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The map label for this gene is clpB

Identifier: 46446362

GI number: 46446362

Start: 883222

End: 885828

Strand: Reverse

Name: clpB

Synonym: pc0728

Alternate gene names: 46446362

Gene position: 885828-883222 (Counterclockwise)

Preceding gene: 46446363

Following gene: 46446357

Centisome position: 36.69

GC content: 39.82

Gene sequence:

>2607_bases
ATGAATCAAAATTTCACAGATCATGTTGCGGAAGCTATTCAAGCCGCTTTTGCAGAAGCACAACGTTTAAATCACACAGA
AGTTACTGAAAATCACCTGCTATGGGCTTTTCTCAAAGATAAAGAAGGATATTTTTACTCGCTTTTAAATGGGCTGGGGA
CAAATCCGCAAAAATTATTTCAAGAGACTGAAAACAATATTCACCATTTACCAACTTACTCGGGTGGAGGGCAAGCCCCA
AATCCTTCCAGAAGCCTACAAAGTCGCATTGTCGATGCTCAAAATATCGCTCAAAGCTGGAAAGATACTTATACGAGCAG
CGATCATTTTTTAATCTCTTATTGGAAAAATGGTGGAGATCCTTTTGCTTCTTGGAAAAAGAAAACTACTATCTCTTTAG
AAAAGCTGGAAGAACAAATAAAAAAAATTCGAGGTGATCGTCATATGGACTCTCCTAGCTCCGAATCAAATTTACAAGCT
CTAGAAAAATATTGCAAAAATCTCACAGATCTGGCTCGTCAAGGTAAGCTCGACCCTGTGATTGGAAGAGATGAAGAAAT
TAGACGAACCATGCAAGTTTTGTGTAGACGAACCAAAAATAATCCTATGCTTATTGGAGATCCGGGAGTTGGTAAAACAG
CGATTGCTGAAGGATTAGCTCAACGCATAGTCCAGCAAGATATTCCCGATTCTTTAAAAAATAAACAGCTACTTGCGTTG
GATATGGGAAGTTTAATTGCCGGTACAAAGTACCGAGGAGAATTTGAAGAAAGGCTGAAAGGTATTTTACAAGACATTGA
GAAAAGCGAAGGGCAGATCATCCTTTTTATTGATGAAGTGCATACTTTAATTGGAGCTGGCGCGACAGATGGAGCGATGG
ATGCCGCCAATTTATTGAAACCCGCACTTGCGAGAGGTATTTTACATTGCATCGGAGCGACTACCCTTAACGAATATCAA
AAATACATTGAAAAGGATGCTGCTCTTGAAAGACGCTTTCAACTTGTCTTAGTTAATGAACCAACTATAGAAGACTCGAT
TGCAATTTTGAGAGGTTTAAGAGAAAGATATGAAATTTACCATGGGGTGCATATCACAGAGTCTGCGATCCACGCTGCCG
TGTTATTGTCTTCTCGCTACATTACAGATCGTCGTCTGCCCGACAAAGCAATCGATTTGATCGACGAATCAGCTAGCTTA
ATTCGTATGCAACTCGGAAGCCGCCCTCTTCCCATCGACAATAAAGAACGAGAGCTGGCGGGCCTAATTGTGGAACAAGA
AGCGATGAAACGAGAAAGCACTCCCCTAGCTAAAAATGAAGTAGAAAAATTAGAAGGGCGCATTGCTCAAATCAAGGAAG
AACTGAAAATTTTACGTGAGCAATGGGATCAAGAGAAAAAAATTATCGAATCTTTAAAAGAGAAAAAAGACAAACTTGAG
AAATTGCGTTTTGAAGAAGAAGCTGCAGAACGTAAAGCCGACTATAACCGTGTAGCAGAGCTGCGCTACAATTTGATCCC
TCAACTACAAAAAGAGATTGAAGAGGCACAGACTCAGCTTAATAACAAACCTAATAGACTTTTGCAGGAAGAAGTAGACG
AGTCCCTCATTGCTCAAATCGTTTCTAAATGGACGGGTATCCCCGTTCATAAAATGTTAGAGGGTGAAGCTGAGCGTCTC
TTACATCTTGAAAACGAACTTGAAAAAAGAGTTGTTGGTCAAGAAATAGCTGTTTCAGCTGTGAGTGAAGCAATTCGTCG
TTCAAGGTCTGGACTAAGTGATCCTAATCGGCCAATGGGTGTTTTTCTTTTCCTGGGTCCGACAGGCGTTGGCAAAACAG
AGCTTGCTAAAGCGTTAGCTTTTCAATTGTTTAACCAAGATGAAGCATTGATTCGGCTAGACATGTCTGAATACATGGAA
AAACACACGGTTTCTAAATTGATTGGCTCCCCTCCCGGGTATATTGGGTATGAGGAAGGAGGGCAATTAACAGAGGCGCT
GCGAAGAAGGCCTTATGCCGTTGTTCTGTTTGATGAGATTGAAAAAGCTCACCCTGATGTATTTAATATTTTACTTCAGG
TGTTCGATGATGGACGCTTAACAGATAGTAAAGGGCGTGTAGTCAATTGTAAAAATGCCCTCTTCATCATGACATCAAAT
ATTGGATCTGACCTCTTATTAGAAAAGATGGAGCAAAACAAACAAGGCCTTGCTAAAGACGAAATTATGTTGGTCTTAGA
TCCTGTAATCAAAAAACATTTCCGCCCAGAATTTATTAACCGCTTAGACGATATTCTTCCTTTTGTTCCTCTACGTGAAC
ATGATATGGAAAAAATTGTCGTCATTCAACTGAATTTACTTGCTAAGCGTTTAAAAGATCGAGATGTCGAATTAATGTGG
ACACCTCAAGCATTGGCACACTTAGCCAAAGAAGGATATGATCCTCATTTTGGAGCACGTCCATTAAAAAGGTATATTCA
GCAAGAAGTTATTAATCAGTTATCGACTGCAATCTTGGAAGGTAAAATTCCTCCTCATAGCCATATCAAACTTGAATTGG
AAGGAAACACAATTCGATTTAAATCGTTTGCTGGAGGAAAAAATTAA

Upstream 100 bases:

>100_bases
TAATAGTCAAAGATTAGATGAGCGAGTGATTGTTCGCTTGCTTTAGTTTTTGGACAATGAGATTGCGATCAAACTTTTTT
CTTAATCATTGGAGTGAAAG

Downstream 100 bases:

>100_bases
ATATTTCCCTATTGTCTACAAGCCTCGATTAAGAAGAAGTTTGTAGACAATCTTTTTTTTATTCTAAAATCATGATTTCG
TCTCTAAAGTAAGCGATTAA

Product: endopeptidase Clp ATP-binding chain

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 868; Mature: 868

Protein sequence:

>868_residues
MNQNFTDHVAEAIQAAFAEAQRLNHTEVTENHLLWAFLKDKEGYFYSLLNGLGTNPQKLFQETENNIHHLPTYSGGGQAP
NPSRSLQSRIVDAQNIAQSWKDTYTSSDHFLISYWKNGGDPFASWKKKTTISLEKLEEQIKKIRGDRHMDSPSSESNLQA
LEKYCKNLTDLARQGKLDPVIGRDEEIRRTMQVLCRRTKNNPMLIGDPGVGKTAIAEGLAQRIVQQDIPDSLKNKQLLAL
DMGSLIAGTKYRGEFEERLKGILQDIEKSEGQIILFIDEVHTLIGAGATDGAMDAANLLKPALARGILHCIGATTLNEYQ
KYIEKDAALERRFQLVLVNEPTIEDSIAILRGLRERYEIYHGVHITESAIHAAVLLSSRYITDRRLPDKAIDLIDESASL
IRMQLGSRPLPIDNKERELAGLIVEQEAMKRESTPLAKNEVEKLEGRIAQIKEELKILREQWDQEKKIIESLKEKKDKLE
KLRFEEEAAERKADYNRVAELRYNLIPQLQKEIEEAQTQLNNKPNRLLQEEVDESLIAQIVSKWTGIPVHKMLEGEAERL
LHLENELEKRVVGQEIAVSAVSEAIRRSRSGLSDPNRPMGVFLFLGPTGVGKTELAKALAFQLFNQDEALIRLDMSEYME
KHTVSKLIGSPPGYIGYEEGGQLTEALRRRPYAVVLFDEIEKAHPDVFNILLQVFDDGRLTDSKGRVVNCKNALFIMTSN
IGSDLLLEKMEQNKQGLAKDEIMLVLDPVIKKHFRPEFINRLDDILPFVPLREHDMEKIVVIQLNLLAKRLKDRDVELMW
TPQALAHLAKEGYDPHFGARPLKRYIQQEVINQLSTAILEGKIPPHSHIKLELEGNTIRFKSFAGGKN

Sequences:

>Translated_868_residues
MNQNFTDHVAEAIQAAFAEAQRLNHTEVTENHLLWAFLKDKEGYFYSLLNGLGTNPQKLFQETENNIHHLPTYSGGGQAP
NPSRSLQSRIVDAQNIAQSWKDTYTSSDHFLISYWKNGGDPFASWKKKTTISLEKLEEQIKKIRGDRHMDSPSSESNLQA
LEKYCKNLTDLARQGKLDPVIGRDEEIRRTMQVLCRRTKNNPMLIGDPGVGKTAIAEGLAQRIVQQDIPDSLKNKQLLAL
DMGSLIAGTKYRGEFEERLKGILQDIEKSEGQIILFIDEVHTLIGAGATDGAMDAANLLKPALARGILHCIGATTLNEYQ
KYIEKDAALERRFQLVLVNEPTIEDSIAILRGLRERYEIYHGVHITESAIHAAVLLSSRYITDRRLPDKAIDLIDESASL
IRMQLGSRPLPIDNKERELAGLIVEQEAMKRESTPLAKNEVEKLEGRIAQIKEELKILREQWDQEKKIIESLKEKKDKLE
KLRFEEEAAERKADYNRVAELRYNLIPQLQKEIEEAQTQLNNKPNRLLQEEVDESLIAQIVSKWTGIPVHKMLEGEAERL
LHLENELEKRVVGQEIAVSAVSEAIRRSRSGLSDPNRPMGVFLFLGPTGVGKTELAKALAFQLFNQDEALIRLDMSEYME
KHTVSKLIGSPPGYIGYEEGGQLTEALRRRPYAVVLFDEIEKAHPDVFNILLQVFDDGRLTDSKGRVVNCKNALFIMTSN
IGSDLLLEKMEQNKQGLAKDEIMLVLDPVIKKHFRPEFINRLDDILPFVPLREHDMEKIVVIQLNLLAKRLKDRDVELMW
TPQALAHLAKEGYDPHFGARPLKRYIQQEVINQLSTAILEGKIPPHSHIKLELEGNTIRFKSFAGGKN
>Mature_868_residues
MNQNFTDHVAEAIQAAFAEAQRLNHTEVTENHLLWAFLKDKEGYFYSLLNGLGTNPQKLFQETENNIHHLPTYSGGGQAP
NPSRSLQSRIVDAQNIAQSWKDTYTSSDHFLISYWKNGGDPFASWKKKTTISLEKLEEQIKKIRGDRHMDSPSSESNLQA
LEKYCKNLTDLARQGKLDPVIGRDEEIRRTMQVLCRRTKNNPMLIGDPGVGKTAIAEGLAQRIVQQDIPDSLKNKQLLAL
DMGSLIAGTKYRGEFEERLKGILQDIEKSEGQIILFIDEVHTLIGAGATDGAMDAANLLKPALARGILHCIGATTLNEYQ
KYIEKDAALERRFQLVLVNEPTIEDSIAILRGLRERYEIYHGVHITESAIHAAVLLSSRYITDRRLPDKAIDLIDESASL
IRMQLGSRPLPIDNKERELAGLIVEQEAMKRESTPLAKNEVEKLEGRIAQIKEELKILREQWDQEKKIIESLKEKKDKLE
KLRFEEEAAERKADYNRVAELRYNLIPQLQKEIEEAQTQLNNKPNRLLQEEVDESLIAQIVSKWTGIPVHKMLEGEAERL
LHLENELEKRVVGQEIAVSAVSEAIRRSRSGLSDPNRPMGVFLFLGPTGVGKTELAKALAFQLFNQDEALIRLDMSEYME
KHTVSKLIGSPPGYIGYEEGGQLTEALRRRPYAVVLFDEIEKAHPDVFNILLQVFDDGRLTDSKGRVVNCKNALFIMTSN
IGSDLLLEKMEQNKQGLAKDEIMLVLDPVIKKHFRPEFINRLDDILPFVPLREHDMEKIVVIQLNLLAKRLKDRDVELMW
TPQALAHLAKEGYDPHFGARPLKRYIQQEVINQLSTAILEGKIPPHSHIKLELEGNTIRFKSFAGGKN

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family

Homologues:

Organism=Homo sapiens, GI13540606, Length=318, Percent_Identity=43.0817610062893, Blast_Score=262, Evalue=1e-69,
Organism=Escherichia coli, GI1788943, Length=856, Percent_Identity=52.2196261682243, Blast_Score=874, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=493, Percent_Identity=37.9310344827586, Blast_Score=282, Evalue=7e-77,
Organism=Saccharomyces cerevisiae, GI6320464, Length=696, Percent_Identity=51.7241379310345, Blast_Score=719, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323002, Length=870, Percent_Identity=41.8390804597701, Blast_Score=665, Evalue=0.0,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): CLPB_PARUW (Q6MD97)

Other databases:

- EMBL:   BX908798
- RefSeq:   YP_007727.1
- ProteinModelPortal:   Q6MD97
- STRING:   Q6MD97
- GeneID:   2780281
- GenomeReviews:   BX908798_GR
- KEGG:   pcu:pc0728
- NMPDR:   fig|264201.1.peg.728
- eggNOG:   COG0542
- HOGENOM:   HBG413133
- OMA:   HITESAI
- PhylomeDB:   Q6MD97
- ProtClustDB:   CLSK871192
- BioCyc:   CPRO264201:PC0728-MONOMER
- GO:   GO:0005737
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150
- Gene3D:   G3DSA:1.10.1780.10
- PRINTS:   PR00300
- SMART:   SM00382

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small

EC number: NA

Molecular weight: Translated: 98547; Mature: 98547

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS00870 CLPAB_1; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQNFTDHVAEAIQAAFAEAQRLNHTEVTENHLLWAFLKDKEGYFYSLLNGLGTNPQKLF
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCHHHHHHHHCCCCHHHHH
QETENNIHHLPTYSGGGQAPNPSRSLQSRIVDAQNIAQSWKDTYTSSDHFLISYWKNGGD
HHHHCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCC
PFASWKKKTTISLEKLEEQIKKIRGDRHMDSPSSESNLQALEKYCKNLTDLARQGKLDPV
CHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
IGRDEEIRRTMQVLCRRTKNNPMLIGDPGVGKTAIAEGLAQRIVQQDIPDSLKNKQLLAL
CCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCHHHCCCEEEEE
DMGSLIAGTKYRGEFEERLKGILQDIEKSEGQIILFIDEVHTLIGAGATDGAMDAANLLK
EHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHCCCCCCCHHHHHHHHH
PALARGILHCIGATTLNEYQKYIEKDAALERRFQLVLVNEPTIEDSIAILRGLRERYEIY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHHHHH
HGVHITESAIHAAVLLSSRYITDRRLPDKAIDLIDESASLIRMQLGSRPLPIDNKERELA
CCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
GLIVEQEAMKRESTPLAKNEVEKLEGRIAQIKEELKILREQWDQEKKIIESLKEKKDKLE
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLRFEEEAAERKADYNRVAELRYNLIPQLQKEIEEAQTQLNNKPNRLLQEEVDESLIAQI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
VSKWTGIPVHKMLEGEAERLLHLENELEKRVVGQEIAVSAVSEAIRRSRSGLSDPNRPMG
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCE
VFLFLGPTGVGKTELAKALAFQLFNQDEALIRLDMSEYMEKHTVSKLIGSPPGYIGYEEG
EEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCCCCC
GQLTEALRRRPYAVVLFDEIEKAHPDVFNILLQVFDDGRLTDSKGRVVNCKNALFIMTSN
CHHHHHHHHCCCEEEEEHHHHHHCCHHHHHHHHHHCCCCEECCCCCEEEECCEEEEEECC
IGSDLLLEKMEQNKQGLAKDEIMLVLDPVIKKHFRPEFINRLDDILPFVPLREHDMEKIV
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCEEE
VIQLNLLAKRLKDRDVELMWTPQALAHLAKEGYDPHFGARPLKRYIQQEVINQLSTAILE
EEHHHHHHHHHCCCCCEEEECHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
GKIPPHSHIKLELEGNTIRFKSFAGGKN
CCCCCCCCEEEEECCCEEEEECCCCCCC
>Mature Secondary Structure
MNQNFTDHVAEAIQAAFAEAQRLNHTEVTENHLLWAFLKDKEGYFYSLLNGLGTNPQKLF
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCHHHHHHHHCCCCHHHHH
QETENNIHHLPTYSGGGQAPNPSRSLQSRIVDAQNIAQSWKDTYTSSDHFLISYWKNGGD
HHHHCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCC
PFASWKKKTTISLEKLEEQIKKIRGDRHMDSPSSESNLQALEKYCKNLTDLARQGKLDPV
CHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
IGRDEEIRRTMQVLCRRTKNNPMLIGDPGVGKTAIAEGLAQRIVQQDIPDSLKNKQLLAL
CCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCHHHCCCEEEEE
DMGSLIAGTKYRGEFEERLKGILQDIEKSEGQIILFIDEVHTLIGAGATDGAMDAANLLK
EHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHCCCCCCCHHHHHHHHH
PALARGILHCIGATTLNEYQKYIEKDAALERRFQLVLVNEPTIEDSIAILRGLRERYEIY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHHHHH
HGVHITESAIHAAVLLSSRYITDRRLPDKAIDLIDESASLIRMQLGSRPLPIDNKERELA
CCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
GLIVEQEAMKRESTPLAKNEVEKLEGRIAQIKEELKILREQWDQEKKIIESLKEKKDKLE
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLRFEEEAAERKADYNRVAELRYNLIPQLQKEIEEAQTQLNNKPNRLLQEEVDESLIAQI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
VSKWTGIPVHKMLEGEAERLLHLENELEKRVVGQEIAVSAVSEAIRRSRSGLSDPNRPMG
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCE
VFLFLGPTGVGKTELAKALAFQLFNQDEALIRLDMSEYMEKHTVSKLIGSPPGYIGYEEG
EEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCCCCC
GQLTEALRRRPYAVVLFDEIEKAHPDVFNILLQVFDDGRLTDSKGRVVNCKNALFIMTSN
CHHHHHHHHCCCEEEEEHHHHHHCCHHHHHHHHHHCCCCEECCCCCEEEECCEEEEEECC
IGSDLLLEKMEQNKQGLAKDEIMLVLDPVIKKHFRPEFINRLDDILPFVPLREHDMEKIV
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCEEE
VIQLNLLAKRLKDRDVELMWTPQALAHLAKEGYDPHFGARPLKRYIQQEVINQLSTAILE
EEHHHHHHHHHCCCCCEEEECHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
GKIPPHSHIKLELEGNTIRFKSFAGGKN
CCCCCCCCEEEEECCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA