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The map label for this gene is kdsB

Identifier: 46446459

GI number: 46446459

Start: 1010297

End: 1011076

Strand: Reverse

Name: kdsB

Synonym: pc0825

Alternate gene names: 46446459

Gene position: 1011076-1010297 (Counterclockwise)

Preceding gene: 46446463

Following gene: 46446458

Centisome position: 41.88

GC content: 38.33

Gene sequence:

>780_bases
TTGAAACATGCAGAGATGACTGGACAAATTATCGGAATTATACCAGCCCGTTATGGTAGCACTCGTTTTCCAGGTAAACC
CCTCGCCTCAATTCTCGGTAAAACTCTTCTTCAAAGAACTTATGAAAATAGCTTAAGGGCTAGCGCTCTCAGCGATCTTA
TTGTTGCCACAGATGATGAACGTATTTTTGAACATGTTCGCTCCTTTAATGGTAAAGTCGTAATGACTTCTGAACAATGC
CCCACTGGAACGGATCGCTTAGCAGAAGTCCTTTCACTCTACCCAGAATGGATGCATGCAACTGCTATTGTTAACATTCA
AGGAGATGAACCTTGTTTAAACCCTTTGACCATCAATTTAGCTGTTCAGGCACTTGTTAATGACCCTCAAGGACAAGTAT
CTACTATTGTGACTCCCTTATTGGATGAAGAAGAAGCTAAAAATTCTTCTATTGTCAAATGTGTGATGGATCAACAGGGA
AACGCACTTTATTTTAGCCGTGCTTTAATCCCTTCCAACAAAACCAACTCTTTTAAAAATGGAGCTATTTATTTTCGTCA
TTTAGGGCTCTATGTCTATAGACCATCATTTATCATAAACTATCAGAAATTACCTTCTACACCCCTGCAGTTAGAAGAAG
ATTTAGAACAATTAAAAGTTTTAGAACACGGATATCGAATCAAAGTTGCGATCGTTGATCAGGCAAATATTGGAGTTGAC
ACTCCTGAGGATATCCACAAAGTTGAGGAATGGCTATGCAAACAAAATACATTTTTATAA

Upstream 100 bases:

>100_bases
TTTATTACTTCCGTAGAAAAACTCTAAAATCAATTTGTATATACAATCACTTGTTATTAATAATTAAATCTTCTAGTATC
TTTGCGATATTAATTTACTT

Downstream 100 bases:

>100_bases
CAGGCGGTGTCTGTTCCTCTTTGGGAAAAGGACTCACTTCTGCAGCAATTGGGTTATTACTCGAAAAAAAAGGGTTAAGA
GTGTCAATGCTTAAATTAGA

Product: 3-deoxy-manno-octulosonate cytidylyltransferase

Products: NA

Alternate protein names: CMP-2-keto-3-deoxyoctulosonic acid synthase; CKS; CMP-KDO synthase

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MKHAEMTGQIIGIIPARYGSTRFPGKPLASILGKTLLQRTYENSLRASALSDLIVATDDERIFEHVRSFNGKVVMTSEQC
PTGTDRLAEVLSLYPEWMHATAIVNIQGDEPCLNPLTINLAVQALVNDPQGQVSTIVTPLLDEEEAKNSSIVKCVMDQQG
NALYFSRALIPSNKTNSFKNGAIYFRHLGLYVYRPSFIINYQKLPSTPLQLEEDLEQLKVLEHGYRIKVAIVDQANIGVD
TPEDIHKVEEWLCKQNTFL

Sequences:

>Translated_259_residues
MKHAEMTGQIIGIIPARYGSTRFPGKPLASILGKTLLQRTYENSLRASALSDLIVATDDERIFEHVRSFNGKVVMTSEQC
PTGTDRLAEVLSLYPEWMHATAIVNIQGDEPCLNPLTINLAVQALVNDPQGQVSTIVTPLLDEEEAKNSSIVKCVMDQQG
NALYFSRALIPSNKTNSFKNGAIYFRHLGLYVYRPSFIINYQKLPSTPLQLEEDLEQLKVLEHGYRIKVAIVDQANIGVD
TPEDIHKVEEWLCKQNTFL
>Mature_259_residues
MKHAEMTGQIIGIIPARYGSTRFPGKPLASILGKTLLQRTYENSLRASALSDLIVATDDERIFEHVRSFNGKVVMTSEQC
PTGTDRLAEVLSLYPEWMHATAIVNIQGDEPCLNPLTINLAVQALVNDPQGQVSTIVTPLLDEEEAKNSSIVKCVMDQQG
NALYFSRALIPSNKTNSFKNGAIYFRHLGLYVYRPSFIINYQKLPSTPLQLEEDLEQLKVLEHGYRIKVAIVDQANIGVD
TPEDIHKVEEWLCKQNTFL

Specific function: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria

COG id: COG1212

COG function: function code M; CMP-2-keto-3-deoxyoctulosonic acid synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsB family

Homologues:

Organism=Escherichia coli, GI1787147, Length=241, Percent_Identity=43.1535269709544, Blast_Score=170, Evalue=9e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KDSB_PARUW (Q6MD00)

Other databases:

- EMBL:   BX908798
- RefSeq:   YP_007824.1
- HSSP:   P44490
- ProteinModelPortal:   Q6MD00
- SMR:   Q6MD00
- STRING:   Q6MD00
- GeneID:   2780433
- GenomeReviews:   BX908798_GR
- KEGG:   pcu:pc0825
- NMPDR:   fig|264201.1.peg.825
- eggNOG:   COG1212
- HOGENOM:   HBG637773
- OMA:   NTRQDAL
- PhylomeDB:   Q6MD00
- ProtClustDB:   PRK05450
- BioCyc:   CPRO264201:PC0825-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00057
- InterPro:   IPR003329
- InterPro:   IPR004528
- TIGRFAMs:   TIGR00466

Pfam domain/function: PF02348 CTP_transf_3

EC number: =2.7.7.38

Molecular weight: Translated: 29003; Mature: 29003

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHAEMTGQIIGIIPARYGSTRFPGKPLASILGKTLLQRTYENSLRASALSDLIVATDDE
CCCCHHCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCHH
RIFEHVRSFNGKVVMTSEQCPTGTDRLAEVLSLYPEWMHATAIVNIQGDEPCLNPLTINL
HHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHCHHHHEEEEEEEECCCCCCCCCEEEEE
AVQALVNDPQGQVSTIVTPLLDEEEAKNSSIVKCVMDQQGNALYFSRALIPSNKTNSFKN
EEEEECCCCCCCHHHHHHHHCCCCCCCCCCEEEEEECCCCCEEEEEEEECCCCCCCCCCC
GAIYFRHLGLYVYRPSFIINYQKLPSTPLQLEEDLEQLKVLEHGYRIKVAIVDQANIGVD
CEEEEEEECEEEECCEEEEEHHHCCCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCC
TPEDIHKVEEWLCKQNTFL
CHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKHAEMTGQIIGIIPARYGSTRFPGKPLASILGKTLLQRTYENSLRASALSDLIVATDDE
CCCCHHCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCHH
RIFEHVRSFNGKVVMTSEQCPTGTDRLAEVLSLYPEWMHATAIVNIQGDEPCLNPLTINL
HHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHCHHHHEEEEEEEECCCCCCCCCEEEEE
AVQALVNDPQGQVSTIVTPLLDEEEAKNSSIVKCVMDQQGNALYFSRALIPSNKTNSFKN
EEEEECCCCCCCHHHHHHHHCCCCCCCCCCEEEEEECCCCCEEEEEEEECCCCCCCCCCC
GAIYFRHLGLYVYRPSFIINYQKLPSTPLQLEEDLEQLKVLEHGYRIKVAIVDQANIGVD
CEEEEEEECEEEECCEEEEEHHHCCCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCC
TPEDIHKVEEWLCKQNTFL
CHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA