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The map label for this gene is purK

Identifier: 45658141

GI number: 45658141

Start: 2765841

End: 2766971

Strand: Direct

Name: purK

Synonym: LIC12293

Alternate gene names: 45658141

Gene position: 2765841-2766971 (Clockwise)

Preceding gene: 45658140

Following gene: 45658147

Centisome position: 64.66

GC content: 37.05

Gene sequence:

>1131_bases
GTGAACAATTCTCGAATGCTTCTTCCAGGTTCCAGGCTGGGAGTGATGGGATCAGGACAACTCGCGAGAATGTTTTGTTT
AGAAGCGATTCCTTTTGGTTACGAGATTTCCGTTTATTCTCCCGAAAAAAATTCTCCGGCCGCAGGAGCGGGAGCAAAAG
AATATATATCCACTTACGAAGACGAAAAAGCTCTGACTTTTTTTTTGGAAAATATAGACGGTCTTACATTTGAATTTGAG
AATATTCCAGAAATTGCACTTACTACAATAGAAAATTTTTCTAAACGAACCGGACTGATAGTTAGACCTTCTCCGAACTG
CGTCAGAATTTCACAAAATCGCTGGAAGGAAAAAACTTCTTTTCAAAAAGCAGGAATTCCTACGGTGAAATTTTATCCGG
TTTTAACGGAAGAAGACAAAAAATCCGTTCTTTCTAAGACTAATTTTCCCTGTATCTTAAAAACGAATACGATGGGTTAC
GACGGTAGGGGGCAGATTCGGTGTATCACCGAACAAGAACTATCTTTAGTATTTTCTAACCTCAACAAACCGGATCATAT
CGTAGAAGAATTTTTCCAATTTACTTCGGAAGCCTCCGTTATTATGGCCAGATTTGAAGACGGCAAAATTTTAAATTTTA
GACCTTCTAAAAACGTTCATAAAAATCATATCTTGGACCTTACATTTTATCCCGGAAATTTTCCAGATAGTATAGAAACT
AAACTTGTAAACTATGCAAAAAAATTAGCGGAAACAATCGATTACGTTGGAGTTTTTGGGATAGAGTTTTTTATCCGAGG
AGACGAAATTTTATGCAACGAATTTGCACCTAGGCCGCATAACTCAGGACATTTTAGTCAAAACTCTGGTACAATTTCTC
AATTTTCCCTTCAGCTGAGAACTCTTTGTAACTTACCTTCCCCAAAAACAATCCTGGCCAACCCAGTATCAATGAAAAAT
ATTTTAGGAGAAGATTATAAACCCGGATCTACTCTTTGGAATAAAACATTAGAAAATCCTTATTATCATCTTCATCTTTA
TGGCAAAACAGAAATTCGAAACGGAAGAAAGATGGGACACTGGAATTACTCCGGCCCCAACATAGAATCTGCTTTTTTAA
ACTGGGACTAA

Upstream 100 bases:

>100_bases
TCAGAATTCTTGCACTTCAAGATCCTATACTTTCCGAAAAACTAGAACGATATCGTAATCAAATTCGAGAAGACGCACTT
TCTAAAAATAAGGATTTATT

Downstream 100 bases:

>100_bases
TGTGAGTTCGATGTAAGAAAATATTGGCGAGTCCTGGTCCTCAACTCTGGTTATTAAATTGCATGCAGGAAACATACTAA
TCTATGGATCGCCGTTCTGG

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit protein

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MNNSRMLLPGSRLGVMGSGQLARMFCLEAIPFGYEISVYSPEKNSPAAGAGAKEYISTYEDEKALTFFLENIDGLTFEFE
NIPEIALTTIENFSKRTGLIVRPSPNCVRISQNRWKEKTSFQKAGIPTVKFYPVLTEEDKKSVLSKTNFPCILKTNTMGY
DGRGQIRCITEQELSLVFSNLNKPDHIVEEFFQFTSEASVIMARFEDGKILNFRPSKNVHKNHILDLTFYPGNFPDSIET
KLVNYAKKLAETIDYVGVFGIEFFIRGDEILCNEFAPRPHNSGHFSQNSGTISQFSLQLRTLCNLPSPKTILANPVSMKN
ILGEDYKPGSTLWNKTLENPYYHLHLYGKTEIRNGRKMGHWNYSGPNIESAFLNWD

Sequences:

>Translated_376_residues
MNNSRMLLPGSRLGVMGSGQLARMFCLEAIPFGYEISVYSPEKNSPAAGAGAKEYISTYEDEKALTFFLENIDGLTFEFE
NIPEIALTTIENFSKRTGLIVRPSPNCVRISQNRWKEKTSFQKAGIPTVKFYPVLTEEDKKSVLSKTNFPCILKTNTMGY
DGRGQIRCITEQELSLVFSNLNKPDHIVEEFFQFTSEASVIMARFEDGKILNFRPSKNVHKNHILDLTFYPGNFPDSIET
KLVNYAKKLAETIDYVGVFGIEFFIRGDEILCNEFAPRPHNSGHFSQNSGTISQFSLQLRTLCNLPSPKTILANPVSMKN
ILGEDYKPGSTLWNKTLENPYYHLHLYGKTEIRNGRKMGHWNYSGPNIESAFLNWD
>Mature_376_residues
MNNSRMLLPGSRLGVMGSGQLARMFCLEAIPFGYEISVYSPEKNSPAAGAGAKEYISTYEDEKALTFFLENIDGLTFEFE
NIPEIALTTIENFSKRTGLIVRPSPNCVRISQNRWKEKTSFQKAGIPTVKFYPVLTEEDKKSVLSKTNFPCILKTNTMGY
DGRGQIRCITEQELSLVFSNLNKPDHIVEEFFQFTSEASVIMARFEDGKILNFRPSKNVHKNHILDLTFYPGNFPDSIET
KLVNYAKKLAETIDYVGVFGIEFFIRGDEILCNEFAPRPHNSGHFSQNSGTISQFSLQLRTLCNLPSPKTILANPVSMKN
ILGEDYKPGSTLWNKTLENPYYHLHLYGKTEIRNGRKMGHWNYSGPNIESAFLNWD

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=353, Percent_Identity=30.3116147308782, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1788155, Length=366, Percent_Identity=23.4972677595628, Blast_Score=98, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6324702, Length=364, Percent_Identity=31.043956043956, Blast_Score=172, Evalue=9e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 42668; Mature: 42668

Theoretical pI: Translated: 7.53; Mature: 7.53

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNSRMLLPGSRLGVMGSGQLARMFCLEAIPFGYEISVYSPEKNSPAAGAGAKEYISTYE
CCCCEEECCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHCC
DEKALTFFLENIDGLTFEFENIPEIALTTIENFSKRTGLIVRPSPNCVRISQNRWKEKTS
CCHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHCCEEECCCCCEEEECHHHHHHHHH
FQKAGIPTVKFYPVLTEEDKKSVLSKTNFPCILKTNTMGYDGRGQIRCITEQELSLVFSN
HHHCCCCEEEEEEEECCCHHHHHHHCCCCCEEEEECCCCCCCCCCEEEECHHHHHHHHHH
LNKPDHIVEEFFQFTSEASVIMARFEDGKILNFRPSKNVHKNHILDLTFYPGNFPDSIET
CCCCHHHHHHHHHHCCCCEEEEEEECCCEEEEECCCCCCCCCEEEEEEECCCCCCCHHHH
KLVNYAKKLAETIDYVGVFGIEFFIRGDEILCNEFAPRPHNSGHFSQNSGTISQFSLQLR
HHHHHHHHHHHHHHHHHEEEEEEEEECCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHH
TLCNLPSPKTILANPVSMKNILGEDYKPGSTLWNKTLENPYYHLHLYGKTEIRNGRKMGH
HHHCCCCCCEEEECCCHHHHHHCCCCCCCHHHHHHHHCCCEEEEEEEECCCCCCCCEECC
WNYSGPNIESAFLNWD
CCCCCCCCCCEEECCC
>Mature Secondary Structure
MNNSRMLLPGSRLGVMGSGQLARMFCLEAIPFGYEISVYSPEKNSPAAGAGAKEYISTYE
CCCCEEECCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHCC
DEKALTFFLENIDGLTFEFENIPEIALTTIENFSKRTGLIVRPSPNCVRISQNRWKEKTS
CCHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHCCEEECCCCCEEEECHHHHHHHHH
FQKAGIPTVKFYPVLTEEDKKSVLSKTNFPCILKTNTMGYDGRGQIRCITEQELSLVFSN
HHHCCCCEEEEEEEECCCHHHHHHHCCCCCEEEEECCCCCCCCCCEEEECHHHHHHHHHH
LNKPDHIVEEFFQFTSEASVIMARFEDGKILNFRPSKNVHKNHILDLTFYPGNFPDSIET
CCCCHHHHHHHHHHCCCCEEEEEEECCCEEEEECCCCCCCCCEEEEEEECCCCCCCHHHH
KLVNYAKKLAETIDYVGVFGIEFFIRGDEILCNEFAPRPHNSGHFSQNSGTISQFSLQLR
HHHHHHHHHHHHHHHHHEEEEEEEEECCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHH
TLCNLPSPKTILANPVSMKNILGEDYKPGSTLWNKTLENPYYHLHLYGKTEIRNGRKMGH
HHHCCCCCCEEEECCCHHHHHHCCCCCCCHHHHHHHHCCCEEEEEEEECCCCCCCCEECC
WNYSGPNIESAFLNWD
CCCCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11756688 [H]