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The map label for this gene is purE

Identifier: 45658140

GI number: 45658140

Start: 2765356

End: 2765844

Strand: Direct

Name: purE

Synonym: LIC12292

Alternate gene names: 45658140

Gene position: 2765356-2765844 (Clockwise)

Preceding gene: 45658139

Following gene: 45658141

Centisome position: 64.65

GC content: 39.47

Gene sequence:

>489_bases
TTGAACACAAAAGTTGCAATCATTATGGGAAGCCATTCCGATTGGGAAACGATGAAAGAAGCGGAGATCATTCTTAAAGA
ATTTGGCGTTTCTATTCACAAAGAAATTGTTTCTGCACATAGATCTCCTGAGCTTATGTTAGAATTTTCTAAATCTGCAA
AAGAAAAAGGTTACTCCGTAATCATCGCAGGAGCAGGAGGTGCGGCCCATCTTCCCGGAATGGTTGCATCGATGACTACT
CTTCCTGTTTTAGGAGTTCCAATACAAAGTAAAACTTTAAACGGATTGGATAGTTTATTATCCATCGTTCAAATGCCAGG
GGGAGTTCCAGTAGGAACTCTTGCGATCGGAACTGCAGGCGCAAAAAATGCTGGTTTATTGGCAGTCAGAATTCTTGCAC
TTCAAGATCCTATACTTTCCGAAAAACTAGAACGATATCGTAATCAAATTCGAGAAGACGCACTTTCTAAAAATAAGGAT
TTATTGTGA

Upstream 100 bases:

>100_bases
CGTCTCGAGGAATTCAATTGGAACGTTTCGTAGAAGCGCTTCCGGTTTAATACTTGCAAACAAGTAAATCTAAAGAAACA
TCTTCCACAGGAGAAAATGT

Downstream 100 bases:

>100_bases
ACAATTCTCGAATGCTTCTTCCAGGTTCCAGGCTGGGAGTGATGGGATCAGGACAACTCGCGAGAATGTTTTGTTTAGAA
GCGATTCCTTTTGGTTACGA

Product: phosphoribosylaminoimidazole carboxylase catalytic subunit protein

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 162; Mature: 162

Protein sequence:

>162_residues
MNTKVAIIMGSHSDWETMKEAEIILKEFGVSIHKEIVSAHRSPELMLEFSKSAKEKGYSVIIAGAGGAAHLPGMVASMTT
LPVLGVPIQSKTLNGLDSLLSIVQMPGGVPVGTLAIGTAGAKNAGLLAVRILALQDPILSEKLERYRNQIREDALSKNKD
LL

Sequences:

>Translated_162_residues
MNTKVAIIMGSHSDWETMKEAEIILKEFGVSIHKEIVSAHRSPELMLEFSKSAKEKGYSVIIAGAGGAAHLPGMVASMTT
LPVLGVPIQSKTLNGLDSLLSIVQMPGGVPVGTLAIGTAGAKNAGLLAVRILALQDPILSEKLERYRNQIREDALSKNKD
LL
>Mature_162_residues
MNTKVAIIMGSHSDWETMKEAEIILKEFGVSIHKEIVSAHRSPELMLEFSKSAKEKGYSVIIAGAGGAAHLPGMVASMTT
LPVLGVPIQSKTLNGLDSLLSIVQMPGGVPVGTLAIGTAGAKNAGLLAVRILALQDPILSEKLERYRNQIREDALSKNKD
LL

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=157, Percent_Identity=57.9617834394904, Blast_Score=151, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6324702, Length=157, Percent_Identity=52.8662420382166, Blast_Score=154, Evalue=6e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17227; Mature: 17227

Theoretical pI: Translated: 8.97; Mature: 8.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTKVAIIMGSHSDWETMKEAEIILKEFGVSIHKEIVSAHRSPELMLEFSKSAKEKGYSV
CCCEEEEEEECCCCHHHHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEE
IIAGAGGAAHLPGMVASMTTLPVLGVPIQSKTLNGLDSLLSIVQMPGGVPVGTLAIGTAG
EEECCCCCHHCCHHHHHHHHHCEECCCCCCHHHHHHHHHHHHHHCCCCCCCHHEEECCCC
AKNAGLLAVRILALQDPILSEKLERYRNQIREDALSKNKDLL
CCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MNTKVAIIMGSHSDWETMKEAEIILKEFGVSIHKEIVSAHRSPELMLEFSKSAKEKGYSV
CCCEEEEEEECCCCHHHHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEE
IIAGAGGAAHLPGMVASMTTLPVLGVPIQSKTLNGLDSLLSIVQMPGGVPVGTLAIGTAG
EEECCCCCHHCCHHHHHHHHHCEECCCCCCHHHHHHHHHHHHHHCCCCCCCHHEEECCCC
AKNAGLLAVRILALQDPILSEKLERYRNQIREDALSKNKDLL
CCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9311113; 11427726 [H]