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The map label for this gene is czcB

Identifier: 45658154

GI number: 45658154

Start: 2780238

End: 2781419

Strand: Reverse

Name: czcB

Synonym: LIC12306

Alternate gene names: 45658154

Gene position: 2781419-2780238 (Counterclockwise)

Preceding gene: 45658155

Following gene: 45658153

Centisome position: 65.03

GC content: 39.09

Gene sequence:

>1182_bases
ATGATCCAAATCATAAAAAGATATAAATTTATTCTGGTTCTTCTCGCGGTTTTAAGTACGGGATATTTAGGGTATAAAAA
ATTCTTCCCGAAAAAAACTGAAGAAAAGAAACAATCGACTGTCGATAAAAACAAATTCACCGTATCCGAAGAGATATTAA
AAAGACATCCTATTACGTTAGTCTCTCTTAAGGAGATTGCTGCAATTGACGAAGTAGCTCTTCCTGGAAGGATTTCGTAC
GACCCAGAAAGTATGGCTAGGGCGGGTTCCACGGTAGAAGCCAGGATCAAAAAAGTTTTAGTGAGAGAAGGGGATCGAGT
CAGTCAGGGTTCTCCACTTGCGATTCTTTCTTCGGTAATGCTTGGGGAAGTGGAAGCTTCTTATGTAAAAGCAAGGGCCA
GTCTTGAAGCCTTAAAGTTACAAGCAGACCGTGCAAAAGAACTTTTTGATATGAAAGTGACTTCTGCAAAAGATTATGAA
TTTGCAAACATGCAATATAAAACCGCTAAAACTGAAGTGGAAACGACTCGAATCAAACTAGAAAACTACGGATTGACTCC
TGCGGAAATCGCTGGAATTGAAAGAGGGGTTTACGTTTCTTCTAATCTAGTTCTAAGAAGTCCTATTAACGGAGAAGTTA
CAGAAAGAAAAGCGGTTCAAGGACAACAAGTGACTAGAAACGAAGATCTGTTTACGATCGCCAATTTAACCAATCTGATG
GTTCTATTAGAAGTTTATGAAAAAGATCTAGGTATGATTTCTGAAGGGGCGGAAGCTCAAATTTATCCATTAGGAGATGA
AAAGTCTCCCGGAATTCGGGGAGAGGTCGCGTATGTGGGAAGCGTTTTAGATAGTATCAAAAGAACAGCAAAACTTAGAA
TCATGGTTTCCAATCGAAACGGAAAACTAAAACCGGGTCAATCTGTAACCGCAAAAGTAAAAGGAATGGTGGCCAATTCT
GGTTCCGAACCAAGAAAGACAATTCCTCTAGAAGCAGTTCATGAAATCGAAGGAAAGTCTTTTGTGTTTCTTCAGAACGA
AGATGGAAGTTTTGAAGCTACTGAAGTAATTGTAGGAGATACCGTGGGAGATGAAGTTGTCATCAAAGCGGGTATTAGAG
AAGGAGCAGAGATCGTTTCTAGAGGATCCTTTATTCTTAAAAGTGAATATTTAAAGCTTTGA

Upstream 100 bases:

>100_bases
ATTATTATGAAGTGTTGTATCTATATTACAACGCGGTTGAAATTTATAAGGCTGCAGTCGGAAAAAAAATGGAGAGGGAC
TAAAAAACTTCGGAGATTCT

Downstream 100 bases:

>100_bases
TTTTACTATTTTTGTGTTGACTTAGCATCTATTCACTACTAAGTTGTTTAGTATGAAAGACCTGACAGACAAACAACAGG
CTGTTCTTGCATTTATCACA

Product: heavy metal efflux pump

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MIQIIKRYKFILVLLAVLSTGYLGYKKFFPKKTEEKKQSTVDKNKFTVSEEILKRHPITLVSLKEIAAIDEVALPGRISY
DPESMARAGSTVEARIKKVLVREGDRVSQGSPLAILSSVMLGEVEASYVKARASLEALKLQADRAKELFDMKVTSAKDYE
FANMQYKTAKTEVETTRIKLENYGLTPAEIAGIERGVYVSSNLVLRSPINGEVTERKAVQGQQVTRNEDLFTIANLTNLM
VLLEVYEKDLGMISEGAEAQIYPLGDEKSPGIRGEVAYVGSVLDSIKRTAKLRIMVSNRNGKLKPGQSVTAKVKGMVANS
GSEPRKTIPLEAVHEIEGKSFVFLQNEDGSFEATEVIVGDTVGDEVVIKAGIREGAEIVSRGSFILKSEYLKL

Sequences:

>Translated_393_residues
MIQIIKRYKFILVLLAVLSTGYLGYKKFFPKKTEEKKQSTVDKNKFTVSEEILKRHPITLVSLKEIAAIDEVALPGRISY
DPESMARAGSTVEARIKKVLVREGDRVSQGSPLAILSSVMLGEVEASYVKARASLEALKLQADRAKELFDMKVTSAKDYE
FANMQYKTAKTEVETTRIKLENYGLTPAEIAGIERGVYVSSNLVLRSPINGEVTERKAVQGQQVTRNEDLFTIANLTNLM
VLLEVYEKDLGMISEGAEAQIYPLGDEKSPGIRGEVAYVGSVLDSIKRTAKLRIMVSNRNGKLKPGQSVTAKVKGMVANS
GSEPRKTIPLEAVHEIEGKSFVFLQNEDGSFEATEVIVGDTVGDEVVIKAGIREGAEIVSRGSFILKSEYLKL
>Mature_393_residues
MIQIIKRYKFILVLLAVLSTGYLGYKKFFPKKTEEKKQSTVDKNKFTVSEEILKRHPITLVSLKEIAAIDEVALPGRISY
DPESMARAGSTVEARIKKVLVREGDRVSQGSPLAILSSVMLGEVEASYVKARASLEALKLQADRAKELFDMKVTSAKDYE
FANMQYKTAKTEVETTRIKLENYGLTPAEIAGIERGVYVSSNLVLRSPINGEVTERKAVQGQQVTRNEDLFTIANLTNLM
VLLEVYEKDLGMISEGAEAQIYPLGDEKSPGIRGEVAYVGSVLDSIKRTAKLRIMVSNRNGKLKPGQSVTAKVKGMVANS
GSEPRKTIPLEAVHEIEGKSFVFLQNEDGSFEATEVIVGDTVGDEVVIKAGIREGAEIVSRGSFILKSEYLKL

Specific function: CzcA and CzcB together would act in zinc efflux nearly as effectively as the complete czc efflux system (CzcABC). The CzcB protein is thought to funnel zinc cations to the CzcA transport protein [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1786787, Length=321, Percent_Identity=22.4299065420561, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1789929, Length=327, Percent_Identity=25.0764525993884, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005695
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 43302; Mature: 43302

Theoretical pI: Translated: 9.34; Mature: 9.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQIIKRYKFILVLLAVLSTGYLGYKKFFPKKTEEKKQSTVDKNKFTVSEEILKRHPITL
CHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCHHHHHHHCCCCCCCHHHHHHHHCCEEE
VSLKEIAAIDEVALPGRISYDPESMARAGSTVEARIKKVLVREGDRVSQGSPLAILSSVM
EEHHHHHHHHHHCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
LGEVEASYVKARASLEALKLQADRAKELFDMKVTSAKDYEFANMQYKTAKTEVETTRIKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCEECCEEEECCCCEEEEEEEEE
ENYGLTPAEIAGIERGVYVSSNLVLRSPINGEVTERKAVQGQQVTRNEDLFTIANLTNLM
ECCCCCHHHHHCCCCCEEEECCEEEECCCCCCHHHHHHHCCCCCCCCCCEEEHHHHHHHH
VLLEVYEKDLGMISEGAEAQIYPLGDEKSPGIRGEVAYVGSVLDSIKRTAKLRIMVSNRN
HHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCEEEEEEEECCC
GKLKPGQSVTAKVKGMVANSGSEPRKTIPLEAVHEIEGKSFVFLQNEDGSFEATEVIVGD
CCCCCCCCCEEEEEEEEECCCCCCCCCCCHHHHHHCCCCEEEEEECCCCCEEEEEEEEEC
TVGDEVVIKAGIREGAEIVSRGSFILKSEYLKL
CCCCCEEEECCCHHHHHHHHCCCEEEEHHHHCC
>Mature Secondary Structure
MIQIIKRYKFILVLLAVLSTGYLGYKKFFPKKTEEKKQSTVDKNKFTVSEEILKRHPITL
CHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCHHHHHHHCCCCCCCHHHHHHHHCCEEE
VSLKEIAAIDEVALPGRISYDPESMARAGSTVEARIKKVLVREGDRVSQGSPLAILSSVM
EEHHHHHHHHHHCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
LGEVEASYVKARASLEALKLQADRAKELFDMKVTSAKDYEFANMQYKTAKTEVETTRIKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCEECCEEEECCCCEEEEEEEEE
ENYGLTPAEIAGIERGVYVSSNLVLRSPINGEVTERKAVQGQQVTRNEDLFTIANLTNLM
ECCCCCHHHHHCCCCCEEEECCEEEECCCCCCHHHHHHHCCCCCCCCCCEEEHHHHHHHH
VLLEVYEKDLGMISEGAEAQIYPLGDEKSPGIRGEVAYVGSVLDSIKRTAKLRIMVSNRN
HHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCEEEEEEEECCC
GKLKPGQSVTAKVKGMVANSGSEPRKTIPLEAVHEIEGKSFVFLQNEDGSFEATEVIVGD
CCCCCCCCCEEEEEEEEECCCCCCCCCCCHHHHHHCCCCEEEEEECCCCCEEEEEEEEEC
TVGDEVVIKAGIREGAEIVSRGSFILKSEYLKL
CCCCCEEEECCCHHHHHHHHCCCEEEEHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8829543 [H]