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The map label for this gene is gcvP1

Identifier: 46445917

GI number: 46445917

Start: 394064

End: 395404

Strand: Direct

Name: gcvP1

Synonym: pc0283

Alternate gene names: 46445917

Gene position: 394064-395404 (Clockwise)

Preceding gene: 46445916

Following gene: 46445918

Centisome position: 16.32

GC content: 34.45

Gene sequence:

>1341_bases
ATGGATTTTATTTCAAATAAAACTCCTCAAATTGAAGCCATGTTAACTGAAATTGGGATTCAAAATGTTGAAGAATTATT
TAAATCAATTCCTTCTTCGTTGATTTTGCAAGCTCCTAGCGTAGATGACGGGCTTTCTGAATATGAGGGAATTCAATTAA
TAGAGTCATTAGCGGTACGTAATACTTTTCCTAATTTAGTCAGTTATTTAGGAGCCGGAGCCTATGAACATCATATTCCA
GCCTTAGTGGGAGCTGTCTGTAGTAAATCTGAATTTTTAACTGCTTATACTCCTTATCAGGCCGAAGCTTCTCAAGGAAT
GCTCCAAATTATTTTTGAATTTCAATCTGCTATATGTGCATTGACGGGAATGGATGTTGCCAATGCATCTGTTTATGATG
GAGCTTCTGCTTGTGCTGAAGCAATTTTAATGTCTCTTAGACATCATAAAACAAGGAGACAAATTCTCCTTTCTGACAGT
TTACATCCCCACTATAAAAAAGTTATTGAACAATACCTCAAAAGTCAAGATTGTGAATTAATTACTGTTCCTTTTCTACA
AGAAGGAACTTTAGATGCCTCTTTTTTAAAAATGTATTTAAATGATCAAACAGCTGCGATTCTTTTACAATCCCCCAATT
TTTTTGGTTGCATAGAAGATGTTCAACCTATTACTGAAATGGCTAAATCTCAAGGAGCCTTAACAATTCTTTGTGCAAAT
CCTATTTCTTATGGACTGTTGTCTTCAGCTAAAGAATTAGGTGTAGATATTGCTGTAGGTGATTGTCAACCATTTGGACT
TTCTCTTTCTTTTGGAGGACCTTATGCAGGCTATATGGCTTGTAAACAAGAGTTAATGAGACAATTGCCAGGCAGGATTG
TTGGGGAAACATTAGATGTTCAAGGGAGTCGTGGTTTTGTTTTAACACTCCAAGCACGAGAACAGCACATTAGAAGAGAA
AAAGCGACTTCCAATATTTGTACTAATCAAGCTTTAGCAGCTTTAGCTAGTTTAGTGGCAATGCTCTGGTATGGCAAAGA
GGGTGTGAAAGAATTAGCATTAACGAATTATCAAAGAGCAAATTATTTGAAATTTCACTTAGGTAAAATTTCTACAATTA
ATGTTTGGAATCAAGGAGCTTCATTTAATGAGTTTGTTGTTGATTTTAAGCAAGATTCTAATCAAGTTTTAGAGTTTTTT
CGGTTAAATGGAATTGAACCTGGGATCGAACTAAAACGATATTATCCTTCTTTAAAAACATGCTTACTGATTGCTGTAAC
GGAAACGAAAAATCAGATTCAATTGGATCAATTCATTAAAGTTTGTAAAGAACTCTTTTAA

Upstream 100 bases:

>100_bases
AAAAGAAGGATGGTTATTTAAACTTCGTTTATCTAATTCCTCAGAATTAGACTTATTAATGGATGAAAAGGATTATCGTG
CGATGTTAAACGGAGCATAA

Downstream 100 bases:

>100_bases
AATCTCATTTTGTGAAAACGTTATGACAAAAACCATTTTTGAAAAATCACAATTTAAACAAAAGGCTTACAGTCTTCCTT
ATTCTTGGGAAAATTTAAAA

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MDFISNKTPQIEAMLTEIGIQNVEELFKSIPSSLILQAPSVDDGLSEYEGIQLIESLAVRNTFPNLVSYLGAGAYEHHIP
ALVGAVCSKSEFLTAYTPYQAEASQGMLQIIFEFQSAICALTGMDVANASVYDGASACAEAILMSLRHHKTRRQILLSDS
LHPHYKKVIEQYLKSQDCELITVPFLQEGTLDASFLKMYLNDQTAAILLQSPNFFGCIEDVQPITEMAKSQGALTILCAN
PISYGLLSSAKELGVDIAVGDCQPFGLSLSFGGPYAGYMACKQELMRQLPGRIVGETLDVQGSRGFVLTLQAREQHIRRE
KATSNICTNQALAALASLVAMLWYGKEGVKELALTNYQRANYLKFHLGKISTINVWNQGASFNEFVVDFKQDSNQVLEFF
RLNGIEPGIELKRYYPSLKTCLLIAVTETKNQIQLDQFIKVCKELF

Sequences:

>Translated_446_residues
MDFISNKTPQIEAMLTEIGIQNVEELFKSIPSSLILQAPSVDDGLSEYEGIQLIESLAVRNTFPNLVSYLGAGAYEHHIP
ALVGAVCSKSEFLTAYTPYQAEASQGMLQIIFEFQSAICALTGMDVANASVYDGASACAEAILMSLRHHKTRRQILLSDS
LHPHYKKVIEQYLKSQDCELITVPFLQEGTLDASFLKMYLNDQTAAILLQSPNFFGCIEDVQPITEMAKSQGALTILCAN
PISYGLLSSAKELGVDIAVGDCQPFGLSLSFGGPYAGYMACKQELMRQLPGRIVGETLDVQGSRGFVLTLQAREQHIRRE
KATSNICTNQALAALASLVAMLWYGKEGVKELALTNYQRANYLKFHLGKISTINVWNQGASFNEFVVDFKQDSNQVLEFF
RLNGIEPGIELKRYYPSLKTCLLIAVTETKNQIQLDQFIKVCKELF
>Mature_446_residues
MDFISNKTPQIEAMLTEIGIQNVEELFKSIPSSLILQAPSVDDGLSEYEGIQLIESLAVRNTFPNLVSYLGAGAYEHHIP
ALVGAVCSKSEFLTAYTPYQAEASQGMLQIIFEFQSAICALTGMDVANASVYDGASACAEAILMSLRHHKTRRQILLSDS
LHPHYKKVIEQYLKSQDCELITVPFLQEGTLDASFLKMYLNDQTAAILLQSPNFFGCIEDVQPITEMAKSQGALTILCAN
PISYGLLSSAKELGVDIAVGDCQPFGLSLSFGGPYAGYMACKQELMRQLPGRIVGETLDVQGSRGFVLTLQAREQHIRRE
KATSNICTNQALAALASLVAMLWYGKEGVKELALTNYQRANYLKFHLGKISTINVWNQGASFNEFVVDFKQDSNQVLEFF
RLNGIEPGIELKRYYPSLKTCLLIAVTETKNQIQLDQFIKVCKELF

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily

Homologues:

Organism=Homo sapiens, GI108773801, Length=345, Percent_Identity=35.6521739130435, Blast_Score=213, Evalue=4e-55,
Organism=Escherichia coli, GI1789269, Length=356, Percent_Identity=33.7078651685393, Blast_Score=165, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17535605, Length=374, Percent_Identity=36.3636363636364, Blast_Score=203, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6323843, Length=363, Percent_Identity=32.2314049586777, Blast_Score=180, Evalue=5e-46,
Organism=Drosophila melanogaster, GI24645648, Length=353, Percent_Identity=37.9603399433428, Blast_Score=246, Evalue=3e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCSPA_PARUW (Q6MEJ2)

Other databases:

- EMBL:   BX908798
- RefSeq:   YP_007282.1
- HSSP:   Q5SKW8
- ProteinModelPortal:   Q6MEJ2
- SMR:   Q6MEJ2
- STRING:   Q6MEJ2
- GeneID:   2780941
- GenomeReviews:   BX908798_GR
- KEGG:   pcu:pc0283
- NMPDR:   fig|264201.1.peg.283
- eggNOG:   COG0403
- HOGENOM:   HBG288345
- OMA:   VTEKRTK
- ProtClustDB:   PRK00451
- BioCyc:   CPRO264201:PC0283-MONOMER
- HAMAP:   MF_00712
- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421
- Gene3D:   G3DSA:3.40.640.10
- PANTHER:   PTHR11773

Pfam domain/function: PF02347 GDC-P; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =1.4.4.2

Molecular weight: Translated: 49350; Mature: 49350

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFISNKTPQIEAMLTEIGIQNVEELFKSIPSSLILQAPSVDDGLSEYEGIQLIESLAVR
CCCCCCCCCHHHHHHHHHCHHHHHHHHHHCCHHHEEECCCCCCCHHHHHHHHHHHHHHHH
NTFPNLVSYLGAGAYEHHIPALVGAVCSKSEFLTAYTPYQAEASQGMLQIIFEFQSAICA
CCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHH
LTGMDVANASVYDGASACAEAILMSLRHHKTRRQILLSDSLHPHYKKVIEQYLKSQDCEL
HHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCE
ITVPFLQEGTLDASFLKMYLNDQTAAILLQSPNFFGCIEDVQPITEMAKSQGALTILCAN
EEECCCCCCCCCHHHHHHHHCCCEEEEEEECCCCCEEHHHHHHHHHHHHCCCCEEEEECC
PISYGLLSSAKELGVDIAVGDCQPFGLSLSFGGPYAGYMACKQELMRQLPGRIVGETLDV
CHHHHHHHHHHHCCCEEEECCCCCCCEEEECCCCHHHHHHHHHHHHHHCCHHHHCCCEEC
QGSRGFVLTLQAREQHIRREKATSNICTNQALAALASLVAMLWYGKEGVKELALTNYQRA
CCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCC
NYLKFHLGKISTINVWNQGASFNEFVVDFKQDSNQVLEFFRLNGIEPGIELKRYYPSLKT
CEEEEECCCEEEEEEECCCCCCCHHHEEHHCCHHHHHHHHHHCCCCCCHHHHHHCCCHHH
CLLIAVTETKNQIQLDQFIKVCKELF
EEEEEEECCCCCCCHHHHHHHHHHHC
>Mature Secondary Structure
MDFISNKTPQIEAMLTEIGIQNVEELFKSIPSSLILQAPSVDDGLSEYEGIQLIESLAVR
CCCCCCCCCHHHHHHHHHCHHHHHHHHHHCCHHHEEECCCCCCCHHHHHHHHHHHHHHHH
NTFPNLVSYLGAGAYEHHIPALVGAVCSKSEFLTAYTPYQAEASQGMLQIIFEFQSAICA
CCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHH
LTGMDVANASVYDGASACAEAILMSLRHHKTRRQILLSDSLHPHYKKVIEQYLKSQDCEL
HHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCE
ITVPFLQEGTLDASFLKMYLNDQTAAILLQSPNFFGCIEDVQPITEMAKSQGALTILCAN
EEECCCCCCCCCHHHHHHHHCCCEEEEEEECCCCCEEHHHHHHHHHHHHCCCCEEEEECC
PISYGLLSSAKELGVDIAVGDCQPFGLSLSFGGPYAGYMACKQELMRQLPGRIVGETLDV
CHHHHHHHHHHHCCCEEEECCCCCCCEEEECCCCHHHHHHHHHHHHHHCCHHHHCCCEEC
QGSRGFVLTLQAREQHIRREKATSNICTNQALAALASLVAMLWYGKEGVKELALTNYQRA
CCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCC
NYLKFHLGKISTINVWNQGASFNEFVVDFKQDSNQVLEFFRLNGIEPGIELKRYYPSLKT
CEEEEECCCEEEEEEECCCCCCCHHHEEHHCCHHHHHHHHHHCCCCCCHHHHHHCCCHHH
CLLIAVTETKNQIQLDQFIKVCKELF
EEEEEEECCCCCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA