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The map label for this gene is lplA

Identifier: 45658180

GI number: 45658180

Start: 2818377

End: 2819363

Strand: Direct

Name: lplA

Synonym: LIC12334

Alternate gene names: 45658180

Gene position: 2818377-2819363 (Clockwise)

Preceding gene: 45658179

Following gene: 45658181

Centisome position: 65.89

GC content: 35.87

Gene sequence:

>987_bases
ATGCGTACTTTTTCGTTCGTTCAAAATTCAATTCGATCTGCTGCGTTTAATCTTGCCATCGAAGAAGCAATCGGGCTTCA
TCTTGTTTCTTCAGGATATGGAGCAGGACTTAGGATCTGGAAAAATCCATTTTCCATTGTACTAGGACTTTCCGAAAAAG
CGGAAGATACTATATTACCCGAAATACTTCTGCATTTTCAAGAATCGAAATTTAGTGGAATGATTGGTTTTGAAGATATA
AAATCCGAAACAAATTTAAACTTAACCCAAAGTAGAAACGATAACTTCTCAAAAAATTTTCACTCTAATTTGGCGCAGGA
AACTTTCGGAAACAATCAAAAAACTAAAATAGAAAATTTCAAATTCAATTCTAAAATAGAAGATCAAAACAGTTTTACAA
AAGAATTTCCTATGATCGTACGAAGGGCAAGCGGAGGCGGAACCGTAGTTCATCATCCAGACGAAAATCTGAACTTTACG
TTTTTTATTTCCTTGGACGTAAAACCAGAACTCTATAAAGTAAAAGAATCCTACGATTATTTTCTAAGTTTGGTGTTGGA
TGCGTTAAAAAGGCAAACGTTAGGCGCTTCTTTACGTGGAAAATCAGATCTCGCGGTGTTAGAAAATGGTCTGGAAAAAA
AAATTTCAGGAAACGCTCAGTTTAGAAAAAGAGGAGCGGTCGTTCATCATGGAACCTTAATTTTGAAACCTTCTCTGATC
GAAAGAGTTTCCAAACTACTCAAACATCCCCCCGAAGAACCGGAATACAGAAAAAATAGAAAACATACCGATTTTGTGAC
CTCTCTTCCGGACAATTTTTCTACAGTAAAATTTAGCCAGGATCTATCTCATGTATTTGCCGAATCCTTGGGTCTTTCCA
AAATAGGCTCAGAGAGTGATCTCCGATTTCAGAAAGTTGTATTTCAAGAAGCAAAATTGCTTTTCGAAAACAAATATTCT
AGGATGGATTTTATCTTCAGAGACTAA

Upstream 100 bases:

>100_bases
TTTTAACAGTAAAAACCTTAGGTCGGAACTACAGACAAATAATCATTCCGATTGCGTAAAAACGTAAGAACCCATAACTT
GCAAATAGAAACCGTTTACG

Downstream 100 bases:

>100_bases
ATCGGACTTTTACTCGGAACTATCAGAAAGAAGGTCCAGATGCAGTTTCTTCCAAAAGCAGATCCAGAAATATTTGCAGC
ATTAAAAAAAGAGGATGAAA

Product: lipoate-protein ligase a

Products: NA

Alternate protein names: Lipoate--protein ligase [H]

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MRTFSFVQNSIRSAAFNLAIEEAIGLHLVSSGYGAGLRIWKNPFSIVLGLSEKAEDTILPEILLHFQESKFSGMIGFEDI
KSETNLNLTQSRNDNFSKNFHSNLAQETFGNNQKTKIENFKFNSKIEDQNSFTKEFPMIVRRASGGGTVVHHPDENLNFT
FFISLDVKPELYKVKESYDYFLSLVLDALKRQTLGASLRGKSDLAVLENGLEKKISGNAQFRKRGAVVHHGTLILKPSLI
ERVSKLLKHPPEEPEYRKNRKHTDFVTSLPDNFSTVKFSQDLSHVFAESLGLSKIGSESDLRFQKVVFQEAKLLFENKYS
RMDFIFRD

Sequences:

>Translated_328_residues
MRTFSFVQNSIRSAAFNLAIEEAIGLHLVSSGYGAGLRIWKNPFSIVLGLSEKAEDTILPEILLHFQESKFSGMIGFEDI
KSETNLNLTQSRNDNFSKNFHSNLAQETFGNNQKTKIENFKFNSKIEDQNSFTKEFPMIVRRASGGGTVVHHPDENLNFT
FFISLDVKPELYKVKESYDYFLSLVLDALKRQTLGASLRGKSDLAVLENGLEKKISGNAQFRKRGAVVHHGTLILKPSLI
ERVSKLLKHPPEEPEYRKNRKHTDFVTSLPDNFSTVKFSQDLSHVFAESLGLSKIGSESDLRFQKVVFQEAKLLFENKYS
RMDFIFRD
>Mature_328_residues
MRTFSFVQNSIRSAAFNLAIEEAIGLHLVSSGYGAGLRIWKNPFSIVLGLSEKAEDTILPEILLHFQESKFSGMIGFEDI
KSETNLNLTQSRNDNFSKNFHSNLAQETFGNNQKTKIENFKFNSKIEDQNSFTKEFPMIVRRASGGGTVVHHPDENLNFT
FFISLDVKPELYKVKESYDYFLSLVLDALKRQTLGASLRGKSDLAVLENGLEKKISGNAQFRKRGAVVHHGTLILKPSLI
ERVSKLLKHPPEEPEYRKNRKHTDFVTSLPDNFSTVKFSQDLSHVFAESLGLSKIGSESDLRFQKVVFQEAKLLFENKYS
RMDFIFRD

Specific function: Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes [H]

COG id: COG0095

COG function: function code H; Lipoate-protein ligase A

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lplA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004143
- InterPro:   IPR005107
- InterPro:   IPR019491
- InterPro:   IPR004562 [H]

Pfam domain/function: PF03099 BPL_LipA_LipB; PF10437 Lip_prot_lig_C [H]

EC number: =2.7.7.63 [H]

Molecular weight: Translated: 37354; Mature: 37354

Theoretical pI: Translated: 9.60; Mature: 9.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTFSFVQNSIRSAAFNLAIEEAIGLHLVSSGYGAGLRIWKNPFSIVLGLSEKAEDTILP
CCCHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCEEEECCCEEEEEECCCCCCHHHHH
EILLHFQESKFSGMIGFEDIKSETNLNLTQSRNDNFSKNFHSNLAQETFGNNQKTKIENF
HHHHHHHHCCCCCCCCHHHHCCCCCCCEECCCCCCCHHHHHHHHHHHHHCCCCCCEECCE
KFNSKIEDQNSFTKEFPMIVRRASGGGTVVHHPDENLNFTFFISLDVKPELYKVKESYDY
ECCCCCCCCHHHHHHHHHHEEECCCCCCEEECCCCCCCEEEEEEEECCCHHHHHHHHHHH
FLSLVLDALKRQTLGASLRGKSDLAVLENGLEKKISGNAQFRKRGAVVHHGTLILKPSLI
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHCCCEEECCEEEECHHHH
ERVSKLLKHPPEEPEYRKNRKHTDFVTSLPDNFSTVKFSQDLSHVFAESLGLSKIGSESD
HHHHHHHHCCCCCCHHHHCCCCCHHHHCCCCCCCEEEHHHHHHHHHHHHCCHHHCCCCCC
LRFQKVVFQEAKLLFENKYSRMDFIFRD
HHHHHHHHHHHHHHHHCCCCCCCEEECC
>Mature Secondary Structure
MRTFSFVQNSIRSAAFNLAIEEAIGLHLVSSGYGAGLRIWKNPFSIVLGLSEKAEDTILP
CCCHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCEEEECCCEEEEEECCCCCCHHHHH
EILLHFQESKFSGMIGFEDIKSETNLNLTQSRNDNFSKNFHSNLAQETFGNNQKTKIENF
HHHHHHHHCCCCCCCCHHHHCCCCCCCEECCCCCCCHHHHHHHHHHHHHCCCCCCEECCE
KFNSKIEDQNSFTKEFPMIVRRASGGGTVVHHPDENLNFTFFISLDVKPELYKVKESYDY
ECCCCCCCCHHHHHHHHHHEEECCCCCCEEECCCCCCCEEEEEEEECCCHHHHHHHHHHH
FLSLVLDALKRQTLGASLRGKSDLAVLENGLEKKISGNAQFRKRGAVVHHGTLILKPSLI
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHCCCEEECCEEEECHHHH
ERVSKLLKHPPEEPEYRKNRKHTDFVTSLPDNFSTVKFSQDLSHVFAESLGLSKIGSESD
HHHHHHHHCCCCCCHHHHCCCCCHHHHCCCCCCCEEEHHHHHHHHHHHHCCHHHCCCCCC
LRFQKVVFQEAKLLFENKYSRMDFIFRD
HHHHHHHHHHHHHHHHCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]