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The map label for this gene is fadB

Identifier: 45659119

GI number: 45659119

Start: 4046951

End: 4048261

Strand: Direct

Name: fadB

Synonym: LIC13300

Alternate gene names: 45659119

Gene position: 4046951-4048261 (Clockwise)

Preceding gene: 45659118

Following gene: 45659120

Centisome position: 94.62

GC content: 42.33

Gene sequence:

>1311_bases
ATGAGAGAAATCAAAACAGTAACAGTATTGGGCGCGAACGGTACCATGGGCGCCGGATCTGCGGCAATTGTTGCCTCATT
CGGAAAGGCAAAAGTTCACATGCTCGCTAGGGACACAAACAAAGCGAAAGAAGGTATCGAAAAAGCAATCGGCTCGGTTA
AAACAGATACAATCCGTCCCAGACTGATTCCAGGTTCGTATGATGCGGATTTAGAAAAAGCAGTTTCAGAATCCGATTGG
GTTTTCGAACTCGTTGCAGAAAGTTACGAAGTAAAAGAACCAATCAACAAAAGAATCGCAAGCTCAAGAAGACCGGGAAC
CATCGTTTCCACCGTATCATCCGGTCTTTCTATCGAAAGACTTTCTAAAGCTTTTGACGAAGACGGACAAAAACATTATT
TCGGAACTCACTTCTTTAATCCTCCTTACAAAATGATTCTTTGTGAACTCGTTTCTCACAAAGGTTCGGATAAAAAAGTT
CTCAAACAACTCGGCGAATACTTAGAAAAAGTTTTAGGACGTGCGGTCGTTTATACGAATGATACTCCTGCATTTGCAGG
AAACAGAATCGGTTTCCAGCTCATCAACGAGGTTGCACAGATCGCTGAAAAATATTCCGATAAAGGTGGAATTGCTCTGA
TGGACGCGATCATGAGTGGTTACACCGGAAGAGCGATGGCTCCTCTAGATACTGCGGATTTCGTAGGATTAGACGTTCAC
AAAGCGATTGTAGATAATCTCTACGAAATGACAAAAGATGCGGCTCATTCTACTTTTAAAATGCCAGACTACTTCCAGAA
GCTCATTGATAAAGGCGATTTAGGAAGAAAAACAGGTGGTGGACTTTATAAGATGTCCAAAACCCCAGATGGTAAAAAAG
AAAAATTAGTCTATAATATAGGTGCTGATTTGTATGAACCGGTTCCTAAGTTCGAGATTGATTTTATTCGTCAGGCGAAT
AAAAGAATTTCGGAAGCGGATTACACAGGCGCGATGAACATCGTAAAAGAAGCGAAAGGTTTTGAAGCGGATCTTGCAAG
ATATTTTATCGCAAGATACGTTAGTTACTCTCTATCTATCGTTGGCGAAGTTGTAGACACAAAAGAAATGGCGGACCTCG
CAATGGGAACCGGATTCAACTGGGCTCCCGCTTCCGCGTTTGTGGATTTCTTAGGCGGACCTAAGGACGCGATCCAACTG
ATCGAAAAAGCAAAACTTCCGGTTCCTGAAGTATTAGCAAAAGCGAAACCAGGAAAGCCGTTTTACGAGTTGAAAGAAAA
GCTGGATGCTCGTTCACTTTTCAAAGGATAA

Upstream 100 bases:

>100_bases
AATTCTCTATCCGTCCAGTGATGAAAAAAACTTTCCTCCCCACCTGGCTGTTTTAAACAAGTCCTATTCCATTGGGAAAT
CCAAGAATTGGTATAGTTTC

Downstream 100 bases:

>100_bases
TTTAGGGGGGTCAACATGAGCGATAAGATTTACGTCCTCGGCGGAGAACAAACCGACTTTCAAAGAAACTGGACCAAAGA
AGGTAAAACCTTCATGTCCT

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MREIKTVTVLGANGTMGAGSAAIVASFGKAKVHMLARDTNKAKEGIEKAIGSVKTDTIRPRLIPGSYDADLEKAVSESDW
VFELVAESYEVKEPINKRIASSRRPGTIVSTVSSGLSIERLSKAFDEDGQKHYFGTHFFNPPYKMILCELVSHKGSDKKV
LKQLGEYLEKVLGRAVVYTNDTPAFAGNRIGFQLINEVAQIAEKYSDKGGIALMDAIMSGYTGRAMAPLDTADFVGLDVH
KAIVDNLYEMTKDAAHSTFKMPDYFQKLIDKGDLGRKTGGGLYKMSKTPDGKKEKLVYNIGADLYEPVPKFEIDFIRQAN
KRISEADYTGAMNIVKEAKGFEADLARYFIARYVSYSLSIVGEVVDTKEMADLAMGTGFNWAPASAFVDFLGGPKDAIQL
IEKAKLPVPEVLAKAKPGKPFYELKEKLDARSLFKG

Sequences:

>Translated_436_residues
MREIKTVTVLGANGTMGAGSAAIVASFGKAKVHMLARDTNKAKEGIEKAIGSVKTDTIRPRLIPGSYDADLEKAVSESDW
VFELVAESYEVKEPINKRIASSRRPGTIVSTVSSGLSIERLSKAFDEDGQKHYFGTHFFNPPYKMILCELVSHKGSDKKV
LKQLGEYLEKVLGRAVVYTNDTPAFAGNRIGFQLINEVAQIAEKYSDKGGIALMDAIMSGYTGRAMAPLDTADFVGLDVH
KAIVDNLYEMTKDAAHSTFKMPDYFQKLIDKGDLGRKTGGGLYKMSKTPDGKKEKLVYNIGADLYEPVPKFEIDFIRQAN
KRISEADYTGAMNIVKEAKGFEADLARYFIARYVSYSLSIVGEVVDTKEMADLAMGTGFNWAPASAFVDFLGGPKDAIQL
IEKAKLPVPEVLAKAKPGKPFYELKEKLDARSLFKG
>Mature_436_residues
MREIKTVTVLGANGTMGAGSAAIVASFGKAKVHMLARDTNKAKEGIEKAIGSVKTDTIRPRLIPGSYDADLEKAVSESDW
VFELVAESYEVKEPINKRIASSRRPGTIVSTVSSGLSIERLSKAFDEDGQKHYFGTHFFNPPYKMILCELVSHKGSDKKV
LKQLGEYLEKVLGRAVVYTNDTPAFAGNRIGFQLINEVAQIAEKYSDKGGIALMDAIMSGYTGRAMAPLDTADFVGLDVH
KAIVDNLYEMTKDAAHSTFKMPDYFQKLIDKGDLGRKTGGGLYKMSKTPDGKKEKLVYNIGADLYEPVPKFEIDFIRQAN
KRISEADYTGAMNIVKEAKGFEADLARYFIARYVSYSLSIVGEVVDTKEMADLAMGTGFNWAPASAFVDFLGGPKDAIQL
IEKAKLPVPEVLAKAKPGKPFYELKEKLDARSLFKG

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=297, Percent_Identity=30.976430976431, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI296179427, Length=311, Percent_Identity=29.903536977492, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI20127408, Length=301, Percent_Identity=25.2491694352159, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1787661, Length=294, Percent_Identity=29.9319727891156, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1790281, Length=379, Percent_Identity=25.065963060686, Blast_Score=75, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17549919, Length=300, Percent_Identity=27.3333333333333, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17553560, Length=302, Percent_Identity=26.4900662251656, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17508951, Length=300, Percent_Identity=27.3333333333333, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17508953, Length=300, Percent_Identity=27.3333333333333, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI25144276, Length=300, Percent_Identity=27.3333333333333, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17558304, Length=416, Percent_Identity=25.2403846153846, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17563036, Length=296, Percent_Identity=27.3648648648649, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24583077, Length=450, Percent_Identity=24.8888888888889, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24583079, Length=450, Percent_Identity=24.8888888888889, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI19921000, Length=450, Percent_Identity=24.8888888888889, Blast_Score=75, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR001753
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N; PF00378 ECH [H]

EC number: =1.1.1.35 [H]

Molecular weight: Translated: 47838; Mature: 47838

Theoretical pI: Translated: 9.09; Mature: 9.09

Prosite motif: PS00228 TUBULIN_B_AUTOREG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREIKTVTVLGANGTMGAGSAAIVASFGKAKVHMLARDTNKAKEGIEKAIGSVKTDTIRP
CCCEEEEEEECCCCCCCCCCHHHHHHCCCHHEEHHHHCCHHHHHHHHHHHCCCCCCCCCC
RLIPGSYDADLEKAVSESDWVFELVAESYEVKEPINKRIASSRRPGTIVSTVSSGLSIER
EECCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCHHH
LSKAFDEDGQKHYFGTHFFNPPYKMILCELVSHKGSDKKVLKQLGEYLEKVLGRAVVYTN
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCEEEEEC
DTPAFAGNRIGFQLINEVAQIAEKYSDKGGIALMDAIMSGYTGRAMAPLDTADFVGLDVH
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCHHHCCHHHH
KAIVDNLYEMTKDAAHSTFKMPDYFQKLIDKGDLGRKTGGGLYKMSKTPDGKKEKLVYNI
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCHHHEEEEC
GADLYEPVPKFEIDFIRQANKRISEADYTGAMNIVKEAKGFEADLARYFIARYVSYSLSI
CCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
VGEVVDTKEMADLAMGTGFNWAPASAFVDFLGGPKDAIQLIEKAKLPVPEVLAKAKPGKP
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHCCCCCCC
FYELKEKLDARSLFKG
HHHHHHHHHHHHHCCC
>Mature Secondary Structure
MREIKTVTVLGANGTMGAGSAAIVASFGKAKVHMLARDTNKAKEGIEKAIGSVKTDTIRP
CCCEEEEEEECCCCCCCCCCHHHHHHCCCHHEEHHHHCCHHHHHHHHHHHCCCCCCCCCC
RLIPGSYDADLEKAVSESDWVFELVAESYEVKEPINKRIASSRRPGTIVSTVSSGLSIER
EECCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCHHH
LSKAFDEDGQKHYFGTHFFNPPYKMILCELVSHKGSDKKVLKQLGEYLEKVLGRAVVYTN
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCEEEEEC
DTPAFAGNRIGFQLINEVAQIAEKYSDKGGIALMDAIMSGYTGRAMAPLDTADFVGLDVH
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCHHHCCHHHH
KAIVDNLYEMTKDAAHSTFKMPDYFQKLIDKGDLGRKTGGGLYKMSKTPDGKKEKLVYNI
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCHHHEEEEC
GADLYEPVPKFEIDFIRQANKRISEADYTGAMNIVKEAKGFEADLARYFIARYVSYSLSI
CCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
VGEVVDTKEMADLAMGTGFNWAPASAFVDFLGGPKDAIQLIEKAKLPVPEVLAKAKPGKP
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHCCCCCCC
FYELKEKLDARSLFKG
HHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]