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The map label for this gene is csd [H]

Identifier: 45656532

GI number: 45656532

Start: 772830

End: 774080

Strand: Direct

Name: csd [H]

Synonym: LIC10634

Alternate gene names: 45656532

Gene position: 772830-774080 (Clockwise)

Preceding gene: 45656531

Following gene: 45656533

Centisome position: 18.07

GC content: 39.57

Gene sequence:

>1251_bases
TTGACAGATATGAGTTTCTCTGCCGAAAGAATTAGAACCGACTTCCCGATTTTGGGAACTAAGATGAACGGGAAACCACT
CGTTTTTTTAGATAGCGCCGCTAGTTCTCAGAAACCGTTTACGGTTATTGATACGATCGAGAAGTATTATCGAGAAGAGA
ACGCCAACATTCATCGTGGAATTTATTATCTTTCTCAAAAAGCTACTGAAAAATATGAACTGAGTAGGATTCGTCTTTCT
AAATTTATCGGAGCGCAATGCGCAAAGGTTTGTATTTTTACGAGAAACGCCACAGAGTCGATCAATTTAGTCGCCCAAAC
TTGGGGGAGAACTCAGATTAAAGAAGGGGATGAGATCGTACTCAACGAATTAGAGCATCATTCTAACATCGTACCTTGGC
AGATGTTGGCCCAGGAAAAAAAAGCGGTCTTAAAATTCATTCCTTTAAACGAAGATAGTACTTTAGATTTTTCTAATTTA
CAAGAGATTATCACAACCAAAACAAAGTTAGTTGCTATTTCTCAGATGTCTAACGTGACCGGGACGATTCATGATATTCT
TCCCGTGCAAAAACGTGCAAAAGAAGTAGGCGCCAAACTATTAGTAGACGGTGCTCAGGGAGTTTGTCATCTTCCTGTAA
ATATGAAGGAAATGGAATATGATTTTTATGTTTTTTCTGCGCATAAGATGTTGGGTCCGACCGGAGTAGGGGTTTTGTAT
GCAAAGGAAGAAATCTTAGAAGAGATGCCTCCTTGGATGGGTGGAGGAGATATGATTGCTCAAGTATATAAGGAAAAATC
TACTTATGCGGAACTTCCATCCAAACTGGAAGCGGGAACTCCGAATATTGCGGGCGTAATTGGATTTGGATCTGCGATCG
AATATCTCGAAAATATAGGGATGCAAGAAATTAGAAATCATGAAATAGAATTGCTCTCGTATGCTTTGAATCGATTGGAT
GATTTTGGTGGTTTGGAACTTTATGGAACTAGGGATTTATCCAAAAGAGGAGGAGTGATTTCTTTTAACTTTCCAGGTGT
ACATCCTCATGACGTAGGAACAATTTTAGACGAAGAGGGAATTGCAATCCGAGTCGGGCATCATTGTGCGCAACCTTTTA
TGGCGTTTCAAAATATTCCTGGGACTTGTCGGGCGAGTCTTTATCTTTATAATACAAAAGATGACATTGATCGATTGATT
CAAGGTCTAATTAAGGTAAAGGAGATTTTCTCCCGTGTCCTTAAGCGATAG

Upstream 100 bases:

>100_bases
CCATCAAAACCGGAAAAGCGCTTTGTATGCCCGCTGTGGAAAATCTTCCGGTTTATCCGGTGAGAATCGTAGATGACTCC
GTCGAGGTAGATTTGGAGGA

Downstream 100 bases:

>100_bases
TTTATATAAAGAAGTAATTCTAGATCATTATCAAAACCCTAGATTTCGGGGAAAACTGGAATCTGCCGATTTATACGAAC
ATGGGATCAATCCACTTTGT

Product: selenocysteine reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MTDMSFSAERIRTDFPILGTKMNGKPLVFLDSAASSQKPFTVIDTIEKYYREENANIHRGIYYLSQKATEKYELSRIRLS
KFIGAQCAKVCIFTRNATESINLVAQTWGRTQIKEGDEIVLNELEHHSNIVPWQMLAQEKKAVLKFIPLNEDSTLDFSNL
QEIITTKTKLVAISQMSNVTGTIHDILPVQKRAKEVGAKLLVDGAQGVCHLPVNMKEMEYDFYVFSAHKMLGPTGVGVLY
AKEEILEEMPPWMGGGDMIAQVYKEKSTYAELPSKLEAGTPNIAGVIGFGSAIEYLENIGMQEIRNHEIELLSYALNRLD
DFGGLELYGTRDLSKRGGVISFNFPGVHPHDVGTILDEEGIAIRVGHHCAQPFMAFQNIPGTCRASLYLYNTKDDIDRLI
QGLIKVKEIFSRVLKR

Sequences:

>Translated_416_residues
MTDMSFSAERIRTDFPILGTKMNGKPLVFLDSAASSQKPFTVIDTIEKYYREENANIHRGIYYLSQKATEKYELSRIRLS
KFIGAQCAKVCIFTRNATESINLVAQTWGRTQIKEGDEIVLNELEHHSNIVPWQMLAQEKKAVLKFIPLNEDSTLDFSNL
QEIITTKTKLVAISQMSNVTGTIHDILPVQKRAKEVGAKLLVDGAQGVCHLPVNMKEMEYDFYVFSAHKMLGPTGVGVLY
AKEEILEEMPPWMGGGDMIAQVYKEKSTYAELPSKLEAGTPNIAGVIGFGSAIEYLENIGMQEIRNHEIELLSYALNRLD
DFGGLELYGTRDLSKRGGVISFNFPGVHPHDVGTILDEEGIAIRVGHHCAQPFMAFQNIPGTCRASLYLYNTKDDIDRLI
QGLIKVKEIFSRVLKR
>Mature_415_residues
TDMSFSAERIRTDFPILGTKMNGKPLVFLDSAASSQKPFTVIDTIEKYYREENANIHRGIYYLSQKATEKYELSRIRLSK
FIGAQCAKVCIFTRNATESINLVAQTWGRTQIKEGDEIVLNELEHHSNIVPWQMLAQEKKAVLKFIPLNEDSTLDFSNLQ
EIITTKTKLVAISQMSNVTGTIHDILPVQKRAKEVGAKLLVDGAQGVCHLPVNMKEMEYDFYVFSAHKMLGPTGVGVLYA
KEEILEEMPPWMGGGDMIAQVYKEKSTYAELPSKLEAGTPNIAGVIGFGSAIEYLENIGMQEIRNHEIELLSYALNRLDD
FGGLELYGTRDLSKRGGVISFNFPGVHPHDVGTILDEEGIAIRVGHHCAQPFMAFQNIPGTCRASLYLYNTKDDIDRLIQ
GLIKVKEIFSRVLKR

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=270, Percent_Identity=23.7037037037037, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI156713448, Length=327, Percent_Identity=25.0764525993884, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI1787970, Length=408, Percent_Identity=49.2647058823529, Blast_Score=429, Evalue=1e-121,
Organism=Escherichia coli, GI1789175, Length=405, Percent_Identity=40, Blast_Score=333, Evalue=1e-92,
Organism=Escherichia coli, GI48994898, Length=351, Percent_Identity=24.5014245014245, Blast_Score=90, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI25143064, Length=230, Percent_Identity=27.8260869565217, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI193211090, Length=381, Percent_Identity=24.9343832020997, Blast_Score=88, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6319831, Length=233, Percent_Identity=26.1802575107296, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI20129463, Length=320, Percent_Identity=25.625, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 46687; Mature: 46556

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDMSFSAERIRTDFPILGTKMNGKPLVFLDSAASSQKPFTVIDTIEKYYREENANIHRG
CCCCCCCHHHHCCCCCEEEECCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCHHHH
IYYLSQKATEKYELSRIRLSKFIGAQCAKVCIFTRNATESINLVAQTWGRTQIKEGDEIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHCCCCCCCCCCHHH
LNELEHHSNIVPWQMLAQEKKAVLKFIPLNEDSTLDFSNLQEIITTKTKLVAISQMSNVT
HHHHHHCCCCCCHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHEEEHHHHHCCC
GTIHDILPVQKRAKEVGAKLLVDGAQGVCHLPVNMKEMEYDFYVFSAHKMLGPTGVGVLY
HHHHHHHHHHHHHHHCCCEEEEECCCCEEECCCCHHHCEEEEEEEEHHHHCCCCCCEEEE
AKEEILEEMPPWMGGGDMIAQVYKEKSTYAELPSKLEAGTPNIAGVIGFGSAIEYLENIG
EHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHCCCCCCCEEEEEHHHHHHHHHHCC
MQEIRNHEIELLSYALNRLDDFGGLELYGTRDLSKRGGVISFNFPGVHPHDVGTILDEEG
HHHHHCHHHHHHHHHHHHHCCCCCEEEEECCCHHHCCCEEEECCCCCCCCCCHHHCCCCC
IAIRVGHHCAQPFMAFQNIPGTCRASLYLYNTKDDIDRLIQGLIKVKEIFSRVLKR
CEEEECHHHHHHHHHHHCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TDMSFSAERIRTDFPILGTKMNGKPLVFLDSAASSQKPFTVIDTIEKYYREENANIHRG
CCCCCCHHHHCCCCCEEEECCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCHHHH
IYYLSQKATEKYELSRIRLSKFIGAQCAKVCIFTRNATESINLVAQTWGRTQIKEGDEIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHCCCCCCCCCCHHH
LNELEHHSNIVPWQMLAQEKKAVLKFIPLNEDSTLDFSNLQEIITTKTKLVAISQMSNVT
HHHHHHCCCCCCHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHEEEHHHHHCCC
GTIHDILPVQKRAKEVGAKLLVDGAQGVCHLPVNMKEMEYDFYVFSAHKMLGPTGVGVLY
HHHHHHHHHHHHHHHCCCEEEEECCCCEEECCCCHHHCEEEEEEEEHHHHCCCCCCEEEE
AKEEILEEMPPWMGGGDMIAQVYKEKSTYAELPSKLEAGTPNIAGVIGFGSAIEYLENIG
EHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHCCCCCCCEEEEEHHHHHHHHHHCC
MQEIRNHEIELLSYALNRLDDFGGLELYGTRDLSKRGGVISFNFPGVHPHDVGTILDEEG
HHHHHCHHHHHHHHHHHHHCCCCCEEEEECCCHHHCCCEEEECCCCCCCCCCHHHCCCCC
IAIRVGHHCAQPFMAFQNIPGTCRASLYLYNTKDDIDRLIQGLIKVKEIFSRVLKR
CEEEECHHHHHHHHHHHCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA