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The map label for this gene is gcvP2 [H]

Identifier: 46445918

GI number: 46445918

Start: 395427

End: 396869

Strand: Direct

Name: gcvP2 [H]

Synonym: pc0284

Alternate gene names: 46445918

Gene position: 395427-396869 (Clockwise)

Preceding gene: 46445917

Following gene: 46445920

Centisome position: 16.38

GC content: 36.8

Gene sequence:

>1443_bases
ATGACAAAAACCATTTTTGAAAAATCACAATTTAAACAAAAGGCTTACAGTCTTCCTTATTCTTGGGAAAATTTAAAAGA
ATTCTCTTTACCTAAGAAGTTTTTAAGACAGACCTCTGTTCCACTGCCTGAAGTTTCTGAGATTGATTTAACTCGTCATT
TTGCAGTTCTTGCTAAACGTAATATGGGAATTGATACAAATTTCTATCCTTTAGGTAGTTGTACGATGAAATTGAATCCT
CGGATCAATGAATGGTGTGCAAATTTGCCTAATTTTACTAGGGTTCATCCATTAGCTCCAGATCATACCGTACAAGGTAA
TTTGCAAATCATTGACGAACTCATTCAAATGTTATGTAAAGTCAGCGGAATGACGGCAGGTTCATTGGTTCCTAATGCAG
GAGCTCAAGGGGAGTTTGCTGGTATTCAAATGATTGCTGCCTACCATCAACATCACGGGGATTTTGAACGAAATGAATTA
CTTATTCCAGATAATGCTCACGGCACAAATCCGGCTACAGCAGCAATGGCGGGATTTAAAACAATTTCTTTAAGAACAAA
TGCTCAAGGGGATGTAGATATTGATCATTTGAAAAGTCTTGTTTCAGACAAAACAGCAGGGCTGATGTTAACAAATCCTA
ATACGCTTGGTTTGTTTAGTTCGGTAATTAAGGAGATAGCTGAAATTGTTCATAAAGTTGGTGGTTTTCTGTATTACGAT
GGGGCCAATCTTAATTCCATTTTAAATGTTGCGCGGCCAGGAGACATGGGATTTGATGTGATGCATATCAATCTTCATAA
GACATTTTCAACTCCTCATGGTGGAGGAGGTCCAGGGTCTGGACCTGTTCTTTGTGGAGATCTTTTAAAACCTTTTCTTC
CTAATCCAAGAGTAGAAAAAGAGAATGATCATTATGTGGTCAAGTGGAAGGATTCGATGAGCATAGGACAAATAGCGTCT
TTTCACGGTAACTTTGCTATTTATTTAAGAGCTTATTTGTATGCCAAATTGCATGGTCATTATGGGTTAAGAAAAATTGC
TGAAGTAGCTGTTCTCAATGCTAATTATTTAAAAAAGAGAATCTCGAAATTATTTAACATTCCATTTGAACAATTTTGCA
TGCATGAATTTGTAGTACAGGCCGATAACTACTTAGGAAAAGGAGTTAGGGCATTAGATATTGCGAAACGTTTATTAGAT
TACGGCGTGCATGCACCAACCGTTTATTTCCCTTTGATTATTAAAGAGTGTATGCTCATTGAACCGACAGAAAGTGAATC
TAAAAACACTCTTGATCAATTCGTTTCAATTTTAGAAAGGATCGTAGCAGAGATTCACCAAGATCCCCAAACTGTAAAAA
ATGCTCCTCATCAACAATCCGTTAGTCGTCTAGATGAAGTGTTAGCAGCAAAAAGGCCTATTTTAAAACACCAAGCTGAT
TGA

Upstream 100 bases:

>100_bases
TTACTGATTGCTGTAACGGAAACGAAAAATCAGATTCAATTGGATCAATTCATTAAAGTTTGTAAAGAACTCTTTTAAAA
TCTCATTTTGTGAAAACGTT

Downstream 100 bases:

>100_bases
TTTATGAGCCTTTGCTTCGCGTTAAATAGAGATATTTGATAAACATGCGGACTAGATAAATGAGAAGTGAAATGGTGGCA
AAAATAAACAATCCTAAATA

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2 [H]

Number of amino acids: Translated: 480; Mature: 479

Protein sequence:

>480_residues
MTKTIFEKSQFKQKAYSLPYSWENLKEFSLPKKFLRQTSVPLPEVSEIDLTRHFAVLAKRNMGIDTNFYPLGSCTMKLNP
RINEWCANLPNFTRVHPLAPDHTVQGNLQIIDELIQMLCKVSGMTAGSLVPNAGAQGEFAGIQMIAAYHQHHGDFERNEL
LIPDNAHGTNPATAAMAGFKTISLRTNAQGDVDIDHLKSLVSDKTAGLMLTNPNTLGLFSSVIKEIAEIVHKVGGFLYYD
GANLNSILNVARPGDMGFDVMHINLHKTFSTPHGGGGPGSGPVLCGDLLKPFLPNPRVEKENDHYVVKWKDSMSIGQIAS
FHGNFAIYLRAYLYAKLHGHYGLRKIAEVAVLNANYLKKRISKLFNIPFEQFCMHEFVVQADNYLGKGVRALDIAKRLLD
YGVHAPTVYFPLIIKECMLIEPTESESKNTLDQFVSILERIVAEIHQDPQTVKNAPHQQSVSRLDEVLAAKRPILKHQAD

Sequences:

>Translated_480_residues
MTKTIFEKSQFKQKAYSLPYSWENLKEFSLPKKFLRQTSVPLPEVSEIDLTRHFAVLAKRNMGIDTNFYPLGSCTMKLNP
RINEWCANLPNFTRVHPLAPDHTVQGNLQIIDELIQMLCKVSGMTAGSLVPNAGAQGEFAGIQMIAAYHQHHGDFERNEL
LIPDNAHGTNPATAAMAGFKTISLRTNAQGDVDIDHLKSLVSDKTAGLMLTNPNTLGLFSSVIKEIAEIVHKVGGFLYYD
GANLNSILNVARPGDMGFDVMHINLHKTFSTPHGGGGPGSGPVLCGDLLKPFLPNPRVEKENDHYVVKWKDSMSIGQIAS
FHGNFAIYLRAYLYAKLHGHYGLRKIAEVAVLNANYLKKRISKLFNIPFEQFCMHEFVVQADNYLGKGVRALDIAKRLLD
YGVHAPTVYFPLIIKECMLIEPTESESKNTLDQFVSILERIVAEIHQDPQTVKNAPHQQSVSRLDEVLAAKRPILKHQAD
>Mature_479_residues
TKTIFEKSQFKQKAYSLPYSWENLKEFSLPKKFLRQTSVPLPEVSEIDLTRHFAVLAKRNMGIDTNFYPLGSCTMKLNPR
INEWCANLPNFTRVHPLAPDHTVQGNLQIIDELIQMLCKVSGMTAGSLVPNAGAQGEFAGIQMIAAYHQHHGDFERNELL
IPDNAHGTNPATAAMAGFKTISLRTNAQGDVDIDHLKSLVSDKTAGLMLTNPNTLGLFSSVIKEIAEIVHKVGGFLYYDG
ANLNSILNVARPGDMGFDVMHINLHKTFSTPHGGGGPGSGPVLCGDLLKPFLPNPRVEKENDHYVVKWKDSMSIGQIASF
HGNFAIYLRAYLYAKLHGHYGLRKIAEVAVLNANYLKKRISKLFNIPFEQFCMHEFVVQADNYLGKGVRALDIAKRLLDY
GVHAPTVYFPLIIKECMLIEPTESESKNTLDQFVSILERIVAEIHQDPQTVKNAPHQQSVSRLDEVLAAKRPILKHQAD

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=431, Percent_Identity=38.7470997679814, Blast_Score=268, Evalue=1e-71,
Organism=Escherichia coli, GI1789269, Length=432, Percent_Identity=37.962962962963, Blast_Score=269, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI17535605, Length=409, Percent_Identity=40.0977995110024, Blast_Score=278, Evalue=4e-75,
Organism=Caenorhabditis elegans, GI32564013, Length=365, Percent_Identity=40.8219178082192, Blast_Score=255, Evalue=4e-68,
Organism=Saccharomyces cerevisiae, GI6323843, Length=474, Percent_Identity=39.873417721519, Blast_Score=302, Evalue=9e-83,
Organism=Drosophila melanogaster, GI24645648, Length=458, Percent_Identity=39.7379912663755, Blast_Score=285, Evalue=4e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 53509; Mature: 53378

Theoretical pI: Translated: 8.17; Mature: 8.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKTIFEKSQFKQKAYSLPYSWENLKEFSLPKKFLRQTSVPLPEVSEIDLTRHFAVLAKR
CCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHC
NMGIDTNFYPLGSCTMKLNPRINEWCANLPNFTRVHPLAPDHTVQGNLQIIDELIQMLCK
CCCCCCCCEECCCEEEEECCCHHHHHCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHH
VSGMTAGSLVPNAGAQGEFAGIQMIAAYHQHHGDFERNELLIPDNAHGTNPATAAMAGFK
HCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCHHHHHHHCCE
TISLRTNAQGDVDIDHLKSLVSDKTAGLMLTNPNTLGLFSSVIKEIAEIVHKVGGFLYYD
EEEEEECCCCCCCHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCEEEEC
GANLNSILNVARPGDMGFDVMHINLHKTFSTPHGGGGPGSGPVLCGDLLKPFLPNPRVEK
CCCHHHHHHHCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCEEEHHHHHHCCCCCCCCC
ENDHYVVKWKDSMSIGQIASFHGNFAIYLRAYLYAKLHGHYGLRKIAEVAVLNANYLKKR
CCCEEEEEECCCCCHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
ISKLFNIPFEQFCMHEFVVQADNYLGKGVRALDIAKRLLDYGVHAPTVYFPLIIKECMLI
HHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEE
EPTESESKNTLDQFVSILERIVAEIHQDPQTVKNAPHQQSVSRLDEVLAAKRPILKHQAD
CCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHCCCHHCCCC
>Mature Secondary Structure 
TKTIFEKSQFKQKAYSLPYSWENLKEFSLPKKFLRQTSVPLPEVSEIDLTRHFAVLAKR
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHC
NMGIDTNFYPLGSCTMKLNPRINEWCANLPNFTRVHPLAPDHTVQGNLQIIDELIQMLCK
CCCCCCCCEECCCEEEEECCCHHHHHCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHH
VSGMTAGSLVPNAGAQGEFAGIQMIAAYHQHHGDFERNELLIPDNAHGTNPATAAMAGFK
HCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCHHHHHHHCCE
TISLRTNAQGDVDIDHLKSLVSDKTAGLMLTNPNTLGLFSSVIKEIAEIVHKVGGFLYYD
EEEEEECCCCCCCHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCEEEEC
GANLNSILNVARPGDMGFDVMHINLHKTFSTPHGGGGPGSGPVLCGDLLKPFLPNPRVEK
CCCHHHHHHHCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCEEEHHHHHHCCCCCCCCC
ENDHYVVKWKDSMSIGQIASFHGNFAIYLRAYLYAKLHGHYGLRKIAEVAVLNANYLKKR
CCCEEEEEECCCCCHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
ISKLFNIPFEQFCMHEFVVQADNYLGKGVRALDIAKRLLDYGVHAPTVYFPLIIKECMLI
HHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEE
EPTESESKNTLDQFVSILERIVAEIHQDPQTVKNAPHQQSVSRLDEVLAAKRPILKHQAD
CCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA