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The map label for this gene is paaJ [C]

Identifier: 45659120

GI number: 45659120

Start: 4048277

End: 4049542

Strand: Direct

Name: paaJ [C]

Synonym: LIC13301

Alternate gene names: 45659120

Gene position: 4048277-4049542 (Clockwise)

Preceding gene: 45659119

Following gene: 45659121

Centisome position: 94.65

GC content: 43.21

Gene sequence:

>1266_bases
ATGAGCGATAAGATTTACGTCCTCGGCGGAGAACAAACCGACTTTCAAAGAAACTGGACCAAAGAAGGTAAAACCTTCAT
GTCCTTAATGCGAGAAGCCGTTCAAGACGGATTAGAAGCTGTCGGAATCACATCCGATGAAATCAAAAAACTGAATAAAC
AAAATCGAATTGGAATTTTCGTTGGTAACTTTGACGCAGAACAATACGCAACTCAAGGCCACTTGGGTGCATTCTTAACC
GAAGTTGATCCCGCATTCTATGGAATTCCAGGTGGTCGTTTTGAAGCAGCCTGCGCTTCTGGTTCCATCGCACTTGACGC
GGCGGCTACAAAAATTCGTGCAAAAGACTACGACGTTGCGATTGTTCTCGGAATCGAGATCATGAAAACAGTAAGTTCTT
CCGTGGGTGGGGACTTTTTAGGAACCGCAGCCTACTATGAAAAAGAAGCAAAAGGAGTTCAATTTCCTTTTCCTAAACTT
TTCGGTAAACTCGCGGATGTAATTCTCGAAAGGTATAAACTTCCAGAACAAAGATTTATGGGAGCGTTAGCCGAAATATC
AAGAATCAACTACGACAACGCAAAAAGAAATCCAAAAGCACAAACTCGTTCTTGGTTTATGAACAAGGAACACGCAAACG
CAAGAGGCGGAGAATACAACATGGCTGTCGGAGGAAGGCTCTGTATTACAGATTGTTCTCAAGTTACCGACGGCGCTGCC
ATGGTAGTTCTCGCTAACAAATCCTACACCGAAGAATACGCTAAAAAAAGAGGAAAGAAGATCAACACAATCCCAAGATT
AAAAGGCTGGGGACACAGAGTAGCTCCGATCACTTTTGAAGCAAAGGTAGCTGAATCCAAAGGAGATAAATTCATTCTAC
CTTGGACTAGACAAACCGTAAAAGACGCTTACGATAGAGCAGAGCTGGGAGTCAAAGACATCGACGTTTTTGAAACTCAC
GATTGTTTTACTTCTTCCGAATACGCTGCTATTTCTGCTTTTGGAATTTCTCAACCTGGTAAAGAACACGAAGCAATCGA
AGAAGGTGTAATTGACTTTAAAGGCAAAAAACCAATCAACCCATCCGGTGGATTGATCGGAGTTGGTCACCCAGTAGGCG
CTTCTGGAGTTCGTATGATGCTTGATCTTTATAAACAAGTAACTGGAACCGCTGGAGATTACCAAGTAGAAGGCGCTAAG
AATGGACTGATGCTGAATATCGGCGGGTCCGCAACGACTAACGTGGTTTTCATCGTAGGAAAATAA

Upstream 100 bases:

>100_bases
TGAAGTATTAGCAAAAGCGAAACCAGGAAAGCCGTTTTACGAGTTGAAAGAAAAGCTGGATGCTCGTTCACTTTTCAAAG
GATAATTTAGGGGGGTCAAC

Downstream 100 bases:

>100_bases
AAATGAGTTTAAAGACTGCGAAAGATTGGAATCAATTTCTTTTAAGATTATTTATCGCTTTCGGCTTTTGGGAAGTGATC
TCTGTACCTCTTCGTAGTCT

Product: acetyl-CoA acetyltransferase

Products: CoA; 3-oxoacyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 421; Mature: 420

Protein sequence:

>421_residues
MSDKIYVLGGEQTDFQRNWTKEGKTFMSLMREAVQDGLEAVGITSDEIKKLNKQNRIGIFVGNFDAEQYATQGHLGAFLT
EVDPAFYGIPGGRFEAACASGSIALDAAATKIRAKDYDVAIVLGIEIMKTVSSSVGGDFLGTAAYYEKEAKGVQFPFPKL
FGKLADVILERYKLPEQRFMGALAEISRINYDNAKRNPKAQTRSWFMNKEHANARGGEYNMAVGGRLCITDCSQVTDGAA
MVVLANKSYTEEYAKKRGKKINTIPRLKGWGHRVAPITFEAKVAESKGDKFILPWTRQTVKDAYDRAELGVKDIDVFETH
DCFTSSEYAAISAFGISQPGKEHEAIEEGVIDFKGKKPINPSGGLIGVGHPVGASGVRMMLDLYKQVTGTAGDYQVEGAK
NGLMLNIGGSATTNVVFIVGK

Sequences:

>Translated_421_residues
MSDKIYVLGGEQTDFQRNWTKEGKTFMSLMREAVQDGLEAVGITSDEIKKLNKQNRIGIFVGNFDAEQYATQGHLGAFLT
EVDPAFYGIPGGRFEAACASGSIALDAAATKIRAKDYDVAIVLGIEIMKTVSSSVGGDFLGTAAYYEKEAKGVQFPFPKL
FGKLADVILERYKLPEQRFMGALAEISRINYDNAKRNPKAQTRSWFMNKEHANARGGEYNMAVGGRLCITDCSQVTDGAA
MVVLANKSYTEEYAKKRGKKINTIPRLKGWGHRVAPITFEAKVAESKGDKFILPWTRQTVKDAYDRAELGVKDIDVFETH
DCFTSSEYAAISAFGISQPGKEHEAIEEGVIDFKGKKPINPSGGLIGVGHPVGASGVRMMLDLYKQVTGTAGDYQVEGAK
NGLMLNIGGSATTNVVFIVGK
>Mature_420_residues
SDKIYVLGGEQTDFQRNWTKEGKTFMSLMREAVQDGLEAVGITSDEIKKLNKQNRIGIFVGNFDAEQYATQGHLGAFLTE
VDPAFYGIPGGRFEAACASGSIALDAAATKIRAKDYDVAIVLGIEIMKTVSSSVGGDFLGTAAYYEKEAKGVQFPFPKLF
GKLADVILERYKLPEQRFMGALAEISRINYDNAKRNPKAQTRSWFMNKEHANARGGEYNMAVGGRLCITDCSQVTDGAAM
VVLANKSYTEEYAKKRGKKINTIPRLKGWGHRVAPITFEAKVAESKGDKFILPWTRQTVKDAYDRAELGVKDIDVFETHD
CFTSSEYAAISAFGISQPGKEHEAIEEGVIDFKGKKPINPSGGLIGVGHPVGASGVRMMLDLYKQVTGTAGDYQVEGAKN
GLMLNIGGSATTNVVFIVGK

Specific function: Thiolytic Cleavage Of Beta-Ketoadipyl-CoA To Succinate And Acetyl-CoA (By Similarity). [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI19923233, Length=430, Percent_Identity=26.9767441860465, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI302344767, Length=346, Percent_Identity=28.9017341040462, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI302344760, Length=346, Percent_Identity=28.9017341040462, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI302344762, Length=265, Percent_Identity=29.811320754717, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI55956775, Length=220, Percent_Identity=28.6363636363636, Blast_Score=79, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17537653, Length=418, Percent_Identity=27.511961722488, Blast_Score=124, Evalue=8e-29,
Organism=Drosophila melanogaster, GI24585051, Length=431, Percent_Identity=23.8979118329466, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI19921506, Length=431, Percent_Identity=23.8979118329466, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020617
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16

Molecular weight: Translated: 45839; Mature: 45708

Theoretical pI: Translated: 8.26; Mature: 8.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDKIYVLGGEQTDFQRNWTKEGKTFMSLMREAVQDGLEAVGITSDEIKKLNKQNRIGIF
CCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHCCCCCEEEE
VGNFDAEQYATQGHLGAFLTEVDPAFYGIPGGRFEAACASGSIALDAAATKIRAKDYDVA
EECCCHHHHHHCCCHHHHHHHCCCHHCCCCCCCEEHHHCCCCEEEEHHHHEEECCCCCEE
IVLGIEIMKTVSSSVGGDFLGTAAYYEKEAKGVQFPFPKLFGKLADVILERYKLPEQRFM
EEEHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHH
GALAEISRINYDNAKRNPKAQTRSWFMNKEHANARGGEYNMAVGGRLCITDCSQVTDGAA
HHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCCCEEEEEECCEEEEECHHHCCCCEE
MVVLANKSYTEEYAKKRGKKINTIPRLKGWGHRVAPITFEAKVAESKGDKFILPWTRQTV
EEEEECCHHHHHHHHHCCCCCCCCCCCCCCCCEECEEEEEEEECCCCCCEEEECCCHHHH
KDAYDRAELGVKDIDVFETHDCFTSSEYAAISAFGISQPGKEHEAIEEGVIDFKGKKPIN
HHHHHHHHCCCCCCEEEECCCCCCCCCCEEEEEECCCCCCHHHHHHHHCCEECCCCCCCC
PSGGLIGVGHPVGASGVRMMLDLYKQVTGTAGDYQVEGAKNGLMLNIGGSATTNVVFIVG
CCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEECCCCCCEEEEECCCCCCEEEEEEE
K
C
>Mature Secondary Structure 
SDKIYVLGGEQTDFQRNWTKEGKTFMSLMREAVQDGLEAVGITSDEIKKLNKQNRIGIF
CCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHCCCCCEEEE
VGNFDAEQYATQGHLGAFLTEVDPAFYGIPGGRFEAACASGSIALDAAATKIRAKDYDVA
EECCCHHHHHHCCCHHHHHHHCCCHHCCCCCCCEEHHHCCCCEEEEHHHHEEECCCCCEE
IVLGIEIMKTVSSSVGGDFLGTAAYYEKEAKGVQFPFPKLFGKLADVILERYKLPEQRFM
EEEHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHH
GALAEISRINYDNAKRNPKAQTRSWFMNKEHANARGGEYNMAVGGRLCITDCSQVTDGAA
HHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCCCEEEEEECCEEEEECHHHCCCCEE
MVVLANKSYTEEYAKKRGKKINTIPRLKGWGHRVAPITFEAKVAESKGDKFILPWTRQTV
EEEEECCHHHHHHHHHCCCCCCCCCCCCCCCCEECEEEEEEEECCCCCCEEEECCCHHHH
KDAYDRAELGVKDIDVFETHDCFTSSEYAAISAFGISQPGKEHEAIEEGVIDFKGKKPIN
HHHHHHHHCCCCCCEEEECCCCCCCCCCEEEEEECCCCCCHHHHHHHHCCEECCCCCCCC
PSGGLIGVGHPVGASGVRMMLDLYKQVTGTAGDYQVEGAKNGLMLNIGGSATTNVVFIVG
CCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEECCCCCCEEEEECCCCCCEEEEEEE
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetyl-CoA

Specific reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]