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The map label for this gene is rnc

Identifier: 46445908

GI number: 46445908

Start: 385653

End: 386381

Strand: Reverse

Name: rnc

Synonym: pc0274

Alternate gene names: 46445908

Gene position: 386381-385653 (Counterclockwise)

Preceding gene: 46445911

Following gene: 46445907

Centisome position: 16.0

GC content: 37.59

Gene sequence:

>729_bases
TTGTTGCCTAGAATACTTTACATGAATCCAATTGAACATGTAATTAGACAAGCTCCTGCCATTGAAGCCAAATTAGGCTA
TACTTTTAAAGATCCACAACTCCTCGTGCTTGCATTTGTACATCGTTCATTTATCAATGAAAATCGAGAAGTTAACCAAC
ACAACGAACGTTTGGAGTTTTTAGGAGATTCTGTACTGGGTATGTTAATTTCCGATTATCTTTATTGCAAACTCCCCAAA
ACTCCAGAAGGACAACTTTCTTATTTACGCTCTCGCCTCGTCGAAGCCAGCTCGTGTGTGCATTACATTCAATCCCTAGA
TTTAAGTGGCTATTTACTACTTGGAAAAGGAGAACGCATGAATGATGGAAGAGGTAGAGAATCTATTTTGGCAGATTTAT
TTGAAGCTATCATTGGAGCCATTTACTTGGATGGAGGTCTCCAAGCAGCAAAGGATTTTCTTTTTAAAAACTTCCATCAG
CATATTGAAATAATATTAGCGACCCCTCTACGTAATTGGAAAGCTCTATTACAAGATTATTGCCAAAAAAATTATCAACA
AACCCCTCTATATCAAGTTCTACACGAATCAGGTCCTGATCATAGTAAAGTTTTTCAAATTTCTGTTTGGATTCAAGATA
GAGAATTAGGTAGAGGAAAGGGAACATCCAAAAAAGAAGCTCAGCAAGCTGCCGCTGCTGATGCTCTTTCACGAGTTGAA
CTTCCTTAA

Upstream 100 bases:

>100_bases
AATAGCAAATTTCATAAAATAAAATTATAATAATGAGGTAATATAATGCGTTCAATTATAAGTGACTAACTGAATCGAAT
AAGGCTAGCAGAAAAAAGGA

Downstream 100 bases:

>100_bases
TGTTTTTCTTAAAGGTACGTTTAAATGGCTAAGCAAAAAACTGTCTGGTATTGCTCTGAATGTGGGCACAAACAACTTAA
ATGGTTAGGACAATGTCCTT

Product: putative ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 242; Mature: 242

Protein sequence:

>242_residues
MLPRILYMNPIEHVIRQAPAIEAKLGYTFKDPQLLVLAFVHRSFINENREVNQHNERLEFLGDSVLGMLISDYLYCKLPK
TPEGQLSYLRSRLVEASSCVHYIQSLDLSGYLLLGKGERMNDGRGRESILADLFEAIIGAIYLDGGLQAAKDFLFKNFHQ
HIEIILATPLRNWKALLQDYCQKNYQQTPLYQVLHESGPDHSKVFQISVWIQDRELGRGKGTSKKEAQQAAAADALSRVE
LP

Sequences:

>Translated_242_residues
MLPRILYMNPIEHVIRQAPAIEAKLGYTFKDPQLLVLAFVHRSFINENREVNQHNERLEFLGDSVLGMLISDYLYCKLPK
TPEGQLSYLRSRLVEASSCVHYIQSLDLSGYLLLGKGERMNDGRGRESILADLFEAIIGAIYLDGGLQAAKDFLFKNFHQ
HIEIILATPLRNWKALLQDYCQKNYQQTPLYQVLHESGPDHSKVFQISVWIQDRELGRGKGTSKKEAQQAAAADALSRVE
LP
>Mature_242_residues
MLPRILYMNPIEHVIRQAPAIEAKLGYTFKDPQLLVLAFVHRSFINENREVNQHNERLEFLGDSVLGMLISDYLYCKLPK
TPEGQLSYLRSRLVEASSCVHYIQSLDLSGYLLLGKGERMNDGRGRESILADLFEAIIGAIYLDGGLQAAKDFLFKNFHQ
HIEIILATPLRNWKALLQDYCQKNYQQTPLYQVLHESGPDHSKVFQISVWIQDRELGRGKGTSKKEAQQAAAADALSRVE
LP

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030234, Length=235, Percent_Identity=30.6382978723404, Blast_Score=114, Evalue=7e-26,
Organism=Homo sapiens, GI155030236, Length=235, Percent_Identity=30.6382978723404, Blast_Score=114, Evalue=8e-26,
Organism=Escherichia coli, GI1788920, Length=236, Percent_Identity=37.2881355932203, Blast_Score=126, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI193202651, Length=232, Percent_Identity=30.1724137931034, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17506883, Length=232, Percent_Identity=30.1724137931034, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6323895, Length=116, Percent_Identity=36.2068965517241, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17137682, Length=232, Percent_Identity=31.0344827586207, Blast_Score=103, Evalue=9e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_PARUW (Q6MEK1)

Other databases:

- EMBL:   BX908798
- RefSeq:   YP_007273.1
- ProteinModelPortal:   Q6MEK1
- SMR:   Q6MEK1
- STRING:   Q6MEK1
- GeneID:   2780184
- GenomeReviews:   BX908798_GR
- KEGG:   pcu:pc0274
- NMPDR:   fig|264201.1.peg.274
- eggNOG:   COG0571
- HOGENOM:   HBG744556
- OMA:   ALTHKSF
- PhylomeDB:   Q6MEK1
- ProtClustDB:   CLSK2762116
- BioCyc:   CPRO264201:PC0274-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 27542; Mature: 27542

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPRILYMNPIEHVIRQAPAIEAKLGYTFKDPQLLVLAFVHRSFINENREVNQHNERLEF
CCCCCCEECHHHHHHHHCCCCHHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHH
LGDSVLGMLISDYLYCKLPKTPEGQLSYLRSRLVEASSCVHYIQSLDLSGYLLLGKGERM
HHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCC
NDGRGRESILADLFEAIIGAIYLDGGLQAAKDFLFKNFHQHIEIILATPLRNWKALLQDY
CCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
CQKNYQQTPLYQVLHESGPDHSKVFQISVWIQDRELGRGKGTSKKEAQQAAAADALSRVE
HHCCCCCCHHHHHHHCCCCCCCEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCC
LP
CC
>Mature Secondary Structure
MLPRILYMNPIEHVIRQAPAIEAKLGYTFKDPQLLVLAFVHRSFINENREVNQHNERLEF
CCCCCCEECHHHHHHHHCCCCHHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHH
LGDSVLGMLISDYLYCKLPKTPEGQLSYLRSRLVEASSCVHYIQSLDLSGYLLLGKGERM
HHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCC
NDGRGRESILADLFEAIIGAIYLDGGLQAAKDFLFKNFHQHIEIILATPLRNWKALLQDY
CCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
CQKNYQQTPLYQVLHESGPDHSKVFQISVWIQDRELGRGKGTSKKEAQQAAAADALSRVE
HHCCCCCCHHHHHHHCCCCCCCEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCC
LP
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA