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The map label for this gene is lpxC [H]

Identifier: 46446035

GI number: 46446035

Start: 539098

End: 539976

Strand: Direct

Name: lpxC [H]

Synonym: pc0401

Alternate gene names: 46446035

Gene position: 539098-539976 (Clockwise)

Preceding gene: 46446034

Following gene: 46446036

Centisome position: 22.33

GC content: 36.75

Gene sequence:

>879_bases
GTGACCGTCAATCCAGCATTGGAAACAATTGTTCGCAAGCAACGTACATTAAAAGATGTTGCCGTTTTTTCTGGTATTGG
TATTCATACTGGAAAAGAAGTGGGACTTCGATTTTGTCCTGCTAAAGAAGGTACAGGAATTGTTTTTAAGCGTATTGATT
TGGTTGGACAACCGATTATTCCAGCGACTATTGAGTATGTTCAAGATACTGCGCGCAGCACGACAATTGGAATTAATGAT
GTTCGTATTCACACAGTTGAACATGTCCTTTCTGCGGTAAAAGCTTATCAAATTGATAATTTATGTATTGAAATTACAAG
TATAGAACCTCCAGTTGGAAACGGTAGTTCCGACGTTTTTGTAGAAATGATTGAAAAAGTAGGGATAAGAACACAAGAAC
AAGCGATACCCGTTGTAAAGCTCAAACACCCTGTATATTTATCTGAAGGTGATATTCATTTAGTGGCTTTACCCTTCGAT
GGTTATCGTATTAGCTACACTTTGAGTTATCCAGGATCCTCCTTTTTGCGCGGTCAATTTCATTCTGTTATAGTAAATGA
AGAAAATTTTAAAAAAGAGATTGCTCCTTGTCGCACTTTTTCCCTTTATAAAGAAATATCTGCTTTGATGGATAGAGGGT
TAATTAAAGGAGGAAGTTTGGATAATGCTGTTGTAATTAAAGACGAAGTGATCTTGAGTAAAGGTGGGCTCTTTTTTCCA
GATGAAATGGCACGACATAAAATTTTGGACCTGATCGGCGATCTTTCTTTAGTGGGATATGATTTCCATGCTCACATCAT
TGCGATTCGATCGGGACATTTGACAAACTTTCTTTTTGCTAAAGAATTATTAAAACATATCACTATGGAGAGTCATTGA

Upstream 100 bases:

>100_bases
TTAATAGAAAAATTTGATGAGTGCCATGATTACTTCCTTGCTTTAAAACCGATTTATAATTAACATACTCAACTTCTTAC
AAATAACTAAAGGTTGATGC

Downstream 100 bases:

>100_bases
TGGTTAATCTTTCAGATAACCCACAGGCATTGGATATCAATCAAATCATCAATATTTTACCCCACCGTTATCCTTTTCTG
CTTGTCGATCGTGTCTTAGA

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:

>292_residues
MTVNPALETIVRKQRTLKDVAVFSGIGIHTGKEVGLRFCPAKEGTGIVFKRIDLVGQPIIPATIEYVQDTARSTTIGIND
VRIHTVEHVLSAVKAYQIDNLCIEITSIEPPVGNGSSDVFVEMIEKVGIRTQEQAIPVVKLKHPVYLSEGDIHLVALPFD
GYRISYTLSYPGSSFLRGQFHSVIVNEENFKKEIAPCRTFSLYKEISALMDRGLIKGGSLDNAVVIKDEVILSKGGLFFP
DEMARHKILDLIGDLSLVGYDFHAHIIAIRSGHLTNFLFAKELLKHITMESH

Sequences:

>Translated_292_residues
MTVNPALETIVRKQRTLKDVAVFSGIGIHTGKEVGLRFCPAKEGTGIVFKRIDLVGQPIIPATIEYVQDTARSTTIGIND
VRIHTVEHVLSAVKAYQIDNLCIEITSIEPPVGNGSSDVFVEMIEKVGIRTQEQAIPVVKLKHPVYLSEGDIHLVALPFD
GYRISYTLSYPGSSFLRGQFHSVIVNEENFKKEIAPCRTFSLYKEISALMDRGLIKGGSLDNAVVIKDEVILSKGGLFFP
DEMARHKILDLIGDLSLVGYDFHAHIIAIRSGHLTNFLFAKELLKHITMESH
>Mature_291_residues
TVNPALETIVRKQRTLKDVAVFSGIGIHTGKEVGLRFCPAKEGTGIVFKRIDLVGQPIIPATIEYVQDTARSTTIGINDV
RIHTVEHVLSAVKAYQIDNLCIEITSIEPPVGNGSSDVFVEMIEKVGIRTQEQAIPVVKLKHPVYLSEGDIHLVALPFDG
YRISYTLSYPGSSFLRGQFHSVIVNEENFKKEIAPCRTFSLYKEISALMDRGLIKGGSLDNAVVIKDEVILSKGGLFFPD
EMARHKILDLIGDLSLVGYDFHAHIIAIRSGHLTNFLFAKELLKHITMESH

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=281, Percent_Identity=36.2989323843416, Blast_Score=177, Evalue=1e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.-

Molecular weight: Translated: 32350; Mature: 32219

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVNPALETIVRKQRTLKDVAVFSGIGIHTGKEVGLRFCPAKEGTGIVFKRIDLVGQPII
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCEEECCCCCCCCEEEEEHHHCCCCCC
PATIEYVQDTARSTTIGINDVRIHTVEHVLSAVKAYQIDNLCIEITSIEPPVGNGSSDVF
HHHHHHHHHHCCCEEECCCCEEHHHHHHHHHHHHHHEECCEEEEEEECCCCCCCCCHHHH
VEMIEKVGIRTQEQAIPVVKLKHPVYLSEGDIHLVALPFDGYRISYTLSYPGSSFLRGQF
HHHHHHHCCCCHHHCCCEEEECCCEEEECCCEEEEEEECCCEEEEEEEECCCCHHHCCCE
HSVIVNEENFKKEIAPCRTFSLYKEISALMDRGLIKGGSLDNAVVIKDEVILSKGGLFFP
EEEEECCHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEECCCCCCC
DEMARHKILDLIGDLSLVGYDFHAHIIAIRSGHLTNFLFAKELLKHITMESH
HHHHHHHHHHHHCCHHHEEEEEEEEEEEEECCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TVNPALETIVRKQRTLKDVAVFSGIGIHTGKEVGLRFCPAKEGTGIVFKRIDLVGQPII
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCEEECCCCCCCCEEEEEHHHCCCCCC
PATIEYVQDTARSTTIGINDVRIHTVEHVLSAVKAYQIDNLCIEITSIEPPVGNGSSDVF
HHHHHHHHHHCCCEEECCCCEEHHHHHHHHHHHHHHEECCEEEEEEECCCCCCCCCHHHH
VEMIEKVGIRTQEQAIPVVKLKHPVYLSEGDIHLVALPFDGYRISYTLSYPGSSFLRGQF
HHHHHHHCCCCHHHCCCEEEECCCEEEECCCEEEEEEECCCEEEEEEEECCCCHHHCCCE
HSVIVNEENFKKEIAPCRTFSLYKEISALMDRGLIKGGSLDNAVVIKDEVILSKGGLFFP
EEEEECCHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEECCCCCCC
DEMARHKILDLIGDLSLVGYDFHAHIIAIRSGHLTNFLFAKELLKHITMESH
HHHHHHHHHHHHCCHHHEEEEEEEEEEEEECCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]