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The map label for this gene is acd

Identifier: 45658958

GI number: 45658958

Start: 3845185

End: 3846972

Strand: Direct

Name: acd

Synonym: LIC13136

Alternate gene names: 45658958

Gene position: 3845185-3846972 (Clockwise)

Preceding gene: 45658957

Following gene: 45658959

Centisome position: 89.9

GC content: 39.21

Gene sequence:

>1788_bases
TTGGGCATAATTAGAGGTATAAACTCAATGATTATCAGCAATTACTTTCAAGACAATGAAGATCTCAAACTCGTTTTTAA
CCAGTTGATCGATTGGAAAGAAATCATTCACGCGTACGAACATAAATTCGAAGACGCAGAAGAATATAAAAAAACCGGCA
ATGAAAGATTGGCTTATGCACCTTCCAATGTTGAAGAAGCAATAGAATATTATAAATCCGTTTTAGAATCTTTAGGCGAA
ATTATGGGAGAATTCGTAGCTCCTCGCAGCAAGGAAATGGATCAAATCGGACTTAAATATGAAAACGGAAAAGTGATTTT
TCCAAAGGCACAAGAAGAATGTTATAACACTCTTCGAGACGCTGGTTTAATGCCGGTTTCGCTTAGTAGAAAATACGGCG
GCATGGGACTTCCTGCAACGGTTCAATCTTTTATGATGGAAGTTGCTGCAAGAGCAGATGCGGCTTTTTGTCTCTCATAC
GGAAATATAAACATTGTAGAAATTATGGAAAGATATGCTTCTTCCGAAATGTGCGAAAAATGGATTCCGGAAATTTCCGC
AGGAAAATACAGCGCGGCAATGGCACTCACAGAACCAAACTATGGATCAGATCTTCCTAATGTTCAAACAAGAGCCACTC
AAGATGCTAATGGAATCTGGAGAATTAACGGAGCCAAACGTTTTATTACACACGCTTGCGGTTATATTAATGCACCTTCC
GTAATTCTTACGTTAGCGAGAACAGGCTCGCCCGAGAGTGGTGCAAGAGGTTTATCTTTTTTTCTCGTAAAAGGAAGCGA
CGTACATATTGCGGGTGTTGAGCATAAGTTGGGGCTTCATTGTTCTCCCACTTGTGAAGTAGTTTTTGATAATTCTCCAG
GAGAACTGATCGGTAAGACTGGATATGGACTCGTAAAATATTCAATGGGAATGATGAACGCTGCCAGACTTACAATTGCT
ACTCAATCTTTGGGAATTGCAACGGCCGCCTATTACGAAGCTAAAAAATACGCCTCTGAAAGAATTCAATTCGGAAAACC
AATCGAACAAATTCCAGCAGTAAGAAAAATTTTGGATCGTATGGAAAGAGAAATTTTAGCTACCAGAGTTCTAATTGCTG
AAACCGGAAAGGCAATCGATCTTTATCACTGGCCGAAAGAACATCTTATCAAAATAGAAGGTAAATCGGAAAAAGAAGTA
AATCAGAATGAATCCATTCGTCGTTGGGAAAAACTTGCAGACCTTTTTACTCCACTAAGTAAGTATTACGCTTCAGAAGG
ATGTGTTGCAATTGCATCGGACGCATTACAAATTCATGGTGGAAGTGGTTACACTGAAGACTACGACGTAGCTCGAATTT
ATAGAGATAGTAGAATCACTACGATCTACGAAGGAACAACCCAATTACAAATCGTCGCCGCAATCGGAGGTGTTGTATCC
GGAATGTCTCCAACCGGACAACTCAGACAATATTCGGAAATGGAACTTTCTAAATTCTCCGCTTCCGAAGACCTCAAAAA
AGTTTGGAAAGATTTAGATACAAGTATAGGACTTTACAAATCCATTCACAACGGAGACTTAAGGGATTCTTTAGCATTTG
AAGTTGTAGAAATAGCGGCTCGTTTTCTATGCGGGCTTCTTTTGGAAAAATCTTTGAAAGTGTTAAATGGAAAAGAACTC
GAAAATCGAAGAACGATTTCTCAAGCCTATAACTTGGATAGTATAGCTATCACTAGCGCGAACTTGATCAAACTGGAAAG
AACTTCTAAACAAGCGATTGCAGTTTAA

Upstream 100 bases:

>100_bases
AATTGGCGAACTGCCAAAGTTAAAAAAATTAAAAGAAGAGGATAAGACTACAAATTAGTTTTCTTTGATGCTTGACATCT
CTTCTCGATACTCTTAATTA

Downstream 100 bases:

>100_bases
CACAAAATAAACTCCTAGGCAAATCCTTCGCCCGATGATTGGTTTGCCTTTGTATTAATTTGAATATAATAAAATTATTA
ACTAATTTTAGTTTATTTTA

Product: acyl-CoA dehydrogenase

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 595; Mature: 594

Protein sequence:

>595_residues
MGIIRGINSMIISNYFQDNEDLKLVFNQLIDWKEIIHAYEHKFEDAEEYKKTGNERLAYAPSNVEEAIEYYKSVLESLGE
IMGEFVAPRSKEMDQIGLKYENGKVIFPKAQEECYNTLRDAGLMPVSLSRKYGGMGLPATVQSFMMEVAARADAAFCLSY
GNINIVEIMERYASSEMCEKWIPEISAGKYSAAMALTEPNYGSDLPNVQTRATQDANGIWRINGAKRFITHACGYINAPS
VILTLARTGSPESGARGLSFFLVKGSDVHIAGVEHKLGLHCSPTCEVVFDNSPGELIGKTGYGLVKYSMGMMNAARLTIA
TQSLGIATAAYYEAKKYASERIQFGKPIEQIPAVRKILDRMEREILATRVLIAETGKAIDLYHWPKEHLIKIEGKSEKEV
NQNESIRRWEKLADLFTPLSKYYASEGCVAIASDALQIHGGSGYTEDYDVARIYRDSRITTIYEGTTQLQIVAAIGGVVS
GMSPTGQLRQYSEMELSKFSASEDLKKVWKDLDTSIGLYKSIHNGDLRDSLAFEVVEIAARFLCGLLLEKSLKVLNGKEL
ENRRTISQAYNLDSIAITSANLIKLERTSKQAIAV

Sequences:

>Translated_595_residues
MGIIRGINSMIISNYFQDNEDLKLVFNQLIDWKEIIHAYEHKFEDAEEYKKTGNERLAYAPSNVEEAIEYYKSVLESLGE
IMGEFVAPRSKEMDQIGLKYENGKVIFPKAQEECYNTLRDAGLMPVSLSRKYGGMGLPATVQSFMMEVAARADAAFCLSY
GNINIVEIMERYASSEMCEKWIPEISAGKYSAAMALTEPNYGSDLPNVQTRATQDANGIWRINGAKRFITHACGYINAPS
VILTLARTGSPESGARGLSFFLVKGSDVHIAGVEHKLGLHCSPTCEVVFDNSPGELIGKTGYGLVKYSMGMMNAARLTIA
TQSLGIATAAYYEAKKYASERIQFGKPIEQIPAVRKILDRMEREILATRVLIAETGKAIDLYHWPKEHLIKIEGKSEKEV
NQNESIRRWEKLADLFTPLSKYYASEGCVAIASDALQIHGGSGYTEDYDVARIYRDSRITTIYEGTTQLQIVAAIGGVVS
GMSPTGQLRQYSEMELSKFSASEDLKKVWKDLDTSIGLYKSIHNGDLRDSLAFEVVEIAARFLCGLLLEKSLKVLNGKEL
ENRRTISQAYNLDSIAITSANLIKLERTSKQAIAV
>Mature_594_residues
GIIRGINSMIISNYFQDNEDLKLVFNQLIDWKEIIHAYEHKFEDAEEYKKTGNERLAYAPSNVEEAIEYYKSVLESLGEI
MGEFVAPRSKEMDQIGLKYENGKVIFPKAQEECYNTLRDAGLMPVSLSRKYGGMGLPATVQSFMMEVAARADAAFCLSYG
NINIVEIMERYASSEMCEKWIPEISAGKYSAAMALTEPNYGSDLPNVQTRATQDANGIWRINGAKRFITHACGYINAPSV
ILTLARTGSPESGARGLSFFLVKGSDVHIAGVEHKLGLHCSPTCEVVFDNSPGELIGKTGYGLVKYSMGMMNAARLTIAT
QSLGIATAAYYEAKKYASERIQFGKPIEQIPAVRKILDRMEREILATRVLIAETGKAIDLYHWPKEHLIKIEGKSEKEVN
QNESIRRWEKLADLFTPLSKYYASEGCVAIASDALQIHGGSGYTEDYDVARIYRDSRITTIYEGTTQLQIVAAIGGVVSG
MSPTGQLRQYSEMELSKFSASEDLKKVWKDLDTSIGLYKSIHNGDLRDSLAFEVVEIAARFLCGLLLEKSLKVLNGKELE
NRRTISQAYNLDSIAITSANLIKLERTSKQAIAV

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501859, Length=451, Percent_Identity=27.0509977827051, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI4501857, Length=402, Percent_Identity=26.6169154228856, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI4557233, Length=372, Percent_Identity=29.0322580645161, Blast_Score=126, Evalue=7e-29,
Organism=Homo sapiens, GI21361497, Length=440, Percent_Identity=25.9090909090909, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI226958412, Length=422, Percent_Identity=25.3554502369668, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI7656849, Length=414, Percent_Identity=27.2946859903382, Blast_Score=117, Evalue=4e-26,
Organism=Homo sapiens, GI226958414, Length=371, Percent_Identity=26.1455525606469, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI76496475, Length=425, Percent_Identity=25.1764705882353, Blast_Score=109, Evalue=8e-24,
Organism=Homo sapiens, GI4557235, Length=425, Percent_Identity=25.1764705882353, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI187960098, Length=367, Percent_Identity=26.9754768392371, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI4557231, Length=367, Percent_Identity=26.9754768392371, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI4503943, Length=361, Percent_Identity=24.9307479224377, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI7669494, Length=343, Percent_Identity=25.0728862973761, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI87081958, Length=370, Percent_Identity=30.5405405405405, Blast_Score=132, Evalue=6e-32,
Organism=Escherichia coli, GI87082384, Length=281, Percent_Identity=27.0462633451957, Blast_Score=99, Evalue=9e-22,
Organism=Escherichia coli, GI1786223, Length=372, Percent_Identity=22.5806451612903, Blast_Score=94, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17538396, Length=366, Percent_Identity=27.8688524590164, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17508101, Length=421, Percent_Identity=24.9406175771971, Blast_Score=122, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17534899, Length=408, Percent_Identity=27.4509803921569, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17506239, Length=395, Percent_Identity=24.8101265822785, Blast_Score=110, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI86563383, Length=316, Percent_Identity=29.1139240506329, Blast_Score=109, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI86563381, Length=316, Percent_Identity=29.1139240506329, Blast_Score=109, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI71985184, Length=309, Percent_Identity=28.8025889967638, Blast_Score=108, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17533517, Length=365, Percent_Identity=26.8493150684932, Blast_Score=107, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17569725, Length=408, Percent_Identity=26.9607843137255, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17570075, Length=305, Percent_Identity=25.5737704918033, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17534353, Length=360, Percent_Identity=25.2777777777778, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71990804, Length=264, Percent_Identity=28.030303030303, Blast_Score=93, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI71985192, Length=200, Percent_Identity=31, Blast_Score=83, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI71982178, Length=286, Percent_Identity=26.2237762237762, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI32563615, Length=241, Percent_Identity=26.1410788381743, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17505929, Length=405, Percent_Identity=23.4567901234568, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24666513, Length=410, Percent_Identity=27.8048780487805, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI21356377, Length=381, Percent_Identity=28.6089238845144, Blast_Score=131, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24646207, Length=412, Percent_Identity=26.9417475728155, Blast_Score=127, Evalue=3e-29,
Organism=Drosophila melanogaster, GI281363737, Length=429, Percent_Identity=25.8741258741259, Blast_Score=114, Evalue=3e-25,
Organism=Drosophila melanogaster, GI21355753, Length=394, Percent_Identity=25.6345177664975, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24660351, Length=374, Percent_Identity=29.144385026738, Blast_Score=103, Evalue=5e-22,
Organism=Drosophila melanogaster, GI19920834, Length=238, Percent_Identity=27.3109243697479, Blast_Score=76, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 66149; Mature: 66018

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIIRGINSMIISNYFQDNEDLKLVFNQLIDWKEIIHAYEHKFEDAEEYKKTGNERLAYA
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCEEEEC
PSNVEEAIEYYKSVLESLGEIMGEFVAPRSKEMDQIGLKYENGKVIFPKAQEECYNTLRD
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCEECCCEEECCCCHHHHHHHHHH
AGLMPVSLSRKYGGMGLPATVQSFMMEVAARADAAFCLSYGNINIVEIMERYASSEMCEK
CCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHH
WIPEISAGKYSAAMALTEPNYGSDLPNVQTRATQDANGIWRINGAKRFITHACGYINAPS
HCCCCCCCCCEEEEEEECCCCCCCCCCCCHHCCCCCCCEEEECCHHHHHHHHCCCCCCCH
VILTLARTGSPESGARGLSFFLVKGSDVHIAGVEHKLGLHCSPTCEVVFDNSPGELIGKT
HEEEEECCCCCCCCCCCEEEEEEECCCEEEEECCCCCCCCCCCCEEEEEECCCCCEECCC
GYGLVKYSMGMMNAARLTIATQSLGIATAAYYEAKKYASERIQFGKPIEQIPAVRKILDR
CCCHHHHHHHHHHHHEEEEEEHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
MEREILATRVLIAETGKAIDLYHWPKEHLIKIEGKSEKEVNQNESIRRWEKLADLFTPLS
HHHHHHHHHHHHCCCCCEEEEEECCHHHEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHH
KYYASEGCVAIASDALQIHGGSGYTEDYDVARIYRDSRITTIYEGTTQLQIVAAIGGVVS
HHHCCCCCEEEECCCEEEECCCCCCCCCHHHHHHHCCCEEEEECCCCCEEHHHHHHHHHC
GMSPTGQLRQYSEMELSKFSASEDLKKVWKDLDTSIGLYKSIHNGDLRDSLAFEVVEIAA
CCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHH
RFLCGLLLEKSLKVLNGKELENRRTISQAYNLDSIAITSANLIKLERTSKQAIAV
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEECCCEEEEECCCCHHCCC
>Mature Secondary Structure 
GIIRGINSMIISNYFQDNEDLKLVFNQLIDWKEIIHAYEHKFEDAEEYKKTGNERLAYA
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCEEEEC
PSNVEEAIEYYKSVLESLGEIMGEFVAPRSKEMDQIGLKYENGKVIFPKAQEECYNTLRD
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCEECCCEEECCCCHHHHHHHHHH
AGLMPVSLSRKYGGMGLPATVQSFMMEVAARADAAFCLSYGNINIVEIMERYASSEMCEK
CCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHH
WIPEISAGKYSAAMALTEPNYGSDLPNVQTRATQDANGIWRINGAKRFITHACGYINAPS
HCCCCCCCCCEEEEEEECCCCCCCCCCCCHHCCCCCCCEEEECCHHHHHHHHCCCCCCCH
VILTLARTGSPESGARGLSFFLVKGSDVHIAGVEHKLGLHCSPTCEVVFDNSPGELIGKT
HEEEEECCCCCCCCCCCEEEEEEECCCEEEEECCCCCCCCCCCCEEEEEECCCCCEECCC
GYGLVKYSMGMMNAARLTIATQSLGIATAAYYEAKKYASERIQFGKPIEQIPAVRKILDR
CCCHHHHHHHHHHHHEEEEEEHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
MEREILATRVLIAETGKAIDLYHWPKEHLIKIEGKSEKEVNQNESIRRWEKLADLFTPLS
HHHHHHHHHHHHCCCCCEEEEEECCHHHEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHH
KYYASEGCVAIASDALQIHGGSGYTEDYDVARIYRDSRITTIYEGTTQLQIVAAIGGVVS
HHHCCCCCEEEECCCEEEECCCCCCCCCHHHHHHHCCCEEEEECCCCCEEHHHHHHHHHC
GMSPTGQLRQYSEMELSKFSASEDLKKVWKDLDTSIGLYKSIHNGDLRDSLAFEVVEIAA
CCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHH
RFLCGLLLEKSLKVLNGKELENRRTISQAYNLDSIAITSANLIKLERTSKQAIAV
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEECCCEEEEECCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]