACTATACATCCTGTGATTTCTTTATTAAGTGAGCA
AAGAGGTTTACAAGACCTTGGAGGTACAATGCGTCTTGGAGCTTATATTTGTGATTTGAAACTTCACACAAAAGCTTATC
AAGCTTATAAAAGTTCACAAATCAGCGAACGGCATCGACATCGTTATGAATTTAATAATACTTACAAAGAACAAATGGAA
AAAGCTGGTTTTGTAGTTGCAGGAACGTTAAAAGGTGAGAATCTTTGCGAAATAGCTGAAGTCAAAGATCATCCTTGGAT
GATTGGAGTTCAATTTCACCCTGAATTTAAATCAAAACCAACAGACCCTCATCCACTTTTCCGTGACTTTATTCAAGCGA
TGATTATTTACCATAAGAGTCAGCATGGAAAATAA

Upstream 100 bases:

>100_bases
AATTAAAAGTTTTAGAACACGGATATCGAATCAAAGTTGCGATCGTTGATCAGGCAAATATTGGAGTTGACACTCCTGAG
GATATCCACAAAGTTGAGGA

Downstream 100 bases:

>100_bases
GCCAAAGCCCAGTAGAATTTTAGGCATCGATTTTGGGATGAGCCGAATAGGCTTGGCTCAATCCGACGAAAGAAAGATTA
TAGCCATGCCTCTTATCACT

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase [H]

Number of amino acids: Translated: 544; Mature: 543

Protein sequence:

>544_residues
MAMQTKYIFITGGVCSSLGKGLTSAAIGLLLEKKGLRVSMLKLDPYLNVDPGTMSPFQHGEVYVTDDGAETDLDLGHYYR
YTNSFLSKASNATSGQIYNTVIKRERHGDYLGKTVQVIPHITNEIKQRIVNCGKQQENIDVVLVEIGGTAGDIESLPFLE
AIRQFTYDHRNNCLNIHLTYVPYLKAAGEVKTKPSQHSVQVLRGIGIFPDIIVCRCEVNLSDEVKDKISLFCNVNRRAVI
EEKDVEHSIYEVPLDLHKQGIDALICELLHLPNPSINLSEWEKILETIKNPKGTVTVGIVGKYVQHQDAYKSVFESLTHG
ALAAGYKLQIKRFEADKLPLDDNQLAKTIEGCDGYLVPGGFGERGWLGKIHTAKLCREKKIPYFGICLGMQVMAVEFARH
VVGLNEANSTEFDPDTIHPVISLLSEQRGLQDLGGTMRLGAYICDLKLHTKAYQAYKSSQISERHRHRYEFNNTYKEQME
KAGFVVAGTLKGENLCEIAEVKDHPWMIGVQFHPEFKSKPTDPHPLFRDFIQAMIIYHKSQHGK

Sequences:

>Translated_544_residues
MAMQTKYIFITGGVCSSLGKGLTSAAIGLLLEKKGLRVSMLKLDPYLNVDPGTMSPFQHGEVYVTDDGAETDLDLGHYYR
YTNSFLSKASNATSGQIYNTVIKRERHGDYLGKTVQVIPHITNEIKQRIVNCGKQQENIDVVLVEIGGTAGDIESLPFLE
AIRQFTYDHRNNCLNIHLTYVPYLKAAGEVKTKPSQHSVQVLRGIGIFPDIIVCRCEVNLSDEVKDKISLFCNVNRRAVI
EEKDVEHSIYEVPLDLHKQGIDALICELLHLPNPSINLSEWEKILETIKNPKGTVTVGIVGKYVQHQDAYKSVFESLTHG
ALAAGYKLQIKRFEADKLPLDDNQLAKTIEGCDGYLVPGGFGERGWLGKIHTAKLCREKKIPYFGICLGMQVMAVEFARH
VVGLNEANSTEFDPDTIHPVISLLSEQRGLQDLGGTMRLGAYICDLKLHTKAYQAYKSSQISERHRHRYEFNNTYKEQME
KAGFVVAGTLKGENLCEIAEVKDHPWMIGVQFHPEFKSKPTDPHPLFRDFIQAMIIYHKSQHGK
>Mature_543_residues
AMQTKYIFITGGVCSSLGKGLTSAAIGLLLEKKGLRVSMLKLDPYLNVDPGTMSPFQHGEVYVTDDGAETDLDLGHYYRY
TNSFLSKASNATSGQIYNTVIKRERHGDYLGKTVQVIPHITNEIKQRIVNCGKQQENIDVVLVEIGGTAGDIESLPFLEA
IRQFTYDHRNNCLNIHLTYVPYLKAAGEVKTKPSQHSVQVLRGIGIFPDIIVCRCEVNLSDEVKDKISLFCNVNRRAVIE
EKDVEHSIYEVPLDLHKQGIDALICELLHLPNPSINLSEWEKILETIKNPKGTVTVGIVGKYVQHQDAYKSVFESLTHGA
LAAGYKLQIKRFEADKLPLDDNQLAKTIEGCDGYLVPGGFGERGWLGKIHTAKLCREKKIPYFGICLGMQVMAVEFARHV
VGLNEANSTEFDPDTIHPVISLLSEQRGLQDLGGTMRLGAYICDLKLHTKAYQAYKSSQISERHRHRYEFNNTYKEQMEK
AGFVVAGTLKGENLCEIAEVKDHPWMIGVQFHPEFKSKPTDPHPLFRDFIQAMIIYHKSQHGK

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen [H]

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI148491070, Length=560, Percent_Identity=43.5714285714286, Blast_Score=458, Evalue=1e-129,
Organism=Homo sapiens, GI28559085, Length=547, Percent_Identity=43.327239488117, Blast_Score=449, Evalue=1e-126,
Organism=Homo sapiens, GI28559083, Length=547, Percent_Identity=43.327239488117, Blast_Score=449, Evalue=1e-126,
Organism=Homo sapiens, GI221316689, Length=547, Percent_Identity=43.327239488117, Blast_Score=449, Evalue=1e-126,
Organism=Escherichia coli, GI1789142, Length=550, Percent_Identity=53.0909090909091, Blast_Score=566, Evalue=1e-163,
Organism=Caenorhabditis elegans, GI25148299, Length=605, Percent_Identity=37.1900826446281, Blast_Score=395, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6322563, Length=559, Percent_Identity=40.608228980322, Blast_Score=417, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6319432, Length=559, Percent_Identity=40.2504472271914, Blast_Score=410, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24664469, Length=551, Percent_Identity=43.1941923774955, Blast_Score=422, Evalue=1e-118,
Organism=Drosophila melanogaster, GI21357815, Length=496, Percent_Identity=42.1370967741936, Blast_Score=356, Evalue=3e-98,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase [H]

EC number: =6.3.4.2 [H]

Molecular weight: Translated: 61076; Mature: 60945

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMQTKYIFITGGVCSSLGKGLTSAAIGLLLEKKGLRVSMLKLDPYLNVDPGTMSPFQHG
CCCEEEEEEEECHHHHHHCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCC
EVYVTDDGAETDLDLGHYYRYTNSFLSKASNATSGQIYNTVIKRERHGDYLGKTVQVIPH
EEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHH
ITNEIKQRIVNCGKQQENIDVVLVEIGGTAGDIESLPFLEAIRQFTYDHRNNCLNIHLTY
HHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEE
VPYLKAAGEVKTKPSQHSVQVLRGIGIFPDIIVCRCEVNLSDEVKDKISLFCNVNRRAVI
ECHHHCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHEEECCCCCEEE
EEKDVEHSIYEVPLDLHKQGIDALICELLHLPNPSINLSEWEKILETIKNPKGTVTVGIV
CHHCCCHHHHHCCHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEEEEH
GKYVQHQDAYKSVFESLTHGALAAGYKLQIKRFEADKLPLDDNQLAKTIEGCDGYLVPGG
HHHHHHHHHHHHHHHHHHCCHHHCCEEEEEEEECCCCCCCCHHHHHHHHHCCCCEECCCC
FGERGWLGKIHTAKLCREKKIPYFGICLGMQVMAVEFARHVVGLNEANSTEFDPDTIHPV
CCCCCCCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
ISLLSEQRGLQDLGGTMRLGAYICDLKLHTKAYQAYKSSQISERHRHRYEFNNTYKEQME
HHHHHHHCCHHHHCCHHEECEEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
KAGFVVAGTLKGENLCEIAEVKDHPWMIGVQFHPEFKSKPTDPHPLFRDFIQAMIIYHKS
HCCEEEEEECCCCCCHHHHHCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHC
QHGK
CCCC
>Mature Secondary Structure 
AMQTKYIFITGGVCSSLGKGLTSAAIGLLLEKKGLRVSMLKLDPYLNVDPGTMSPFQHG
CCEEEEEEEECHHHHHHCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCC
EVYVTDDGAETDLDLGHYYRYTNSFLSKASNATSGQIYNTVIKRERHGDYLGKTVQVIPH
EEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHH
ITNEIKQRIVNCGKQQENIDVVLVEIGGTAGDIESLPFLEAIRQFTYDHRNNCLNIHLTY
HHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEE
VPYLKAAGEVKTKPSQHSVQVLRGIGIFPDIIVCRCEVNLSDEVKDKISLFCNVNRRAVI
ECHHHCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHEEECCCCCEEE
EEKDVEHSIYEVPLDLHKQGIDALICELLHLPNPSINLSEWEKILETIKNPKGTVTVGIV
CHHCCCHHHHHCCHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEEEEH
GKYVQHQDAYKSVFESLTHGALAAGYKLQIKRFEADKLPLDDNQLAKTIEGCDGYLVPGG
HHHHHHHHHHHHHHHHHHCCHHHCCEEEEEEEECCCCCCCCHHHHHHHHHCCCCEECCCC
FGERGWLGKIHTAKLCREKKIPYFGICLGMQVMAVEFARHVVGLNEANSTEFDPDTIHPV
CCCCCCCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
ISLLSEQRGLQDLGGTMRLGAYICDLKLHTKAYQAYKSSQISERHRHRYEFNNTYKEQME
HHHHHHHCCHHHHCCHHEECEEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
KAGFVVAGTLKGENLCEIAEVKDHPWMIGVQFHPEFKSKPTDPHPLFRDFIQAMIIYHKS
HCCEEEEEECCCCCCHHHHHCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHC
QHGK
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA