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The map label for this gene is adrA [H]

Identifier: 45658959

GI number: 45658959

Start: 3847833

End: 3848816

Strand: Direct

Name: adrA [H]

Synonym: LIC13137

Alternate gene names: 45658959

Gene position: 3847833-3848816 (Clockwise)

Preceding gene: 45658958

Following gene: 45658962

Centisome position: 89.96

GC content: 35.26

Gene sequence:

>984_bases
ATGACCTTAAAAGACTCAAAACCGGAATTAATTAAATTATACTCTTCTCTTGGAAAAATTATTACCTCTTCATTAGAGCA
GCAAGAAGTACTAAGCGCAGTAATGGAAGAAGTTCGTTTATTTTTTAGTCCTAAAAATTGGAGTTTGATGCGTTACGATG
AAAATTCGGAAGAATTATTTTTTCTAATAGCGGAAGGAATACAATTCAATCATATTAGAAGCATTCGATTAAAGTCGGGA
GAAGGAATTGCCGGTTCAGTTGTCCAAACAAAGTCTCCGATCTTTGTAGAAAACGTAAAAAATGATCCTAGATTTTCCAA
AAAAGTCGACGAAAAGACAGGGTTTGAAACAAAAACGATCATTGCGGTCCCAATGATATTCAGAGGAGAGGTTCACGGAG
TTATCGAATTAGTAAATCGTTTTGACGGATCATCTTTCTCTCCTGAAGATTTAGTCATTCTTCAGACGATAGCCGATTTT
ACTGCAATTTCGTTAGCACATTCAGATCAATACGAAAAAACAAAGATACTTGCGTTTAGAGATTCATTAACTGGAGCGTT
TAACCGTAATAAGTTGAATCATCTCAAAGAAAAATGGTCTAACAGGACAATGGAAAACCAAATTGCGTTAGTCGCTCTTT
TAGACTTAAACGGTTTTAAAATGATCAACGATACTTATGGCCATAAAACGGGAGATCAAGTGCTTTGTTATTTTGCAGAT
ATTCTTCGCTACGTAATTCGTGGAACGGATAAAATATTCAGAATCGGAGGAGATGAATTTTTAATTTTAGTACGACATGA
AAATCAGGAAAAAATACTCCAAACCCAAAATCGATTTCGAGAAACAATGTCCGTGCTTCTAAAAAAATGTAAGGAGAACG
ATCCTCCTTTTAATTTTACTTGGGGAATGTCGATCGGCTCTATTCAAAAACTAGATGAGTTGATACACGAGGCGGATTTA
TCTATGTATGCATCCAAAGGATGA

Upstream 100 bases:

>100_bases
ATAGGGATCAACACTAGAATAAAATTATAATTTTCCTGGAAATATCTTGATAAATAACGCTTCAAACTCTTAATAAAATA
AAAAAGAGCAAAAAATACCA

Downstream 100 bases:

>100_bases
TCCAAGATTTATCATTCTTCATAATCCACAAACAACATGTAGTATCTAATCTTCAAGCTGTCATAAATCTATTAGAAATT
CATTATAAATATCTAAAAGA

Product: cGMP-specific phosphodiesterase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MTLKDSKPELIKLYSSLGKIITSSLEQQEVLSAVMEEVRLFFSPKNWSLMRYDENSEELFFLIAEGIQFNHIRSIRLKSG
EGIAGSVVQTKSPIFVENVKNDPRFSKKVDEKTGFETKTIIAVPMIFRGEVHGVIELVNRFDGSSFSPEDLVILQTIADF
TAISLAHSDQYEKTKILAFRDSLTGAFNRNKLNHLKEKWSNRTMENQIALVALLDLNGFKMINDTYGHKTGDQVLCYFAD
ILRYVIRGTDKIFRIGGDEFLILVRHENQEKILQTQNRFRETMSVLLKKCKENDPPFNFTWGMSIGSIQKLDELIHEADL
SMYASKG

Sequences:

>Translated_327_residues
MTLKDSKPELIKLYSSLGKIITSSLEQQEVLSAVMEEVRLFFSPKNWSLMRYDENSEELFFLIAEGIQFNHIRSIRLKSG
EGIAGSVVQTKSPIFVENVKNDPRFSKKVDEKTGFETKTIIAVPMIFRGEVHGVIELVNRFDGSSFSPEDLVILQTIADF
TAISLAHSDQYEKTKILAFRDSLTGAFNRNKLNHLKEKWSNRTMENQIALVALLDLNGFKMINDTYGHKTGDQVLCYFAD
ILRYVIRGTDKIFRIGGDEFLILVRHENQEKILQTQNRFRETMSVLLKKCKENDPPFNFTWGMSIGSIQKLDELIHEADL
SMYASKG
>Mature_326_residues
TLKDSKPELIKLYSSLGKIITSSLEQQEVLSAVMEEVRLFFSPKNWSLMRYDENSEELFFLIAEGIQFNHIRSIRLKSGE
GIAGSVVQTKSPIFVENVKNDPRFSKKVDEKTGFETKTIIAVPMIFRGEVHGVIELVNRFDGSSFSPEDLVILQTIADFT
AISLAHSDQYEKTKILAFRDSLTGAFNRNKLNHLKEKWSNRTMENQIALVALLDLNGFKMINDTYGHKTGDQVLCYFADI
LRYVIRGTDKIFRIGGDEFLILVRHENQEKILQTQNRFRETMSVLLKKCKENDPPFNFTWGMSIGSIQKLDELIHEADLS
MYASKG

Specific function: Unknown

COG id: COG2199

COG function: function code T; FOG: GGDEF domain

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GGDEF domain [H]

Homologues:

Organism=Homo sapiens, GI5729972, Length=153, Percent_Identity=30.0653594771242, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI194595488, Length=153, Percent_Identity=30.0653594771242, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI226246591, Length=191, Percent_Identity=28.7958115183246, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI4505657, Length=191, Percent_Identity=28.7958115183246, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI219802706, Length=191, Percent_Identity=28.7958115183246, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1786584, Length=173, Percent_Identity=29.4797687861272, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI87081881, Length=159, Percent_Identity=32.0754716981132, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1787262, Length=160, Percent_Identity=32.5, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI145693134, Length=118, Percent_Identity=32.2033898305085, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787541, Length=198, Percent_Identity=28.2828282828283, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI87081977, Length=156, Percent_Identity=28.8461538461538, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1787816, Length=149, Percent_Identity=32.8859060402685, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI193202333, Length=189, Percent_Identity=31.2169312169312, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI161076953, Length=103, Percent_Identity=31.0679611650485, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI161076955, Length=103, Percent_Identity=31.0679611650485, Blast_Score=68, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR007894 [H]

Pfam domain/function: PF00990 GGDEF; PF05230 MASE2 [H]

EC number: NA

Molecular weight: Translated: 37421; Mature: 37289

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLKDSKPELIKLYSSLGKIITSSLEQQEVLSAVMEEVRLFFSPKNWSLMRYDENSEELF
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEE
FLIAEGIQFNHIRSIRLKSGEGIAGSVVQTKSPIFVENVKNDPRFSKKVDEKTGFETKTI
EEEECCCCCCCEEEEEEECCCCCCCCCEECCCCEEEECCCCCCCHHHHHHHHCCCCCEEE
IAVPMIFRGEVHGVIELVNRFDGSSFSPEDLVILQTIADFTAISLAHSDQYEKTKILAFR
EEECHHHCCHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCCCHHEEEEEH
DSLTGAFNRNKLNHLKEKWSNRTMENQIALVALLDLNGFKMINDTYGHKTGDQVLCYFAD
HHHCCCCCHHHHHHHHHHHHCCCHHCCEEEEEEEECCCCEEECCCCCCCCCHHHHHHHHH
ILRYVIRGTDKIFRIGGDEFLILVRHENQEKILQTQNRFRETMSVLLKKCKENDPPFNFT
HHHHHHHCCCEEEEECCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
WGMSIGSIQKLDELIHEADLSMYASKG
ECCCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TLKDSKPELIKLYSSLGKIITSSLEQQEVLSAVMEEVRLFFSPKNWSLMRYDENSEELF
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEE
FLIAEGIQFNHIRSIRLKSGEGIAGSVVQTKSPIFVENVKNDPRFSKKVDEKTGFETKTI
EEEECCCCCCCEEEEEEECCCCCCCCCEECCCCEEEECCCCCCCHHHHHHHHCCCCCEEE
IAVPMIFRGEVHGVIELVNRFDGSSFSPEDLVILQTIADFTAISLAHSDQYEKTKILAFR
EEECHHHCCHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCCCHHEEEEEH
DSLTGAFNRNKLNHLKEKWSNRTMENQIALVALLDLNGFKMINDTYGHKTGDQVLCYFAD
HHHCCCCCHHHHHHHHHHHHCCCHHCCEEEEEEEECCCCEEECCCCCCCCCHHHHHHHHH
ILRYVIRGTDKIFRIGGDEFLILVRHENQEKILQTQNRFRETMSVLLKKCKENDPPFNFT
HHHHHHHCCCEEEEECCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
WGMSIGSIQKLDELIHEADLSMYASKG
ECCCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]