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The map label for this gene is ribD

Identifier: 45658378

GI number: 45658378

Start: 3074366

End: 3075766

Strand: Reverse

Name: ribD

Synonym: LIC12536

Alternate gene names: 45658378

Gene position: 3075766-3074366 (Counterclockwise)

Preceding gene: 45658379

Following gene: 45658377

Centisome position: 71.91

GC content: 34.98

Gene sequence:

>1401_bases
ATGACTTCCCTCCCGGAAAAATTTCGGGAGGAATTGCGCAAACTTTCCTTTTTATCCATGGGGGAAAGTTCGCCGAACCC
CCCTGTTTCTTGTCTCATTACGGATGTTGAAAACAAACGAATATTTGCCAAAGGTAGAACTTCACCTACCGGTGGACCAC
ATGCGGAAAGAAATGCATATTATGAATTTATTAATAATGGGCTTTTATCAAAACCGCATAACGTGTGGGTGACTTTTGAG
CCTTGTACACATCATGGTAAAACCCCTCCTTGTTTAGATTTAATTTTAGAACATAAACCGAAAACGCTATACTACGGTTT
AAAAGATCCTAATCCTCTCGTTCGTAAAAACGAAGGTTTAGAAATTTGTAGGAATGCTGGAATTCAAGTTGTTTCAGATT
TTGGTTTAAAAGAAATTGCAGAAGAAAGTTTATTTGGATTTATTTCTAGAATTGAAAAACAAAAACCTTCTATGATTATC
AAATCGGCGGTTTCTAAAGAAGGTTTTTTTACCACTAAGGATAAGGCTACGGTTCGTCTTTCTGGAAATTTATCAGATCG
CCTAACTTCTATTTTGCGAGCAAAATGCGACGCTGTACTTATTGGTCCTAGAACCTTATTCCAAGATCTACCTGGTTTAG
ATTTTAGGATTGGAGGCAATTGGGCTACCGATTTGGGAACCATTCAGGAAAATATTTTTGGGGAAAGTAATGGATTTGAT
ATAAGCCGCTGGTTTGAAGCAGGAGTTGATTTGGAACGGGCAGGAGTTTTAAAATTTGAGCATGGGGCTTATTTTGAGAG
AGGGGATGAAATTAAGGATTTAGAAAAAAATTTGGGAGTAGGTTCTGAAATTAAGAACTCAGAAGGGACTTCTCGATTTT
TAAAGAATATTTTAAAATACGGTTTTAATCCGGAAATTTCGGAAATTCATCGTAAGGATCAAGAGAATTATCAACCATAT
CGCGTTTTTATTATATTCGAAGAAAAAAATATACCCGAAAGTTGGGTCGAAAAACAAAGAAGAATCAATAAAAAAAATAA
TTCTAAAAAATGTATTTTTTTTCTAAAACGAAACGAATCTTTCAGCGAAAAAATTAGAGAGTTACTTAAGTCCTTAACGG
ATAATAAAATTTATACATTTGATCCGGAAACGATGGCAGAGGAATGTTTAAATGTTTTATCTTCGATAGGAGCTAATCTC
ATACTAGTTGAAGGTGGAAATCTAATGTATGAAACTTTTTCTTCTAAAATGAGAGATGACGATTTGATTTTAAAAATTCG
ATCTACTTTTACCATACCGGAAGGTATAAAACCCAAGTTGATTACAAATTCTGAAACCTTAATCTGGAAAACAAGTGTCG
GGAAAGATATTTGGGAGGTGCACGGATGTTTACCGGTTTAG

Upstream 100 bases:

>100_bases
TTCTTACGTTTGGAATTGTGATTGGAACGTATTCTTCGATTTTTATTGCAGCCCCTCTTGTAGATATTTACGACCAAGTT
ATACGAAAGGCTCGCGACTG

Downstream 100 bases:

>100_bases
TCGAAACCACTGGAAGAATTTCTGAAATTCAAGAAACGACTGAGGGAAGAAGTTTTTTAGTGGAGACAAAGTGGGTGCGT
CCGGATCTCAAGTTAGGTGA

Product: hypothetical protein

Products: NA

Alternate protein names: Diaminohydroxyphosphoribosylaminopyrimidine deaminase; DRAP deaminase; Riboflavin-specific deaminase; 5-amino-6-(5-phosphoribosylamino)uracil reductase; HTP reductase [H]

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MTSLPEKFREELRKLSFLSMGESSPNPPVSCLITDVENKRIFAKGRTSPTGGPHAERNAYYEFINNGLLSKPHNVWVTFE
PCTHHGKTPPCLDLILEHKPKTLYYGLKDPNPLVRKNEGLEICRNAGIQVVSDFGLKEIAEESLFGFISRIEKQKPSMII
KSAVSKEGFFTTKDKATVRLSGNLSDRLTSILRAKCDAVLIGPRTLFQDLPGLDFRIGGNWATDLGTIQENIFGESNGFD
ISRWFEAGVDLERAGVLKFEHGAYFERGDEIKDLEKNLGVGSEIKNSEGTSRFLKNILKYGFNPEISEIHRKDQENYQPY
RVFIIFEEKNIPESWVEKQRRINKKNNSKKCIFFLKRNESFSEKIRELLKSLTDNKIYTFDPETMAEECLNVLSSIGANL
ILVEGGNLMYETFSSKMRDDDLILKIRSTFTIPEGIKPKLITNSETLIWKTSVGKDIWEVHGCLPV

Sequences:

>Translated_466_residues
MTSLPEKFREELRKLSFLSMGESSPNPPVSCLITDVENKRIFAKGRTSPTGGPHAERNAYYEFINNGLLSKPHNVWVTFE
PCTHHGKTPPCLDLILEHKPKTLYYGLKDPNPLVRKNEGLEICRNAGIQVVSDFGLKEIAEESLFGFISRIEKQKPSMII
KSAVSKEGFFTTKDKATVRLSGNLSDRLTSILRAKCDAVLIGPRTLFQDLPGLDFRIGGNWATDLGTIQENIFGESNGFD
ISRWFEAGVDLERAGVLKFEHGAYFERGDEIKDLEKNLGVGSEIKNSEGTSRFLKNILKYGFNPEISEIHRKDQENYQPY
RVFIIFEEKNIPESWVEKQRRINKKNNSKKCIFFLKRNESFSEKIRELLKSLTDNKIYTFDPETMAEECLNVLSSIGANL
ILVEGGNLMYETFSSKMRDDDLILKIRSTFTIPEGIKPKLITNSETLIWKTSVGKDIWEVHGCLPV
>Mature_465_residues
TSLPEKFREELRKLSFLSMGESSPNPPVSCLITDVENKRIFAKGRTSPTGGPHAERNAYYEFINNGLLSKPHNVWVTFEP
CTHHGKTPPCLDLILEHKPKTLYYGLKDPNPLVRKNEGLEICRNAGIQVVSDFGLKEIAEESLFGFISRIEKQKPSMIIK
SAVSKEGFFTTKDKATVRLSGNLSDRLTSILRAKCDAVLIGPRTLFQDLPGLDFRIGGNWATDLGTIQENIFGESNGFDI
SRWFEAGVDLERAGVLKFEHGAYFERGDEIKDLEKNLGVGSEIKNSEGTSRFLKNILKYGFNPEISEIHRKDQENYQPYR
VFIIFEEKNIPESWVEKQRRINKKNNSKKCIFFLKRNESFSEKIRELLKSLTDNKIYTFDPETMAEECLNVLSSIGANLI
LVEGGNLMYETFSSKMRDDDLILKIRSTFTIPEGIKPKLITNSETLIWKTSVGKDIWEVHGCLPV

Specific function: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate [H]

COG id: COG0117

COG function: function code H; Pyrimidine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the HTP reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786616, Length=206, Percent_Identity=31.5533980582524, Blast_Score=97, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193
- InterPro:   IPR004794
- InterPro:   IPR011549
- InterPro:   IPR002734 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1; PF01872 RibD_C [H]

EC number: =3.5.4.26; =1.1.1.193 [H]

Molecular weight: Translated: 52990; Mature: 52859

Theoretical pI: Translated: 7.76; Mature: 7.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSLPEKFREELRKLSFLSMGESSPNPPVSCLITDVENKRIFAKGRTSPTGGPHAERNAY
CCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCEEEECCCCCCCCCCCCHHHHH
YEFINNGLLSKPHNVWVTFEPCTHHGKTPPCLDLILEHKPKTLYYGLKDPNPLVRKNEGL
HHHHHCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCCH
EICRNAGIQVVSDFGLKEIAEESLFGFISRIEKQKPSMIIKSAVSKEGFFTTKDKATVRL
HHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEECCCEEEEE
SGNLSDRLTSILRAKCDAVLIGPRTLFQDLPGLDFRIGGNWATDLGTIQENIFGESNGFD
ECCHHHHHHHHHHHCCCEEEECCHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCCCCCC
ISRWFEAGVDLERAGVLKFEHGAYFERGDEIKDLEKNLGVGSEIKNSEGTSRFLKNILKY
HHHHHHCCCCCHHCCEEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHC
GFNPEISEIHRKDQENYQPYRVFIIFEEKNIPESWVEKQRRINKKNNSKKCIFFLKRNES
CCCCCHHHHHHHHCCCCCCEEEEEEEECCCCCHHHHHHHHHCCCCCCCCEEEEEEECCCC
FSEKIRELLKSLTDNKIYTFDPETMAEECLNVLSSIGANLILVEGGNLMYETFSSKMRDD
HHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHCCCCEEEEECCCEEHHHHHHHCCCC
DLILKIRSTFTIPEGIKPKLITNSETLIWKTSVGKDIWEVHGCLPV
CEEEEEECCCCCCCCCCCCEEECCCEEEEECCCCCHHHHHCCCCCC
>Mature Secondary Structure 
TSLPEKFREELRKLSFLSMGESSPNPPVSCLITDVENKRIFAKGRTSPTGGPHAERNAY
CCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCEEEECCCCCCCCCCCCHHHHH
YEFINNGLLSKPHNVWVTFEPCTHHGKTPPCLDLILEHKPKTLYYGLKDPNPLVRKNEGL
HHHHHCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCCH
EICRNAGIQVVSDFGLKEIAEESLFGFISRIEKQKPSMIIKSAVSKEGFFTTKDKATVRL
HHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEECCCEEEEE
SGNLSDRLTSILRAKCDAVLIGPRTLFQDLPGLDFRIGGNWATDLGTIQENIFGESNGFD
ECCHHHHHHHHHHHCCCEEEECCHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCCCCCC
ISRWFEAGVDLERAGVLKFEHGAYFERGDEIKDLEKNLGVGSEIKNSEGTSRFLKNILKY
HHHHHHCCCCCHHCCEEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHC
GFNPEISEIHRKDQENYQPYRVFIIFEEKNIPESWVEKQRRINKKNNSKKCIFFLKRNES
CCCCCHHHHHHHHCCCCCCEEEEEEEECCCCCHHHHHHHHHCCCCCCCCEEEEEEECCCC
FSEKIRELLKSLTDNKIYTFDPETMAEECLNVLSSIGANLILVEGGNLMYETFSSKMRDD
HHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHCCCCEEEEECCCEEHHHHHHHCCCC
DLILKIRSTFTIPEGIKPKLITNSETLIWKTSVGKDIWEVHGCLPV
CEEEEEECCCCCCCCCCCCEEECCCEEEEECCCCCHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8522537 [H]